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Volumn 230, Issue 1-2, 2011, Pages 52-64

2′-Hydroxycinnamaldehyde targets low-density lipoprotein receptor-related protein-1 to inhibit lipopolysaccharide-induced microglial activation

Author keywords

2 Hydroxycinnamaldehyde; Central nervous system; Cytokines; Low density lipoprotein receptor related protein 1; Macrophages; Microglia; Neuroinflammation; Neuroprotection; Nitric oxide

Indexed keywords

2' BEZOYLOXYCINNAMALDEHYDE; 2' HYDROXYCINNAMALDEHYDE; CINNAMALDEHYDE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ACROLEIN; ANTIINFLAMMATORY AGENT; CINNAMALDEHYDE; CYTOKINE; DRUG DERIVATIVE; LEUKOCYTE ANTIGEN; LRP1 PROTEIN, HUMAN; NEUROPROTECTIVE AGENT; PLANT EXTRACT;

EID: 78650977518     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2010.08.021     Document Type: Article
Times cited : (32)

References (70)
  • 1
    • 0028174061 scopus 로고
    • Function and activation of NF-kappa B in the immune system
    • Baeuerle P.A., Henkel T. Function and activation of NF-kappa B in the immune system. Annu. Rev. Immunol. 1994, 12:141-179.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 141-179
    • Baeuerle, P.A.1    Henkel, T.2
  • 2
    • 0025233694 scopus 로고
    • Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus
    • Blasi E., Barluzzi R., Bocchini V., Mazzolla R., Bistoni F. Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus. J. Neuroimmunol. 1990, 27:229-237.
    • (1990) J. Neuroimmunol. , vol.27 , pp. 229-237
    • Blasi, E.1    Barluzzi, R.2    Bocchini, V.3    Mazzolla, R.4    Bistoni, F.5
  • 3
    • 33845768784 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
    • Block M.L., Zecca L., Hong J.S. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat. Rev. Neurosci. 2007, 8:57-69.
    • (2007) Nat. Rev. Neurosci. , vol.8 , pp. 57-69
    • Block, M.L.1    Zecca, L.2    Hong, J.S.3
  • 5
    • 33847112418 scopus 로고    scopus 로고
    • The NF-kappaB regulatory network
    • Brasier A.R. The NF-kappaB regulatory network. Cardiovasc. Toxicol. 2006, 6:111-130.
    • (2006) Cardiovasc. Toxicol. , vol.6 , pp. 111-130
    • Brasier, A.R.1
  • 6
    • 0028298886 scopus 로고
    • Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons
    • Bu G., Maksymovitch E.A., Nerbonne J.M., Schwartz A.L. Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons. J. Biol. Chem. 1994, 269:18521-18528.
    • (1994) J. Biol. Chem. , vol.269 , pp. 18521-18528
    • Bu, G.1    Maksymovitch, E.A.2    Nerbonne, J.M.3    Schwartz, A.L.4
  • 7
    • 34250811784 scopus 로고    scopus 로고
    • LRP in amyloid-beta production and metabolism
    • Bu G., Cam J., Zerbinatti C. LRP in amyloid-beta production and metabolism. Ann. NY Acad. Sci. 2006, 1086:35-53.
    • (2006) Ann. NY Acad. Sci. , vol.1086 , pp. 35-53
    • Bu, G.1    Cam, J.2    Zerbinatti, C.3
  • 8
    • 0034959741 scopus 로고    scopus 로고
    • Characterization of a novel brain-derived microglial cell line isolated from neonatal rat brain
    • Cheepsunthorn P., Radov L., Menzies S., Reid J., Connor J.R. Characterization of a novel brain-derived microglial cell line isolated from neonatal rat brain. Glia 2001, 35:53-62.
    • (2001) Glia , vol.35 , pp. 53-62
    • Cheepsunthorn, P.1    Radov, L.2    Menzies, S.3    Reid, J.4    Connor, J.R.5
  • 12
    • 0141918823 scopus 로고    scopus 로고
    • By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation
    • Gardai S.J., Xiao Y.Q., Dickinson M., Nick J.A., Voelker D.R., Greene K.E., Henson P.M. By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation. Cell 2003, 115:13-23.
