Inhibition of telomerase activity in U937 human monocytic leukemia cells by Compound K, a ginseng saponin metabolite

Biotechnology and Bioprocess Engineering

Volumn 11, Issue 1, 2006, Pages 7-12

  Kang, Kyoung Ah ^a   Lee, Kyoung Hwa ^a   Chae, Sungwook ^a   Kim, Jeong Ki ^a   Seo, Jung Yeon ^a   Ham, Yong Ho ^b   Lee, Kee Ho ^b   Kim, Bum Joon ^c   Kim, Hee Sun ^d   Kim, Dong Hyun ^e   Hyun, Jin Won ^a  

^a Jeju National University   (South Korea)

^b Korea Institute of Radiation and Medical Science   (South Korea)

^c Seoul National University   (South Korea)

^d Ewha Womans University School of Medicine   (South Korea)

^e Kyung Hee University   (South Korea)

Author keywords

Compound K; Human telomerase reverse transcriptase; Telomerase

Indexed keywords

20 O DELTA GLUCOPYRANOSYL 20 PROTOPANAXADIOL; GINSENG SAPONIN; MYC PROTEIN; PLANT EXTRACT; PROTOPANAXADIOL 20 GLUCOSIDE; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER THERAPY; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA; LEUKEMIA CELL LINE; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STRUCTURE ANALYSIS; TELOMERIC REPEAT AMPLIFICATION PROTOCOL; WESTERN BLOTTING;

PANAX GINSENG;

EID: 33644786182     PISSN: 12268372     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02931861     Document Type: Article

References (35)

