-
1
-
-
0029150110
-
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains CD25 breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
-
Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995; 155: 1151-1164.
-
(1995)
J. Immunol.
, vol.155
, pp. 1151-1164
-
-
Sakaguchi, S.1
Sakaguchi, N.2
Asano, M.3
Itoh, M.4
Toda, M.5
-
2
-
-
66149190937
-
Molecular orchestration of differentiation and function of regulatory T cells
-
Lu LF, Rudensky A. Molecular orchestration of differentiation and function of regulatory T cells. Genes Dev 2009; 23: 1270-1282.
-
(2009)
Genes. Dev.
, vol.23
, pp. 1270-1282
-
-
Lu, L.F.1
Rudensky, A.2
-
3
-
-
33646165128
-
A central role for central tolerance
-
Kyewski B, Klein L. A central role for central tolerance. Annu Rev Immunol 2006; 24: 571-606.
-
(2006)
Annu. Rev. Immunol.
, vol.24
, pp. 571-606
-
-
Kyewski, B.1
Klein, L.2
-
4
-
-
0037112047
-
Projection of an immunological self shadow within the thymus by the aire protein
-
Anderson MS, Venanzi ES, Klein L, Chen Z, Berzins SP, Turley SJ et al. Projection of an immunological self shadow within the thymus by the aire protein. Science 2002; 298: 1395-1401.
-
(2002)
Science
, vol.298
, pp. 1395-1401
-
-
Anderson, M.S.1
Venanzi, E.S.2
Klein, L.3
Chen, Z.4
Berzins, S.P.5
Turley, S.J.6
-
5
-
-
0346599403
-
Finnish-German apeced consortium an autoimmune disease APECED caused by mutations in a novel gene featuring two PHD-type zinc-finger domains
-
Finnish-German APECED Consortium. An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat Genet 1997; 17: 399-403.
-
(1997)
Nat. Genet.
, vol.17
, pp. 399-403
-
-
-
6
-
-
16944367194
-
Positional cloning of the APECED gene
-
Nagamine K, Peterson P, Scott HS, Kudoh J, Minoshima S, Heino M et al. Positional cloning of the APECED gene. Nat Genet 1997; 17: 393-398.
-
(1997)
Nat. Genet.
, vol.17
, pp. 393-398
-
-
Nagamine, K.1
Peterson, P.2
Scott, H.S.3
Kudoh, J.4
Minoshima, S.5
Heino, M.6
-
7
-
-
26844450449
-
How defects in central tolerance impinge on a deficiency in regulatory T cells
-
USA
-
Chen Z, Benoist C, Mathis D. How defects in central tolerance impinge on a deficiency in regulatory T cells. Proc Natl Acad Sci USA 2005; 102: 14735-14740.
-
(2005)
Proc. Natl. Acad. Sci.
, vol.102
, pp. 14735-14740
-
-
Chen, Z.1
Benoist, C.2
Mathis, D.3
-
8
-
-
14944348965
-
The role of BH3-only proteins in the immune system
-
Strasser A. The role of BH3-only proteins in the immune system. Nat Rev Immunol 2005; 5: 189-200.
-
(2005)
Nat. Rev. Immunol.
, vol.5
, pp. 189-200
-
-
Strasser, A.1
-
9
-
-
78651098126
-
Bcl-2-regulated cell death signalling in the prevention of autoimmunity
-
doi:10.1038/cddis.2010.27.
-
Tischner D, Woess C, Ottina E, Villunger A. Bcl-2-regulated cell death signalling in the prevention of autoimmunity. Cell Death Dis 2010; 1, e48; doi:10.1038/cddis.2010.27.
-
(2010)
Cell. Death Dis.
, vol.1
-
-
Tischner, D.1
Woess, C.2
Ottina, E.3
Villunger, A.4
-
10
-
-
37549048249
-
The BCL-2 protein family: Opposing activities that mediate cell death
-
Youle RJ, Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol 2008; 9: 47-59.
-
(2008)
Nat. Rev. Mol. Cell. Biol.
, vol.9
, pp. 47-59
-
-
Youle, R.J.1
Strasser, A.2
-
11
-
-
0026568919
-
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
-
Watanabe-Fukunaga R, Brannan CI, Copeland NG, Jenkins NA, Nagata S. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 1992; 356: 314-317.
