A significantly improved condition for cyclization of phenethylcarbamates to N-alkylated 3,4-dihydroisoquinolones

Tetrahedron Letters

Volumn 39, Issue 37, 1998, Pages 6609-6612

  Wang, Xiao Jun ^a   Tan, Jonathan ^a   Grozinger, Karl ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMIC ACID DERIVATIVE; ISOQUINOLINE DERIVATIVE;

ARTICLE; CYCLIZATION; DRUG ISOLATION; DRUG SYNTHESIS; ELECTRON TRANSPORT;

EID: 0032505249     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)01395-1     Document Type: Article

References (19)

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19. 3 promoted cyclization of primary phenethylcarbamates 5a and 5b to give 3,4-dihydroisoquinolones 6a and 6b in low yields. (equation presented) 5a: R=H 6a: R=H 36% 5b: R=OMe 6b: R=OMe 25%