-
1
-
-
0037032835
-
The protein kinase complement of the human genome
-
Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. The protein kinase complement of the human genome. Science 2002; 298(5600): 1912-34.
-
(2002)
Science
, vol.298
, Issue.5600
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
2
-
-
68449102462
-
CDC25A and B dual-specificity phosphatase inhibitors: Potential agents for cancer therapy
-
Lavecchia A, Di Giovanni C, Novellino E. CDC25A and B dual-specificity phosphatase inhibitors: Potential agents for cancer therapy. Curr Med Chem 2009; 16(15): 1831-49.
-
(2009)
Curr Med Chem
, vol.16
, Issue.15
, pp. 1831-1849
-
-
Lavecchia, A.1
Di Giovanni, C.2
Novellino, E.3
-
3
-
-
77955317205
-
Emerging links between CDK cell cycle regulators and Wnt signaling
-
Davidson G, Niehrs C. Emerging links between CDK cell cycle regulators and Wnt signaling. Trends Cell Biol 2010; 20(8): 453-60.
-
(2010)
Trends Cell Biol
, vol.20
, Issue.8
, pp. 453-460
-
-
Davidson, G.1
Niehrs, C.2
-
4
-
-
67649863759
-
Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53- mediated Bax activation and mitochondrial apoptosis in AML
-
Kojima K, Shimanuki M, Shikami M, Andreeff M, Nakakuma H. Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53- mediated Bax activation and mitochondrial apoptosis in AML. Cancer Sci 2009; 100(6): 1128-36.
-
(2009)
Cancer Sci
, vol.100
, Issue.6
, pp. 1128-1136
-
-
Kojima, K.1
Shimanuki, M.2
Shikami, M.3
Andreeff, M.4
Nakakuma, H.5
-
5
-
-
77950795072
-
Cyclin-dependent kinase inhibitors as anticancer drugs
-
Krystof V, Uldrijan S. Cyclin-dependent kinase inhibitors as anticancer drugs. Curr Drug Targets 2010; 11(3): 291-302.
-
(2010)
Curr Drug Targets
, vol.11
, Issue.3
, pp. 291-302
-
-
Krystof, V.1
Uldrijan, S.2
-
6
-
-
79952703288
-
Cell metabolism: An essential link between cell growth and apoptosis
-
(in press) doi:10.1016/j.bbamcr.2010.08.011
-
Mason EF, Rathmell JC. Cell metabolism: An essential link between cell growth and apoptosis. Biochim Biophys Acta 2010, (in press) doi:10.1016/j.bbamcr.2010.08.011.
-
(2010)
Biochim Biophys Acta
-
-
Mason, E.F.1
Rathmell, J.C.2
-
7
-
-
77951432631
-
The causes of cancer revisited: Mitochondrial malignancy and ROS-induced oncogenic transformation - why mitochondria are targets for cancer therapy
-
Ralph SJ, Rodriguez-Enriquez S, Neuzil J, Saavedra E, Moreno Sanchez R. The causes of cancer revisited: Mitochondrial malignancy and ROS-induced oncogenic transformation - why mitochondria are targets for cancer therapy. Mol Aspects Med 2010; 31(2): 145-70.
-
(2010)
Mol Aspects Med
, vol.31
, Issue.2
, pp. 145-170
-
-
Ralph, S.J.1
Rodriguez-Enriquez, S.2
Neuzil, J.3
Saavedra, E.4
Moreno Sanchez, R.5
-
8
-
-
78049370987
-
Oxidative stress, inflammation, and cancer: How are they linked?
-
(in press) doi:10.1016/j.freeradbiomed.2010. 09.006
-
Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB. Oxidative stress, inflammation, and cancer: How are they linked? Free Radic Biol Med 2010, (in press) doi:10.1016/j.freeradbiomed.2010. 09.006.
-
(2010)
Free Radic Biol Med
-
-
Reute, S.1
Gupta, S.C.2
Chaturvedi, M.M.3
Aggarwal, B.B.4
-
9
-
-
76049121496
-
The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation
-
USA
-
Tong X, Zhao F, Mancuso A, Gruber JJ, Thompson CB. The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation. Proc Natl Acad Sci USA 2009; 106(51): 21660-5.
-
(2009)
Proc Natl Acad Sci
, vol.106
, Issue.51
, pp. 21660-21665
-
-
Tong, X.1
Zhao, F.2
Mancuso, A.3
Gruber, J.J.4
Thompson, C.B.5
-
10
-
-
0032191393
-
Tumor surveillance via the ARF-p53 pathway
-
Sherr CJ. Tumor surveillance via the ARF-p53 pathway. Genes Dev 1998; 12(19): 2984-91.