    • (2003) Cell , vol.115 , pp. 13-23
    • Gardai, S.J.1    Xiao, Y.Q.2    Dickinson, M.3    Nick, J.A.4    Voelker, D.R.5    Greene, K.E.6    Henson, P.M.7
  • 13
    • 33646367900 scopus 로고    scopus 로고
    • Regulation of the composition of the extracellular matrix by low density lipoprotein receptor-related protein-1: activities based on regulation of mRNA expression
    • Gaultier A., Salicioni A.M., Arandjelovic S., Gonias S.L. Regulation of the composition of the extracellular matrix by low density lipoprotein receptor-related protein-1: activities based on regulation of mRNA expression. J. Biol. Chem. 2006, 281:7332-7340.
    • (2006) J. Biol. Chem. , vol.281 , pp. 7332-7340
    • Gaultier, A.1    Salicioni, A.M.2    Arandjelovic, S.3    Gonias, S.L.4
  • 14
    • 45949089484 scopus 로고    scopus 로고
    • Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor
    • Gaultier A., Arandjelovic S., Niessen S., Overton C.D., Linton M.F., Fazio S., Campana W.M., Cravatt B.F., Gonias S.L. Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor. Blood 2008, 111:5316-5325.
    • (2008) Blood , vol.111 , pp. 5316-5325
    • Gaultier, A.1    Arandjelovic, S.2    Niessen, S.3    Overton, C.D.4    Linton, M.F.5    Fazio, S.6    Campana, W.M.7    Cravatt, B.F.8    Gonias, S.L.9
  • 15
    • 33750466230 scopus 로고    scopus 로고
    • Introduction to NF-kappaB: players, pathways, perspectives
    • Gilmore T.D. Introduction to NF-kappaB: players, pathways, perspectives. Oncogene 2006, 25:6680-6684.
    • (2006) Oncogene , vol.25 , pp. 6680-6684
    • Gilmore, T.D.1
  • 16
    • 0032942060 scopus 로고    scopus 로고
    • Microglia as mediators of inflammatory and degenerative diseases
    • Gonzalez-Scarano F., Baltuch G. Microglia as mediators of inflammatory and degenerative diseases. Annu. Rev. Neurosci. 1999, 22:219-240.
    • (1999) Annu. Rev. Neurosci. , vol.22 , pp. 219-240
    • Gonzalez-Scarano, F.1    Baltuch, G.2
  • 18
    • 0034836428 scopus 로고    scopus 로고
    • LRP: a multifunctional scavenger and signaling receptor
    • Herz J., Strickland D.K. LRP: a multifunctional scavenger and signaling receptor. J. Clin. Invest. 2001, 108:779-784.
    • (2001) J. Clin. Invest. , vol.108 , pp. 779-784
    • Herz, J.1    Strickland, D.K.2
  • 19
    • 34447291794 scopus 로고    scopus 로고
    • Apoptosis induction of 2′-hydroxycinnamaldehyde as a proteasome inhibitor is associated with ER stress and mitochondrial perturbation in cancer cells
    • Hong S.H., Kim J., Kim J.M., Lee S.Y., Shin D.S., Son K.H., Han D.C., Sung Y.K., Kwon B.M. Apoptosis induction of 2′-hydroxycinnamaldehyde as a proteasome inhibitor is associated with ER stress and mitochondrial perturbation in cancer cells. Biochem. Pharmacol. 2007, 74:557-565.
    • (2007) Biochem. Pharmacol. , vol.74 , pp. 557-565
    • Hong, S.H.1    Kim, J.2    Kim, J.M.3    Lee, S.Y.4    Shin, D.S.5    Son, K.H.6    Han, D.C.7    Sung, Y.K.8    Kwon, B.M.9
  • 20
    • 67449092717 scopus 로고    scopus 로고
    • Microarray analysis of gene expression profile by treatment of Cinnamomi Ramulus in lipopolysaccharide-stimulated BV-2 cells
    • Hwang S.H., Choi Y.G., Jeong M.Y., Hong Y.M., Lee J.H., Lim S. Microarray analysis of gene expression profile by treatment of Cinnamomi Ramulus in lipopolysaccharide-stimulated BV-2 cells. Gene 2009, 443:83-90.
