Synthesis and biological activity of cinnamaldehydes as angiogenesis inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 19, 1997, Pages 2473-2476

  Kwon, Byoung Mog ^a   Lee, Seung Ho ^a   Cho, Young Kwon ^a   Bok, Song Hae ^a   So, Seung Ho ^b   Youn, Mi Ran ^b   Chang, Soo Ik ^b  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Chungbuk National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; CINNAMALDEHYDE DERIVATIVE;

ANGIOGENESIS; ANIMAL TISSUE; ARTICLE; CHICK EMBRYO; CHORIOALLANTOIS; CONCENTRATION RESPONSE; DRUG ACTIVITY; DRUG SYNTHESIS; EMBRYO; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION;

EID: 0030770505     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)10008-7     Document Type: Article

References (10)

1. Auerbach, W.; Auerbach, R. Pharmacol. Thqr. 1994, 63, 265-311.
2. Fan, T. P. D.; Jaggar, R.; Bicknell, R. TiPS, 1995, 26, 57-66.
3. Liotta, L. A.; Steeg, P. S.; Stetler-Stevenson, W. G. Cell, 1991, 64, 327-336.
4. Pepper, M. S. Reiss, Y.; Goldstein, J. L.; Seabra, M. C.; Casey, P. J.; Brown, M. S. Arterioscler. Thromb. Vasc. Biol. 1997, 17, 605-619.
5. Kwon, B. M.; Cho, Y. K.; Lee, S. H.; Nam, J. Y.; Bok, S. H.; Chun, S. K.; Kim, J. A.; Lee, I. R. Planta Med. 1996, 62, 183-184.
6. Kusaka, M.; Sudo, K.; Fujita, T., Marui, S.; Itoh, F.; Ingber, D.; Folkman, J. Bicohem. Biophys. Res. Comm. 1991, 174, 1070-1076. When the CAMs were treated with compounds, undesirable symptons such as local hemorrhage of embryos and thrombosis were not observed. A thermanox coverslip without sample inhibited the formation of the vascular network of the CAM about 20%.
7. Dorey G.; Leon, P.; Sciberras, S.; Leonce, S.; Guilbaud, N.; Pierre, A.; Atassi, G.; Billington, D. C. Bioorg. Med. Chem. Letters, 1996, 6, 3045-3050.
8. Fotsis, T.; Pepper, M.; Adlercreutz, H.; Fleishmann, G.; Hase, T.; Montesano, R.; Schweigerer, L. Proc. Natl. Acad. Sci. USA 1993, 90, 2690-2694.
9. The structure of all synthetic compounds were confirmed by NMR and HRMS. Spectral data of the new synthetic compounds will be published elsewhere.
10. Arbiser, J. L.; Moses, M. A.; Fernandez, C. A.; Ghiso, N.; Cao, Y., Klauber, N.; Frank, D.; Brownlee, M.; Flynn, E.; Parangi, S.; Byers, H. R.; Folkman, J. Proc. Natl. Acad. Sci. USA 1997, 94, 861-866.