-
(1998)
Genes Dev
, vol.12
, Issue.19
, pp. 2984-2991
-
-
Sherr, C.J.1
-
11
-
-
61649114657
-
Kinase-targeted libraries: The design and synthesis of novel, potent, and selective kinase inhibitors
-
Akritopoulou-Zanze I, Hajduk PJ. Kinase-targeted libraries: The design and synthesis of novel, potent, and selective kinase inhibitors. Drug Discov Today 2009; 14(5-6): 291-7.
-
(2009)
Drug Discov Today
, vol.14
, Issue.5-6
, pp. 291-297
-
-
Akritopoulou-Zanze, I.1
Hajduk, P.J.2
-
12
-
-
75349112388
-
Recent developments in cyclin-dependent kinase biochemical and structural studies
-
Echalier A, Endicott JA, Noble ME. Recent developments in cyclin-dependent kinase biochemical and structural studies. Biochim Biophys Acta 2010; 1804(3): 511-9.
-
(2010)
Biochim Biophys Acta
, vol.1804
, Issue.3
, pp. 511-519
-
-
Echalier, A.1
Endicott, J.A.2
Noble, M.E.3
-
13
-
-
54549101258
-
Cyclin-dependent kinases and cell-cycle transitions: Does one fit all?
-
Hochegger H, Takeda S, Hunt T. Cyclin-dependent kinases and cell-cycle transitions: Does one fit all? Nat Rev Mol Cell Biol 2008; 9(11): 910-6.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, Issue.11
, pp. 910-916
-
-
Hochegger, H.1
Takeda, S.2
Hunt, T.3
-
14
-
-
0842324788
-
Recycling the cell cycle: Cyclins revisited
-
Murray AW. Recycling the cell cycle: Cyclins revisited. Cell 2004; 116(2): 221-34.
-
(2004)
Cell
, vol.116
, Issue.2
, pp. 221-234
-
-
Murray, A.W.1
-
15
-
-
77951760865
-
Identification of substrates for cyclin dependent kinases
-
Errico A, Deshmukh K, Tanaka Y, Pozniakovsky A, Hunt T. Identification of substrates for cyclin dependent kinases. Adv Enzyme Regul 2010; 50(1): 375-99.
-
(2010)
Adv Enzyme Regul
, vol.50
, Issue.1
, pp. 375-399
-
-
Errico, A.1
Deshmukh, K.2
Tanaka, Y.3
Pozniakovsky, A.4
Hunt, T.5
-
16
-
-
0038795172
-
Genetics of melanoma predisposition
-
Hayward NK. Genetics of melanoma predisposition. Oncogene 2003; 22(20): 3053-62.
-
(2003)
Oncogene
, vol.22
, Issue.20
, pp. 3053-3062
-
-
Hayward, N.K.1
-
17
-
-
60749109846
-
Cell cycle, CDKs and cancer: A changing paradigm
-
Malumbres M, Barbacid M. Cell cycle, CDKs and cancer: A changing paradigm. Nat Rev Cancer 2009; 9(3): 153-66.
-
(2009)
Nat Rev Cancer
, vol.9
, Issue.3
, pp. 153-166
-
-
Malumbres, M.1
Barbacid, M.2
-
18
-
-
42449087261
-
Switching cyclin D-CDK4 kinase activity on and off
-
Blain SW. Switching cyclin D-CDK4 kinase activity on and off. Cell Cycle 2008; 7(7): 892-8.
-
(2008)
Cell Cycle
, vol.7
, Issue.7
, pp. 892-898
-
-
Blain, S.W.1
-
19
-
-
67649352637
-
Nuclear cyclin D1: An oncogenic driver in human cancer
-
Kim JK, Diehl JA. Nuclear cyclin D1: An oncogenic driver in human cancer. J Cell Physiol 2009; 220(2): 292-6.
-
(2009)
J Cell Physiol
, vol.220
, Issue.2
, pp. 292-296
-
-
Kim, J.K.1
Diehl, J.A.2
-
20
-
-
70349330577
-
The regulation of protein phosphorylation
-
Johnson LN. The regulation of protein phosphorylation. Biochem Soc Trans 2009; 37(Pt 4): 627-41.
-
(2009)
Biochem Soc Trans
, vol.37
, Issue.PART 4
, pp. 627-641
-
-
Johnson, L.N.1
-
21
-
-
75149130051
-
Targeting the cancer kinome through polypharmacology
-
Knight ZA, Lin H, Shokat KM. Targeting the cancer kinome through polypharmacology. Nat Rev Cancer 2010; 10(2): 130-7.