    • (2009) Gene , vol.443 , pp. 83-90
    • Hwang, S.H.1    Choi, Y.G.2    Jeong, M.Y.3    Hong, Y.M.4    Lee, J.H.5    Lim, S.6
  • 21
    • 77953648658 scopus 로고    scopus 로고
    • Stimulation of glucocorticoid-induced tumor necrosis factor receptor family-related protein ligand (GITRL) induces inflammatory activation of microglia in culture
    • Hwang H., Lee S., Lee W.H., Lee H.J., Suk K. Stimulation of glucocorticoid-induced tumor necrosis factor receptor family-related protein ligand (GITRL) induces inflammatory activation of microglia in culture. J. Neurosci. Res. 2010, 88:2188-2196.
    • (2010) J. Neurosci. Res. , vol.88 , pp. 2188-2196
    • Hwang, H.1    Lee, S.2    Lee, W.H.3    Lee, H.J.4    Suk, K.5
  • 24
    • 0037108887 scopus 로고    scopus 로고
    • Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search
    • Keller A., Nesvizhskii A.I., Kolker E., Aebersold R. Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search. Anal. Chem. 2002, 74:5383-5392.
    • (2002) Anal. Chem. , vol.74 , pp. 5383-5392
    • Keller, A.1    Nesvizhskii, A.I.2    Kolker, E.3    Aebersold, R.4
  • 25
    • 0345707504 scopus 로고    scopus 로고
    • Cinnamon improves glucose and lipids of people with type 2 diabetes
    • Khan A., Safdar M., Ali Khan M.M., Khattak K.N., Anderson R.A. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diab. Care 2003, 26:3215-3218.
    • (2003) Diab. Care , vol.26 , pp. 3215-3218
    • Khan, A.1    Safdar, M.2    Ali Khan, M.M.3    Khattak, K.N.4    Anderson, R.A.5
  • 26
    • 32544445860 scopus 로고    scopus 로고
    • Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice
    • Kim S.H., Hyun S.H., Choung S.Y. Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice. J. Ethnopharmacol. 2006, 104:119-123.
    • (2006) J. Ethnopharmacol. , vol.104 , pp. 119-123
    • Kim, S.H.1    Hyun, S.H.2    Choung, S.Y.3
  • 27
  • 28
    • 0036847840 scopus 로고    scopus 로고
    • Role of p38 and p44/42 mitogen-activated protein kinases in microglia
    • Koistinaho M., Koistinaho J. Role of p38 and p44/42 mitogen-activated protein kinases in microglia. Glia 2002, 40:175-183.
    • (2002) Glia , vol.40 , pp. 175-183
    • Koistinaho, M.1    Koistinaho, J.2
  • 29
    • 0030770505 scopus 로고    scopus 로고
    • Synthesis and biological activity of cinnamaldehydes as angiogenesis inhibitors
    • Kwon B., Lee S., Cho Y., Bok S., So S., Youn M., et al. Synthesis and biological activity of cinnamaldehydes as angiogenesis inhibitors. Bioorg. Med. Chem. Lett. 1997, 7:2473-2476.
    • (1997) Bioorg. Med. Chem. Lett. , vol.7 , pp. 2473-2476
    • Kwon, B.1    Lee, S.2    Cho, Y.3    Bok, S.4    So, S.5    Youn, M.6
  • 30
    • 64649105694 scopus 로고    scopus 로고
    • Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells
    • Kwon H.K., Jeon W.K., Hwang J.S., Lee C.G., So J.S., Park J.A., Ko B.S., Im S.H. Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells. Cancer Lett. 2009, 278:174-182.
    • (2009) Cancer Lett. , vol.278 , pp. 174-182
    • Kwon, H.K.1    Jeon, W.K.2    Hwang, J.S.3    Lee, C.G.4    So, J.S.5    Park, J.A.6    Ko, B.S.7    Im, S.H.8
  • 32
    • 0034813741 scopus 로고    scopus 로고
    • Apolipoprotein E and apolipoprotein E receptors modulate A beta-induced glial neuroinflammatory responses
    • LaDu M.J., Shah J.A., Reardon C.A., Getz G.S., Bu G., Hu J., Guo L., Van Eldik L.J. Apolipoprotein E and apolipoprotein E receptors modulate A beta-induced glial neuroinflammatory responses. Neurochem. Int. 2001, 39:427-434.
    • (2001) Neurochem. Int. , vol.39 , pp. 427-434
    • LaDu, M.J.1    Shah, J.A.2    Reardon, C.A.3    Getz, G.S.4    Bu, G.5    Hu, J.6    Guo, L.7    Van Eldik, L.J.8
  • 33
    • 34447621801 scopus 로고    scopus 로고
    • Heme oxygenase-1 mediates cytoprotective effects of immunostimulation in microglia
    • Lee S., Suk K. Heme oxygenase-1 mediates cytoprotective effects of immunostimulation in microglia. Biochem. Pharmacol. 2007, 74:723-729.
