-
1
-
-
0037169358
-
Apoptosis: A link between cancer genetics and chemotherapy
-
Johnstone RW, Ruefli AA, Lowe SW. Apoptosis: a link between cancer genetics and chemotherapy. Cell. 2002;108:153-164.
-
(2002)
Cell
, vol.108
, pp. 153-164
-
-
Johnstone, R.W.1
Ruefli, A.A.2
Lowe, S.W.3
-
2
-
-
0036716281
-
The bcl-2 family: Regulators of the cellular life-or-death switch
-
Cory S, Adams JM. The bcl-2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer. 2002;2:647-656.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 647-656
-
-
Cory, S.1
Adams, J.M.2
-
3
-
-
0036674617
-
Live or let die: The cell's response to p53
-
Vousden KH, Lu X. Live or let die: the cell's response to p53. Nat Rev Cancer. 2002;2:594-604.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 594-604
-
-
Vousden, K.H.1
Lu, X.2
-
4
-
-
0034641963
-
Defying death after DNA damage
-
Rich T, Allen RL, Wyllie AH. Defying death after DNA damage. Nature. 2000;407:777-783.
-
(2000)
Nature
, vol.407
, pp. 777-783
-
-
Rich, T.1
Allen, R.L.2
Wyllie, A.H.3
-
5
-
-
0027359827
-
WAF1, a potential mediator of p53 tumor suppression
-
El-Deiry WS, Tokino T, Velculescu VE, et al. WAF1, a potential mediator of p53 tumor suppression. Cell. 1993;75:817-825.
-
(1993)
Cell
, vol.75
, pp. 817-825
-
-
El-Deiry, W.S.1
Tokino, T.2
Velculescu, V.E.3
-
6
-
-
0033616501
-
GADD45 induction of a G2/M cell cycle checkpoint
-
U S A
-
Wang XW, Zhan Q, Coursen JD, et al. GADD45 induction of a G2/M cell cycle checkpoint. Proc Natl Acad Sci U S A. 1999;96:3706-3711.
-
(1999)
Proc Natl Acad Sci
, vol.96
, pp. 3706-3711
-
-
Wang, X.W.1
Zhan, Q.2
Coursen, J.D.3
-
7
-
-
0033533612
-
14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage
-
Chan TA, Hermeking H, Lengauer C, Kinzler KW, Vogelstein B. 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage. Nature. 1999;401:616-620.
-
(1999)
Nature
, vol.401
, pp. 616-620
-
-
Chan, T.A.1
Hermeking, H.2
Lengauer, C.3
Kinzler, K.W.4
Vogelstein, B.5
-
8
-
-
0031310665
-
14-3-3 Sigma is a p53-regulated inhibitor of G2/M progression
-
Hermeking H, Lengauer C, Polyak K, et al. 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol Cell. 1997;1:3-11.
-
(1997)
Mol Cell
, vol.1
, pp. 3-11
-
-
Hermeking, H.1
Lengauer, C.2
Polyak, K.3
-
9
-
-
0037349289
-
p53 has a direct apoptogenic role at the mitochondria
-
Mihara M, Erster S, Zaika A, et al. p53 has a direct apoptogenic role at the mitochondria. Mol Cell. 2003;11:577-590.
-
(2003)
Mol Cell
, vol.11
, pp. 577-590
-
-
Mihara, M.1
Erster, S.2
Zaika, A.3
-
10
-
-
18144421236
-
Stress-induced p53 runs a transcription-independent death program
-
Erster S, Moll UM. Stress-induced p53 runs a transcription-independent death program. Biochem Biophys Res Commun. 2005;331:843-850.
-
(2005)
Biochem Biophys Res Commun
, vol.331
, pp. 843-850
-
-
Erster, S.1
Moll, U.M.2
-
11
-
-
0033635733
-
BH3-only proteins: Essential initiators of apoptotic cell death
-
Huang DCS, Strasser A. BH3-only proteins: essential initiators of apoptotic cell death. Cell. 2000;103:839-842.
-
(2000)
Cell
, vol.103
, pp. 839-842
-
-
Huang, D.C.S.1
Strasser, A.2
-
12
-
-
0036097786
-
Keeping killers on a tight leash: Transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins
-
Puthalakath H, Strasser A. Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins. Cell Death Differ. 2002;9:505-512.
-
(2002)
Cell Death Differ
, vol.9
, pp. 505-512
-
-
Puthalakath, H.1
Strasser, A.2
-
14
-
-
0034508217
-
The combined functions of proapoptotic Bcl-2 family members Bak and Bax are essential for normal development of multiple tissues
-
Lindsten T, Ross AJ, King A, et al. The combined functions of proapoptotic Bcl-2 family members Bak and Bax are essential for normal development of multiple tissues. Mol Cell. 2000;6:1389-1399.
