Altered expression of MUTYH and an increase in 8-hydroxydeoxyguanosine are early events in ulcerative colitis-associated carcinogenesis

Journal of Pathology

Volumn 219, Issue 1, 2009, Pages 77-86

  Gushima, Masaki ^a   Hirahashi, Minako ^a   Matsumoto, Takayuki ^a   Fujita, Kouhei ^a   Fujisawa, Ritsuko ^a   Mizumoto, Kazuhiro ^a   Nakabeppu, Yusaku ^b   Iida, Mitsuo ^a   Yao, Takashi ^c   Tsuneyoshi, Masazumi ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c JUNTENDO UNIVERSITY   (Japan)

Author keywords

8 hydroxydeoxyguanosine; Carcinogenesis; Dysplasia; MUTYH; Neoplasia; Oxidative stress; Ulcerative colitis

Indexed keywords

8 HYDROXYDEOXYGUANOSINE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COLON CANCER; COLON CARCINOGENESIS; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN TISSUE; MALE; MUTATIONAL ANALYSIS; MUTATOR GENE; MUTY HOMOLOGUE GENE; NUCLEOTIDE SEQUENCE; ONCOGENE K RAS; OXIDATIVE STRESS; PRIORITY JOURNAL; ULCERATIVE COLITIS;

AGED; AGED, 80 AND OVER; CELL NUCLEUS; COLITIS, ULCERATIVE; COLON; COLONIC NEOPLASMS; CYTOPLASM; DEOXYGUANOSINE; DNA GLYCOSYLASES; DNA MUTATIONAL ANALYSIS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, RAS; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; MALE; MIDDLE AGED; MUTATION; STATISTICS, NONPARAMETRIC; YOUNG ADULT;

EID: 68849121037     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2570     Document Type: Article

References (32)