    • (2007) Biochem. Pharmacol. , vol.74 , pp. 723-729
    • Lee, S.1    Suk, K.2
  • 34
    • 0032970672 scopus 로고    scopus 로고
    • Inhibition of human tumor growth by 2′-hydroxy- and 2′-benzoyloxycinnamaldehydes
    • Lee C.W., Hong D.H., Han S.B., Park S.H., Kim H.K., Kwon B.M., Kim H.M. Inhibition of human tumor growth by 2′-hydroxy- and 2′-benzoyloxycinnamaldehydes. Planta Med. 1999, 65:263-266.
    • (1999) Planta Med. , vol.65 , pp. 263-266
    • Lee, C.W.1    Hong, D.H.2    Han, S.B.3    Park, S.H.4    Kim, H.K.5    Kwon, B.M.6    Kim, H.M.7
  • 35
    • 0344845210 scopus 로고    scopus 로고
    • Cinnamate supplementation enhances hepatic lipid metabolism and antioxidant defense systems in high cholesterol-fed rats
    • Lee J.S., Jeon S.M., Park E.M., Huh T.L., Kwon O.S., Lee M.K., Choi M.S. Cinnamate supplementation enhances hepatic lipid metabolism and antioxidant defense systems in high cholesterol-fed rats. J. Med. Food 2003, 6:183-191.
    • (2003) J. Med. Food , vol.6 , pp. 183-191
    • Lee, J.S.1    Jeon, S.M.2    Park, E.M.3    Huh, T.L.4    Kwon, O.S.5    Lee, M.K.6    Choi, M.S.7
  • 36
    • 24944515407 scopus 로고    scopus 로고
    • Induction of apoptotic cell death by 2′-hydroxycinnamaldehyde is involved with ERK-dependent inactivation of NF-kappaB in TNF-alpha-treated SW620 colon cancer cells
    • Lee S.H., Lee C.W., Lee J.W., Choi M.S., Son D.J., Chung Y.B., Lee C.K., Oh K.W., Moon D.C., Kwon B.M., Hong J.T. Induction of apoptotic cell death by 2′-hydroxycinnamaldehyde is involved with ERK-dependent inactivation of NF-kappaB in TNF-alpha-treated SW620 colon cancer cells. Biochem. Pharmacol. 2005, 70:1147-1157.
    • (2005) Biochem. Pharmacol. , vol.70 , pp. 1147-1157
    • Lee, S.H.1    Lee, C.W.2    Lee, J.W.3    Choi, M.S.4    Son, D.J.5    Chung, Y.B.6    Lee, C.K.7    Oh, K.W.8    Moon, D.C.9    Kwon, B.M.10    Hong, J.T.11
  • 37
    • 13844289126 scopus 로고    scopus 로고
    • Inhibitory effect of 2′-hydroxycinnamaldehyde on nitric oxide production through inhibition of NF-kappa B activation in RAW 264.7 cells
    • Lee S.H., Lee S.Y., Son D.J., Lee H., Yoo H.S., Song S., Oh K.W., Han D.C., Kwon B.M., Hong J.T. Inhibitory effect of 2′-hydroxycinnamaldehyde on nitric oxide production through inhibition of NF-kappa B activation in RAW 264.7 cells. Biochem. Pharmacol. 2005, 69:791-799.
    • (2005) Biochem. Pharmacol. , vol.69 , pp. 791-799
    • Lee, S.H.1    Lee, S.Y.2    Son, D.J.3    Lee, H.4    Yoo, H.S.5    Song, S.6    Oh, K.W.7    Han, D.C.8    Kwon, B.M.9    Hong, J.T.10
  • 40
    • 28344453429 scopus 로고    scopus 로고
    • Beyond endocytosis: LRP function in cell migration, proliferation and vascular permeability
    • Lillis A.P., Mikhailenko I., Strickland D.K. Beyond endocytosis: LRP function in cell migration, proliferation and vascular permeability. J. Thromb. Haemost. 2005, 3:1884-1893.