-
(2010)
Nat Rev Cancer
, vol.10
, Issue.2
, pp. 130-137
-
-
Knight, Z.A.1
Lin, H.2
Shokat, K.M.3
-
22
-
-
70349383205
-
Therapeutic peptides for cancer therapy. Part II cell cycle inhibitory peptides and apoptosis-inducing peptides
-
Raucher D, Moktan S, Massodi I, Bidwell GL, 3rd. Therapeutic peptides for cancer therapy. Part II cell cycle inhibitory peptides and apoptosis-inducing peptides. Expert Opin Drug Deliv 2009; 6(10): 1049-64.
-
(2009)
Expert Opin Drug Deliv
, vol.6
, Issue.10
, pp. 1049-1064
-
-
Raucher, D.1
Moktan, S.2
Massodi, I.3
Bidwell 3rd, G.L.4
-
23
-
-
70749106139
-
Metformin is a potent inhibitor of endometrial cancer cell proliferation-implications for a novel treatment strategy
-
Cantrell LA, Zhou C, Mendivil A, Malloy KM, Gehrig PA, Bae Jump VL. Metformin is a potent inhibitor of endometrial cancer cell proliferation-implications for a novel treatment strategy. Gynecol Oncol 2010; 116(1): 92-8.
-
(2010)
Gynecol Oncol
, vol.116
, Issue.1
, pp. 92-98
-
-
Cantrell, L.A.1
Zhou, C.2
Mendivil, A.3
Malloy, K.M.4
Gehrig, P.A.5
Bae Jump, V.L.6
-
24
-
-
73349105295
-
Metformin as an addition to conventional chemotherapy in breast cancer
-
author reply e60
-
Grenader T, Goldberg A, Shavit L. Metformin as an addition to conventional chemotherapy in breast cancer. J Clin Oncol 2009; 27(35): e259; author reply e60.
-
(2009)
J Clin Oncol
, vol.27
, Issue.35
-
-
Grenader, T.1
Goldberg, A.2
Shavit, L.3
-
25
-
-
73349087844
-
LKB1 and mammalian target of rapamycin as predictive factors for the anticancer efficacy of metformin
-
author reply e7
-
Memmott RM, Dennis PA. LKB1 and mammalian target of rapamycin as predictive factors for the anticancer efficacy of metformin. J Clin Oncol 2009; 27(34): e226; author reply e7.
-
(2009)
J Clin Oncol
, vol.27
, Issue.34
-
-
Memmott, R.M.1
Dennis, P.A.2
-
26
-
-
63849158757
-
Mitochondria: From bioenergetics to the metabolic regulation of carcinogenesis
-
Bellance N, Lestienne P, Rossignol R. Mitochondria: From bioenergetics to the metabolic regulation of carcinogenesis. Front Biosci 2009; 14: 4015-34.
-
(2009)
Front Biosci
, vol.14
, pp. 4015-4034
-
-
Bellance, N.1
Lestienne, P.2
Rossignol, R.3
-
27
-
-
44449147036
-
Tumor Cell Metabolism: Cancer's Achilles' Heel
-
Kroemer G, Pouyssegur J. Tumor cell metabolism: Cancer's Achilles' heel. Cancer Cell 2008; 13(6): 472-82.
-
(2008)
Cancer Cell
, vol.13
, Issue.6
, pp. 472-482
-
-
Kroemer, G.1
Pouyssegur, J.2
-
28
-
-
33846317064
-
Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells
-
Wu M, Neilson A, Swift AL, Moran R, Tamagnine J, Parslow D, et al. Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells. Am J Physiol Cell Physiol 2007; 292(1): C125-36.
-
(2007)
Am J Physiol Cell Physiol
, vol.292
, Issue.1
-
-
Wu, M.1
Neilson, A.2
Swift, A.L.3
Moran, R.4
Tamagnine, J.5
Parslow, D.6
-
29
-
-
0001221508
-
On respiratory impairment in cancer cells
-
Warburg O. On respiratory impairment in cancer cells. Science 1956; 124(3215): 269-70.
-
(1956)
Science
, vol.124
, Issue.3215
, pp. 269-270
-
-
Warburg, O.1
-
30
-
-
0037093411
-
Contribution by different fuels and metabolic pathways to the total ATP turnover of proliferating MCF-7 breast cancer cells
-
Guppy M, Leedman P, Zu X, Russell V. Contribution by different fuels and metabolic pathways to the total ATP turnover of proliferating MCF-7 breast cancer cells. Biochem J 2002; 364 (Pt 1): 309-15.
-
(2002)
Biochem J
, vol.364
, Issue.PART 1
, pp. 309-315
-
-
Guppy, M.1
Leedman, P.2
Zu, X.3
Russell, V.4
-
31
-
-
0347694776
-
Cancer metabolism: Facts, fantasy, and fiction
-
Zu XL, Guppy M. Cancer metabolism: Facts, fantasy, and fiction. Biochem Biophys Res Commun 2004; 313(3): 459-65.
