-
1
-
-
0036274619
-
Medical treatment of active Crohn's disease
-
Scribano, M. L., and C. Prantera. 2002. Medical treatment of active Crohn's disease. Aliment Pharmacol. Ther. 16(Suppl 4):35.
-
(2002)
Aliment Pharmacol. Ther.
, vol.16
, Issue.SUPPL. 4
, pp. 35
-
-
Scribano, M.L.1
Prantera, C.2
-
2
-
-
0037043658
-
Inflammatory bowel disease
-
Podolsky, D. K. 2002. Inflammatory bowel disease. N. Engl. J. Med. 347:417.
-
(2002)
N. Engl. J. Med.
, vol.347
, pp. 417
-
-
Podolsky, D.K.1
-
3
-
-
0027521572
-
Interleukin-10-deficient mice develop chronic enterocolitis
-
Kuhn, R., J. Lohler, D. Rennick, K. Rajewsky, and W. Muller. 1993. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75:263.
-
(1993)
Cell
, vol.75
, pp. 263
-
-
Kuhn, R.1
Lohler, J.2
Rennick, D.3
Rajewsky, K.4
Muller, W.5
-
4
-
-
0027369395
-
Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
-
Sadlack, B., H. Merz, H. Schorle, A. Schimpl, A. C. Feller, and I. Horak. 1993. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75:253.
-
(1993)
Cell
, vol.75
, pp. 253
-
-
Sadlack, B.1
Merz, H.2
Schorle, H.3
Schimpl, A.4
Feller, A.C.5
Horak, I.6
-
5
-
-
0033000343
-
IL-2-deficient mice raised under germfree conditions develop delayed mild focal intestinal inflammation
-
Schultz, M., S. L. Tonkonogy, R. K. Sellon, C. Veltkamp, V. L. Godfrey, J. Kwon, W. B. Grenther, E. Balish, I. Horak, and R. B. Sartor. 1999. IL-2-deficient mice raised under germfree conditions develop delayed mild focal intestinal inflammation. Am. J. Physiol. 276:G1461.
-
(1999)
Am. J. Physiol.
, vol.276
-
-
Schultz, M.1
Tonkonogy, S.L.2
Sellon, R.K.3
Veltkamp, C.4
Godfrey, V.L.5
Kwon, J.6
Grenther, W.B.7
Balish, E.8
Horak, I.9
Sartor, R.B.10
-
6
-
-
0032412057
-
Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice
-
Sellon, R. K., S. Tonkonogy, M. Schultz, L. A. Dieleman, W. Grenther, E. Balish, D. M. Rennick, and R. B. Sartor. 1998. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infect. Immun. 66:5224.
-
(1998)
Infect. Immun.
, vol.66
, pp. 5224
-
-
Sellon, R.K.1
Tonkonogy, S.2
Schultz, M.3
Dieleman, L.A.4
Grenther, W.5
Balish, E.6
Rennick, D.M.7
Sartor, R.B.8
-
7
-
-
0031012926
-
T cell receptor-αβ-deficient mice fail to develop colitis in the absence of a microbial environment
-
Dianda, L., A. M. Hanby, N. A. Wright, A. Sebesteny, A. C. Hayday, and M. J. Owen. 1997. T cell receptor-αβ-deficient mice fail to develop colitis in the absence of a microbial environment. Am. J. Pathol. 150:91.
-
(1997)
Am. J. Pathol.
, vol.150
, pp. 91
-
-
Dianda, L.1
Hanby, A.M.2
Wright, N.A.3
Sebesteny, A.4
Hayday, A.C.5
Owen, M.J.6
-
8
-
-
0029781169
-
Persistent hepatitis and enterocolitis in germfree mice infected with Helicobacter hepaticus
-
Fox, J. G., L. Yan, B. Shames, J. Campbell, J. C. Murphy, and X. Li. 1996. Persistent hepatitis and enterocolitis in germfree mice infected with Helicobacter hepaticus. Infect. Immun. 64:3673.