-
(2000)
Mol Cell
, vol.6
, pp. 1389-1399
-
-
Lindsten, T.1
Ross, A.J.2
King, A.3
-
15
-
-
0842281645
-
Cell death: Critical control points
-
Danial NN, Korsmeyer SJ. Cell death: critical control points. Cell. 2004;116:205-219.
-
(2004)
Cell
, vol.116
, pp. 205-219
-
-
Danial, N.N.1
Korsmeyer, S.J.2
-
16
-
-
0035265823
-
PUMA induces the rapid apoptosis of colorectal cancer cells
-
Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B. PUMA induces the rapid apoptosis of colorectal cancer cells. Molecular Cell. 2001;7:673-682.
-
(2001)
Molecular Cell
, vol.7
, pp. 673-682
-
-
Yu, J.1
Zhang, L.2
Hwang, P.M.3
Kinzler, K.W.4
Vogelstein, B.5
-
17
-
-
0035265686
-
PUMA, a novel proapoptotic gene, is induced by p53
-
Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell. 2001;7:683-694.
-
(2001)
Mol Cell
, vol.7
, pp. 683-694
-
-
Nakano, K.1
Vousden, K.H.2
-
18
-
-
0035949470
-
Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals
-
U S A
-
Han J, Flemington C, Houghton AB, et al. Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. Proc Natl Acad Sci U S A. 2001;98:11318-11323.
-
(2001)
Proc Natl Acad Sci
, vol.98
, pp. 11318-11323
-
-
Han, J.1
Flemington, C.2
Houghton, A.B.3
-
19
-
-
0034640281
-
Noxa, a BH3-only member of the bcl-2 family and candidate mediator of p53-induced apoptosis
-
Oda E, Ohki R, Murasawa H, et al. Noxa, a BH3-only member of the bcl-2 family and candidate mediator of p53-induced apoptosis. Science. 2000;288:1053-1058.
-
(2000)
Science
, vol.288
, pp. 1053-1058
-
-
Oda, E.1
Ohki, R.2
Murasawa, H.3
-
20
-
-
10744228800
-
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
-
Jeffers JR, Parganas E, Lee Y, et al. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell. 2003;4:321-328.
-
(2003)
Cancer Cell
, vol.4
, pp. 321-328
-
-
Jeffers, J.R.1
Parganas, E.2
Lee, Y.3
-
21
-
-
0242410719
-
p53-and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa
-
Villunger A, Michalak EM, Coultas L, et al. p53-and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science. 2003;302:1036-1038.
-
(2003)
Science
, vol.302
, pp. 1036-1038
-
-
Villunger, A.1
Michalak, E.M.2
Coultas, L.3
-
22
-
-
0141818136
-
Integral role of Noxa in p53-mediated apoptotic response
-
Shibue T, Takeda K, Oda E, et al. Integral role of Noxa in p53-mediated apoptotic response. Genes Dev. 2003;17:2233-2238.
-
(2003)
Genes Dev
, vol.17
, pp. 2233-2238
-
-
Shibue, T.1
Takeda, K.2
Oda, E.3
-
23
-
-
0033607506
-
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
-
Bouillet P, Metcalf D, Huang DCS, et al. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science. 1999;286:1735-1738.
-
(1999)
Science
, vol.286
, pp. 1735-1738
-
-
Bouillet, P.1
Metcalf, D.2
Huang, D.C.S.3
-
24
-
-
0037148840
-
BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
-
Bouillet P, Purton JF, Godfrey DI, et al. BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature. 2002;415:922-926.
-
(2002)
Nature
, vol.415
, pp. 922-926
-
-
Bouillet, P.1
Purton, J.F.2
Godfrey, D.I.3
-
25
-
-
0037037543
-
Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim
-
Davey GM, Kurts C, Miller JF, et al. Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim. J Exp Med. 2002;196:947-955.
-
(2002)
J Exp Med
, vol.196
, pp. 947-955
-
-
Davey, G.M.1
Kurts, C.2
Miller, J.F.3
-
26
-
-
2342458871
-
Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling
-
U S A
-
Villunger A, Marsden VS, Zhan Y, et al. Negative selection of semimature CD4(+)8(-)+ HSA thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling. Proc Natl Acad Sci U S A. 2004;101:7052-7057.
-
(2004)
Proc Natl Acad Sci
, vol.101
, pp. 7052-7057
-
-
Villunger, A.1
Marsden, V.S.2
Zhan, Y.3
-
27
-
-
0141959215
-
Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells
-
Enders A, Bouillet P, Puthalakath H, Xu Y, Tarlinton DM, Strasser A. Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells. J Exp Med. 2003;198:1119-1126.