-
(2004)
Biochem Biophys Res Commun
, vol.313
, Issue.3
, pp. 459-465
-
-
Zu, X.L.1
Guppy, M.2
-
32
-
-
33751325626
-
Tumor cell metabolism: The marriage of molecular genetics and proteomics with cellular intermediary metabolism; proceed with caution!
-
Costello LC, Franklin RB. Tumor cell metabolism: The marriage of molecular genetics and proteomics with cellular intermediary metabolism; proceed with caution! Mol Cancer 2006; 5: 59.
-
(2006)
Mol Cancer
, vol.5
, pp. 59
-
-
Costello, L.C.1
Franklin, R.B.2
-
33
-
-
39049106146
-
Mitocans: Mitochondrial targeted anti-cancer drugs as improved therapies and related patent documents
-
Ralph SJ, Low P, Dong L, Lawen A, Neuzil J. Mitocans: Mitochondrial targeted anti-cancer drugs as improved therapies and related patent documents. Recent Pat Anticancer Drug Discov 2006; 1(3): 327-46.
-
(2006)
Recent Pat Anticancer Drug Discov
, vol.1
, Issue.3
, pp. 327-346
-
-
Ralph, S.J.1
Low, P.2
Dong, L.3
Lawen, A.4
Neuzil, J.5
-
34
-
-
10044225745
-
Human ovarian carcinoma cells: Histone deacetylase inhibitors exhibit antiproliferative activity and potently induce apoptosis
-
Takai N, Kawamata N, Gui D, Said JW, Miyakawa I, Koeffler HP. Human ovarian carcinoma cells: Histone deacetylase inhibitors exhibit antiproliferative activity and potently induce apoptosis. Cancer 2004; 101(12): 2760-70.
-
(2004)
Cancer
, vol.101
, Issue.12
, pp. 2760-2770
-
-
Takai, N.1
Kawamata, N.2
Gui, D.3
Said, J.W.4
Miyakawa, I.5
Koeffler, H.P.6
-
35
-
-
60249083822
-
Hexokinase-2 bound to mitochondria: Cancer's stygian link to the Warburg Effect and a pivotal target for effective therapy
-
Mathupala SP, Ko YH, Pedersen PL. Hexokinase-2 bound to mitochondria: Cancer's stygian link to the Warburg Effect and a pivotal target for effective therapy. Semin Cancer Biol 2009; 19(1): 17-24.
-
(2009)
Semin Cancer Biol
, vol.19
, Issue.1
, pp. 17-24
-
-
Mathupala, S.P.1
Ko, Y.H.2
Pedersen, P.L.3
-
36
-
-
33745303045
-
Hypoxia signalling in cancer and approaches to enforce tumour regression
-
Pouyssegur J, Dayan F, Mazure NM. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 2006; 441(7092): 437-43.
-
(2006)
Nature
, vol.441
, Issue.7092
, pp. 437-443
-
-
Pouyssegur, J.1
Dayan, F.2
Mazure, N.M.3
-
37
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat Rev Cancer 2004; 4(11): 891-9.
-
(2004)
Nat Rev Cancer
, vol.4
, Issue.11
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
40
-
-
65549144609
-
Mitochondria as targets for cancer therapy
-
Ralph SJ, Neuzil J. Mitochondria as targets for cancer therapy. Mol Nutr Food Res 2009; 53(1): 9-28.
-
(2009)
Mol Nutr Food Res
, vol.53
, Issue.1
, pp. 9-28
-
-
Ralph, S.J.1
Neuzil, J.2
-
41
-
-
70350641018
-
Bioenergetics of lung tumors: Slteration of mitochondrial biogenesis and respiratory capacity
-
Bellance N, Benard G, Furt F, Begueret H, Smolkova K, Passerieux E, et al. Bioenergetics of lung tumors: Slteration of mitochondrial biogenesis and respiratory capacity. Int J Biochem Cell Biol 2009; 41(12): 2566-77.
-
(2009)
Int J Biochem Cell Biol
, vol.41
, Issue.12
, pp. 2566-2577
-
-
Bellance, N.1
Benard, G.2
Furt, F.3
Begueret, H.4
Smolkova, K.5
Passerieux, E.6
-
42
-
-
68949086533
-
Electron microscopy morphology of the mitochondrial network in human cancer
-
Arismendi-Morillo G. Electron microscopy morphology of the mitochondrial network in human cancer. Int J Biochem Cell Biol 2009; 41(10): 2062-8.