-
(1996)
Infect. Immun.
, vol.64
, pp. 3673
-
-
Fox, J.G.1
Yan, L.2
Shames, B.3
Campbell, J.4
Murphy, J.C.5
Li, X.6
-
9
-
-
0030794060
-
Inflammatory bowel disease: An immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus
-
Cahill, R. J., C. J. Foltz, J. G. Fox, C. A. Dangler, F. Powrie, and D. B. Schauer. 1997. Inflammatory bowel disease: an immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus. Infect. Immun. 65:3126.
-
(1997)
Infect. Immun.
, vol.65
, pp. 3126
-
-
Cahill, R.J.1
Foltz, C.J.2
Fox, J.G.3
Dangler, C.A.4
Powrie, F.5
Schauer, D.B.6
-
10
-
-
0032425062
-
Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and γ interferon-dependent mechanism
-
Kullberg, M. C., J. M. Ward, P. L. Gorelick, P. Caspar, S. Hieny, A. Cheever, D. Jankovic, and A. Sher. 1998. Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and γ interferon-dependent mechanism. Infect. Immun. 66:5157.
-
(1998)
Infect. Immun.
, vol.66
, pp. 5157
-
-
Kullberg, M.C.1
Ward, J.M.2
Gorelick, P.L.3
Caspar, P.4
Hieny, S.5
Cheever, A.6
Jankovic, D.7
Sher, A.8
-
11
-
-
0028325311
-
Helicobacter hepaticus sp. nov., a microaerophilic bacterium isolated from livers and intestinal mucosal scrapings from mice
-
Fox, J. G., F. E. Dewhirst, J. G. Tully, B. J. Paster, L. Yan, N. S. Taylor, M. J. Collins, Jr., P. L. Gorelick, and J. M. Ward. 1994. Helicobacter hepaticus sp. nov., a microaerophilic bacterium isolated from livers and intestinal mucosal scrapings from mice. J. Clin. Microbiol. 32:1238.
-
(1994)
J. Clin. Microbiol.
, vol.32
, pp. 1238
-
-
Fox, J.G.1
Dewhirst, F.E.2
Tully, J.G.3
Paster, B.J.4
Yan, L.5
Taylor, N.S.6
Collins M.J., Jr.7
Gorelick, P.L.8
Ward, J.M.9
-
12
-
-
0037331279
-
+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient mice
-
+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient mice. Am. J. Pathol. 162:691.
-
(2003)
Am. J. Pathol.
, vol.162
, pp. 691
-
-
Erdman, S.E.1
Poutahidis, T.2
Tomczak, M.3
Rogers, A.B.4
Cormier, K.5
Plank, B.6
Horwitz, B.H.7
Fox, J.G.8
-
14
-
-
0027232067
-
NF-κB and Rel: Participants in a multiform transcriptional regulatory system
-
Grilli, M., J. J. Chiu, and M. J. Lenardo. 1993. NF-κB and Rel: participants in a multiform transcriptional regulatory system. Int. Rev. Cytol. 143:1.
-
(1993)
Int. Rev. Cytol.
, vol.143
, pp. 1
-
-
Grilli, M.1
Chiu, J.J.2
Lenardo, M.J.3
-
15
-
-
0030610362
-
A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
-
DiDonato, J. A., M. Hayakawa, D. M. Rothwarf, E. Zandi, and M. Karin. 1997. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature 388:548.