    • (2005) J. Thromb. Haemost. , vol.3 , pp. 1884-1893
    • Lillis, A.P.1    Mikhailenko, I.2    Strickland, D.K.3
  • 41
    • 50349092250 scopus 로고    scopus 로고
    • LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies
    • Lillis A.P., Van Duyn L.B., Murphy-Ullrich J.E., Strickland D.K. LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies. Physiol. Rev. 2008, 88:887-918.
    • (2008) Physiol. Rev. , vol.88 , pp. 887-918
    • Lillis, A.P.1    Van Duyn, L.B.2    Murphy-Ullrich, J.E.3    Strickland, D.K.4
  • 42
    • 0037215645 scopus 로고    scopus 로고
    • Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention
    • Liu B., Hong J.S. Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J. Pharmacol. Exp. Ther. 2003, 304:1-7.
    • (2003) J. Pharmacol. Exp. Ther. , vol.304 , pp. 1-7
    • Liu, B.1    Hong, J.S.2
  • 43
    • 63949084694 scopus 로고    scopus 로고
    • Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease
    • Marzolo M.P., Bu G. Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease. Semin. Cell Dev. Biol. 2009, 20:191-200.
    • (2009) Semin. Cell Dev. Biol. , vol.20 , pp. 191-200
    • Marzolo, M.P.1    Bu, G.2
  • 44
    • 0034194071 scopus 로고    scopus 로고
    • Expression of alpha(2)-macroglobulin receptor/low density lipoprotein receptor-related protein (LRP) in rat microglial cells
    • Marzolo M.P., von Bernhardi R., Bu G., Inestrosa N.C. Expression of alpha(2)-macroglobulin receptor/low density lipoprotein receptor-related protein (LRP) in rat microglial cells. J. Neurosci. Res. 2000, 60:401-411.
    • (2000) J. Neurosci. Res. , vol.60 , pp. 401-411
    • Marzolo, M.P.1    von Bernhardi, R.2    Bu, G.3    Inestrosa, N.C.4
  • 47
    • 33749055328 scopus 로고    scopus 로고
    • NF-kappaB functions in the nervous system: from development to disease
    • Memet S. NF-kappaB functions in the nervous system: from development to disease. Biochem. Pharmacol. 2006, 72:1180-1195.
    • (2006) Biochem. Pharmacol. , vol.72 , pp. 1180-1195
    • Memet, S.1
  • 48
    • 0031985513 scopus 로고    scopus 로고
    • Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide
    • Minghetti L., Levi G. Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide. Prog. Neurobiol. 1998, 54:99-125.
    • (1998) Prog. Neurobiol. , vol.54 , pp. 99-125
    • Minghetti, L.1    Levi, G.2
  • 49
    • 0026731852 scopus 로고
    • Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues
    • Moestrup S.K., Gliemann J., Pallesen G. Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues. Cell Tissue Res. 1992, 269:375-382.
    • (1992) Cell Tissue Res. , vol.269 , pp. 375-382
    • Moestrup, S.K.1    Gliemann, J.2    Pallesen, G.3
  • 50
    • 0029872690 scopus 로고    scopus 로고
    • Novel insight into molecular mechanism of endotoxin shock: biochemical analysis of LPS receptor signaling in a cell-free system targeting NF-kappaB and regulation of cytokine production/action through beta2 integrin in vivo
    • Mukaida N., Ishikawa Y., Ikeda N., Fujioka N., Watanabe S., Kuno K., Matsushima K. Novel insight into molecular mechanism of endotoxin shock: biochemical analysis of LPS receptor signaling in a cell-free system targeting NF-kappaB and regulation of cytokine production/action through beta2 integrin in vivo. J. Leukoc. Biol. 1996, 59:145-151.
    • (1996) J. Leukoc. Biol. , vol.59 , pp. 145-151
    • Mukaida, N.1    Ishikawa, Y.2    Ikeda, N.3    Fujioka, N.4    Watanabe, S.5    Kuno, K.6    Matsushima, K.7
  • 51
    • 0042338362 scopus 로고    scopus 로고
    • A statistical model for identifying proteins by tandem mass spectrometry
    • Nesvizhskii A.I., Keller A., Kolker E., Aebersold R. A statistical model for identifying proteins by tandem mass spectrometry. Anal. Chem. 2003, 75:4646-4658.
