In Vitro and in Vivo Characterization of Helicobacter hepaticus Cytolethal Distending Toxin Mutants

Infection and Immunity

Volumn 72, Issue 5, 2004, Pages 2521-2527

  Young, Vincent B ^a,b   Knox, Kimberly A ^c   Pratt, Jason S ^a   Cortez, Jennifer S ^a,b   Mansfield, Linda S ^a   Rogers, Arlin B ^c   Fox, James G ^c   Schauer, David B ^c  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; CYTOLETHAL DISTENDING TOXIN; CYTOTOXIN; INTERLEUKIN 10; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GENETICS; BACTERIUM MUTANT; CONTROLLED STUDY; ENTERITIS; GENE CLUSTER; GENE INSERTION; HELICOBACTER HEPATICUS; HUMAN; HUMAN CELL; MOUSE; MUTAGENESIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; TRANSPOSON;

ANIMALS; BACTERIAL TOXINS; COLITIS; FEMALE; GENES, BACTERIAL; HELA CELLS; HELICOBACTER HEPATICUS; HELICOBACTER INFECTIONS; HUMANS; INTERLEUKIN-10; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MULTIGENE FAMILY; MUTAGENESIS, INSERTIONAL; MUTATION;

EID: 2142758715     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.72.5.2521-2527.2004     Document Type: Article

References (37)

