Apoptosis induction of 2′-hydroxycinnamaldehyde as a proteasome inhibitor is associated with ER stress and mitochondrial perturbation in cancer cells

Biochemical Pharmacology

Volumn 74, Issue 4, 2007, Pages 557-565

  Hong, Su Hyung ^a   Kim, Jina ^b   Kim, Jung Min ^b   Lee, So Young ^b   Shin, Dae Seop ^b   Son, Kwang Hee ^b   Han, Dong Cho ^b   Sung, Young Kwan ^c   Kwon, Byoung Mog ^b  

^a Kyungpook National University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Kyungpook National University School of Medicine   (South Korea)

Author keywords

2 hydroxycinnamaldehyde; Apoptosis; Endoplasmic reticulum; Mitochondria; Proteasome

Indexed keywords

2' BENZOYLOXYCINNAMALDEHYDE; 2' HYDROXYCINNAMALDEHYDE; BIOTIN; BORTEZOMIB; CASPASE 3; CHYMOTRYPSIN; CINNAMALDEHYDE DERIVATIVE; CYTOCHROME C; GLUCOSE REGULATED PROTEIN 78; HEAT SHOCK PROTEIN; PROTEASOME; PROTEASOME INHIBITOR; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CINNAMOMUM CASSIA; DNA MICROARRAY; DRUG STRUCTURE; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITION; GENE INDUCTION; HUMAN; HUMAN CELL; LABELING INDEX; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN LOCALIZATION; WESTERN BLOTTING;

ADP-RIBOSYL CYCLASE; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CELL LINE, TUMOR; CINNAMATES; CYTOCHROMES C; CYTOSOL; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ENDOPLASMIC RETICULUM; GENE EXPRESSION PROFILING; HEME OXYGENASE-1; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MEMBRANE PROTEINS; MITOCHONDRIAL SWELLING; MOLECULAR STRUCTURE; NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHATIDATE PHOSPHATASE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN TRANSPORT; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRANSCRIPTION FACTOR CHOP;

EID: 34447291794     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.05.016     Document Type: Article

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