Benzopyrazine derivatives: A novel class of growth factor receptor bound protein 7 antagonists

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 1, 2011, Pages 693-701

  Ambaye, Nigus D ^a   Gunzburg, Menachem J ^a   Lim, Reece C C ^a   Price, John T ^a   Wilce, Matthew C J ^a   Wilce, Jacqueline A ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Adapter protein; Benzopyrazines; Cancer cells; Cellular growth assay; Grb7; ITC; Melting point shift assay; SH2 domain; Similarity search; Thermofluor; Virtual screening

Indexed keywords

GROWTH FACTOR RECEPTOR BOUND PROTEIN 7; NSC 642040; NSC 642056; NSC 644743; NSC 644745; NSC 644750; NSC 644770; NSC 646820; NSC 646823; NSC 648589; NSC 648605; NSC 648607; PYRAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BREAST CANCER; CALORIMETRY; CANCER CELL; CANCER CELL CULTURE; DRUG SCREENING; HUMAN; IC 50; MOLECULAR DOCKING; PROTEIN BINDING; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

CELL DIVISION; CELL LINE, TUMOR; DRUG DISCOVERY; GRB7 ADAPTOR PROTEIN; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; PYRAZINES;

EID: 78650739133     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.10.030     Document Type: Article

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