-
(2009)
Int J Biochem Cell Biol
, vol.41
, Issue.10
, pp. 2062-2068
-
-
Arismendi-Morillo, G.1
-
43
-
-
43249112094
-
ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis
-
Ishikawa K, Takenaga K, Akimoto M, Koshikawa N, Yamaguchi A, Imanishi H, et al. ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis. Science 2008; 320(5876): 661-4.
-
(2008)
Science
, vol.320
, Issue.5876
, pp. 661-664
-
-
Ishikawa, K.1
Takenaga, K.2
Akimoto, M.3
Koshikawa, N.4
Yamaguchi, A.5
Imanishi, H.6
-
44
-
-
0036262039
-
Low mitochondrial respiratory chain content correlates with tumor aggressiveness in renal cell carcinoma
-
Simonnet H, Alazard N, Pfeiffer K, Gallou C, Beroud C, Demont J, et al. Low mitochondrial respiratory chain content correlates with tumor aggressiveness in renal cell carcinoma. Carcinogenesis 2002; 23(5): 759-68.
-
(2002)
Carcinogenesis
, vol.23
, Issue.5
, pp. 759-768
-
-
Simonnet, H.1
Alazard, N.2
Pfeiffer, K.3
Gallou, C.4
Beroud, C.5
Demont, J.6
-
46
-
-
33644614520
-
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
-
Kim JW, Tchernyshyov I, Semenza GL, Dang CV. HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia. Cell Metab 2006; 3(3): 177-85.
-
(2006)
Cell Metab
, vol.3
, Issue.3
, pp. 177-185
-
-
Kim, J.W.1
Tchernyshyov, I.2
Semenza, G.L.3
Dang, C.V.4
-
47
-
-
0019815655
-
Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding
-
Bustamante E, Morris HP, Pedersen PL. Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding. J Biol Chem 1981; 256(16): 8699-704.
-
(1981)
J Biol Chem
, vol.256
, Issue.16
, pp. 8699-8704
-
-
Bustamante, E.1
Morris, H.P.2
Pedersen, P.L.3
-
48
-
-
52449119836
-
Regulation of hexokinase binding to VDAC
-
Pastorino JG, Hoek JB. Regulation of hexokinase binding to VDAC. J Bioenerg Biomembr 2008; 40(3): 171-82.
-
(2008)
J Bioenerg Biomembr
, vol.40
, Issue.3
, pp. 171-182
-
-
Pastorino, J.G.1
Hoek, J.B.2
-
49
-
-
33746924468
-
Cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria
-
Mathupala SP, Ko YH, Pedersen PL. Hexokinase II: Cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria. Oncogene 2006; 25(34): 4777-86.
-
(2006)
Oncogene
, vol.25
, Issue.34
, pp. 4777-4786
-
-
Mathupala, S.P.1
Ko, Y.H.2
Pedersen, P.L.3
Hexokinase, I.I.4
-
50
-
-
0034983918
-
Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase
-
Gottlob K, Majewski N, Kennedy S, Kandel E, Robey RB, Hay N. Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes Dev 2001; 15(11): 1406-18.
-
(2001)
Genes Dev
, vol.15
, Issue.11
, pp. 1406-1418
-
-
Gottlob, K.1
Majewski, N.2
Kennedy, S.3
Kandel, E.4
Robey, R.B.5
Hay, N.6
-
51
-
-
0017580293
-
Mechanism of pigeon liver malic enzyme: Kinetics, specificity, and half-site stoichiometry of the alkylation of a cysteinyl residue by the substrate-inhibitor bromopyruvate
-
Chang GG, Hsu RY. Mechanism of pigeon liver malic enzyme: Kinetics, specificity, and half-site stoichiometry of the alkylation of a cysteinyl residue by the substrate-inhibitor bromopyruvate. Biochemistry 1977; 16(2): 311-20.
-
(1977)
Biochemistry
, vol.16
, Issue.2
, pp. 311-320
-
-
Chang, G.G.1
Hsu, R.Y.2
-
52
-
-
0345493676
-
Involvement of alpha-cysteine-62 and beta-tryptophan-135 in human pyruvate dehydrogenase catalysis
-
Korotchkina LG, Ali SM, Patel MS. Involvement of alpha-cysteine-62 and beta-tryptophan-135 in human pyruvate dehydrogenase catalysis. Arch Biochem Biophys 1999; 369(2): 277-87.
-
(1999)
Arch Biochem Biophys
, vol.369
, Issue.2
, pp. 277-287
-
-
Korotchkina, L.G.1
Ali, S.M.2
Patel, M.S.3
-
53
-
-
0017802302
-
Mechanism of inactivation of brain glutamic decarboxylase by 3-bromopyruvate
-
Tunnicliff G, Ngo TT. Mechanism of inactivation of brain glutamic decarboxylase by 3-bromopyruvate. Int J Biochem 1978; 9(4): 249-52.