-
(1992)
Nature
, vol.356
, pp. 314-317
-
-
Watanabe-Fukunaga, R.1
Brannan, C.I.2
Copeland, N.G.3
Jenkins, N.A.4
Nagata, S.5
-
12
-
-
0028223847
-
Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand
-
Takahashi T, Tanaka M, Brannan CI, Jenkins NA, Copeland NG, Suda T et al. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 1994; 76: 969-976.
-
(1994)
Cell
, vol.76
, pp. 969-976
-
-
Takahashi, T.1
Tanaka, M.2
Brannan, C.I.3
Jenkins, N.A.4
Copeland, N.G.5
Suda, T.6
-
13
-
-
0037279111
-
Autoimmune lymphoproliferative syndromes: Genetic defects of apoptosis pathways
-
Rieux-Laucat F, Le DF, Fischer A. Autoimmune lymphoproliferative syndromes: genetic defects of apoptosis pathways. Cell Death Differ 2003; 10: 124-133.
-
(2003)
Cell. Death Differ.
, vol.10
, pp. 124-133
-
-
Rieux-Laucat, F.1
Le, D.F.2
Fischer, A.3
-
14
-
-
0033607506
-
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses leukocyte homeostasis and to preclude autoimmunity
-
Bouillet P, Metcalf D, Huang DC, Tarlinton DM, Kay TW, Köntgen F et al. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 1999; 286: 1735-1738.
-
(1999)
Science
, vol.286
, pp. 1735-1738
-
-
Bouillet, P.1
Metcalf, D.2
Huang, D.C.3
Tarlinton, D.M.4
Kay, T.W.5
Köntgen, F.6
-
15
-
-
34547461299
-
NRAS mutation causes a human autoimmune lymphoproliferative syndrome
-
USA
-
Oliveira JB, Bidere N, Niemela JE, Zheng L, Sakai K, Nix CP et al. NRAS mutation causes a human autoimmune lymphoproliferative syndrome. Proc Natl Acad Sci USA 2007; 104: 8953-8958.
-
(2007)
Proc. Natl. Acad. Sci.
, vol.104
, pp. 8953-8958
-
-
Oliveira, J.B.1
Bidere, N.2
Niemela, J.E.3
Zheng, L.4
Sakai, K.5
Nix, C.P.6
-
16
-
-
72949104779
-
Antigen presentation in the thymus for positive selection and central tolerance induction
-
Klein L, Hinterberger M, Wirnsberger G, Kyewski B. Antigen presentation in the thymus for positive selection and central tolerance induction. Nat Rev Immunol 2009; 9: 833-844.
-
(2009)
Nat. Rev. Immunol.
, vol.9
, pp. 833-844
-
-
Klein, L.1
Hinterberger, M.2
Wirnsberger, G.3
Kyewski, B.4
-
17
-
-
0036794390
-
Deficiency in bak and bax perturbs thymic selection and lymphoid homeostasis
-
Rathmell JC, Lindsten T, ZongWX, Cinalli RM, Thompson CB. Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. Nat Immunol 2002; 3: 932-939.
-
(2002)
Nat. Immunol.
, vol.3
, pp. 932-939
-
-
Rathmell, J.C.1
Lindsten, T.2
Zong, W.X.3
Cinalli, R.M.4
Thompson, C.B.5
-
18
-
-
33845913794
-
Puma cooperates with Bim the rate-limiting BH3-only protein in cell death during lymphocyte development in apoptosis induction
-
Erlacher M, Labi V, Manzl C, Böck G, Tzankov A, Häcker G et al. Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction. J Exp Med 2006; 203: 2939-2951.
-
(2006)
J. Exp. Med.
, vol.203
, pp. 2939-2951
-
-
Erlacher, M.1
Labi, V.2
Manzl, C.3
Böck, G.4
Tzankov, A.5
Häcker, G.6
-
19
-
-
34548495797
-
Loss of Bim results in abnormal accumulation of mature CD4- CD8-CD44-CD25-thymocytes
-
Hutcheson J, Perlman H. Loss of Bim results in abnormal accumulation of mature CD4- CD8-CD44-CD25- thymocytes. Immunobiology 2007; 212: 629-636.