-
(2003)
J Exp Med
, vol.198
, pp. 1119-1126
-
-
Enders, A.1
Bouillet, P.2
Puthalakath, H.3
Xu, Y.4
Tarlinton, D.M.5
Strasser, A.6
-
28
-
-
0036069819
-
Activated T cell death in vivo mediated by pro-apoptotic Bcl-2 family member, Bim
-
Hildeman DA, Zhu Y, Mitchell TC, et al. Activated T cell death in vivo mediated by pro-apoptotic Bcl-2 family member, Bim. Immunity. 2002;16:759-767.
-
(2002)
Immunity
, vol.16
, pp. 759-767
-
-
Hildeman, D.A.1
Zhu, Y.2
Mitchell, T.C.3
-
29
-
-
0344198588
-
Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim
-
U S A
-
Pellegrini M, Belz G, Bouillet P, Strasser A. Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim. Proc Natl Acad Sci U S A. 2003;100:14175-14180.
-
(2003)
Proc Natl Acad Sci
, vol.100
, pp. 14175-14180
-
-
Pellegrini, M.1
Belz, G.2
Bouillet, P.3
Strasser, A.4
-
30
-
-
0033593038
-
Constitutive bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival
-
U S A
-
Ogilvy S, Metcalf D, Print CG, Bath ML, Harris AW, Adams JM. Constitutive bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival. Proc Natl Acad Sci U S A. 1999;96:14943-14948.
-
(1999)
Proc Natl Acad Sci
, vol.96
, pp. 14943-14948
-
-
Ogilvy, S.1
Metcalf, D.2
Print, C.G.3
Bath, M.L.4
Harris, A.W.5
Adams, J.M.6
-
31
-
-
0025786164
-
Bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
-
Strasser A, Harris AW, Cory S. Bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell. 1991;67:889-899.
-
(1991)
Cell
, vol.67
, pp. 889-899
-
-
Strasser, A.1
Harris, A.W.2
Cory, S.3
-
32
-
-
0028072523
-
DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2
-
Strasser A, Harris AW, Jacks T, Cory S. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell. 1994;79:329-339.
-
(1994)
Cell
, vol.79
, pp. 329-339
-
-
Strasser, A.1
Harris, A.W.2
Jacks, T.3
Cory, S.4
-
33
-
-
4344700576
-
Glucocorticoid-induced apoptosis and glucocorticoid resistance: Molecular mechanisms and clinical relevance
-
Schmidt S, Rainer J, Ploner C, Presul E, Riml S, Kofler R. Glucocorticoid-induced apoptosis and glucocorticoid resistance: molecular mechanisms and clinical relevance. Cell Death Differ. 2004;11(suppl 1):S45-S55.
-
(2004)
Cell Death Differ
, vol.11
, Issue.1 SUPPL.
-
-
Schmidt, S.1
Rainer, J.2
Ploner, C.3
Presul, E.4
Riml, S.5
Kofler, R.6
-
34
-
-
0025751550
-
Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
-
Sentman CL, Shutter JR, Hockenbery D, Kanagawa O, Korsmeyer SJ. bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell. 1991;67:879-888.
-
(1991)
Cell
, vol.67
, pp. 879-888
-
-
Sentman, C.L.1
Shutter, J.R.2
Hockenbery, D.3
Kanagawa, O.4
Korsmeyer, S.J.5
-
35
-
-
0037592259
-
Microarray analysis uncovers the induction of the proapoptotic BH3-only protein Bim in multiple models of glucocorticoid-induced apoptosis
-
Wang Z, Malone MH, He H, McColl KS, Distelhorst CW. Microarray analysis uncovers the induction of the proapoptotic BH3-only protein Bim in multiple models of glucocorticoid-induced apoptosis. J Biol Chem. 2003;278:23861-23867.
-
(2003)
J Biol Chem
, vol.278
, pp. 23861-23867
-
-
Wang, Z.1
Malone, M.H.2
He, H.3
McColl, K.S.4
Distelhorst, C.W.5
-
36
-
-
0036143203
-
Recent insights into the mechanism of glucocorticosteroid-induced apoptosis
-
Distelhorst CW. Recent insights into the mechanism of glucocorticosteroid-induced apoptosis. Cell Death Differ. 2002;9:6-19.
-
(2002)
Cell Death Differ
, vol.9
, pp. 6-19
-
-
Distelhorst, C.W.1
-
37
-
-
0035088322
-
Gene expression profiles of proliferating vs. G1/G0 arrested human leukemia cells suggest a mechanism for glucocorticoidinduced apoptosis
-
Tonko M, Ausserlechner MJ, Bernhard D, Helmberg A, Kofler R. Gene expression profiles of proliferating vs. G1/G0 arrested human leukemia cells suggest a mechanism for glucocorticoidinduced apoptosis. FASEB J. 2001;15:693-699.