-
(1978)
Int J Biochem
, vol.9
, Issue.4
, pp. 249-252
-
-
Tunnicliff, G.1
Ngo, T.T.2
-
54
-
-
4744341871
-
Advanced cancers: Eradication in all cases using 3- bromopyruvate therapy to deplete ATP
-
Ko YH, Smith BL, Wang Y, Pomper MG, Rini DA, Torbenson MS, et al. Advanced cancers: Eradication in all cases using 3- bromopyruvate therapy to deplete ATP. Biochem Biophys Res Commun 2004; 324(1): 269-75.
-
(2004)
Biochem Biophys Res Commun
, vol.324
, Issue.1
, pp. 269-275
-
-
Ko, Y.H.1
Smith, B.L.2
Wang, Y.3
Pomper, M.G.4
Rini, D.A.5
Torbenson, M.S.6
-
55
-
-
59849092584
-
Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate
-
Pereira da Silva AP, El-Bacha T, Kyaw N, dos Santos RS, da-Silva WS, Almeida FC, et al. Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate. Biochem J 2009; 417(3): 717-26.
-
(2009)
Biochem J
, vol.417
, Issue.3
-
-
Pereira da Silva, A.P.1
El-Bacha, T.2
Kyaw, N.3
dos Santos, R.S.4
da-Silva, W.S.5
Almeida, F.C.6
-
58
-
-
70350101307
-
Transport by SLC5A8 with subsequent inhibition of histone deacetylase 1 (HDAC1) and HDAC3 underlies the antitumor activity of 3-bromopyruvate
-
Thangaraju M, Karunakaran SK, Itagaki S, Gopal E, Elangovan S, Prasad PD, et al. Transport by SLC5A8 with subsequent inhibition of histone deacetylase 1 (HDAC1) and HDAC3 underlies the antitumor activity of 3-bromopyruvate. Cancer 2009; 115(20): 4655-66.
-
(2009)
Cancer
, vol.115
, Issue.20
, pp. 4655-4666
-
-
Thangaraju, M.1
Karunakaran, S.K.2
Itagaki, S.3
Gopal, E.4
Elangovan, S.5
Prasad, P.D.6
-
60
-
-
78650952586
-
-
US6534501
-
Donald, J., Abraham, C.W., Richmond, D.-D., James, C. Burnett, G. S., Joshi, S. J. H. Allosteric inhibitors of pyruvate kinase. US6534501 (2003).
-
(2003)
Allosteric Inhibitors of Pyruvate Kinase
-
-
Donald, J.1
Abraham, C.W.2
Richmond, D.-D.3
James, C.4
Burnett, G.S.5
Joshi, S.J.H.6
-
62
-
-
0030797585
-
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
-
Gu W, Roeder RG. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 1997; 90(4): 595-606.
-
(1997)
Cell
, vol.90
, Issue.4
, pp. 595-606
-
-
Gu, W.1
Roeder, R.G.2
-
63
-
-
61849144810
-
HDAC family: What are the cancer relevant targets?
-
Witt O, Deubzer HE, Milde T, Oehme I. HDAC family: What are the cancer relevant targets? Cancer Lett 2009; 277(1): 8-21.
-
(2009)
Cancer Lett
, vol.277
, Issue.1
, pp. 8-21
-
-
Witt, O.1
Deubzer, H.E.2
Milde, T.3
Oehme, I.4
-
64
-
-
34249275640
-
Preparative peptide isoelectric focusing as a tool for improving the identification of lysine-acetylated peptides from complex mixtures
-
Xie H, Bandhakavi S, Roe MR, Griffin TJ. Preparative peptide isoelectric focusing as a tool for improving the identification of lysine-acetylated peptides from complex mixtures. J Proteome Res 2007; 6(5): 2019-26.
-
(2007)
J Proteome Res
, vol.6
, Issue.5
, pp. 2019-2026
-
-
Xie, H.1
Bandhakavi, S.2
Roe, M.R.3
Griffin, T.J.4
-
65
-
-
27744479712
-
Modulating molecular chaperone Hsp90 functions through reversible acetylation
-
Aoyagi S, Archer TK. Modulating molecular chaperone Hsp90 functions through reversible acetylation. Trends Cell Biol 2005; 15(11): 565-7.
-
(2005)
Trends Cell Biol
, vol.15
, Issue.11
, pp. 565-567
-
-
Aoyagi, S.1
Archer, T.K.2
-
66
-
-
4143083971
-
Regulation at multiple levels of NF-kappaB- mediated transactivation by protein acetylation
-
Quivy V, Van Lint C. Regulation at multiple levels of NF-kappaB- mediated transactivation by protein acetylation. Biochem Pharmacol 2004; 68(6): 1221-9.
