Design and synthesis of conformationally constrained Grb2 SH2 domain binding peptides employing α-methylphenylalanyl based phosphotyrosyl mimetics

Journal of Medicinal Chemistry

Volumn 48, Issue 3, 2005, Pages 764-772

  Oishi, Shinya ^a   Karki, Rajeshri G ^a   Kang, Sang Uk ^a   Wang, Xiangzhu ^a   Worthy, Karen M ^b   Bindu, Lakshman K ^b   Nicklaus, Marc C ^a   Fisher, Robert J ^b   Burke Jr , Terrence R ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA METHYLPHENYLALANINE; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; PHENYLALANINE DERIVATIVE; PROTEIN SH2; PROTEIN TYROSINE PHOSPHATASE; TETRALIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CYCLIZATION; MATHEMATICAL ANALYSIS; MOLECULAR MIMICRY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; STRUCTURE ANALYSIS; SUBSTITUTION REACTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BINDING SITES; CYCLIZATION; GRB2 ADAPTOR PROTEIN; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR MIMICRY; PHENYLALANINE; PHOSPHONIC ACIDS; PHOSPHOPEPTIDES; PHOSPHOTYROSINE; PROTEIN BINDING; SRC HOMOLOGY DOMAINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDRONAPHTHALENES;

EID: 13444270389     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0492709     Document Type: Article

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