-
2
-
-
0036883940
-
Pancreatic cancer biology and genetics
-
Bardeesy N, DePinho RA. Pancreatic cancer biology and genetics. Nat Rev Cancer 2002;2:897-909.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 897-909
-
-
Bardeesy, N.1
DePinho, R.A.2
-
3
-
-
0035902180
-
Oncogenic kinase signalling
-
Blume-Jensen P, Hunter T. Oncogenic kinase signalling. Nature 2001; 411:355-65.
-
(2001)
Nature
, vol.411
, pp. 355-365
-
-
Blume-Jensen, P.1
Hunter, T.2
-
4
-
-
0842346438
-
Specificity in signal transduction: From phosphotyrosine-SH2 domain interactions to complex cellular systems
-
Pawson T. Specificity in signal transduction: From phosphotyrosine-SH2 domain interactions to complex cellular systems. Cell 2004;116:191-203.
-
(2004)
Cell
, vol.116
, pp. 191-203
-
-
Pawson, T.1
-
5
-
-
12844283323
-
The SH2 domain: Versatile signaling module and pharmaceutical target
-
Machida K, Mayer BJ. The SH2 domain: Versatile signaling module and pharmaceutical target. Biochim Biophys Acta 2005;1747:1-25.
-
(2005)
Biochim Biophys Acta
, vol.1747
, pp. 1-25
-
-
Machida, K.1
Mayer, B.J.2
-
6
-
-
0031034760
-
Coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 in human advanced esophageal carcinoma
-
Tanaka S, Mori M, Akiyoshi T, Tanaka Y, Mafune K, Wands JR, et al. Coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 in human advanced esophageal carcinoma. Cancer Res 1997;57:28-31.
-
(1997)
Cancer Res
, vol.57
, pp. 28-31
-
-
Tanaka, S.1
Mori, M.2
Akiyoshi, T.3
Tanaka, Y.4
Mafune, K.5
Wands, J.R.6
-
7
-
-
0032528990
-
A novel variant of human Grb7 is associated with invasive esophageal carcinoma
-
Tanaka S, Mori M, Akiyoshi T, Tanaka Y, Mafune K, Wands JR, et al. A novel variant of human Grb7 is associated with invasive esophageal carcinoma. J Clin Invest 1998;102:821-7.
-
(1998)
J Clin Invest
, vol.102
, pp. 821-827
-
-
Tanaka, S.1
Mori, M.2
Akiyoshi, T.3
Tanaka, Y.4
Mafune, K.5
Wands, J.R.6
-
8
-
-
0031128420
-
Elegans cell migration gene mig-10 shares similarities with a family of SH2 domain proteins and acts cell nonautonomously in excretory canal development
-
Manser J, Roonprapunt C, Margolis B. C. elegans cell migration gene mig-10 shares similarities with a family of SH2 domain proteins and acts cell nonautonomously in excretory canal development. Dev Biol 1997;184: 150-64.
-
(1997)
Dev Biol
, vol.184
, pp. 150-164
-
-
Manser, J.1
Roonprapunt, C.2
Margolis, B.C.3
-
9
-
-
15144339408
-
Isolation of a candidate gene, CAB1, for cholesterol transport to mitochondria from the c-ERBB-2 amplicon by a modified cDNA selection method
-
Akiyama N, Sasaki H, Ishizuka T, Kishi T, Sakamoto H, Onda M, et al. Isolation of a candidate gene, CAB1, for cholesterol transport to mitochondria from the c-ERBB-2 amplicon by a modified cDNA selection method. Cancer Res 1997;57:3548-53.
-
(1997)
Cancer Res
, vol.57
, pp. 3548-3553
-
-
Akiyama, N.1
Sasaki, H.2
Ishizuka, T.3
Kishi, T.4
Sakamoto, H.5
Onda, M.6
-
10
-
-
0028343550
-
The SH2 domain protein GRB-7 is co-amplified, overexpressed and in a tight complex with HER2 in breast cancer
-
Stein D, Wu J, Fuqua SAW, Roonprapunt C, Yajnik V, Moskow JJ, et al. The SH2 domain protein GRB-7 is co-amplified, overexpressed and in a tight complex with HER2 in breast cancer. EMBO J 1994;13:1331-40.