-
(2004)
Biochem Pharmacol
, vol.68
, Issue.6
, pp. 1221-1229
-
-
Quivy, V.1
van Lint, C.2
-
67
-
-
18644365597
-
Histone deacetylase inhibitors differentially stabilize acetylated p53 and induce cell cycle arrest or apoptosis in prostate cancer cells
-
Roy S, Packman K, Jeffrey R, Tenniswood M. Histone deacetylase inhibitors differentially stabilize acetylated p53 and induce cell cycle arrest or apoptosis in prostate cancer cells. Cell Death Differ 2005; 12(5): 482-91.
-
(2005)
Cell Death Differ
, vol.12
, Issue.5
, pp. 482-491
-
-
Roy, S.1
Packman, K.2
Jeffrey, R.3
Tenniswood, M.4
-
68
-
-
0037012344
-
Modulation of p53, ErbB1, ErbB2, and Raf-1 expression in lung cancer cells by depsipeptide FR901228
-
Yu X, Guo ZS, Marcu MG, Neckers L, Nguyen DM, Chen GA, et al. Modulation of p53, ErbB1, ErbB2, and Raf-1 expression in lung cancer cells by depsipeptide FR901228. J Natl Cancer Inst 2002; 94(7): 504-13.
-
(2002)
J Natl Cancer Inst
, vol.94
, Issue.7
, pp. 504-513
-
-
Yu, X.1
Guo, Z.S.2
Marcu, M.G.3
Neckers, L.4
Nguyen, D.M.5
Chen, G.A.6
-
69
-
-
78650956294
-
-
FDA approval and New Drug Application (NDA) documents for ZolinzaTM (SAHA,vorinostat)Availablefrom:http://www.accessdata.fda.gov/dr ugsatfda_docs/nda/2006/021991s000_ZolinzaTOC.cfm
-
-
-
-
70
-
-
71449109387
-
New patented histone deacetylase inhibitors
-
Wang H, Dymock, BW. New patented histone deacetylase inhibitors. Expert Opin Ther Pat 2009; 19(12): 1727-57.
-
(2009)
Expert Opin Ther Pat
, vol.19
, Issue.12
, pp. 1727-1757
-
-
Wang, H.1
Dymock, B.W.2
-
71
-
-
20044390016
-
Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors
-
Ungerstedt JS, Sowa Y, Xu WS, Shao Y, Dokmanovic M, Perez G, et al. Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors. Proc Natl Acad Sci USA 2005; 102(3): 673-8.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, Issue.3
, pp. 673-678
-
-
Ungerstedt, J.S.1
Sowa, Y.2
Xu, W.S.3
Shao, Y.4
Dokmanovic, M.5
Perez, G.6
-
72
-
-
0033565359
-
Effect of glucose and deoxyglucose on the redistribution of calcium in ehrlich ascites tumour and Zajdela hepatoma cells and its consequences for mitochondrial energetics. Further arguments for the role of Ca(2+) in the mechanism of the crabtree effect
-
Wojtczak L, Teplova VV, Bogucka K, Czyz A, Makowska A, Wieckowski MR, et al. Effect of glucose and deoxyglucose on the redistribution of calcium in ehrlich ascites tumour and Zajdela hepatoma cells and its consequences for mitochondrial energetics. Further arguments for the role of Ca(2+) in the mechanism of the crabtree effect. Eur J Biochem 1999; 263(2): 495-501.
-
(1999)
Eur J Biochem
, vol.263
, Issue.2
, pp. 495-501
-
-
Wojtczak, L.1
Teplova, V.V.2
Bogucka, K.3
Czyz, A.4
Makowska, A.5
Wieckowski, M.R.6
-
73
-
-
41149105722
-
Mitochondria in cancer cells: What is so special about them?
-
Gogvadze V, Orrenius S, Zhivotovsky B. Mitochondria in cancer cells: What is so special about them? Trends Cell Biol 2008; 18(4): 165-73.
-
(2008)
Trends Cell Biol
, vol.18
, Issue.4
, pp. 165-173
-
-
Gogvadze, V.1
Orrenius, S.2
Zhivotovsky, B.3
-
74
-
-
30944436851
-
Role of mitochondria in tamoxifen-induced rapid death of MCF-7 breast cancer cells
-
Kallio A, Zheng A, Dahllund J, Heiskanen KM, Harkonen P. Role of mitochondria in tamoxifen-induced rapid death of MCF-7 breast cancer cells. Apoptosis 2005; 10(6): 1395-410.
