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Volumn 1804, Issue 3, 2010, Pages 511-519

Recent developments in cyclin-dependent kinase biochemical and structural studies

Author keywords

CDK; Cell cycle regulation; Cyclin; X ray crystallography

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 9;

EID: 75349112388     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2009.10.002     Document Type: Review
Times cited : (106)

References (58)
  • 1
    • 0031466305 scopus 로고    scopus 로고
    • Cyclin-dependent kinases: engines, clocks, and microprocessors
    • Morgan D.O. Cyclin-dependent kinases: engines, clocks, and microprocessors. Annu. Rev. Cell Dev. Biol. 13 (1997) 261-291
    • (1997) Annu. Rev. Cell Dev. Biol. , vol.13 , pp. 261-291
    • Morgan, D.O.1
  • 2
  • 3
    • 8644219655 scopus 로고    scopus 로고
    • Living with or without cyclins and cyclin-dependent kinases
    • Sherr C.J., and Roberts J.M. Living with or without cyclins and cyclin-dependent kinases. Genes Dev. 18 (2004) 2699-2711
    • (2004) Genes Dev. , vol.18 , pp. 2699-2711
    • Sherr, C.J.1    Roberts, J.M.2
  • 4
    • 25144525540 scopus 로고    scopus 로고
    • CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis
    • Mailand N., and Diffley J.F. CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis. Cell 122 (2005) 915-926
    • (2005) Cell , vol.122 , pp. 915-926
    • Mailand, N.1    Diffley, J.F.2
  • 5
    • 29244468847 scopus 로고    scopus 로고
    • Secrets of a double agent: CDK7 in cell-cycle control and transcription
    • Fisher R.P. Secrets of a double agent: CDK7 in cell-cycle control and transcription. J. Cell. Sci. 118 (2005) 5171-5180
    • (2005) J. Cell. Sci. , vol.118 , pp. 5171-5180
    • Fisher, R.P.1
  • 6
    • 44549087848 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 9: a key transcriptional regulator and potential drug target in oncology, virology and cardiology
    • Wang S., and Fischer P.M. Cyclin-dependent kinase 9: a key transcriptional regulator and potential drug target in oncology, virology and cardiology. Trends Pharmacol. Sci. 29 (2008) 302-313
    • (2008) Trends Pharmacol. Sci. , vol.29 , pp. 302-313
    • Wang, S.1    Fischer, P.M.2
  • 7
    • 67649726156 scopus 로고    scopus 로고
    • Protein kinase inhibitors: contributions from structure to clinical compounds
    • Johnson L.N. Protein kinase inhibitors: contributions from structure to clinical compounds. Q. Rev. Biophys. 42 (2009) 1-40
    • (2009) Q. Rev. Biophys. , vol.42 , pp. 1-40
    • Johnson, L.N.1
  • 8
    • 0038795172 scopus 로고    scopus 로고
    • Genetics of melanoma predisposition
    • Hayward N.K. Genetics of melanoma predisposition. Oncogene 22 (2003) 3053-3062
    • (2003) Oncogene , vol.22 , pp. 3053-3062
    • Hayward, N.K.1
  • 9
    • 33645802169 scopus 로고    scopus 로고
    • Cyclin-dependent kinase pathways as targets for cancer treatment
    • Shapiro G.I. Cyclin-dependent kinase pathways as targets for cancer treatment. J. Clin. Oncol. 24 (2006) 1770-1783
    • (2006) J. Clin. Oncol. , vol.24 , pp. 1770-1783
    • Shapiro, G.I.1
  • 10
    • 0033574614 scopus 로고    scopus 로고
    • Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors
    • Pavletich N.P. Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors. J. Mol. Biol. 287 (1999) 821-828
    • (1999) J. Mol. Biol. , vol.287 , pp. 821-828
    • Pavletich, N.P.1
  • 11
    • 0037013143 scopus 로고    scopus 로고
    • The conformational plasticity of protein kinases
