Involvement of p38 MAPK- and JNK-modulated expression of Bcl-2 and Bax in Naja nigricollis CMS-9-induced apoptosis of human leukemia K562 cells

Toxicon

Volumn 55, Issue 7, 2010, Pages 1306-1316

  Chen, Ying Jung ^a   Liu, Wen Hsin ^a   Kao, Pei Hsiu ^a   Wang, Jeh Jeng ^b   Chang, Long Sen ^a  

^a NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Ca2+; Catalytic activity; JNK; Modulation of Bcl 2 proteins; P38 MAPK; Phospholipase A2; ROS

Indexed keywords

CALCIUM ION; CASPASE 3; CASPASE 9; CYTOCHROME C; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOLIPASE A2; PROTEIN BAX; PROTEIN BCL 2; PROTEIN CMS 9; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; NAJA NIGRICOLLIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; SNAKE;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CASPASES; CELL SURVIVAL; CHELATING AGENTS; COBRA VENOMS; CYTOCHROMES C; CYTOSOL; FATTY ACIDS; FREE RADICAL SCAVENGERS; HUMANS; K562 CELLS; MAP KINASE KINASE 4; MEMBRANE POTENTIALS; MITOCHONDRIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOLIPASES A2; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES;

NAJA NIGRICOLLIS;

EID: 77951652653     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2010.01.024     Document Type: Article

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