-
(1994)
EMBO J
, vol.13
, pp. 1331-1340
-
-
Stein, D.1
Wu, J.2
Fuqua, S.A.W.3
Roonprapunt, C.4
Yajnik, V.5
Moskow, J.J.6
-
11
-
-
0026644391
-
High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains
-
Margolis B, Silvennoinen O, Comoglio F, Roonprapunt C, Skolnik E, Ullrich A, Schlessinger J. High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains. Proc Natl Acad Sci USA 1992;89:8894-8.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 8894-8898
-
-
Margolis, B.1
Silvennoinen, O.2
Comoglio, F.3
Roonprapunt, C.4
Skolnik, E.5
Ullrich, A.6
Schlessinger, J.7
-
12
-
-
0032571234
-
Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3
-
Fiddes RJ, Campbell DH, Janes PW, Sivertsen SP, Sasaki H, Wallasch C, Daly RJ. Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3. J Biol Chem 1998;273: 7717-24.
-
(1998)
J Biol Chem
, vol.273
, pp. 7717-7724
-
-
Fiddes, R.J.1
Campbell, D.H.2
Janes, P.W.3
Sivertsen, S.P.4
Sasaki, H.5
Wallasch, C.6
Daly, R.J.7
-
13
-
-
0034666146
-
Role of Grb7 targeting to focal contacts and its phosphorylation by focal adhesion kinase in regulation of cell migration
-
Han DC, Shen TL, Guan JL. Role of Grb7 targeting to focal contacts and its phosphorylation by focal adhesion kinase in regulation of cell migration. J Biol Chem 2000;275:28911-7.
-
(2000)
J Biol Chem
, vol.275
, pp. 28911-28917
-
-
Han, D.C.1
Shen, T.L.2
Guan, J.L.3
-
14
-
-
0036056156
-
Cancer cell motility - On the road from c-erbB-2 receptor steered signaling to actin reorganization
-
Feldner JC, Brandt BH. Cancer cell motility - on the road from c-erbB-2 receptor steered signaling to actin reorganization. Exp Cell Res 2002;272: 93-108.
-
(2002)
Exp Cell Res
, vol.272
, pp. 93-108
-
-
Feldner, J.C.1
Brandt, B.H.2
-
15
-
-
21744435478
-
The role of focal-adhesion kinase in cancer - A new therapeutic opportunity
-
McLean GW, Carragher NO, Avizienyte E, Evans J, Brunton VG, Frame MC. The role of focal-adhesion kinase in cancer - a new therapeutic opportunity. Nat Rev Cancer 2005;5:505-15.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 505-515
-
-
McLean, G.W.1
Carragher, N.O.2
Avizienyte, E.3
Evans, J.4
Brunton, V.G.5
Frame, M.C.6
-
16
-
-
0031713878
-
The Grb7 family of signalling proteins
-
Daly RJ. The Grb7 family of signalling proteins. Cell Signal 1998;10: 613-8.
-
(1998)
Cell Signal
, vol.10
, pp. 613-618
-
-
Daly, R.J.1
-
17
-
-
0035473462
-
The Grb7 family proteins: Structure, interactions with other signaling molecules and potential cellular functions
-
Han DC, Shen TL, Guan JL. The Grb7 family proteins: Structure, interactions with other signaling molecules and potential cellular functions. Oncogene 2001;20:6315-21.
-
(2001)
Oncogene
, vol.20
, pp. 6315-6321
-
-
Han, D.C.1
Shen, T.L.2
Guan, J.L.3
-
19
-
-
15144350558
-
Nonphosphorylated peptide ligands for the Grb2 Src homology 2 domain
-
Oligino L, Lung FD, Sastry L, Bigelow J, Cao T, Curran M, et al. Nonphosphorylated peptide ligands for the Grb2 Src homology 2 domain. J Biol Chem 1997;272:29046-52.