    • Huse M., and Kuriyan J. The conformational plasticity of protein kinases. Cell 109 (2002) 275-282
    • (2002) Cell , vol.109 , pp. 275-282
    • Huse, M.1    Kuriyan, J.2
  • 12
    • 17144420076 scopus 로고    scopus 로고
    • Molecular motions of human cyclin-dependent kinase 2
    • Barrett C.P., and Noble M.E. Molecular motions of human cyclin-dependent kinase 2. J. Biol. Chem. 280 (2005) 13993-14005
    • (2005) J. Biol. Chem. , vol.280 , pp. 13993-14005
    • Barrett, C.P.1    Noble, M.E.2
  • 16
    • 0034671563 scopus 로고    scopus 로고
    • Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors
    • Jeffrey P.D., Tong L., and Pavletich N.P. Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors. Genes Dev. 14 (2000) 3115-3125
    • (2000) Genes Dev. , vol.14 , pp. 3115-3125
    • Jeffrey, P.D.1    Tong, L.2    Pavletich, N.P.3
  • 17
    • 14844307019 scopus 로고    scopus 로고
    • The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles
    • Honda R., Lowe E.D., Dubinina E., Skamnaki V., Cook A., Brown N.R., and Johnson L.N. The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles. EMBO J. 24 (2005) 452-463
    • (2005) EMBO J. , vol.24 , pp. 452-463
    • Honda, R.1    Lowe, E.D.2    Dubinina, E.3    Skamnaki, V.4    Cook, A.5    Brown, N.R.6    Johnson, L.N.7
  • 18
    • 36248959857 scopus 로고    scopus 로고
    • Structure of the Pho85-Pho80 CDK-cyclin complex of the phosphate-responsive signal transduction pathway
    • Huang K., Ferrin-O'Connell I., Zhang W., Leonard G.A., O'Shea E.K., and Quiocho F.A. Structure of the Pho85-Pho80 CDK-cyclin complex of the phosphate-responsive signal transduction pathway. Mol. Cell 28 (2007) 614-623
    • (2007) Mol. Cell , vol.28 , pp. 614-623
    • Huang, K.1    Ferrin-O'Connell, I.2    Zhang, W.3    Leonard, G.A.4    O'Shea, E.K.5    Quiocho, F.A.6
  • 19
    • 0033224309 scopus 로고    scopus 로고
    • The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases
    • Brown N.R., Noble M.E., Endicott J.A., and Johnson L.N. The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases. Nat. Cell Biol. 1 (1999) 438-443
    • (1999) Nat. Cell Biol. , vol.1 , pp. 438-443
    • Brown, N.R.1    Noble, M.E.2    Endicott, J.A.3    Johnson, L.N.4
  • 20
    • 34547697834 scopus 로고    scopus 로고
    • Cyclin B and cyclin A confer different substrate recognition properties on CDK2
    • Brown N.R., Lowe E.D., Petri E., Skamnaki V., Antrobus R., and Johnson L.N. Cyclin B and cyclin A confer different substrate recognition properties on CDK2. Cell Cycle 6 (2007) 1350-1359
    • (2007) Cell Cycle , vol.6 , pp. 1350-1359
    • Brown, N.R.1    Lowe, E.D.2    Petri, E.3    Skamnaki, V.4    Antrobus, R.5    Johnson, L.N.6
  • 21
    • 0035265679 scopus 로고    scopus 로고
    • Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2
    • Song H., Hanlon N., Brown N.R., Noble M.E., Johnson L.N., and Barford D. Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2. Mol. Cell 7 (2001) 615-626
    • (2001) Mol. Cell , vol.7 , pp. 615-626
    • Song, H.1    Hanlon, N.2    Brown, N.R.3    Noble, M.E.4    Johnson, L.N.5    Barford, D.6
  • 23
    • 0029644732 scopus 로고
    • Two structures of the catalytic domain of phosphorylase kinase: an active protein kinase complexed with substrate analogue and product
    • Owen D.J., Noble M.E., Garman E.F., Papageorgiou A.C., and Johnson L.N. Two structures of the catalytic domain of phosphorylase kinase: an active protein kinase complexed with substrate analogue and product. Structure 3 (1995) 467-482
    • (1995) Structure , vol.3 , pp. 467-482
