2-Hydroxycinnamaldehyde inhibits SW620 colon cancer cell growth through AP-1 inactivation

Journal of Pharmacological Sciences

Volumn 104, Issue 1, 2007, Pages 19-28

  Chung, Woo Lee ^a   Seung, Ho Lee ^a   Jae, Woong Lee ^a   Jung, Ok Ban ^a   So, Yong Lee ^a   Han, Soo Yoo ^a   Jae, Kyung Jung ^a   Dong, Cheul Moon ^a   Ki, Wan Oh ^a   Jin, Tae Hong ^a  

^a Chungbuk National University   (South Korea)

Author keywords

2 hydroxycinnamaldehyde (HCA); AP 1; Cell growth inhibition; Colon cancer

Indexed keywords

2 HYDROXYCINNAMALDEHYDE; CASPASE 3; CINNAMALDEHYDE; PROTEIN BCL 2; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL GROWTH; COLON CANCER; DNA BINDING; DOSE RESPONSE; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IC 50; ONCOGENE C FOS; PROTEIN EXPRESSION;

EID: 34249029917     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.FP0061204     Document Type: Article

References (29)

1. Lee CW, Hong DH, Han SB, Park SH, Kim HK, Kwon BM. Inhibition of human tumor growth by 2′-hydroxy- and 2′-benzoyloxycinnamaldehydes. Planta Med. 1999;65:263-266.
2. Kwon BM, Cho YK, Lee SH, Nam JY, Bok SH, Chun SK. 2′- Hydroxycinnamaldehyde from stem bark of Cinnamomum cassia. Planta Med. 1996;62:183-184.
3. Kwon BM, Lee SH, Cho YK, Bok SH, So SH, Youn MR. Synthesis and biological activity of cinnamaldehydes as angiogenesis inhibitors. Bioorg Med Chem Lett. 1997;7:2473-2476.
4. Koh WS, Yoon SY, Kwon BM, Jeong TC, Nam KS, Han MY. Cinnamaldehyde inhibits lymphocyte proliferation and modulates T-cell differentiation. Int J Immunopharmacol. 1998;20:643-660.
5. Erwin FW. AP-1 Introductory remarks. Oncogene. 2001;20:2334-2335.
6. Wolfram J, Emmanuelle PA, Erwin FW. AP-1 in mouse development and tumorigenesis. Oncogene. 2001;20:2401-2412.
7. Shaulian E, Karin M. AP-1 as a regulator of cell life and death. Nat Cell Biol. 2002;4:131-136.
8. Young MR, Yang HS, Colburn NH. Promising molecular targets for cancer prevention: AP-1, NF-kappa B and Pdcd4. Trends Mol Med. 2003;9:36-41.
9. Alani R, Brown P, Binetruy B, Dosaka H, Rosenberg RK, Angel P, et al. The transactivating domain of the c-Jun proto-oncoprotein is required for cotransformation of rat embryo cells. Mol Cell Biol. 1991;11:6286-6295.
10. Kundu JK, Surh YJ. Molecular basis of chemoprevention by resveratrol: F-kappaB and AP-1 as potential targets. Mutat Res. 2004;555:65-80.
11. MacGregor JI, Jordan VC. Basic guide to the mechanisms of antiestrogen action. Pharmacol Rev. 1998;50:151-196.
12. Lee SH, Lee SY, Son DJ, Lee H, Yoo HS, Song S, et al. Inhibitory effect of 2'-hydroxycinnamaldehyde on nitric oxide production through inhibition of NF-kappa B activation in RAW 264.7 cells. Biochem Pharmacol. 2005;69:791-799.
13. Cernuda-Morollon E, Pineda-Molina E, Canada FJ, Perez-Sala D. 15-Deoxy-Delta 12,14-prostaglandin J2 inhibition of NF-kappaB-DNA binding through covalent modification of the p50 subunit. J Biol Chem. 2001;276:35530-35536.
14. Abate C, Patel L, Rauscher FJ, III, Curran T. Redox regulation of fos and jun DNA-binding activity in vitro. Science. 1990;249:1157-1161.
15. Klatt P, Pineda-Molina E, Lacoba MGD, Padilla CA, Martínez- Galisteo E, Bárcena JA, et al. Redox regulation of c-Jun DNA binding by reversible S-glutathiolation. FASEB J. 1999;13:1481-1490.
16. Klatt P, Pineda-Molina E, Lamas S. Nitric oxide inhibits c-Jun DNA binding by specifically targeted S-glutathionylation. J Biol Chem. 1999;274:15857-15864.
17. Glover JN, Harrison SC. Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA. Nature. 1995;373:257-261.
18. Rossi A, Kapahi P, Natoli G, Takahashi T, Chen Y, Karin M. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. Nature. 2000;403:103-108.
19. Kwok BHB, Koh B, Ndubuisi MI, Elofsson M, Crews CM. The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase. Chem Biol. 2001;8:759-766.
20. Chuan Jl, Kevin RK, Lawrence JM. IkappaB kinase, a molecular target for inhibition by 4-hydroxy-2-nonenal. J Biol Chem. 2001;276:18223-18228.
21. Adams JM, Cory S. The Bcl-2 protein family: arbiters of cell survival. Science. 1998;281:1322-1326.
22. Baldwin AS. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol. 1996;14:649-683.
23. Wu SJ, Ng LT, Lin CC. Cinnamaldehyde-induced apoptosis in human PLC/PRF/5 cells through activation of the proapoptotic Bcl-2 family proteins and MAPK pathway. Life Sci. 2005;77:938-951.
24. Xia M, Wang D, Wang M, Tashiro S, Onodera S, Minami M, et al. Dracorhodin perchlorate induces apoptosis via activation of caspases and generation of reactive oxygen species. Pharmacol Sci. 2004;95:273-283.
25. Lee SH, Lee CW, Lee JW, Choi MS, Son DJ, Chung YB, et al. Induction of apoptotic cell death by 2′-hydroxycinnamaldehyde is involved with ERK-dependent inactivation of NF-kappaB in TNF-alpha-treated SW620 colon cancer cells. Biochem Pharmacol. 2005;70:1147-1157.
26. Moll UM, Wolff S, Speidel D, Deppert W. Transcription-independent pro-apoptotic functions of p53. Curr Opin Cell Biol. 2005;17:631-636.
27. Yee KS, Vousden KH. Complicating the complexity of p53. Carcinogenesis. 2005;26:1317-1322.
28. Sakai T, Banno Y, Kato Y, Nozawa Y, Kawaguchi M. Pepsindigested bovine lactoferrin induces apoptotic cell death with JNK/SAPKactivation in oral cancer cells. J Pharmacol Sci. 2005;98:41-48.
29. Han DC, Lee MY, Shin KD, Jeon SB, Kim JM, Son KH, et al. 2′-benzoyloxycinnamaldehyde induces apoptosis in human carcinoma via reactive oxygen species. J Biol Chem. 2004;279:6911-6920.