-
3
-
-
0346599403
-
An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains
-
Aaltonen, J., P. Björses, J. Perheentupa, N. Horelli-Kuitunen, A. Palotie, L. Peltonen, Y. S. Lee, F. Francis, S. Henning, C. Thiel, et al. 1997. An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat. Genet. 17: 399-403.
-
(1997)
Nat. Genet.
, vol.17
, pp. 399-403
-
-
Aaltonen, J.1
Björses, P.2
Perheentupa, J.3
Horelli-Kuitunen, N.4
Palotie, A.5
Peltonen, L.6
Lee, Y.S.7
Francis, F.8
Henning, S.9
Thiel, C.10
-
4
-
-
16944367194
-
Positional cloning of the APECED gene
-
Nagamine, K., P. Peterson, H. S. Scott, J. Kudoh, S. Minoshima, M. Heino, K. J. Krohn, M. D. Lalioti, P. E. Mullis, S. E. Antonarakis, et al. 1997. Positional cloning of the APECED gene. Nat. Genet. 17: 393-398.
-
(1997)
Nat. Genet.
, vol.17
, pp. 393-398
-
-
Nagamine, K.1
Peterson, P.2
Scott, H.S.3
Kudoh, J.4
Minoshima, S.5
Heino, M.6
Krohn, K.J.7
Lalioti, M.D.8
Mullis, P.E.9
Antonarakis, S.E.10
-
5
-
-
23844558032
-
The cellular mechanism of Aire control of T cell tolerance
-
Anderson, M. S., E. S. Venanzi, Z. Chen, S. P. Berzins, C. Benoist, and D. Mathis. 2005. The cellular mechanism of Aire control of T cell tolerance. Immunity 23: 227-239.
-
(2005)
Immunity
, vol.23
, pp. 227-239
-
-
Anderson, M.S.1
Venanzi, E.S.2
Chen, Z.3
Berzins, S.P.4
Benoist, C.5
Mathis, D.6
-
6
-
-
7244227646
-
Gene dosage-limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity
-
Liston, A., D. H. Gray, S. Lesage, A. L. Fletcher, J. Wilson, K. E. Webster, H. S. Scott, R. L. Boyd, L. Peltonen, and C. C. Goodnow. 2004. Gene dosage-limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity. J. Exp. Med. 200: 1015-1026.
-
(2004)
J. Exp. Med.
, vol.200
, pp. 1015-1026
-
-
Liston, A.1
Gray, D.H.2
Lesage, S.3
Fletcher, A.L.4
Wilson, J.5
Webster, K.E.6
Scott, H.S.7
Boyd, R.L.8
Peltonen, L.9
Goodnow, C.C.10
-
7
-
-
0037383758
-
Aire regulates negative selection of organ-specific T cells
-
Liston, A., S. Lesage, J. Wilson, L. Peltonen, and C. C. Goodnow. 2003. Aire regulates negative selection of organ-specific T cells. Nat. Immunol. 4: 350-354.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 350-354
-
-
Liston, A.1
Lesage, S.2
Wilson, J.3
Peltonen, L.4
Goodnow, C.C.5
-
8
-
-
33845607123
-
Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling
-
Daniels, M. A., E. Teixeiro, J. Gill, B. Hausmann, D. Roubaty, K. Holmberg, G. Werlen, G. A. Hollander, N. R. Gascoigne, and E. Palmer. 2006. Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling. Nature 444: 724-729.