1. Blackburn, E. H. (1991) Telomeres. Trends Biochem. Sci. 16: 378-381.
2. Harley, C. B. (1991) Telomere loss: mitotic clock or genetic time bomb? Mutat. Res. 256: 271-282.
3. van Steensel, B., A. Smogorzewska, and T. de Lange (1998) TRF2 protects human telomeres from end-to-end fusions. Cell 92: 401-413.
4. Karlseder, J., D. Broccoli, Y. Dai, S. Hardy, and T. de Lange (1999) p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283: 1321-1325.
5. Hahn, W. C., S. A. Stewart, M. W. Brooks, S. G. York, E. Eaton, A. Kurachi, R. L. Beijersbergen, J. H. Knoll, M. Meyerson, and R. A. Weinberg (1999) Inhibition of telomerase limits the growth of human cancer cells. Nat. Med. 5: 1164-1170.
6. Zhang, X., V. Mar, W. Zhou, L. Harrington, and M. O. Robinson (1999) Telomere shortening and apoptosis in telomerase-inhibited human tumor cells. Genes Dev. 13: 2388-2399.
7. Delhommeau, F., A. Thierry, D. Feneux, E. Lauret, E. Leclercq, M. H. Courtier, F. Sainteny, W. Vainchenker, and A. Bennaceur-Griscelli (2002) Telomere dysfunction and telomerase reactivation in human leukemia cell lines after telomerase inhibition by the expression of a dominant-negative hTERT mutant. Oncogene 21: 8262-8271.
8. Tauchi, T., A. Nakajima, G. Sashida, T. Shimamoto, J. H. Ohyashiki, K. Abe, K. Yamamoto, and K. Ohyashiki (2002) Inhibition of human telomerase enhances the effect of the tyrosine kinase inhibitor, imatinib, in BCR-ABL-positive leukemia cells. Clin. Cancer Res. 8: 3341-3347.
9. Nakajima, A., T. Tauchi, G. Sashida, M. Sumi, K. Abe, K. Yamamoto, J. H. Ohyashiki, and K. Ohyashiki (2003) Telomerase inhibition enhances apoptosis in human acute leukemia cells: possibility of antitelomerase therapy. Leukemia 17: 560-567.
10. Bearss, D. J., L. H. Hurley, and D. D. Von Hoff (2000) Telomere maintenance mechanisms as a target for drug development. Oncogene 19: 6632-6641.
11. Hasegawa, H., J. H. Sung, S. Matsumiya, and M. Uchiyama (1996) Main ginseng saponin metabolites formed by intestinal bacteria. Planta Med. 62: 453-457.
12. Kang, K. A., H. K. Lim, S. U. Kim, Y. W. Kim, W. T. Kim, H. S. Chung, M. K. Choo, D. H. Kim, H. S. Kim, M. J. Shim, M. H. Chung, and J. W. Hyun (2005) Induction of apoptosis by ginseng saponin metabolite in U937 human monocytic leukemia cells. J. Food Biochem. 29: 27-40.
13. 1 Phase by ginseng metabolite, compound K, in U937 human monocytic leukemia cells. Arch. Pharm. Res. 28: 685-690.
14. Hasegawa, H., S. Matsumiya, M. Uchiyama, T. Kurokawa, Y. Inouye, R. Kasai, S. Ishibashi, and K. Yamasaki (1995) Inhibitory effect of some triterpenoid saponins on glucose transport in tumor cells and its application to in vitro cytotoxic and antiviral activities. Planta Med. 60: 240-243.
15. Hasegawa, H., J. H. Sung, S. Matsumiya, M. Uchiyama, Y. Inouye, R. Kasai, and K. Yamasaki (1995) Reversal of daunomycin and vinblastin resistance in multidrug resistant P388 leukemia in vitro through enhanced cytotoxicity by triterpenoids. Planta Med. 61: 409-413.
16. Lee, B. H., S. J. Lee, J. H. Hur, S. Lee, J. H. Sung, J. D. Huh, and C. K. Moon (1998) In vitro antigenotoxic activity of novel ginseng saponin metabolites formed by intestinal bacteria. Planta Med. 64: 500-503.
17. Hasegawa, H., J. H. Sung, and J. D. Huh (1997) Ginseng intestinal bacteria metabolite IH901 as a new anti-metastatic agent. Arch. Pharm. Res. 20: 539-544.
18. Lee, J. Y., J. W. Shin, K. S. Chun, K. K. Park, W. Y. Chung, Y. J. Bang, J. H. Sung, and Y. J. Surh (2005) Anti-tumor promotional effects of a novel intestinal bacterial metabolite (IH-901) derived from the protopanaxadiol type ginsenosides in mouse skin. Carcinogenesis 26: 359-367.
19. Yim, H. W., H. S. Jong, T. Y. Kim, H. H. Choi, S. G. Kim, S. H. Song, J. Kim, S. G. Ko, J. W. Lee, T. Y. Kim, and Y. J. Bang (2005) Cyclooxygenase-2 inhibits novel ginseng metabolite-mediated apoptosis. Cancer Res. 65: 1952-1960.
20. Nicoletti, I., G. Migliorati, M. C. Pagliacci, F. Grignani, and C. Riccardi (1991) A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods 139: 271-279.
21. You, K. M., S. H. Lee, A. Im, and S. B. Lee (2003) Aptamers as functional nucleic acids: in vitro selection and biotechnological applications. Biotechnol. Bioprocess Eng. 8: 64-75.
22. Schneider-Stock, R., T. Emrich, B. Peters, V. Jaeger, and A. Roessner (2001) Analysis of human telomerase reverse transcriptase mRNA (hTERT) expression in myxoid liposarcomas using LightCycler real-time quantitative reverse transcriptase-polymerase chain reaction. Electrophoresis 22: 1098-1101.
23. Morin, G. B. (1989) The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell 59: 521-529.
24. Kim, N. W., M. A. Piatyszek, K. R. Prowse, C. B. Harley, M. D. West, P. L. Ho, G. M. Coviello, W. E. Wright, S. L. Weinrich, and J. W. Shay (1994) Specific association of human telomerase activity with immortal cells and cancer. Science 266: 2011-2015.
25. Shay, J. W. and S. Bacchetti (1997) A survey of telom erase activity in human cancer. Eur. J. Cancer 33: 787-791.
26. Hiyama, E., L. Gollahon, T. Kataoka, K. Kuroi, T. Yokoyama, A. F. Gazdar, K. Hiyama, M. A. Piatyszek, and J. W. Shay (1996) Telomerase activity in human breast tumors. J. Natl. Cancer Inst. 88: 116-122.
27. Tsao, J., Y. Zhao, J. Lukas, X. Yang, A. Shah, M. Press, and D. Shibata (1997) Telomerase activity in normal and neoplastic breast. Clin. Cancer Res. 3: 627-631.
28. Fu, W., J. G. Begley, M. W. Killen, and M. P. Mattson (1999) Anti-apoptotic role of telomerase in pheochromocytoma cells. J. Biol. Chem. 274: 7264-7271.
29. Liu, W. J., J. F. Jiang, D. Xiao, and J. Ding (2002) Down-regulation of telomerase activity via protein phosphatase 2A activation in salvicine-induced human leukemia HL-60 cell apoptosis. Biochem. Pharmacol. 64: 1677-1687.
30. Kim, E. J. and T. H. Park (2003) Anti-apoptosis engineering. Biotechnol. Bioprocess Eng. 8: 76-82.
31. Choi, D. B., W. S. Cha, S. H. Kang, and B. R. Lee (2004) Effect of Pleurotus ferulae extracts on viability of human lung cancer and cervical cancer cell lines. Biotechnol. Bioprocess Eng. 9: 356-361.
32. Lee, J. B., J. S. Bae, J. H. Choi, J. H. Ham, Y. K. Min, H. M. Yang, T. Othman, and K. Shimizu (2004) Anticancer efficacies of doxorubicin, verapamil and quercetin on FM3A cells under hyperthermic temperature. Biotechnol. Bioprocess Eng. 9: 261-266.
33. Takakura, M., S. Kyo, T. Kanaya, M. Tanaka, and M. Inoue (1998) Expression of human telomerase subunits and correlation with telomerase activity in cervical cancer. Cancer Res. 58: 1558-1561.
34. Ito, H., S. Kyo, T. Kanaya, M. Takakura, M. Inoue, and M. Namiki (1998) Expression of human telomerase subunits and correlation with telomerase activity in urothelial cancer. Clin. Cancer Res. 4: 1603-1608.
35. Kyo, S., M. Takakura, T. Taira, T. Kanaya, H. Itoh, M. Yutsudo, H. Ariga, and M. Inoue (2000) Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT). Nucleic Acids Res. 28: 669-677.