Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 1: Identification and synthesis of phenyl-tetrazolyl acetophenones

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 21, 2004, Pages 5329-5332

  Pinkerton, Anthony B ^a   Cube, Rowena V ^a   Hutchinson, John H ^a   Rowe, Blake A ^a   Schaffhauser, Hervé ^a   Zhao, Xiumin ^a   Daggett, Lorrie P ^a   Vernier, Jean Michel ^a  

^a GENERAL ATOMICS   (United States)

Author keywords

GPCRs; Metabotropic glutamate receptors

Indexed keywords

ACETOPHENONE DERIVATIVE; GLUTAMATE RECEPTOR 2; GLUTAMATE RECEPTOR AGONIST;

ALLOSTERISM; ARTICLE; DRUG IDENTIFICATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ACETOPHENONES; ALLOSTERIC REGULATION; RECEPTORS, METABOTROPIC GLUTAMATE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLES;

EID: 5344253953     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.08.020     Document Type: Article

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23. All final compounds displayed spectral data (NMR, MS) that was consistent with the assigned structure