-
(2007)
Immunobiology
, vol.212
, pp. 629-636
-
-
Hutcheson, J.1
Perlman, H.2
-
21
-
-
65549089187
-
Thymic progenitor homing and lymphocyte homeostasis are linked via S1P-controlled expression of thymic Pselectin/ CCL25
-
Gossens K, Naus S, Corbel SY, Lin S, Rossi FM, Kast J et al. Thymic progenitor homing and lymphocyte homeostasis are linked via S1P-controlled expression of thymic Pselectin/ CCL25. J Exp Med 2009; 206: 761-778.
-
(2009)
J. Exp. Med.
, vol.206
, pp. 761-778
-
-
Gossens, K.1
Naus, S.2
Corbel, S.Y.3
Lin, S.4
Rossi, F.M.5
Kast, J.6
-
23
-
-
0028784289
-
Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment
-
Willerford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt FW. Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 1995; 3: 521-530.
-
(1995)
Immunity
, vol.3
, pp. 521-530
-
-
Willerford, D.M.1
Chen, J.2
Ferry, J.A.3
Davidson, L.4
Ma, A.5
Alt, F.W.6
-
24
-
-
0027015928
-
Glucocorticoid-induced apoptosis in the thymus
-
Cohen JJ. Glucocorticoid-induced apoptosis in the thymus. Semin Immunol 1992; 4: 363-369.
-
(1992)
Semin Immunol.
, vol.4
, pp. 363-369
-
-
Cohen, J.J.1
-
25
-
-
27944498156
-
TCR signaling inhibits glucocorticoid-induced apoptosis in murine thymocytes depending on the stage of development
-
Erlacher M, Knoflach M, Stec IE, Bock G, Wick G, Wiegers GJ. TCR signaling inhibits glucocorticoid-induced apoptosis in murine thymocytes depending on the stage of development. Eur J Immunol 2005; 35: 3287-3296.
-
(2005)
Eur. J. Immunol.
, vol.35
, pp. 3287-3296
-
-
Erlacher, M.1
Knoflach, M.2
Stec, I.E.3
Bock, G.4
Wick, G.5
Wiegers, G.J.6
-
26
-
-
0022645487
-
Rapid in vivo effects of glucocorticoids on the integrity of rat lymphocyte genomic deoxyribonucleic acid
-
Compton MM, Cidlowski JA. Rapid in vivo effects of glucocorticoids on the integrity of rat lymphocyte genomic deoxyribonucleic acid. Endocrinology 1986; 118: 38-45.
-
(1986)
Endocrinology
, vol.118
, pp. 38-45
-
-
Compton, M.M.1
Cidlowski, J.A.2
-
27
-
-
0027238610
-
+ thymocytes in vivo by anti-CD3 or 5¢-N-ethyl-carboxamide adenosine is blocked by glucocorticoid receptor antagonist RU-486
-
+ thymocytes in vivo by anti-CD3 or 5¢-(N-ethyl)-carboxamide adenosine is blocked by glucocorticoid receptor antagonist RU-486. Eur J Immunol 1993; 23: 1246-1250.
-
(1993)
Eur. J. Immunol.
, vol.23
, pp. 1246-1250
-
-
Jondal, M.1
Okret, S.2
McConkey, D.3
-
28
-
-
0028219361
-
Thymocyte apoptosis induced by elevated endogenous corticosterone levels
-
Gruber J, Sgonc R, Hu YH, Beug H, Wick G. Thymocyte apoptosis induced by elevated endogenous corticosterone levels. Eur J Immunol 1994; 24: 1115-1121.
-
(1994)
Eur. J. Immunol.
, vol.24
, pp. 1115-1121
-
-
Gruber, J.1
Sgonc, R.2
Hu, Y.H.3
Beug, H.4
Wick, G.5
-
29
-
-
85025401429
-
The influence of the suprarenal gland on the thymus: III stimulation of the growth of the thymus gland following double suprarenalectomy in young rats
-
Jaffe HL. The influence of the suprarenal gland on the thymus: iii. Stimulation of the growth of the thymus gland following double suprarenalectomy in young rats. J ExpMed 1924; 40: 753-759.