1. Lashner BA, Silverstein MD, Hanauer SB. Hazard rates for dysplasia and cancer in ulcerative colitis. Result from a surveillance program. Dig Dis Sci 1989;34:1536-1541.
2. Ekbom A, Helmick C, Zack M, Adami HO. Ulcerative colitis and colorectal cancer. A population-based study. N Engl J Med 1990;323:1228-1233.
3. Eaden JA, Abrams KR, Mayberry JF. The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut 2001;48:526-535.
4. Riddell RH, Goldman H, Ransohoff DF, Appelman HD, Fenoglio CM, Haggitt RC, et al. Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications. Hum Pathol 1983;14:931-968.
5. Lih-Brody L, Powell SR, Collier KP, Reddy GM, Cerchia R, Kahn E, et al. Increased oxidative stress and decreased antioxidant defenses in mucosa of inflammatory bowel disease. Dig Dis Sci 1996;41:2078-2086.
6. Simmonds NJ, Allen RE, Stevens TR, Van Someren RN, Blake DR, Rampton DS. Chemiluminescence assay of mucosal reactive oxygen metabolites in inflammatory bowel disease. Gastroenterology 1992;103:186-196.
7. Rachmilewitz D, Stamler JS, Bachwich D, Karmeli F, Ackerman D, Podolsky DK. Enhanced colonic nitric oxide generation and nitric oxide synthase activity in ulcerative colitis and Crohn's disease. Gut 1995;36:718-723.
8. Kimura H, Miura S, Shigematsu T, Ohkubo N, Tsuzuki Y, Kurose I, et al. Increased nitric oxide production and inducible nitric oxide synthase activity in colonic mucosa of patients with active ulcerative colitis and Crohn's disease. Dig Dis Sci 1997;42:1047-1054.
9. Al-Tassan N, Chmiel NH, Maynald J, Fleming N, Livingston AL, Williams GT, et al. Inherited variants of MYH associated with somatic G:C → T:A mutations in colorectal tumors. Nature Genet 2002;30:227-232.
10. Michaels ML, Miller JH. The GO system protects organisms from the mutagenic effects of spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8- oxoguanine). J Bacteriol 1992;174:6321-6325.
11. Ohtsubo T, Nishioka K, Imaiso Y, Iwai S, Shimokawa H, Oda H, et al. Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria. Nucleic Acids Res 2000;28:1355-1364.
12. Kamiya H, Kasai H. Formation of 2-hydroxydeoxyadenosine triphosphaste, an oxidatively damaged nucleotide, and its incorporation by DNA polymerases. Steady-state kinetics of the incorporation. J Biol Chem 1995;270:19446-19450.
13. Peterlongo P, Mitra N, Chuai S, Kirchhoff T, Palmer C, Huang H, et al. Colorectal cancer risk in individuals with biallelic or monoallelic mutation of MYH. Int J Cancer 2005;114:505-507.
14. Kondo S, Toyokuni S, Iwasa Y, Tanaka T, Onodera H, Hiai H, et al. Persistent oxidative stress in human colorectal carcinoma but not in adenoma. Free Radic Biol Med 1999;27:401-410.
15. D'Inca R, Cardin R, Benazzato L, Angriman I, Martines D, Sturniolo GC. Oxidative DNA damage in the mucosa of ulcerative colitis increases with disease duration and dysplasia. Inflamm Bowel Dis 2004;10:23-27.
16. Seki S, Kitada T, Yamada T, Sakaguchi H, Nakatani K, Onoda N, et al. Immunohistochemical detection of 8-hydroxydeoxyguanosine, a marker of oxidative DNA damage, in human chronic cholecystitis. Histopathology 2002;40:531-535.
17. Hori Y, Oda Y, Kiyoshima K, Yamada Y, Nakashima Y, Naito S, et al. Oxidative stress and DNA hypermethylation status in renal cell carcinoma arising in patients on dialysis. J Pathol 2007;212:218-226.
18. Di Gregorio C, Frattini M, Maffei S, Ponti G, Losi L, Pedroni M, et al. Immunohistochemical expression of MYH protein can be used to indentify patients with MYH-associated polyposis. Gastroenterology 2006;131:439-444.
19. Yanaru-Fujisawa R, Matsumoto T, Ushijima Y, Esaki M, Hirahashi M, Gushima M, et al. Genomic and functional analyses of MUTYH in Japanese patients with adenomatous polyposis. Clin Genet 2008;73:545-553.
20. Koketsu S, Watanabe T, Nagawa H. Expression of DNA repair protein: MYH, NTH1, and MTH1 in colorectal cancer. Hepatogastroenterology 2004;51:638-642.
21. Shinmura K, Yamaguchi S, Saitoh T, Takeuchi-Sasaki M, Kim SR, Nohmi T, et al. Adenine excisional repair function of MYH protein on the adenine: 8-hydroxyguanine base pair in double-standard DNA. Nucleic Acids Res 2000;28:4912-4918.
22. Arai T, Fukae J, Hatano T, Kubo S, Ohtsubo T, Nakabeppu Y, et al. Up-regulation of hMUTYH, a DNA repair enzyme, in the mitochondria of substantia nigra in Parkinson's disease. Acta Neuropathol 2006;112:139-145.
23. Ichinoe A, Behmanesh M, Tominaga Y, Ushijima Y, Hirano S, Sakai Y, et al. Identification and characterization of two forms of mouse MUTYH proteins encoded by alternatively spliced transcripts. Nucleic Acids Res 2004;32:477-487.
24. Tao H, Shinmura K, Hanaoka T, Natsukawa S, Shaura K, Koizumi Y, et al. A novel splice-site variant of base excision repair gene MYH is associated with production of an aberrant mRNA transcript encoding a truncated MYH protein not localized in the nucleus. Carcinogenesis 2004;25:1859-1866.
25. Van der Post RS, Kets CM, Ligtenberg MJ, van Krieken JH, Hoogerbrugge N. Immunohistochemistry is not an accurate first step towards the molecular diagnosis of MUTYH-associated polyposis. Virchows Arch 2009;454:25-29.
26. O'Shea AM, Cleary SP, Croitoru MA, Kim H, Berk T, Monga N, et al. Pathological features of colorectal carcinomas in MYH-associated polyposis. Histopathology 2008;53:184-194.
27. Bourgatef K, Marrakchi R, Kourda N, Ben Lahely YB, Jileni SB, El Khil HK, et al. Somatic mutation of MutYH in Tunisian patients with sporadic colorectal cancer. J Clin Lab Anal 2007;21:372-374.
28. Jones S, Emmerson P, Maynard J, Best JM, Jordan S,Williams GT, et al. Biallelic germline mutations in MYH predispose to multiple colorectal adenomas and somatic G:C > T:A mutations. Hum Mol Genet 2002;11:2961-2967.
29. Kim JC, Ka IH, Lee YM, Koo KH, Kim HC, Yu CS, et al. MYH, OGG1, MTH1, and APC alterations involved in the colorectal tumorigenesis of Korean patients with multiple adenomas. Virchows Arch 2007;450:311-319.
30. Kambara T, Whitehall VL, Spring KJ, Barker MA, Arnold S, Wynter CV, et al. Role of inherited defects of MYH in the development of sporadic colorectal cancer. Genes Chromosomes Cancer 2004;40:1-9.
31. Jones S, Lambert S, Williams GT, Best JM, Sampson JR, Cheadle JP. Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas. Br J Cancer 2004;90:1591-1593.
32. Lyda MH, Noffsinger A, Belli J, Fenoglio-Preise CM. Microsatellite instability and K-ras mutations in patients with ulcerative colitis. Hum Pathol 2000;31:665-671.