    • Owen, D.J.1    Noble, M.E.2    Garman, E.F.3    Papageorgiou, A.C.4    Johnson, L.N.5
  • 25
    • 0033695002 scopus 로고    scopus 로고
    • Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C
    • Takizawa C.G., and Morgan D.O. Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C. Curr. Opin. Cell Biol. 12 (2000) 658-665
    • (2000) Curr. Opin. Cell Biol. , vol.12 , pp. 658-665
    • Takizawa, C.G.1    Morgan, D.O.2
  • 26
    • 0034707047 scopus 로고    scopus 로고
    • The DNA damage response: putting checkpoints in perspective
    • Zhou B.B., and Elledge S.J. The DNA damage response: putting checkpoints in perspective. Nature 408 (2000) 433-439
    • (2000) Nature , vol.408 , pp. 433-439
    • Zhou, B.B.1    Elledge, S.J.2
  • 27
    • 0043066731 scopus 로고    scopus 로고
    • Regulating mammalian checkpoints through Cdc25 inactivation
    • Donzelli M., and Draetta G.F. Regulating mammalian checkpoints through Cdc25 inactivation. EMBO Rep. 4 (2003) 671-677
    • (2003) EMBO Rep. , vol.4 , pp. 671-677
    • Donzelli, M.1    Draetta, G.F.2
  • 31
    • 47249130291 scopus 로고    scopus 로고
    • Regulatory phosphorylation of cyclin-dependent kinase 2: insights from molecular dynamics simulations
    • Bartova I., Koca J., and Otyepka M. Regulatory phosphorylation of cyclin-dependent kinase 2: insights from molecular dynamics simulations. J. Mol. Model 14 (2008) 761-768
    • (2008) J. Mol. Model , vol.14 , pp. 761-768
    • Bartova, I.1    Koca, J.2    Otyepka, M.3
  • 32
    • 0036169172 scopus 로고    scopus 로고
    • Cdk5 behind the wheel: a role in trafficking and transport?
    • Smith D.S., and Tsai L.H. Cdk5 behind the wheel: a role in trafficking and transport?. Trends Cell Biol. 12 (2002) 28-36
    • (2002) Trends Cell Biol. , vol.12 , pp. 28-36
    • Smith, D.S.1    Tsai, L.H.2
  • 33
    • 33646379621 scopus 로고    scopus 로고
    • Different mechanisms of CDK5 and CDK2 activation as revealed by CDK5/p25 and CDK2/cyclin A dynamics
    • Otyepka M., Bartova I., Kriz Z., and Koca J. Different mechanisms of CDK5 and CDK2 activation as revealed by CDK5/p25 and CDK2/cyclin A dynamics. J. Biol. Chem. 281 (2006) 7271-7281
    • (2006) J. Biol. Chem. , vol.281 , pp. 7271-7281
    • Otyepka, M.1    Bartova, I.2    Kriz, Z.3    Koca, J.4
  • 35
    • 25444444192 scopus 로고    scopus 로고
    • CAK-Cyclin-dependent activating kinase: a key kinase in cell cycle control and a target for drugs?
    • Lolli G., and Johnson L.N. CAK-Cyclin-dependent activating kinase: a key kinase in cell cycle control and a target for drugs?. Cell Cycle 4 (2005) 572-577
    • (2005) Cell Cycle , vol.4 , pp. 572-577
    • Lolli, G.1    Johnson, L.N.2
  • 38
    • 0034747803 scopus 로고    scopus 로고
    • Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop
    • Garrett S., Barton W.A., Knights R., Jin P., Morgan D.O., and Fisher R.P. Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop. Mol. Cell. Biol. 21 (2001) 88-99
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 88-99
    • Garrett, S.1    Barton, W.A.2    Knights, R.3    Jin, P.4    Morgan, D.O.5    Fisher, R.P.6
  • 40
    • 0034947953 scopus 로고    scopus 로고
    • Mutational analysis of the Cy motif from p21 reveals sequence degeneracy and specificity for different cyclin-dependent kinases
    • Wohlschlegel J.A., Dwyer B.T., Takeda D.Y., and Dutta A. Mutational analysis of the Cy motif from p21 reveals sequence degeneracy and specificity for different cyclin-dependent kinases. Mol. Cell. Biol. 21 (2001) 4868-4874