-
(1924)
J. Exp. Med.
, vol.40
, pp. 753-759
-
-
Jaffe, H.L.1
-
30
-
-
26444472492
-
Thymus-derived glucocorticoids are insufficient for normal thymus homeostasis in the adult mouse
-
Pruett SB, Padgett EL. Thymus-derived glucocorticoids are insufficient for normal thymus homeostasis in the adult mouse. BMC Immunol 2004; 5: 24.
-
(2004)
BMC Immunol.
, vol.5
, pp. 24
-
-
Pruett, S.B.1
Padgett, E.L.2
-
31
-
-
0028806218
-
A targeted glucocorticoid receptor antisense transgene increases thymocyte apoptosis and alters thymocyte development
-
King LB, Vacchio MS, Dixon K, Hunziker R, Margulies DH, Ashwell JD. A targeted glucocorticoid receptor antisense transgene increases thymocyte apoptosis and alters thymocyte development. Immunity 1995; 3: 647-656.
-
(1995)
Immunity
, vol.3
, pp. 647-656
-
-
King, L.B.1
Vacchio, M.S.2
Dixon, K.3
Hunziker, R.4
Margulies, D.H.5
Ashwell, J.D.6
-
32
-
-
0034143917
-
Thymocyte resistance to glucocorticoids leads to antigen-specific unresponsiveness due to holes in the T cell repertoire
-
Lu FW, Yasutomo K, Goodman GB, McHeyzer-Williams LJ, McHeyzer-Williams MG, Germain RN et al. Thymocyte resistance to glucocorticoids leads to antigen-specific unresponsiveness due to holes in the T cell repertoire. Immunity 2000; 12: 183-192.
-
(2000)
Immunity
, vol.12
, pp. 183-192
-
-
Lu, F.W.1
Yasutomo, K.2
Goodman, G.B.3
McHeyzer-Williams, L.J.4
McHeyzer-Williams, M.G.5
Germain, R.N.6
-
33
-
-
0036581326
-
Effects of altered glucocorticoid sensitivity in the T cell lineage on thymocyte and T cell homeostasis
-
Pazirandeh A, Xue Y, Prestegaard T, Jondal M, Okret S. Effects of altered glucocorticoid sensitivity in the T cell lineage on thymocyte and T cell homeostasis. FASEB J 2002; 16: 727-729.
-
(2002)
FASEB J.
, vol.16
, pp. 727-729
-
-
Pazirandeh, A.1
Xue, Y.2
Prestegaard, T.3
Jondal, M.4
Okret, S.5
-
34
-
-
0033715726
-
Intrathymic T cell development and selection proceeds normally in the absence of glucocorticoid receptor signaling
-
Purton JF, Boyd RL, Cole TJ, Godfrey DI. Intrathymic T cell development and selection proceeds normally in the absence of glucocorticoid receptor signaling. Immunity 2000; 13: 179-186.
-
(2000)
Immunity
, vol.13
, pp. 179-186
-
-
Purton, J.F.1
Boyd, R.L.2
Cole, T.J.3
Godfrey, D.I.4
-
35
-
-
0036909641
-
Glucocorticoid receptor deficient thymic and peripheral T cells develop normally in adult mice
-
Purton JF, Zhan Y, Liddicoat DR, Hardy CL, Lew AM, Cole TJ et al. Glucocorticoid receptor deficient thymic and peripheral T cells develop normally in adult mice. Eur J Immunol 2002; 32: 3546-3555.
-
(2002)
Eur. J. Immunol.
, vol.32
, pp. 3546-3555
-
-
Purton, J.F.1
Zhan, Y.2
Liddicoat, D.R.3
Hardy, C.L.4
Lew, A.M.5
Cole, T.J.6
-
36
-
-
0042767698
-
Disruption of glucocorticoid receptor exon 2 yields a ligandresponsive C-terminal fragment that regulates gene expression
-
Mittelstadt PR, Ashwell JD. Disruption of glucocorticoid receptor exon 2 yields a ligandresponsive C-terminal fragment that regulates gene expression. Mol Endocrinol 2003; 17: 1534-1542.
-
(2003)
Mol. Endocrinol.