1. Ananieva, O., I. Nilsson, T. Vorobjova, R. Uibo, and T. Wadström. 2002. Immune responses to bile-tolerant Helicobacter species in patients with chronic liver diseases, a randomized population group, and healthy blood donors. Clin. Diagn. Lab. Immunol. 9:1160-1164.
2. Avenaud, P., A. Marais, L. Monteiro, B. Le Bail, P. Bioulac Sage, C. Balabaud, and F. Megraud. 2000. Detection of Helicobacter species in the liver of patients with and without primary liver carcinoma. Cancer 89:1431-1439.
3. Blaser, M. J., and J. Parsonnet. 1994. Parasitism by the "slow" bacterium Helicobacter pylori leads to altered gastric homeostasis and neoplasia. J. Clin. Investig. 94:4-8.
4. Burich, A., R. Hershberg, K. Waggle, W. Zeng, T. Brabb, G. Westrich, J. L. Viney, and L. Maggio-Price. 2001. Helicobacter-induced inflammatory bowel disease in IL-10- and T cell-deficient mice. Am. J. Physiol. Gastrointest. Liver Physiol. 281:G764-G778.
5. Cahill, R. J., C. J. Foltz, J. G. Fox, C. A. Dangler, F. Powrie, and D. B. Schauer. 1997. Inflammatory bowel disease: an immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus. Infect. Immun. 65:3126-3131.
6. Chien, C. C., N. S. Taylor, Z. Ge, D. B. Schauer, V. B. Young, and J. G. Fox. 2000. Identification of cdtB homologues and cytolethal distending toxin activity in enterohepatic Helicobacter spp. J. Med. Microbiol. 49:525-534.
7. Chin, E. Y., C. A. Dangler, J. G. Fox, and D. B. Schauer. 2000. Helicobacter hepaticus infection triggers inflammatory bowel disease in T cell receptor alpha/beta mutant mice. Comp. Med. 50:586-594.
8. De Rycke, J., and E. Oswald. 2001. Cytolethal distending toxin (CDT): a bacterial weapon to control host cell proliferation? FEMS Microbiol. Lett. 203:141-148.
9. Elwell, C., K. Chao, K. Patel, and L. Dreyfus. 2001. Escherichia coli CdtB mediates cytolethal distending toxin cell cycle arrest. Infect. Immun. 69:3418-3422.
10. Erdman, S. E., J. G. Fox, C. A. Dangler, D. Feldman, and B. H. Horwitz. 2001. Typhlocolitis in NF-κB-deficient mice. J. Immunol. 166:1443-1447.
11. Fox, J. G. 2002. The non-H pylori helicobacters: their expanding role in gastrointestinal and systemic diseases. Gut 50:273-283.
12. Fox, J. G., F. E. Dewhirst, Z. Shen, Y. Feng, N. S. Taylor, B. J. Paster, R. L. Ericson, C. N. Lau, P. Correa, J. C. Araya, and I. Roa. 1998. Hepatic Helicobacter species identified in bile and gallbladder tissue from Chileans with chronic cholecystitis. Gastroenterology 114:755-763.
13. Fox, J. G., F. E. Dewhirst, J. G. Tully, B. J. Paster, L. Yan, N. S. Taylor, M. J. Collins, Jr., P. L. Gorelick, and J. M. Ward. 1994. Helicobacter hepaticus sp. nov., a microaerophilic bacterium isolated from livers and intestinal mucosal scrapings from mice. J. Clin. Microbiol. 32:1238-1245.
14. Ge, Z., K. Hiratsuka, and D. E. Taylor. 1995. Nucleotide sequence and mutational analysis indicate that two Helicobacter pylori genes encode a P-type ATPase and a cation-binding protein associated with copper transport. Mol. Microbiol. 15:97-106.
15. Hassane, D. C., R. B. Lee, and C. L. Pickett. 2003. Campylobacter jejuni cytolethal distending toxin promotes DNA repair responses in normal human cells. Infect. Immun. 71:541-545.
16. Lara-Tejero, M., and J. E. Galan. 2000. A bacterial toxin that controls cell cycle progression as a deoxyribonuclease I-like protein. Science 290:354-357.
17. Lara-Tejero, M., and J. E. Galán. 2001. CdtA, CdtB, and CdtC form a tripartite complex that is required for cytolethal distending toxin activity. Infect. Immun. 69:4358-4365.
18. Lara-Tejero, M., and J. E. Galan. 2002. Cytolethal distending toxin: limited damage as a strategy to modulate cellular functions. Trends Microbiol. 10:147-152.
19. Lewis, D. A., M. K. Stevens, J. L. Latimer, C. K. Ward, K. Deng, R. Blick, S. R. Lumbley, C. A. Ison, and E. J. Hansen. 2001. Characterization of Haemophilus ducreyi cdtA, cdtB, and cdtC mutants in in vitro and in vivo systems. Infect. Immun. 69:5626-5634.
20. Li, L., A. Sharipo, E. Chaves-Olarte, M. G. Masucci, V. Levitsky, M. Thelestam, and T. Frisan. 2002. The Haemophilus ducreyi cytolethal distending toxin activates sensors of DNA damage and repair complexes in proliferating and non-proliferating cells. Cell. Microbiol. 4:87-99.
21. + T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J. Exp. Med. 197:111-119.
22. Nilsson, H. O., R. Mulchandani, K. G. Tranberg, and T. Wadstrom. 2001. Helicobacter species identified in liver from patients with cholangiocarcinoma and hepatocellular carcinoma. Gastroenterology 120:323-324.
23. Nilsson, I., S. Lindgren, S. Eriksson, and T. Wadstrom. 2000. Serum antibodies to Helicobacter hepaticus and Helicobacter pylori in patients with chronic liver disease. Gut 46:410-414.
24. On, S. L., S. Hynes, and T. Wadstrom. 2002. Extragastric Helicobacter species. Helicobacter 7(Suppl. 1):63-67.
25. Pickett, C. L., and C. A. Whitehouse. 1999. The cytolethal distending toxin family. Trends Microbiol. 7:292-297.
26. Purdy, D., C. M. Buswell, A. E. Hodgson, K. McAlpine, I. Henderson, and S. A. Leach. 2000. Characterisation of cytolethal distending toxin (CDT) mutants of Campylobacter jejuni. J. Med. Microbiol. 49:473-479.
27. Sears, C. L., and J. B. Kaper. 1996. Enteric bacterial toxins: mechanisms of action and linkage to intestinal secretion. Microbiol. Rev. 60:167-215.
28. Shames, B., J. G. Fox, F. Dewhirst, L. Yan, Z. Shen, and N. S. Taylor. 1995. Identification of widespread Helicobacter hepaticus infection in feces in commercial mouse colonies by culture and PCR assay. J. Clin. Microbiol. 33:2968-2972.
29. Solnick, J. V., and D. B. Schauer. 2001. Emergence of diverse Helicobacter species in the pathogenesis of gastric and enterohepatic diseases. Clin. Microbiol. Rev. 14:59-97.
30. Stevens, M. K., J. L. Latimer, S. R. Lumbley, C. K. Ward, L. D. Cope, T. Lagergard, and E. J. Hansen. 1999. Characterization of a Haemophilus ducreyi mutant deficient in expression of cytolethal distending toxin. Infect. Immun. 67:3900-3908.
31. Taylor, N. S., J. G. Fox, and L. Yan. 1995. In-vitro hepatotoxic factor in Helicobacter hepaticus, H. pylori and other Helicobacter species. J. Med. Microbiol. 42:48-52.
32. Ward, J. M., J. G. Fox, M. R. Anver, D. C. Haines, C. V. George, M. J. Collins, Jr., P. L. Gorelick, K. Nagashima, M. A. Gonda, and R. V. Gilden. 1994. Chronic active hepatitis and associated liver tumors in mice caused by a persistent bacterial infection with a novel Helicobacter species. J. Natl. Cancer Inst. 86:1222-1227.
33. Whary, M. T., J. H. Cline, A. E. King, K. M. Hewes, D. Chojnacky, A. Salvarrey, and J. G. Fox. 2000. Monitoring sentinel mice for Helicobacter hepaticus, H rodentium, and H bilis infection by use of polymerase chain reaction analysis and serologic testing. Comp. Med. 50:436-443.
34. Young, R. S., K. R. Fortney, V. Gelfanova, C. L. Phillips, B. P. Katz, A. F. Hood, J. L. Latimer, R. S. Munson, Jr., E. J. Hansen, and S. M. Spinola. 2001. Expression of cytolethal distending toxin and hemolysin is not required for pustule formation by Haemophilus ducreyi in human volunteers. Infect. Immun. 69:1938-1942.
35. Young, V. B., C. C. Chien, K. A. Knox, N. S. Taylor, D. B. Schauer, and J. G. Fox. 2000. Cytolethal distending toxin in avian and human isolates of Helicobacter pullorum. J. Infect. Dis. 182:620-623.
36. Young, V. B., K. A. Knox, and D. B. Schauer. 2000. Cytolethal distending toxin sequence and activity in the enterohepatic pathogen Helicobacter hepaticus. Infect. Immun. 68:184-191.
37. Young, V. B., and D. B. Schauer. 2000. Cytolethal distending toxin: a bacterial toxin which disrupts the eukaryotic cell cycle. Chem. Res. Toxicol. 13:936-939.