-
(2006)
Nature
, vol.444
, pp. 724-729
-
-
Daniels, M.A.1
Teixeiro, E.2
Gill, J.3
Hausmann, B.4
Roubaty, D.5
Holmberg, K.6
Werlen, G.7
Hollander, G.A.8
Gascoigne, N.R.9
Palmer, E.10
-
9
-
-
0035500758
-
Duration and strength of extracellular signal-regulated kinase signals are altered during positive versus negative thymocyte selection
-
Mariathasan, S., A. Zakarian, D. Bouchard, A. M. Michie, J. C. Zuniga-Pflucker, and P. S. Ohashi. 2001. Duration and strength of extracellular signal-regulated kinase signals are altered during positive versus negative thymocyte selection. J. Immunol. 167: 4966-4973. (Pubitemid 33009727)
-
(2001)
Journal of Immunology
, vol.167
, Issue.9
, pp. 4966-4973
-
-
Mariathasan, S.1
Zakarian, A.2
Bouchard, D.3
Michie, A.M.4
Zuniga-Pflucker, J.C.5
Ohashi, P.S.6
-
10
-
-
26444483956
-
A requirement for sustained ERK signaling during thymocyte positive selection in vivo
-
McNeil, L. K., T. K. Starr, and K. A. Hogquist. 2005. A requirement for sustained ERK signaling during thymocyte positive selection in vivo. Proc. Natl. Acad. Sci. USA 102: 13574-13579.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 13574-13579
-
-
McNeil, L.K.1
Starr, T.K.2
Hogquist, K.A.3
-
11
-
-
58249087468
-
Origin of the sharp boundary that discriminates positive and negative selection of thymocytes
-
Prasad, A., J. Zikherman, J. Das, J. P. Roose, A. Weiss, and A. K. Chakraborty. 2009. Origin of the sharp boundary that discriminates positive and negative selection of thymocytes. Proc. Natl. Acad. Sci. USA 106: 528-533.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 528-533
-
-
Prasad, A.1
Zikherman, J.2
Das, J.3
Roose, J.P.4
Weiss, A.5
Chakraborty, A.K.6
-
12
-
-
0034720881
-
A motif in the αβ T-cell receptor controls positive selection by modulating ERK activity
-
DOI 10.1038/35019094
-
Werlen, G., B. Hausmann, and E. Palmer. 2000. A motif in the αβ T-cell receptor controls positive selection by modulating ERK activity. Nature 406: 422-426. (Pubitemid 30625563)
-
(2000)
Nature
, vol.406
, Issue.6794
, pp. 422-426
-
-
Werlen, G.1
Hausmann, B.2
Palmer, E.3
-
13
-
-
34548724573
-
Transcriptional analysis of clonal deletion in vivo
-
Baldwin, T. A., and K. A. Hogquist. 2007. Transcriptional analysis of clonal deletion in vivo. J. Immunol. 179: 837-844.
-
(2007)
J. Immunol.
, vol.179
, pp. 837-844
-
-
Baldwin, T.A.1
Hogquist, K.A.2
-
14
-
-
0037769101
-
Characterization of transcriptional regulation during negative selection in vivo
-
DeRyckere, D., D. L. Mann, and J. DeGregori. 2003. Characterization of transcriptional regulation during negative selection in vivo. J. Immunol. 171: 802-811. (Pubitemid 36871391)
-
(2003)
Journal of Immunology
, vol.171
, Issue.2
, pp. 802-811
-
-
DeRyckere, D.1
Mann, D.L.2
DeGregori, J.3
-
15
-
-
1842737707
-
Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals
-
Huang, Y. H., D. Li, A. Winoto, and E. A. Robey. 2004. Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals. Proc. Natl. Acad. Sci. USA 101: 4936-4941.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 4936-4941
-
-
Huang, Y.H.1
Li, D.2
Winoto, A.3
Robey, E.A.4
-
16
-
-
34147128008
-
Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: Genomic analysis by mRNA profiling
-
DOI 10.1186/gb-2007-8-1-r12
-
Liston, A., K. Hardy, Y. Pittelkow, S. R. Wilson, L. E. Makaroff, A. M. Fahrer, and C. C. Goodnow. 2007. Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling. Genome Biol. 8: R12. (Pubitemid 351910990)
-
(2007)
Genome Biology
, vol.8
, Issue.1
-
-
Liston, A.1
Hardy, K.2
Pittelkow, Y.3
Wilson, S.R.4
Makaroff, L.E.5
Fahrer, A.M.6
Goodnow, C.C.7
-
17
-
-
6344274985
-
The regulated expression of a diverse set of genes during thymocyte positive selection in vivo
-
Mick, V. E., T. K. Starr, T. M. McCaughtry, L. K. McNeil, and K. A. Hogquist. 2004. The regulated expression of a diverse set of genes during thymocyte positive selection in vivo. J. Immunol. 173: 5434-5444.
-
(2004)
J. Immunol.
, vol.173
, pp. 5434-5444
-
-
Mick, V.E.1
Starr, T.K.2
McCaughtry, T.M.3
McNeil, L.K.4
Hogquist, K.A.5
-
18
-
-
0141840803
-
Gene expression analysis of thymocyte selection in vivo
-
Schmitz, I., L. K. Clayton, and E. L. Reinherz. 2003. Gene expression analysis of thymocyte selection in vivo. Int. Immunol. 15: 1237-1248.