, vol.17
, pp. 1534-1542
-
-
Mittelstadt, P.R.1
Ashwell, J.D.2
-
37
-
-
0037103223
-
Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo
-
Brewer JA, Kanagawa O, Sleckman BP, Muglia LJ. Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo. J Immunol 2002; 169: 1837-1843.
-
(2002)
J. Immunol.
, vol.169
, pp. 1837-1843
-
-
Brewer, J.A.1
Kanagawa, O.2
Sleckman, B.P.3
Muglia, L.J.4
-
38
-
-
0142137222
-
T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation
-
Brewer JA, Khor B, Vogt SK, Muglia LM, Fujiwara H, Haegele KE et al. T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation. Nat Med 2003; 9: 1318-1322.
-
(2003)
Nat. Med.
, vol.9
, pp. 1318-1322
-
-
Brewer, J.A.1
Khor, B.2
Vogt, S.K.3
Muglia, L.M.4
Fujiwara, H.5
Haegele, K.E.6
-
39
-
-
22144465538
-
Glucocorticoids inhibit activation-induced cell death AICD via direct DNA-dependent repression of the CD95 ligand gene by a glucocorticoid receptor dimer
-
Baumann S, Dostert A, Novac N, Bauer A, Schmid W, Fas SC et al. Glucocorticoids inhibit activation-induced cell death (AICD) via direct DNA-dependent repression of the CD95 ligand gene by a glucocorticoid receptor dimer. Blood 2005; 106: 617-625.
-
(2005)
Blood
, vol.106
, pp. 617-625
-
-
Baumann, S.1
Dostert, A.2
Novac, N.3
Bauer, A.4
Schmid, W.5
Fas, S.C.6
-
40
-
-
18144444807
-
DNA binding of the glucocorticoid receptor is not essential for survival
-
Reichardt HM, Kaestner KH, Tuckermann J, Kretz O, Wessely O, Bock R et al. DNA binding of the glucocorticoid receptor is not essential for survival. Cell 1998; 93: 531-541.
-
(1998)
Cell
, vol.93
, pp. 531-541
-
-
Reichardt, H.M.1
Kaestner, K.H.2
Tuckermann, J.3
Kretz, O.4
Wessely, O.5
Bock, R.6
-
41
-
-
0028233225
-
Steroid production in the thymus: Implications for thymocyte selection
-
Vacchio MS, Papadopoulos V, Ashwell JD. Steroid production in the thymus: implications for thymocyte selection. J Exp Med 1994; 179: 1835-1846.
-
(1994)
J. Exp. Med.
, vol.179
, pp. 1835-1846
-
-
Vacchio, M.S.1
Papadopoulos, V.2
Ashwell, J.D.3
-
42
-
-
0032896835
-
Paracrine glucocorticoid activity produced by mouse thymic epithelial cells
-
Pazirandeh A, Xue Y, Rafter I, Sjovall J, Jondal M, Okret S. Paracrine glucocorticoid activity produced by mouse thymic epithelial cells. FASEB J 1999; 13: 893-901.
-
(1999)
FASEB J.
, vol.13
, pp. 893-901
-
-
Pazirandeh, A.1
Xue, Y.2
Rafter, I.3
Sjovall, J.4
Jondal, M.5
Okret, S.6
-
43
-
-
0033485432
-
Specialized ability of thymic epithelial cells to mediate positive selection does not require expression of the steroidogenic enzyme p450scc
-
Jenkinson EJ, Parnell S, Shuttleworth J, Owen JJ, Anderson G. Specialized ability of thymic epithelial cells to mediate positive selection does not require expression of the steroidogenic enzyme p450scc. J Immunol 1999; 163: 5781-5785.
-
(1999)
J. Immunol.
, vol.163
, pp. 5781-5785
-
-
Jenkinson, E.J.1
Parnell, S.2
Shuttleworth, J.3
Owen, J.J.4
Anderson, G.5
-
44
-
-
0343550300
-
Glucocorticoid production in the murine thymus
-
Lechner O, Wiegers GJ, Oliveira-Dos-Santos AJ, Dietrich H, Recheis H, Waterman M et al. Glucocorticoid production in the murine thymus. Eur J Immunol 2000; 30: 337-346.
-
(2000)
Eur. J. Immunol.