-
(2001)
FASEB J
, vol.15
, pp. 693-699
-
-
Tonko, M.1
Ausserlechner, M.J.2
Bernhard, D.3
Helmberg, A.4
Kofler, R.5
-
38
-
-
0037443492
-
Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival
-
Villunger A, Scott C, Bouillet P, Strasser A. Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival. Blood. 2003;101:2393-2400.
-
(2003)
Blood
, vol.101
, pp. 2393-2400
-
-
Villunger, A.1
Scott, C.2
Bouillet, P.3
Strasser, A.4
-
39
-
-
0027319521
-
p53 is required for radiation-induced apoptosis in mouse thymocytes
-
Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature. 1993;362:847-849.
-
(1993)
Nature
, vol.362
, pp. 847-849
-
-
Lowe, S.W.1
Schmitt, E.M.2
Smith, S.W.3
Osborne, B.A.4
Jacks, T.5
-
40
-
-
0027258466
-
Thymocyte apoptosis induced by p53-dependent and independent pathways
-
Clarke AR, Purdie CA, Harrison DJ, et al. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature. 1993;362:849-852.
-
(1993)
Nature
, vol.362
, pp. 849-852
-
-
Clarke, A.R.1
Purdie, C.A.2
Harrison, D.J.3
-
41
-
-
0034598365
-
Ionizing radiation and chemotherapeutic drugs induce apoptosis in lymphocytes in the absence of fas or FADD/MORT1 signaling: Implications for cancer therapy
-
Newton K, Strasser A. Ionizing radiation and chemotherapeutic drugs induce apoptosis in lymphocytes in the absence of fas or FADD/MORT1 signaling: implications for cancer therapy. J Exp Med. 2000;191:195-200.
-
(2000)
J Exp Med
, vol.191
, pp. 195-200
-
-
Newton, K.1
Strasser, A.2
-
42
-
-
0029609086
-
Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis
-
Strasser A, Harris AW, Huang DCS, Krammer PH, Cory S. Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J. 1995;14:6136-6147.
-
(1995)
EMBO J
, vol.14
, pp. 6136-6147
-
-
Strasser, A.1
Harris, A.W.2
Huang, D.C.S.3
Krammer, P.H.4
Cory, S.5
-
43
-
-
7144263731
-
FADD: Essential for embryo development and signaling from some, but not all, inducers of apoptosis
-
Yeh WC, Pompa JL, McCurrach ME, et al. FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis. Science. 1998;279:1954-1958.
-
(1998)
Science
, vol.279
, pp. 1954-1958
-
-
Yeh, W.C.1
Pompa, J.L.2
McCurrach, M.E.3
-
44
-
-
0032143986
-
Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally
-
Varfolomeev EE, Schuchmann M, Luria V, et al. Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Immunity. 1998;9:267-276.
-
(1998)
Immunity
, vol.9
, pp. 267-276
-
-
Varfolomeev, E.E.1
Schuchmann, M.2
Luria, V.3
-
45
-
-
0033607006
-
Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis
-
Yin X-M, Wang K, Gross A, et al. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature. 1999;400:886-891.
-
(1999)
Nature
, vol.400
, pp. 886-891
-
-
Yin, X.-M.1
Wang, K.2
Gross, A.3
-
46
-
-
0842347424
-
Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death
-
Coultas L, Bouillet P, Stanley EG, Brodnicki TC, Adams JM, Strasser A. Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death. Mol Cell Biol. 2004;24:1570-1581.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 1570-1581
-
-
Coultas, L.1
Bouillet, P.2
Stanley, E.G.3
Brodnicki, T.C.4
Adams, J.M.5
Strasser, A.6
-
47
-
-
1942437456
-
Bim is a suppressor of Myc-induced mouse B cell leukemia
-
U S A
-
Egle A, Harris AW, Bouillet P, Cory S. Bim is a suppressor of Myc-induced mouse B cell leukemia. Proc Natl Acad Sci U S A. 2004;101:6164-6169.
-
(2004)
Proc Natl Acad Sci
, vol.101
, pp. 6164-6169
-
-
Egle, A.1
Harris, A.W.2
Bouillet, P.3
Cory, S.4
-
48
-
-
19944432123
-
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
-
Chen L, Willis SN, Wei A, et al. Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell. 2005;17:393-403.
-
(2005)
Mol Cell
, vol.17
, pp. 393-403
-
-
Chen, L.1
Willis, S.N.2
Wei, A.3
-
49
-
-
14944348965
-
The role of BH3-only proteins in the immune system
-
Strasser A. The role of BH3-only proteins in the immune system. Nat Rev Immunol. 2005;5:189-200.
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 189-200
-
-
Strasser, A.1
|