-
(2003)
Int. Immunol.
, vol.15
, pp. 1237-1248
-
-
Schmitz, I.1
Clayton, L.K.2
Reinherz, E.L.3
-
19
-
-
15244338878
-
Defective central tolerance induction in NOD mice: Genomics and genetics
-
DOI 10.1016/j.immuni.2005.01.015
-
Zucchelli, S., P. Holler, T. Yamagata, M. Roy, C. Benoist, and D. Mathis. 2005. Defective central tolerance induction in NOD mice: genomics and genetics. Immunity 22: 385-396. (Pubitemid 40387479)
-
(2005)
Immunity
, vol.22
, Issue.3
, pp. 385-396
-
-
Zucchelli, S.1
Holler, P.2
Yamagata, T.3
Roy, M.4
Benoist, C.5
Mathis, D.6
-
20
-
-
0037148840
-
BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
-
DOI 10.1038/415922a
-
Bouillet, P., J. F. Purton, D. I. Godfrey, L. C. Zhang, L. Coultas, H. Puthalakath, M. Pellegrini, S. Cory, J. M. Adams, and A. Strasser. 2002. BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature 415: 922-926. (Pubitemid 34174755)
-
(2002)
Nature
, vol.415
, Issue.6874
, pp. 922-926
-
-
Bouillet, P.1
Purton, J.F.2
Godfrey, D.I.3
Zhang, L.-C.4
Coultas, L.5
Puthalakath, H.6
Pellegrini, M.7
Cory, S.8
Adams, J.M.9
Strasser, A.10
-
21
-
-
2342458871
-
-HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling
-
-HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling. Proc. Natl. Acad. Sci. USA 101: 7052-7057.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 7052-7057
-
-
Villunger, A.1
Marsden, V.S.2
Zhan, Y.3
Erlacher, M.4
Lew, A.M.5
Bouillet, P.6
Berzins, S.7
Godfrey, D.I.8
Heath, W.R.9
Strasser, A.10
-
22
-
-
0033607506
-
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
-
Bouillet, P., D. Metcalf, D. C. Huang, D. M. Tarlinton, T. W. Kay, F. Kontgen, J. M. Adams, and A. Strasser. 1999. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286: 1735-1738. (Pubitemid 129515880)
-
(1999)
Science
, vol.286
, Issue.5445
, pp. 1735-1738
-
-
Bouillet, P.1
Metcalf, D.2
Huang, D.C.S.3
Tarlinton, D.M.4
Kay, T.W.H.5
Kontgen, F.6
Adams, J.M.7
Strasser, A.8
-
23
-
-
0028807837
-
A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection
-
Calnan, B. J., S. Szychowski, F. K. Chan, D. Cado, and A. Winoto. 1995. A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection. Immunity 3: 273-282.
-
(1995)
Immunity
, vol.3
, pp. 273-282
-
-
Calnan, B.J.1
Szychowski, S.2
Chan, F.K.3
Cado, D.4
Winoto, A.5
-
24
-
-
33750825270
-
+ thymocytes and mature T cells regulate Nur77 distinctly in response to TCR stimulation
-
+ thymocytes and mature T cells regulate Nur77 distinctly in response to TCR stimulation. J. Immunol. 177: 6660-6666.
-
(2006)
J. Immunol.
, vol.177
, pp. 6660-6666
-
-
Cunningham, N.R.1
Artim, S.C.2
Fornadel, C.M.3
Sellars, M.C.4
Edmonson, S.G.5
Scott, G.6
Albino, F.7
Mathur, A.8
Punt, J.A.9
-
25
-
-
0032723235
-
Nur77 transcription activity correlates with its apoptotic function in vivo
-
Kuang, A. A., D. Cado, and A. Winoto. 1999. Nur77 transcription activity correlates with its apoptotic function in vivo. Eur. J. Immunol. 29: 3722-3728.
-
(1999)
Eur. J. Immunol.