, vol.30
, pp. 337-346
-
-
Lechner, O.1
Wiegers, G.J.2
Oliveira-Dos-Santos, A.J.3
Dietrich, H.4
Recheis, H.5
Waterman, M.6
-
45
-
-
51649089799
-
Age-related synthesis of glucocorticoids in thymocytes
-
Qiao S, Chen L, Okret S, Jondal M. Age-related synthesis of glucocorticoids in thymocytes. Exp Cell Res 2008; 314: 3027-3035.
-
(2008)
Exp. Cell. Res.
, vol.314
, pp. 3027-3035
-
-
Qiao, S.1
Chen, L.2
Okret, S.3
Jondal, M.4
-
46
-
-
18844421375
-
Conditional expression of a glucocorticoid receptor transgene in thymocytes reveals a role for thymic-derived glucocorticoids in thymopoiesis in vivo
-
Pazirandeh A, Jondal M, Okret S. Conditional expression of a glucocorticoid receptor transgene in thymocytes reveals a role for thymic-derived glucocorticoids in thymopoiesis in vivo. Endocrinology 2005; 146: 2501-2507.
-
(2005)
Endocrinology
, vol.146
, pp. 2501-2507
-
-
Pazirandeh, A.1
Jondal, M.2
Okret, S.3
-
47
-
-
69249150559
-
Thymocyte-synthesized glucocorticoids play a role in thymocyte homeostasis and are down-regulated by adrenocorticotropic hormone
-
Qiao S, Okret S, Jondal M. Thymocyte-synthesized glucocorticoids play a role in thymocyte homeostasis and are down-regulated by adrenocorticotropic hormone. Endocrinology 2009; 150: 4163-4169.
-
(2009)
Endocrinology
, vol.150
, pp. 4163-4169
-
-
Qiao, S.1
Okret, S.2
Jondal, M.3
-
48
-
-
78649739588
-
Thymus-derived glucocorticoids mediate androgen effects on thymocyte homeostasis
-
e-pub ahead of print 26 August 2010; doi:10.1096/fj.10-168724).
-
Chen Y, Qiao S, Tuckermann J, Okret S, Jondal M. Thymus-derived glucocorticoids mediate androgen effects on thymocyte homeostasis. FASEB J 2010 (e-pub ahead of print 26 August 2010; doi:10.1096/fj.10-168724).
-
(2010)
FASEB J.
-
-
Chen, Y.1
Qiao, S.2
Tuckermann, J.3
Okret, S.4
Jondal, M.5
-
49
-
-
23444461765
-
Activation of thymic regeneration in mice and humans following androgen blockade
-
Sutherland JS, Goldberg GL, Hammett MV, Uldrich AP, Berzins SP, Heng TS et al. Activation of thymic regeneration in mice and humans following androgen blockade. J Immunol 2005; 175: 2741-2753.
-
(2005)
J. Immunol.
, vol.175
, pp. 2741-2753
-
-
Sutherland, J.S.1
Goldberg, G.L.2
Hammett, M.V.3
Uldrich, A.P.4
Berzins, S.P.5
Heng, T.S.6
-
50
-
-
28844472952
-
BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation-and glucocorticoid-induced apoptosis of lymphoid cells in vivo
-
Erlacher M, Michalak EM, Kelly PN, Labi V, Niederegger H, Coultas L et al. BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo. Blood 2005; 106: 4131-4138.
-
(2005)
Blood
, vol.106
, pp. 4131-4138
-
-
Erlacher, M.1
Michalak, E.M.2
Kelly, P.N.3
Labi, V.4
Niederegger, H.5
Coultas, L.6
-
52
-
-
27744485874
-
Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion
-
Thien CB, Blystad FD, Zhan Y, Lew AM, Voigt V, Andoniou CE et al. Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion. EMBO J 2005; 24: 3807-3819.
-
(2005)
EMBO J.