    • (2003) Anal. Chem. , vol.75 , pp. 4646-4658
    • Nesvizhskii, A.I.1    Keller, A.2    Kolker, E.3    Aebersold, R.4
  • 52
    • 65049084462 scopus 로고    scopus 로고
    • Anti-inflammatory effects of a fluorovinyloxyacetamide compound KT-15087 in microglia cells
    • Ock J., Kim S., Suk K. Anti-inflammatory effects of a fluorovinyloxyacetamide compound KT-15087 in microglia cells. Pharmacol. Res. 2009, 59:414-422.
    • (2009) Pharmacol. Res. , vol.59 , pp. 414-422
    • Ock, J.1    Kim, S.2    Suk, K.3
  • 53
    • 77950202753 scopus 로고    scopus 로고
    • Obovatol attenuates microglia-mediated neuroinflammation by modulating redox regulation
    • Ock J., Han H.S., Hong S.H., Lee S.Y., Han Y.M., Kwon B.M., Suk K. Obovatol attenuates microglia-mediated neuroinflammation by modulating redox regulation. Br. J. Pharmacol. 2010, 159:1646-1662.
    • (2010) Br. J. Pharmacol. , vol.159 , pp. 1646-1662
    • Ock, J.1    Han, H.S.2    Hong, S.H.3    Lee, S.Y.4    Han, Y.M.5    Kwon, B.M.6    Suk, K.7
  • 55
    • 33947715605 scopus 로고    scopus 로고
    • Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse
    • Overton C.D., Yancey P.G., Major A.S., Linton M.F., Fazio S. Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse. Circ. Res. 2007, 100:670-677.
    • (2007) Circ. Res. , vol.100 , pp. 670-677
    • Overton, C.D.1    Yancey, P.G.2    Major, A.S.3    Linton, M.F.4    Fazio, S.5
  • 56
    • 66249122077 scopus 로고    scopus 로고
    • Low-density lipoprotein receptors regulate microglial inflammation through c-Jun N-terminal kinase
    • Pocivavsek A., Burns M.P., Rebeck G.W. Low-density lipoprotein receptors regulate microglial inflammation through c-Jun N-terminal kinase. Glia 2009, 57:444-453.
    • (2009) Glia , vol.57 , pp. 444-453
    • Pocivavsek, A.1    Burns, M.P.2    Rebeck, G.W.3
  • 57
    • 69949112770 scopus 로고    scopus 로고
    • Microglial low-density lipoprotein receptor-related protein 1 modulates c-Jun N-terminal kinase activation
    • Pocivavsek A., Mikhailenko I., Strickland D.K., Rebeck G.W. Microglial low-density lipoprotein receptor-related protein 1 modulates c-Jun N-terminal kinase activation. J. Neuroimmunol. 2009, 214:25-32.
    • (2009) J. Neuroimmunol. , vol.214 , pp. 25-32
    • Pocivavsek, A.1    Mikhailenko, I.2    Strickland, D.K.3    Rebeck, G.W.4
  • 58
    • 0344013138 scopus 로고    scopus 로고
    • High-yield isolation of murine microglia by mild trypsinization
    • Saura J., Tusell J.M., Serratosa J. High-yield isolation of murine microglia by mild trypsinization. Glia 2003, 44:183-189.
    • (2003) Glia , vol.44 , pp. 183-189
    • Saura, J.1    Tusell, J.M.2    Serratosa, J.3
  • 59
    • 0024380087 scopus 로고
    • Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells
    • Schreiber E., Matthias P., Muller M.M., Schaffner W. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res. 1989, 17:6419.
    • (1989) Nucleic Acids Res. , vol.17 , pp. 6419
    • Schreiber, E.1    Matthias, P.2    Muller, M.M.3    Schaffner, W.4
  • 61
    • 0029927505 scopus 로고    scopus 로고
    • Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels
    • Shevchenko A., Wilm M., Vorm O., Mann M. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal. Chem. 1996, 68:850-858.
    • (1996) Anal. Chem. , vol.68 , pp. 850-858
    • Shevchenko, A.1    Wilm, M.2    Vorm, O.3    Mann, M.4
  • 62
    • 0033822411 scopus 로고    scopus 로고
    • Extract prepared from the bark of Cinnamomum cassia Blume prevents glutamate-induced neuronal death in cultured cerebellar granule cells
    • Shimada Y., Goto H., Kogure T., Kohta K., Shintani T., Itoh T., Terasawa K. Extract prepared from the bark of Cinnamomum cassia Blume prevents glutamate-induced neuronal death in cultured cerebellar granule cells. Phytother. Res. 2000, 14:466-468.