, vol.29
, pp. 3722-3728
-
-
Kuang, A.A.1
Cado, D.2
Winoto, A.3
-
26
-
-
10744221976
-
Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor
-
DOI 10.1093/emboj/cdg620
-
Rajpal, A., Y. A. Cho, B. Yelent, P. H. Koza-Taylor, D. Li, E. Chen, M. Whang, C. Kang, T. G. Turi, and A. Winoto. 2003. Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor. EMBO J. 22: 6526-6536. (Pubitemid 38009600)
-
(2003)
EMBO Journal
, vol.22
, Issue.24
, pp. 6526-6536
-
-
Rajpal, A.1
Cho, Y.A.2
Yelent, B.3
Koza-Taylor, P.H.4
Li, D.5
Chen, E.6
Whang, M.7
Kang, C.8
Turi, T.G.9
Winoto, A.10
-
27
-
-
43549097825
-
During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain
-
Thompson, J., and A. Winoto. 2008. During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain. J. Exp. Med. 205: 1029-1036.
-
(2008)
J. Exp. Med.
, vol.205
, pp. 1029-1036
-
-
Thompson, J.1
Winoto, A.2
-
28
-
-
35748975673
-
Bim and bcl-2 mutually affect the expression of the other in T cells
-
Jorgensen, T. N., A. McKee, M. Wang, E. Kushnir, J. White, Y. Refaeli, J. W. Kappler, and P. Marrack. 2007. Bim and bcl-2 mutually affect the expression of the other in T cells. J. Immunol. 179: 3417-3424.
-
(2007)
J. Immunol.
, vol.179
, pp. 3417-3424
-
-
Jorgensen, T.N.1
McKee, A.2
Wang, M.3
Kushnir, E.4
White, J.5
Refaeli, Y.6
Kappler, J.W.7
Marrack, P.8
-
29
-
-
22344450566
-
The timing of TCRα expression critically influences T cell development and selection
-
Baldwin, T. A., M. M. Sandau, S. C. Jameson, and K. A. Hogquist. 2005. The timing of TCRα expression critically influences T cell development and selection. J. Exp. Med. 202: 111-121.
-
(2005)
J. Exp. Med.
, vol.202
, pp. 111-121
-
-
Baldwin, T.A.1
Sandau, M.M.2
Jameson, S.C.3
Hogquist, K.A.4
-
30
-
-
57249095650
-
Central tolerance: What have we learned from mice? Semin
-
McCaughtry, T. M., and K. A. Hogquist. 2008. Central tolerance: what have we learned from mice? Semin. Immunopathol. 30: 399-409.
-
(2008)
Immunopathol.
, vol.30
, pp. 399-409
-
-
McCaughtry, T.M.1
Hogquist, K.A.2
-
31
-
-
58149154739
-
Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla
-
McCaughtry, T. M., T. A. Baldwin, M. S. Wilken, and K. A. Hogquist. 2008. Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla. J. Exp. Med. 205: 2575-2584.
-
(2008)
J. Exp. Med.
, vol.205
, pp. 2575-2584
-
-
McCaughtry, T.M.1
Baldwin, T.A.2
Wilken, M.S.3
Hogquist, K.A.4
-
32
-
-
0034610980
-
Facilitation of β selection and modification of positive selection in the thymus of PD-1-deficient mice
-
Nishimura, H., T. Honjo, and N. Minato. 2000. Facilitation of β selection and modification of positive selection in the thymus of PD-1-deficient mice. J. Exp. Med. 191: 891-898.
-
(2000)
J. Exp. Med.
, vol.191
, pp. 891-898
-
-
Nishimura, H.1
Honjo, T.2
Minato, N.3
-
34
-
-
58549090499
-
Regulation of lymphocyte progenitor survival by the proapoptotic activities of Bim and Bid
-
Mandal, M., K. M. Crusio, F. Meng, S. Liu, M. Kinsella, M. R. Clark, O. Takeuchi, and I. Aifantis. 2008. Regulation of lymphocyte progenitor survival by the proapoptotic activities of Bim and Bid. Proc. Natl. Acad. Sci. USA 105: 20840-20845.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 20840-20845
-
-
Mandal, M.1
Crusio, K.M.2
Meng, F.3
Liu, S.4
Kinsella, M.5
Clark, M.R.6
Takeuchi, O.7
Aifantis, I.8
-
35
-
-
0034507693
-
Impact of negative selection on the T cell repertoire reactive to a self-peptide: A large fraction of T cell clones escapes clonal deletion
-
DOI 10.1016/S1074-7613(00)00080-7
-
Bouneaud, C., P. Kourilsky, and P. Bousso. 2000. Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion. Immunity 13: 829-840. (Pubitemid 32041805)
-
(2000)
Immunity
, vol.13
, Issue.6
, pp. 829-840
-
-
Bouneaud, C.1
Kourilsky, P.2
Bousso, P.3
-
36
-
-
33747092627
-
T Cells with Low Avidity for a Tissue-Restricted Antigen Routinely Evade Central and Peripheral Tolerance and Cause Autoimmunity
-
DOI 10.1016/j.immuni.2006.06.009, PII S1074761306003426
-
Zehn, D., and M. J. Bevan. 2006. T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity. Immunity 25: 261-270. (Pubitemid 44224142)
-
(2006)
Immunity
, vol.25
, Issue.2
, pp. 261-270
-
-
Zehn, D.1
Bevan, M.J.2
-
37
-
-
38949119408
-
Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity
-
Hughes, P. D., G. T. Belz, K. A. Fortner, R. C. Budd, A. Strasser, and P. Bouillet. 2008. Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity. Immunity 28: 197-205.