, vol.24
, pp. 3807-3819
-
-
Thien, C.B.1
Blystad, F.D.2
Zhan, Y.3
Lew, A.M.4
Voigt, V.5
Andoniou, C.E.6
-
53
-
-
77951230459
-
c-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol 3-kinase/Akt pathway
-
Thien CB, Dagger SA, Steer JH, Koentgen F, Jansen ES, Scott CL et al. c-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol 3- kinase/Akt pathway. J Biol Chem 2010; 285: 10969-10981.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 10969-10981
-
-
Thien, C.B.1
Dagger, S.A.2
Steer, J.H.3
Koentgen, F.4
Jansen, E.S.5
Scott, C.L.6
-
54
-
-
12344298492
-
Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes
-
McCarty N, Paust S, Ikizawa K, Dan I, Li X, Cantor H. Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes. Nat Immunol 2005; 6: 65-72.
-
(2005)
Nat. Immunol.
, vol.6
, pp. 65-72
-
-
McCarty, N.1
Paust, S.2
Ikizawa, K.3
Dan, I.4
Li, X.5
Cantor, H.6
-
56
-
-
68149105937
-
Bim and Bmf in tissue homeostasis and malignant disease
-
Pinon JD, Labi V, Egle A, Villunger A. Bim and Bmf in tissue homeostasis and malignant disease. Oncogene 2008; 27(Suppl 1): S41-S52.
-
(2008)
Oncogene
, vol.27
, Issue.1
-
-
Pinon, J.D.1
Labi, V.2
Egle, A.3
Villunger, A.4
-
57
-
-
0037148840
-
BH3-only Bcl-2 family member bim is required for apoptosis of autoreactive thymocytes
-
Bouillet P, Purton JF, Godfrey DI, Zhang LC, Coultas L, Puthalakath H et al. BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature 2002; 415: 922-926.
-
(2002)
Nature
, vol.415
, pp. 922-926
-
-
Bouillet, P.1
Purton, J.F.2
Godfrey, D.I.3
Zhang, L.C.4
Coultas, L.5
Puthalakath, H.6
-
58
-
-
2342458871
-
+8-HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling
-
USA
-
Villunger A, Marsden VS, Zhan Y, Erlacher M, Lew AM, Bouillet P et al. Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling. Proc Natl Acad Sci USA 2004; 101: 7052-7057.
-
(2004)
Proc. Natl. Acad. Sci.
, Issue.101
, pp. 7052-7057
-
-
Villunger, A.1
Marsden, V.S.2
Zhan, Y.3
Erlacher, M.4
Lew, A.M.5
Bouillet, P.6
-
59
-
-
10344231974
-
Generalized resistance to thymic deletion in the NOD mouse; A polygenic trait characterized by defective induction of bim
-
Liston A, Lesage S, Gray DH, OReilly LA, Strasser A, Fahrer AM et al. Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim. Immunity 2004; 21: 817-830.
-
(2004)
Immunity
, vol.21
, pp. 817-830
-
-
Liston, A.1
Lesage, S.2
Gray, D.H.3
O'Reilly, L.A.4
Strasser, A.5
Fahrer, A.M.6
-
60
-
-
0035514046
-
Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist bim
-
Bouillet P, Cory S, Zhang LC, Strasser A, Adams JM. Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim. Dev Cell 2001; 1: 645-653.
-
(2001)
Dev. Cell.
, vol.1
, pp. 645-653
-
-
Bouillet, P.1
Cory, S.2
Zhang, L.C.3
Strasser, A.4
Adams, J.M.5
-
61
-
-
67650999861
-
Critical roles of Bim in T cell activation and T cell-mediated autoimmune inflammation in mice
-
Ludwinski MW, Sun J, Hilliard B, Gong S, Xue F, Carmody RJ et al. Critical roles of Bim in T cell activation and T cell-mediated autoimmune inflammation in mice. J Clin Invest 2009; 119: 1706-1713.
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 1706-1713
-
-
Ludwinski, M.W.1
Sun, J.2
Hilliard, B.3
Gong, S.4
Xue, F.5
Carmody, R.J.6
-
62
-
-
76249119276
-
Bim-mediated apoptosis is not necessary for thymic negative selection to ubiquitous self-antigens
-
Hu Q, Sader A, Parkman JC, Baldwin TA. Bim-mediated apoptosis is not necessary for thymic negative selection to ubiquitous self-antigens. J Immunol 2009; 183: 7761-7767.