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 4868-4874
    • Wohlschlegel, J.A.1    Dwyer, B.T.2    Takeda, D.Y.3    Dutta, A.4
  • 42
    • 0035910422 scopus 로고    scopus 로고
    • A bipartite substrate recognition motif for cyclin-dependent kinases
    • Takeda D.Y., Wohlschlegel J.A., and Dutta A. A bipartite substrate recognition motif for cyclin-dependent kinases. J. Biol. Chem. 276 (2001) 1993-1997
    • (2001) J. Biol. Chem. , vol.276 , pp. 1993-1997
    • Takeda, D.Y.1    Wohlschlegel, J.A.2    Dutta, A.3
  • 43
    • 0029665852 scopus 로고    scopus 로고
    • Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex
    • Russo A.A., Jeffrey P.D., Patten A.K., Massague J., and Pavletich N.P. Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Nature 382 (1996) 325-331
    • (1996) Nature , vol.382 , pp. 325-331
    • Russo, A.A.1    Jeffrey, P.D.2    Patten, A.K.3    Massague, J.4    Pavletich, N.P.5
  • 44
    • 37549061066 scopus 로고    scopus 로고
    • Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activity
    • James M.K., Ray A., Leznova D., and Blain S.W. Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activity. Mol. Cell. Biol. 28 (2008) 498-510
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 498-510
    • James, M.K.1    Ray, A.2    Leznova, D.3    Blain, S.W.4
  • 46
    • 0033559264 scopus 로고    scopus 로고
    • The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts
    • Cheng M., Olivier P., Diehl J.A., Fero M., Roussel M.F., Roberts J.M., and Sherr C.J. The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J. 18 (1999) 1571-1583
    • (1999) EMBO J. , vol.18 , pp. 1571-1583
    • Cheng, M.1    Olivier, P.2    Diehl, J.A.3    Fero, M.4    Roussel, M.F.5    Roberts, J.M.6    Sherr, C.J.7
  • 48
    • 59449106702 scopus 로고    scopus 로고
    • p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes
    • Ray A., James M.K., Larochelle S., Fisher R.P., and Blain S.W. p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes. Mol. Cell. Biol. 29 (2009) 986-999
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 986-999
    • Ray, A.1    James, M.K.2    Larochelle, S.3    Fisher, R.P.4    Blain, S.W.5
  • 49
    • 60749109846 scopus 로고    scopus 로고
    • Cell cycle, CDKs and cancer: a changing paradigm
    • Malumbres M., and Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. Nat. Rev. Cancer 9 (2009) 153-166
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 153-166
    • Malumbres, M.1    Barbacid, M.2
  • 50
    • 69249230769 scopus 로고    scopus 로고
    • Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms
    • Satyanarayana A., and Kaldis P. Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms. Oncogene 28 (2009) 2925-2939
    • (2009) Oncogene , vol.28 , pp. 2925-2939
    • Satyanarayana, A.1    Kaldis, P.2
  • 51
    • 54549101258 scopus 로고    scopus 로고
    • Cyclin-dependent kinases and cell-cycle transitions: does one fit all?
    • Hochegger H., Takeda S., and Hunt T. Cyclin-dependent kinases and cell-cycle transitions: does one fit all?. Nat. Rev. Mol. Cell Biol. (2008) 9
    • (2008) Nat. Rev. Mol. Cell Biol. , pp. 9
    • Hochegger, H.1    Takeda, S.2    Hunt, T.3
  • 57
    • 34548232365 scopus 로고    scopus 로고
    • Inference of macromolecular assemblies from crystalline state
    • Krissinel E., and Henrick K. Inference of macromolecular assemblies from crystalline state. J. Mol. Biol. 372 (2007) 774-797
    • (2007) J. Mol. Biol. , vol.372 , pp. 774-797
    • Krissinel, E.1    Henrick, K.2


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