-
(2008)
Immunity
, vol.28
, pp. 197-205
-
-
Hughes, P.D.1
Belz, G.T.2
Fortner, K.A.3
Budd, R.C.4
Strasser, A.5
Bouillet, P.6
-
38
-
-
38949209522
-
Combined Deficiency of Proapoptotic Regulators Bim and Fas Results in the Early Onset of Systemic Autoimmunity
-
DOI 10.1016/j.immuni.2007.12.015, PII S1074761308000356
-
Hutcheson, J., J. C. Scatizzi, A. M. Siddiqui, G. K. Haines, 3rd, T. Wu, Q. Z. Li, L. S. Davis, C. Mohan, and H. Perlman. 2008. Combined deficiency of proapoptotic regulators Bim and Fas results in the early onset of systemic autoimmunity. Immunity 28: 206-217. (Pubitemid 351215233)
-
(2008)
Immunity
, vol.28
, Issue.2
, pp. 206-217
-
-
Hutcheson, J.1
Scatizzi, J.C.2
Siddiqui, A.M.3
Haines III, G.K.4
Wu, T.5
Li, Q.-Z.6
Davis, L.S.7
Mohan, C.8
Perlman, H.9
-
40
-
-
0038725685
-
Negative selection: Clearing out the bad apples from the T-cell repertoire
-
Palmer, E. 2003. Negative selection: clearing out the bad apples from the T-cell repertoire. Nat. Rev. Immunol. 3: 383-391.
-
(2003)
Nat. Rev. Immunol.
, vol.3
, pp. 383-391
-
-
Palmer, E.1
-
41
-
-
0141958201
-
The central tolerance response to male antigen in normal mice is deletion and not receptor editing
-
Holman, P. O., E. R. Walsh, and K. A. Hogquist. 2003. The central tolerance response to male antigen in normal mice is deletion and not receptor editing. J. Immunol. 171: 4048-4053.
-
(2003)
J. Immunol.
, vol.171
, pp. 4048-4053
-
-
Holman, P.O.1
Walsh, E.R.2
Hogquist, K.A.3
-
42
-
-
42649125225
-
PD-1 and its ligands in tolerance and immunity
-
Keir, M. E., M. J. Butte, G. J. Freeman, and A. H. Sharpe. 2008. PD-1 and its ligands in tolerance and immunity. Annu. Rev. Immunol. 26: 677-704.
-
(2008)
Annu. Rev. Immunol.
, vol.26
, pp. 677-704
-
-
Keir, M.E.1
Butte, M.J.2
Freeman, G.J.3
Sharpe, A.H.4
-
43
-
-
32244432265
-
CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance
-
DOI 10.1016/j.immuni.2005.12.011, PII S1074761306000021
-
Kurobe, H., C. Liu, T. Ueno, F. Saito, I. Ohigashi, N. Seach, R. Arakaki, Y. Hayashi, T. Kitagawa, M. Lipp, et al. 2006. CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance. Immunity 24: 165-177. (Pubitemid 43214586)
-
(2006)
Immunity
, vol.24
, Issue.2
, pp. 165-177
-
-
Kurobe, H.1
Liu, C.2
Ueno, T.3
Saito, F.4
Ohigashi, I.5
Seach, N.6
Arakaki, R.7
Hayashi, Y.8
Kitagawa, T.9
Lipp, M.10
Boyd, R.L.11
Takahama, Y.12
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