-
(1997)
Nature
, vol.388
, pp. 548
-
-
DiDonato, J.A.1
Hayakawa, M.2
Rothwarf, D.M.3
Zandi, E.4
Karin, M.5
-
16
-
-
0029143632
-
Regulation of interleukin 12 p40 expression through an NF-κB half-site
-
Murphy, T. L., M. G. Cleveland, P. Kulesza, J. Magram, and K. M. Murphy. 1995. Regulation of interleukin 12 p40 expression through an NF-κB half-site. Mol. Cell. Biol. 15:5258.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 5258
-
-
Murphy, T.L.1
Cleveland, M.G.2
Kulesza, P.3
Magram, J.4
Murphy, K.M.5
-
17
-
-
0030872393
-
Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: Evidence of functional synergy between C/EBP and Rel proteins
-
Plevy, S. E., J. H. Gemberling, S. Hsu, A. J. Dorner, and S. T. Smale. 1997. Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins. Mol. Cell. Biol. 17:4572.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 4572
-
-
Plevy, S.E.1
Gemberling, J.H.2
Hsu, S.3
Dorner, A.J.4
Smale, S.T.5
-
18
-
-
0034972172
-
Helicobacter hepaticus-induced colitis in interleukin-10-deficient mice: Cytokine requirements for the induction and maintenance of intestinal inflammation
-
Kullberg, M. C., A. G. Rothfuchs, D. Jankovic, P. Caspar, T. A. Wynn, P. L. Gorelick, A. W. Cheever, and A. Sher. 2001. Helicobacter hepaticus-induced colitis in interleukin-10-deficient mice: cytokine requirements for the induction and maintenance of intestinal inflammation. Infect. Immun. 69:4232.
-
(2001)
Infect. Immun.
, vol.69
, pp. 4232
-
-
Kullberg, M.C.1
Rothfuchs, A.G.2
Jankovic, D.3
Caspar, P.4
Wynn, T.A.5
Gorelick, P.L.6
Cheever, A.W.7
Sher, A.8
-
19
-
-
0025943986
-
The p65 subunit is responsible for the strong transcription activating potential of NF-κB
-
Schmitz, M. L., and P. A. Baeuerle. 1991. The p65 subunit is responsible for the strong transcription activating potential of NF-κB. EMBO J. 10:3805.
-
(1991)
EMBO J.
, vol.10
, pp. 3805
-
-
Schmitz, M.L.1
Baeuerle, P.A.2
-
21
-
-
0032588289
-
NF-κB1 (p50) is upregulated in lipopolysaccharide tolerance and can block tumor necrosis factor gene expression
-
Kastenbauer, S., and H. W. Ziegler-Heitbrock. 1999. NF-κB1 (p50) is upregulated in lipopolysaccharide tolerance and can block tumor necrosis factor gene expression. Infect. Immun. 67:1553.
-
(1999)
Infect. Immun.
, vol.67
, pp. 1553
-
-
Kastenbauer, S.1
Ziegler-Heitbrock, H.W.2
-
22
-
-
0032211810
-
Regulation of an essential innate immune response by the p50 subunit of NF-κB
-
Bohuslav, J., V. V. Kravchenko, G. C. Parry, J. H. Erlich, S. Gerondakis, N. Mackman, and R. J. Ulevitch. 1998. Regulation of an essential innate immune response by the p50 subunit of NF-κB. J. Clin. Invest. 102:1645.
-
(1998)
J. Clin. Invest.
, vol.102
, pp. 1645
-
-
Bohuslav, J.1
Kravchenko, V.V.2
Parry, G.C.3
Erlich, J.H.4
Gerondakis, S.5
Mackman, N.6
Ulevitch, R.J.7
-
23
-
-
0035665020
-
Possible new role for NF-κB in the resolution of inflammation
-
Lawrence, T., D. W. Gilroy, P. R. Colville-Nash, and D. A. Willoughby. 2001. Possible new role for NF-κB in the resolution of inflammation. Nat. Med 7:1291.
-
(2001)
Nat. Med.
, vol.7
, pp. 1291
-
-
Lawrence, T.1
Gilroy, D.W.2
Colville-Nash, P.R.3
Willoughby, D.A.4
-
24
-
-
0031985287
-
Nuclear factor (NF)-κB2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses
-
Caamano, J. H., C. A. Rizzo, S. K. Durham, D. S. Barton, C. Raventos-Suarez, C. M. Snapper, and R. Bravo. 1998. Nuclear factor (NF)-κB2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses. J. Exp. Med. 187:185.