    • (2000) Phytother. Res. , vol.14 , pp. 466-468
    • Shimada, Y.1    Goto, H.2    Kogure, T.3    Kohta, K.4    Shintani, T.5    Itoh, T.6    Terasawa, K.7
  • 63
    • 34547106574 scopus 로고    scopus 로고
    • A comparison of chemical, antioxidant and antimicrobial studies of cinnamon leaf and bark volatile oils, oleoresins and their constituents
    • Singh G., Maurya S., DeLampasona M.P., Catalan C.A. A comparison of chemical, antioxidant and antimicrobial studies of cinnamon leaf and bark volatile oils, oleoresins and their constituents. Food Chem. Toxicol. 2007, 45:1650-1661.
    • (2007) Food Chem. Toxicol. , vol.45 , pp. 1650-1661
    • Singh, G.1    Maurya, S.2    DeLampasona, M.P.3    Catalan, C.A.4
  • 64
    • 0032937860 scopus 로고    scopus 로고
    • The role of microglia and macrophages in the pathophysiology of the CNS
    • Stoll G., Jander S. The role of microglia and macrophages in the pathophysiology of the CNS. Prog. Neurobiol. 1999, 58:233-247.
    • (1999) Prog. Neurobiol. , vol.58 , pp. 233-247
    • Stoll, G.1    Jander, S.2
  • 65
    • 0036847816 scopus 로고    scopus 로고
    • Microglia as neuroprotective, immunocompetent cells of the CNS
    • Streit W.J. Microglia as neuroprotective, immunocompetent cells of the CNS. Glia 2002, 40:133-139.
    • (2002) Glia , vol.40 , pp. 133-139
    • Streit, W.J.1
  • 66
    • 77950847889 scopus 로고    scopus 로고
    • Combined analysis of the glia secretome and the CSF proteome: neuroinflammation and novel biomarkers
    • Suk K. Combined analysis of the glia secretome and the CSF proteome: neuroinflammation and novel biomarkers. Expert Rev. Proteomics 2010, 7:263-274.
    • (2010) Expert Rev. Proteomics , vol.7 , pp. 263-274
    • Suk, K.1
  • 67
    • 0026693345 scopus 로고
    • Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain
    • Wolf B.B., Lopes M.B., VandenBerg S.R., Gonias S.L. Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain. Am. J. Pathol. 1992, 141:37-42.
    • (1992) Am. J. Pathol. , vol.141 , pp. 37-42
    • Wolf, B.B.1    Lopes, M.B.2    VandenBerg, S.R.3    Gonias, S.L.4
  • 68
    • 72049096104 scopus 로고    scopus 로고
    • Microglial low-density lipoprotein receptor-related protein 1 mediates the effect of tissue-type plasminogen activator on matrix metalloproteinase-9 activity in the ischemic brain
    • Zhang C., An J., Haile W.B., Echeverry R., Strickland D.K., Yepes M. Microglial low-density lipoprotein receptor-related protein 1 mediates the effect of tissue-type plasminogen activator on matrix metalloproteinase-9 activity in the ischemic brain. J. Cereb. Blood Flow Metab. 2009, 29:1946-1954.
    • (2009) J. Cereb. Blood Flow Metab. , vol.29 , pp. 1946-1954
    • Zhang, C.1    An, J.2    Haile, W.B.3    Echeverry, R.4    Strickland, D.K.5    Yepes, M.6
  • 69
    • 59649103200 scopus 로고    scopus 로고
    • The low-density lipoprotein receptor-related protein 1 mediates tissue-type plasminogen activator-induced microglial activation in the ischemic brain
    • Zhang C., An J., Strickland D.K., Yepes M. The low-density lipoprotein receptor-related protein 1 mediates tissue-type plasminogen activator-induced microglial activation in the ischemic brain. Am. J. Pathol. 2009, 174:586-594.
    • (2009) Am. J. Pathol. , vol.174 , pp. 586-594
    • Zhang, C.1    An, J.2    Strickland, D.K.3    Yepes, M.4
  • 70
    • 39149120805 scopus 로고    scopus 로고
    • Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity
    • Zheng L.T., Ock J., Kwon B.M., Suk K. Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity. Int. Immunopharmacol. 2008, 8:484-494.
    • (2008) Int. Immunopharmacol. , vol.8 , pp. 484-494
    • Zheng, L.T.1    Ock, J.2    Kwon, B.M.3    Suk, K.4


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