Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in rats

Journal of Medicinal Chemistry

Volumn 54, Issue 1, 2011, Pages 342-353

  Dhanya, Raveendra Panickar ^a   Sidique, Shyama ^a   Sheffler, Douglas J ^b   Nickols, Hilary Highfield ^b   Herath, Ananda ^a   Yang, Li ^a   Dahl, Russell ^a   Ardecky, Robert ^a   Semenova, Svetlana ^c   Markou, Athina ^c   Conn, P Jeffrey ^b   Cosford, Nicholas D P ^a  

^a BURNHAM INSTITUTE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 CHLORO 3' [(2 CYCLOPENTYL 3 OXO 2,3 DIHYDROBENZO(DEXTRO)ISOTHIAZOL 6 YLOXY)METHYL]BIPHENYL 4 CARBOXYLIC ACID; CARBOXYLIC ACID; COCAINE; METABOTROPIC RECEPTOR 2; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; COCAINE DEPENDENCE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BRAIN LEVEL; DRUG DESIGN; DRUG HALF LIFE; DRUG MEGADOSE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SELF ADMINISTRATION; DRUG SYNTHESIS; IN VITRO STUDY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ALLOSTERIC REGULATION; ANIMALS; BENZOTHIAZOLES; BIOLOGICAL AVAILABILITY; BRAIN; CHLOROBENZOATES; COCAINE; COCAINE-RELATED DISORDERS; DRUG DESIGN; HEK293 CELLS; HUMANS; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; SELF ADMINISTRATION; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION;

EID: 78651098964     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1012165     Document Type: Article

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