-
(2009)
J. Immunol.
, vol.183
, pp. 7761-7767
-
-
Hu, Q.1
Sader, A.2
Parkman, J.C.3
Baldwin, T.A.4
-
63
-
-
77649252927
-
A novel TCR transgenic model reveals that negative selection involves an immediate bim-dependent pathway and a delayed bim-independent pathway
-
Kovalovsky D, Pezzano M, Ortiz BD, Santangelo DB. A novel TCR transgenic model reveals that negative selection involves an immediate, Bim-dependent pathway and a delayed, Bim-independent pathway. PLoS One 2010; 5: e8675.
-
(2010)
PLoS One
, vol.5
-
-
Kovalovsky, D.1
Pezzano, M.2
Ortiz, B.D.3
Santangelo, D.B.4
-
64
-
-
43549097825
-
During negative selection Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain
-
Thompson J, Winoto A. During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain. J Exp Med 2008; 205: 1029-1036.
-
(2008)
J. Exp. Med.
, vol.205
, pp. 1029-1036
-
-
Thompson, J.1
Winoto, A.2
-
65
-
-
0025751550
-
Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
-
Sentman CL, Shutter JR, Hockenbery D, Kanagawa O, Korsmeyer SJ. bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 1991; 67: 879-888.
-
(1991)
Cell
, vol.67
, pp. 879-888
-
-
Sentman, C.L.1
Shutter, J.R.2
Hockenbery, D.3
Kanagawa, O.4
Korsmeyer, S.J.5
-
66
-
-
62249131518
-
Complete but curtailed T-cell response to very low-affinity antigen
-
Zehn D, Lee SY, Bevan MJ. Complete but curtailed T-cell response to very low-affinity antigen. Nature 2009; 458: 211-214.
-
(2009)
Nature
, vol.458
, pp. 211-214
-
-
Zehn, D.1
Lee, S.Y.2
Bevan, M.J.3
-
67
-
-
77953909758
-
Apoptosis threshold set by Noxa and Mcl-1 after T cell activation regulates competitive selection of high-affinity clones
-
Wensveen FM, van Gisbergen KP, Derks IA, Gerlach C, Schumacher TN, van Lier RA et al. Apoptosis threshold set by Noxa and Mcl-1 after T cell activation regulates competitive selection of high-affinity clones. Immunity 2010; 32: 754-765.
-
(2010)
Immunity
, vol.32
, pp. 754-765
-
-
Wensveen, F.M.1
Van Gisbergen, K.P.2
Derks, I.A.3
Gerlach, C.4
Schumacher, T.N.5
Van Lier, R.A.6
-
68
-
-
68149153007
-
Noxa: at the tip of the balance between life and death
-
Ploner C, Kofler R, Villunger A. Noxa: at the tip of the balance between life and death. Oncogene 2008; 27(Suppl 1): S84-S92.
-
(2008)
Oncogene
, vol.27
, Issue.1
-
-
Ploner, C.1
Kofler, R.2
Villunger, A.3
-
69
-
-
77953882820
-
Only the strong survive
-
Villunger A. Only the strong survive. Immunity 2010; 32: 729-731.
-
(2010)
Immunity
, vol.32
, pp. 729-731
-
-
Villunger, A.1
-
70
-
-
67649198526
-
The Bcl-2 family antagonist ABT-737 significantly inhibits multiple animal models of autoimmunity
-
Bardwell PD, Gu J, McCarthy D, Wallace C, Bryant S, Goess C et al. The Bcl-2 family antagonist ABT-737 significantly inhibits multiple animal models of autoimmunity. J Immunol 2009; 182: 7482-7489.
-
(2009)
J. Immunol.
, vol.182
, pp. 7482-7489
-
-
Bardwell, P.D.1
Gu, J.2
McCarthy, D.3
Wallace, C.4
Bryant, S.5
Goess, C.6
-
71
-
-
75749091858
-
Bim-Bcl-2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis
-
Scatizzi JC, Hutcheson J, Pope RM, Firestein GS, Koch AE, Mavers M et al. Bim-Bcl-2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis. Arthritis Rheum 2010; 62: 441-451.
-
(2010)
Arthritis Rheum.
, vol.62
, pp. 441-451
-
-
Scatizzi, J.C.1
Hutcheson, J.2
Pope, R.M.3
Firestein, G.S.4
Koch, A.E.5
Mavers, M.6
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