-
(2005)
Apoptosis
, vol.10
, Issue.6
, pp. 1395-1410
-
-
Kallio, A.1
Zheng, A.2
Dahllund, J.3
Heiskanen, K.M.4
Harkonen, P.5
-
75
-
-
0035408191
-
Resveratrol, a tumor-suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bcl-2
-
Tinhofer I, Bernhard D, Senfter M, Anether G, Loeffler M, Kroemer G, et al. Resveratrol, a tumor-suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bcl-2. FASEB J 2001; 15(9): 1613-5.
-
(2001)
FASEB J
, vol.15
, Issue.9
, pp. 1613-1615
-
-
Tinhofer, I.1
Bernhard, D.2
Senfter, M.3
Anether, G.4
Loeffler, M.5
Kroemer, G.6
-
76
-
-
0026611398
-
Cytochrome aa3 depletion is the cause of the deficient mitochondrial respiration induced by chronic valproate administration
-
Ponchaut S, van Hoof F, Veitch K. Cytochrome aa3 depletion is the cause of the deficient mitochondrial respiration induced by chronic valproate administration. Biochem Pharmacol 1992; 43(3): 644-7.
-
(1992)
Biochem Pharmacol
, vol.43
, Issue.3
, pp. 644-647
-
-
Ponchaut, S.1
van Hoof, F.2
Veitch, K.3
-
77
-
-
0035964970
-
Differential effect of valproate and its Delta2- and Delta4- unsaturated metabolites, on the beta-oxidation rate of long-chain and medium-chain fatty acids
-
Silva MF, Ruiter JP, Ijlst L, Jakobs C, Duran M, de Almeida IT, et al. Differential effect of valproate and its Delta2- and Delta4- unsaturated metabolites, on the beta-oxidation rate of long-chain and medium-chain fatty acids. Chem Biol Interact 2001; 137(3): 203-12.
-
(2001)
Chem Biol Interact
, vol.137
, Issue.3
, pp. 203-212
-
-
Silva, M.F.1
Ruiter, J.P.2
Ijlst, L.3
Jakobs, C.4
Duran, M.5
de Almeida, I.T.6
-
78
-
-
0020512410
-
The effects of valproate on intermediary metabolism in isolated rat hepatocytes and intact rats
-
Turnbull DM, Bone AJ, Bartlett K, Koundakjian PP, Sherratt HS. The effects of valproate on intermediary metabolism in isolated rat hepatocytes and intact rats. Biochem Pharmacol 1983; 32(12): 1887-92.
-
(1983)
Biochem Pharmacol
, vol.32
, Issue.12
, pp. 1887-1892
-
-
Turnbull, D.M.1
Bone, A.J.2
Bartlett, K.3
Koundakjian, P.P.4
Sherratt, H.S.5
-
79
-
-
0033761352
-
Butyrate metabolism upstream and downstream acetyl-CoA synthesis and growth control of human colon carcinoma cells
-
Leschelle X, Delpal S, Goubern M, Blottiere HM, Blachier F. Butyrate metabolism upstream and downstream acetyl-CoA synthesis and growth control of human colon carcinoma cells. Eur J Biochem 2000; 267(21): 6435-42.
-
(2000)
Eur J Biochem
, vol.267
, Issue.21
, pp. 6435-6442
-
-
Leschelle, X.1
Delpal, S.2
Goubern, M.3
Blottiere, H.M.4
Blachier, F.5
-
80
-
-
0042208239
-
The stable isotope-based dynamic metabolic profile of butyrate-induced HT29 cell differentiation
-
Boren J, Lee WN, Bassilian S, Centelles JJ, Lim S, Ahmed S, et al. The stable isotope-based dynamic metabolic profile of butyrate-induced HT29 cell differentiation. J Biol Chem 2003; 278(31): 28395-402.
-
(2003)
J Biol Chem
, vol.278
, Issue.31
, pp. 28395-28402
-
-
Boren, J.1
Lee, W.N.2
Bassilian, S.3
Centelles, J.J.4
Lim, S.5
Ahmed, S.6
-
81
-
-
61449093727
-
Glucose metabolism as a target of histone deacetylase inhibitors
-
Wardell SE, Ilkayeva OR, Wieman HL, Frigo DE, Rathmell JC, Newgard CB, et al. Glucose metabolism as a target of histone deacetylase inhibitors. Mol Endocrinol 2009; 23(3): 388-401.
-
(2009)
Mol Endocrinol
, vol.23
, Issue.3
, pp. 388-401
-
-
Wardell, S.E.1
Ilkayeva, O.R.2
Wieman, H.L.3
Frigo, D.E.4
Rathmell, J.C.5
Newgard, C.B.6
|