-
(1998)
J. Exp. Med.
, vol.187
, pp. 185
-
-
Caamano, J.H.1
Rizzo, C.A.2
Durham, S.K.3
Barton, D.S.4
Raventos-Suarez, C.5
Snapper, C.M.6
Bravo, R.7
-
25
-
-
0036569015
-
NF-κB2 is required for optimal CD40-induced IL-12 production but dispensable for Th1 cell differentiation
-
Speirs, K., J. Caamano, M. H. Goldschmidt, C. A. Hunter, and P. Scott. 2002. NF-κB2 is required for optimal CD40-induced IL-12 production but dispensable for Th1 cell differentiation. J. Immunol. 168:4406.
-
(2002)
J. Immunol.
, vol.168
, pp. 4406
-
-
Speirs, K.1
Caamano, J.2
Goldschmidt, M.H.3
Hunter, C.A.4
Scott, P.5
-
26
-
-
0035260357
-
Typhlocolitis in NF-κB-deficient mice
-
Erdman, S., J. G. Fox, C. A. Dangler, D. Feldman, and B. H. Horwitz. 2001. Typhlocolitis in NF-κB-deficient mice. J. Immunol. 166:1443.
-
(2001)
J. Immunol.
, vol.166
, pp. 1443
-
-
Erdman, S.1
Fox, J.G.2
Dangler, C.A.3
Feldman, D.4
Horwitz, B.H.5
-
27
-
-
0029813545
-
+ Th1-like responses
-
+ Th1-like responses. J. Clin. Invest. 98:1010.
-
(1996)
J. Clin. Invest.
, vol.98
, pp. 1010
-
-
Berg, D.J.1
Davidson, N.2
Kuhn, R.3
Muller, W.4
Menon, S.5
Holland, G.6
Thompson-Snipes, L.7
Leach, M.W.8
Rennick, D.9
-
28
-
-
0034800289
-
Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease
-
Kanai, T., M. Watanabe, A. Okazawa, T. Sato, M. Yamazaki, S. Okamoto, H. Ishii, T. Totsuka, R. Iiyama, R. Okamoto, et al. 2001. Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease. Gastroenterology 121:875.
-
(2001)
Gastroenterology
, vol.121
, pp. 875
-
-
Kanai, T.1
Watanabe, M.2
Okazawa, A.3
Sato, T.4
Yamazaki, M.5
Okamoto, S.6
Ishii, H.7
Totsuka, T.8
Iiyama, R.9
Okamoto, R.10
-
29
-
-
0028804551
-
Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
-
Sha, W. C., H. C. Liou, E. I. Tuomanen, and D. Baltimore. 1995. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell 80:321.
-
(1995)
Cell
, vol.80
, pp. 321
-
-
Sha, W.C.1
Liou, H.C.2
Tuomanen, E.I.3
Baltimore, D.4
-
30
-
-
0033638507
-
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
-
Oppmann, B., R. Lesley, B. Blom, J. C. Timans, Y. Xu, B. Hunte, F. Vega, N. Yu, J. Wang, K. Singh, et al. 2000. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13:715.
-
(2000)
Immunity
, vol.13
, pp. 715
-
-
Oppmann, B.1
Lesley, R.2
Blom, B.3
Timans, J.C.4
Xu, Y.5
Hunte, B.6
Vega, F.7
Yu, N.8
Wang, J.9
Singh, K.10
-
31
-
-
0028987562
-
Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice
-
Wysocka, M., M. Kubin, L. Q. Vieira, L. Ozmen, G. Garotta, P. Scott, and G. Trinchieri. 1995. Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice. Eur. J. Immunol. 25:672.
-
(1995)
Eur. J. Immunol.
