NMR analysis of G7-18NATE, a nonphosphorylated cyclic peptide inhibitor of the Grb7 adapter protein

Biopolymers - Peptide Science Section

Volumn 88, Issue 2, 2007, Pages 174-181

  Porter, C J ^a   Wilce, J A ^b  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

Cyclic nonphosphorylated peptide; Grb7 inhibitor; NMR spectroscopy; SH2 domain; Solution structure

Indexed keywords

CYCLIC NONPHOSPHORYLATED PEPTIDE; GRB7 INHIBITOR; SH2 DOMAIN; SOLUTION STRUCTURE;

CELL PROLIFERATION; ENZYME INHIBITION; LIGANDS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH EFFECTS; TUMORS;

PEPTIDES;

ASPARAGINE; CYCLOPEPTIDE; GROWTH FACTOR RECEPTOR BOUND PROTEIN 7; PEPTIDE G7 18NATE; PROLINE; PROTEIN SH2; SODIUM CHLORIDE; TYROSINE; UNCLASSIFIED DRUG; WATER;

AMINO ACID SEQUENCE; BINDING AFFINITY; BINDING COMPETITION; BINDING SITE; CANCER CELL CULTURE; CELL MIGRATION; CONFERENCE PAPER; HYDROGEN BOND; ISOMERIZATION; NUCLEAR MAGNETIC RESONANCE; PANCREAS CANCER; PROTEIN CONFORMATION; PROTEIN MOTIF; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; GRB7 ADAPTOR PROTEIN; HUMANS; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES, CYCLIC; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY;

EID: 34247527821     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.20667     Document Type: Conference Paper

References (23)

1. Fiddes, R. J.; Campbell, D. H.; Janes, P. W.; Sivertsen, S. P.; Sasaki, H.; Wallasch, C.; Daly, R. J. J Biol Chem 1998, 273, 7717-7724.
2. Stein, D.; Wu, J.; Fuqua, S. A.; Roonprapunt, C.; Yajnik, V.; D'Eustachio, P.; Moskow J. J.; Buchberg, A. M.; Osborne, C. K.; Margolis, B. EMBO J 1994, 13, 1331-1340.
3. Han, D. C.; Guan, J. L. J Biol Chem 1999, 274, 24425-24430.
4. Normanno, N.; Bianco, C.; Strizzi, L.; Mancino, M.; Maiello, M. R.; De Luca, A.; Caponigro, F.; Salomon, D. S. Curr Drug Targets 2005, 6, 243-257.
5. McLean, G. W.; Carragher, N. O.; Avizienyte, E.; Evans, J.; Brunton, V. G.; Frame, M. C. Nat Rev Cancer 2005, 5, 505-515.
6. Tanaka, S.; Mori, M.; Akiyoshi, T.; Tanaka, Y.; Mafune, K.; Wands, J. R.; Sugimachi, K. Cancer Res 1997, 57, 28-31.
7. Kishi, T.; Sasaki, H.; Akiyama, N.; Ishizuka, T.; Sakamoto, H.; Aizawa, S.; Sugimura, T.; Terada, M. Biochem Biophys Res Commun 1997, 232, 5-9.
8. Pero, S. C.; Daly, R. J.; Krag, D. N. Expert Rev Mol Med 2003, 2003, 1-11.
9. Pawson, T. Adv Cancer Res 1994, 64, 87-110.
10. Kuriyan, J.; Cowburn, D. Annu Rev Biophys Biomol Struct 1997, 26, 259-288.
11. Machida, K.; Mayer, B. J. Biochim Biophys Acta 2005, 1747, 1-25.
12. Pero, S. C.; Oligino, L.; Daly, R. J.; Soden, A. L.; Liu, C.; Roller, P. P.; Li, P.; Krag, D. N. J Biol Chem 2002, 277, 11918-11926.
13. Tanaka, S.; Pero, S. C.; Taguchi, K.; Shimada, M.; Mori, M.; Krag, D. N.; Arii, S. J Natl Cancer Inst 2006, 98, 491-498.
14. Lung, F. G.; King, C. R.; Roller, P. P. Lett Peptide Sci 1999, 6, 45-49.
15. Hwang, T. L.; Shaka, A. J. J Magn Reson A 1995, 112, 275-279.
16. Bax, A.; Davis, D. G. J Magn Reson 1985, 65, 355-360.
17. Kumar, A.; Ernst, R. R.; Wuthrich, K. Biochem Biophys Res Commun 1980, 95, 1-6.
18. Sklenar, V.; Piotto, M.; Leppik, R.; Saudek, V. J. Magn Reson A 1993, 102, 241-245.
19. Mayo, K. H. Methods Enzymol 1997, 289, 646-671.
20. Wuthrich, K. NMR of Proteins and Nucleic Acids. John Wiley: New York; 1986.
21. Wishart, D. S.; Sykes, B. D.; Richards, F. M. Biochemistry 1992, 31, 1647-1651.
22. Schwarzinger, S.; Kroon, G. J.; Foss, T. R.; Wright, P. E.; Dyson, H. J. J Biomol NMR 2000, 18, 43-48; erratum in 2001, 19, 95.
23. Mielke, S. P.; Krishnan, V. V. J Biomol NMR 2004, 30, 143-153.