GRB-7 facilitates HER-2/Neu-mediated signal transduction and tumor formation

Carcinogenesis

Volumn 29, Issue 3, 2008, Pages 473-479

  Bai, Tao ^a   Luoh, Shiuh Wen ^a  

^a PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; GROWTH FACTOR RECEPTOR BOUND PROTEIN 7; PHOSPHATIDYLINOSITIDE; PROTEIN KINASE B; PROTEIN KINASE C; RNA; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER CELL; CELL STRAIN MCF 7; CHROMOSOME 17Q; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; FEMALE; GENE AMPLIFICATION; GENE OVEREXPRESSION; GENETIC ASSOCIATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; NONHUMAN; NUCLEOTIDE SEQUENCE; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR GROWTH;

ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMES, HUMAN, PAIR 17; ENZYME ACTIVATION; FEMALE; GRB7 ADAPTOR PROTEIN; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, ERBB-2; SIGNAL TRANSDUCTION;

EID: 40949086031     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgm221     Document Type: Article

References (40)

1. Shen,T.L. et al. (2004) Grb7 in intracellular signaling and its role in cell regulation. Front. Biosci., 9, 192-200.
2. Stein,D. et al. (1994) The SH2 domain protein GRB-7 is co-amplified, overexpressed and in a tight complex with HER2 in breast cancer. EMBO J., 13, 1331-40.
3. Cariou,B. et al. (2004) Regulation and functional roles of Grb14. Front. Biosci., 9, 1626-36.
4. Lim,M.A. et al. (2004) Grb10: More than a simple adaptor protein. Front. Biosci., 9, 387-403.
5. Riedel,H. (2004) Grb10 exceeding the boundaries of a common signaling adapter. Front. Biosci., 9, 603-18.
6. Kauraniemi,P. et al. (2003) Amplification of a 280-kilobase core region at the ERBB2 locus leads to activation of two hypothetical proteins in breast cancer. Am. J. Pathol., 163, 1979-84.
7. Kauraniemi,P. et al. (2001) New amplified and highly expressed genes discovered in the ERBB2 amplicon in breast cancer by cDNA microarrays. Cancer Res., 61, 8235-40.
8. Luoh,S.W. (2002) Amplification and expression of genes from the 17q11-q12 amplicon in breast cancer cells. Cancer Genet. Cytogenet. 136, 43-47.
9. Kauraniemi,P. et al. (2006) Activation of multiple cancer-associated genes at the ERBB2 amplicon in breast cancer. Endocr. Relat. Cancer, 13, 39-49.
10. Slamon,D.J. et al. (1987) Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science, 235, 177-82.
11. Slamon,D.J. et al. (1989) Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science, 244, 707-12.
12. Pietras,RJ. et al. (1994) Antibody to HER-2/neu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells. Oncogene, 9, 1829-38.
13. Benz,C.C. et al. (1993) Estrogen-dependent, tamoxifen-resistant tumorigenic growth of MCF-7 cells transfected with HER2/neu. Breast Cancer Res. Treat., 24, 85-95.
14. Vinatzer,U. et al. (2005) Expression of HER2 and the coamplified genes GRB7 and MLN64 in human breast cancer: Quantitative real-time reverse transcription-PCR as a diagnostic alternative to immunohistochemistry and fluorescence in situ hybridization. Clin. Cancer Res., 11, 8348-57.
15. Cobleigh,M.A. et al. (2005) Tumor gene expression and prognosis in breast cancer patients with 10 or more positive lymph nodes. Clin. Cancer Res., 11, 8623-31.
16. Peles,E. et al. (1991) Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase C gamma. EMBO J., 10, 2077-86.
17. Ouyang,X. et al. (1998) Adjacent carboxyterminal tyrosine phosphorylation events identify functionally distinct ErbB2 receptor subsets: Implications for molecular diagaostics. Exp. Cell Res., 241, 467-75.
18. Dittmar,T. et al. (2002) Induction of cancer cell migration by epidermal growth factor is initiated by specific phosphorylation of tyrosine 1248 of c-erbB-2 receptor via EGFR. FASEB J., 16, 1823-5.
19. Olayioye,M.A. et al. (2000) The ErbB signaling network: Receptor heterodimerization in development and cancer. EMBO J., 19, 3159-67.
20. Sundaram,M. et al. (2004) The MARCKS family of phospholipid binding proteins: Regulation of phospholipase D and other cellular components. Biochem. Cell Biol., 82, 191-200.
21. Savelyeva,L. et al.(2001) Amplification of oncogenes revisited: from expression profiling to clinical application. Cancer Lett., 167, 115-23.
22. Di Fiore,P.P. et al. (1987) erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells. Science, 237, 178-82.
23. Mori,K. et al. (2005) Distinct Grb10 domain requirements for effects on glucose uptake and insulin signaling. Mol. Cell Endocrinol., 230, 39-50.
24. Cooney,G.J. et al. (2004) Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice. EMBO J., 23, 582-93.
25. Bereziat,V. et al. (2002) Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14. J. Biol. Chem., 277 4845-52.
26. Han,D.C. et al. (2002) EphB1 associates with Grb7 and regulates cell migration. J. Biol. Chem., 277, 45655-61.
27. Jahn,T. et al. (2002) Role for the adaptor protein Grb10 in the activation of Akt. Mol. Cell Biol., 22, 979-91.
28. Han,D.C. et al. (2000) Role of Grb7 targeting to focal contacts and its phosphorylation by focal adhesion kinase in regulation of cell migration. J. Biol. Chem., 275, 28911-7.
29. Shen,T.L. et al. (2002) Association of Grb7 with phosphoinositides and its role in the regulation of cell migration. J. Biol. Chem., 277, 29069-77.
30. Li,H. et al. (2005) The adaptor Grb7 is a novel calmodulin-binding protein: Functional implications of the interaction of calmodulin with Grb7. Oncogene, 24, 4206-19.
31. Tanaka,S. et al. (1998) A novel variant of human Grb7 is associated with invasive esophageal carcinoma. J. Clin. Invest., 102, 821-7.
32. Haran,M. et al. (2004) Grb7 expression and cellular migration in chronic lymphocytic leukemia: A comparative study of early and advanced stage disease. Leukemia, 18, 1948-50.
33. Skotheim,R.I. et al. (2002) New insights into testicular germ cell tumorigenesis from gene expression profiling. Cancer Res., 62 2359-64.
34. Hodgson,J.G. et al. (2005) Copy number aberrations in mouse breast tumors reveal loci and genes important in tumorigenic receptor tyrosine kinase signaling. Cancer Res., 65, 9695-704.
35. Slamon,D.J. et al. (2001) Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N. Engl. J. Med., 344, 783-92.
36. Romond,E.H. et al. (2005) Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N. Engl. J. Med., 353 1673-84.
37. Piccart-Gebhart,M.J. et al. (2005) Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N. Engl. J. Med., 353, 1659-1672.
38. Tanaka,S. et al. (2006) Specific peptide ligand for Grb7 signal transduction protein and pancreatic cancer metastasis. J. Natl Cancer Inst., 98, 491-8.
39. Kao,J. et al. (2006) RNA interference-based functional dissection of the 17q12 amplicon in breast cancer reveals contribution of coamplified genes. Genes Chromosomes Cancer, 45, 761-9.
40. Hann,H.W. et al. (1992) Antitumor effect of deferoxamine on human hepatocellular carcinoma growing in athymic nude mice. Cancer, 70, 2051-6.