, vol.25
, pp. 672
-
-
Wysocka, M.1
Kubin, M.2
Vieira, L.Q.3
Ozmen, L.4
Garotta, G.5
Scott, P.6
Trinchieri, G.7
-
32
-
-
0032530697
-
IL-12, but not LFN-γ, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice
-
Davidson, N. J., S. A. Hudak, R. E. Lesley, S. Menon, M. W. Leach, and D. M. Rennick. 1998. IL-12, but not LFN-γ, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice. J. Immunol. 161:3143.
-
(1998)
J. Immunol.
, vol.161
, pp. 3143
-
-
Davidson, N.J.1
Hudak, S.A.2
Lesley, R.E.3
Menon, S.4
Leach, M.W.5
Rennick, D.M.6
-
34
-
-
0032533480
-
IL-7 deficiency prevents development of a non-T cell non-B cell-mediated colitis
-
von Freeden-Jeffry, U., N. Davidson, R. Wiler, M. Fort, S. Burdach, and R. Murray. 1998. IL-7 deficiency prevents development of a non-T cell non-B cell-mediated colitis. J. Immunol. 161:5673.
-
(1998)
J. Immunol.
, vol.161
, pp. 5673
-
-
Von Freeden-Jeffry, U.1
Davidson, N.2
Wiler, R.3
Fort, M.4
Burdach, S.5
Murray, R.6
-
35
-
-
0033748023
-
Selective requirement for c-Rel during IL-12 p40 gene induction in macrophages
-
Sanjabi, S., A. Hoffmann, H. C. Liou, D. Baltimore, and S. T. Smale. 2000. Selective requirement for c-Rel during IL-12 p40 gene induction in macrophages. Proc. Natl. Acad. Sci. USA 97:12705.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 12705
-
-
Sanjabi, S.1
Hoffmann, A.2
Liou, H.C.3
Baltimore, D.4
Smale, S.T.5
-
36
-
-
0035221154
-
Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event
-
Weinmann, A. S., D. M. Mitchell, S. Sanjabi, M. N. Bradley, A. Hoffmann, H. C. Liou, and S. T. Smale. 2001. Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event. Nat. Immun. 2:51.
-
(2001)
Nat. Immun.
, vol.2
, pp. 51
-
-
Weinmann, A.S.1
Mitchell, D.M.2
Sanjabi, S.3
Bradley, M.N.4
Hoffmann, A.5
Liou, H.C.6
Smale, S.T.7
-
37
-
-
0036203419
-
The phosphorylation status of nuclear NF-κB determines its association with CBP/p300 or HDAC-1
-
Zhong, H., M. J. May, E. Jimi, and S. Ghosh. 2002. The phosphorylation status of nuclear NF-κB determines its association with CBP/p300 or HDAC-1. Mol. Cell 9:625.
-
(2002)
Mol. Cell
, vol.9
, pp. 625
-
-
Zhong, H.1
May, M.J.2
Jimi, E.3
Ghosh, S.4
-
38
-
-
0034802887
-
The p65 (RelA) subunit of NF-κB interacts with the histone deacetylase (HDAC) corepressors HDACI and HDAC2 to negatively regulate gene expression
-
Ashburner, B. P., S. D. Westerheide, and A. S. Baldwin, Jr. 2001. The p65 (RelA) subunit of NF-κB interacts with the histone deacetylase (HDAC) corepressors HDACI and HDAC2 to negatively regulate gene expression. Mol. Cell. Biol. 21:7065.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 7065
-
-
Ashburner, B.P.1
Westerheide, S.D.2
Baldwin A.S., Jr.3
-
39
-
-
0031017252
-
Interferon-α/β inhibition of interleukin 12 and interferon-γ production in vitro and endogenously during viral infection
-
Cousens, L. P., J. S. Orange, H. C. Su, and C. A. Biron. 1997. Interferon-α/β inhibition of interleukin 12 and interferon-γ production in vitro and endogenously during viral infection. Proc. Natl. Acad. Sci. USA 94:634.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 634
-
-
Cousens, L.P.1
Orange, J.S.2
Su, H.C.3
Biron, C.A.4
|