-
(1997)
J Biol Chem
, vol.272
, pp. 29046-29052
-
-
Oligino, L.1
Lung, F.D.2
Sastry, L.3
Bigelow, J.4
Cao, T.5
Curran, M.6
-
20
-
-
0037023768
-
Identification of novel non-phosphorylated ligands, which bind selectively to the SH2 domain of Grb7
-
Pero SC, Oligino L, Daly RJ, Soden AL, Liu C, Roller PP, et al. Identification of novel non-phosphorylated ligands, which bind selectively to the SH2 domain of Grb7. J Biol Chem 2002;277:11918-26.
-
(2002)
J Biol Chem
, vol.277
, pp. 11918-11926
-
-
Pero, S.C.1
Oligino, L.2
Daly, R.J.3
Soden, A.L.4
Liu, C.5
Roller, P.P.6
-
22
-
-
0034056773
-
Grb7 signal transduction protein mediates metastatic progression of esophageal carcinoma
-
Tanaka S, Sugimachi K, Kawaguchi H, Saeki H, Ohno S, Wands JR, et al. Grb7 signal transduction protein mediates metastatic progression of esophageal carcinoma. J Cell Physiol 2000;183:411-5.
-
(2000)
J Cell Physiol
, vol.183
, pp. 411-415
-
-
Tanaka, S.1
Sugimachi, K.2
Kawaguchi, H.3
Saeki, H.4
Ohno, S.5
Wands, J.R.6
-
23
-
-
7244236377
-
Coamplification and coexpression of GRB7 and ERBB2 is found in high grade intraepithelial neoplasia and in invasive Barrett's carcinoma
-
Walch A, Specht K, Braselmann H, Stein H, Siewert JR, Hopt U, et al. Coamplification and coexpression of GRB7 and ERBB2 is found in high grade intraepithelial neoplasia and in invasive Barrett's carcinoma. Int J Cancer 2004;112:747-53.
-
(2004)
Int J Cancer
, vol.112
, pp. 747-753
-
-
Walch, A.1
Specht, K.2
Braselmann, H.3
Stein, H.4
Siewert, J.R.5
Hopt, U.6
-
24
-
-
0348014774
-
Approaches for the sequence-specific knockdown of mRNA
-
Scherer LJ, Ross JJ. Approaches for the sequence-specific knockdown of mRNA. Nat Biotechnol 2003;21:1457-60.
-
(2003)
Nat Biotechnol
, vol.21
, pp. 1457-1460
-
-
Scherer, L.J.1
Ross, J.J.2
-
26
-
-
0032939205
-
Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma
-
Tanaka S, Mori M, Sakamoto Y, Makuuchi M, Sugimachi K, Wands JR. Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma. J Clin Invest 1999;103:341-5.
-
(1999)
J Clin Invest
, vol.103
, pp. 341-345
-
-
Tanaka, S.1
Mori, M.2
Sakamoto, Y.3
Makuuchi, M.4
Sugimachi, K.5
Wands, J.R.6
-
27
-
-
0029998031
-
A carboxy-terminal truncated IRS-1 dominant negative protein reverses the human hepatocellular carcinoma malignant phenotype
-
Tanaka S, Wands JR. A carboxy-terminal truncated IRS-1 dominant negative protein reverses the human hepatocellular carcinoma malignant phenotype. J Clin Invest 1996;98:2100-8.
-
(1996)
J Clin Invest
, vol.98
, pp. 2100-2108
-
-
Tanaka, S.1
Wands, J.R.2
-
28
-
-
0034793404
-
Overexpression of the HER-2/neu oncogene in pancreatic adenocarcinoma
-
Safran H, Steinhoff M, Mangray S, Rathore R, King TC, Chai L, et al. Overexpression of the HER-2/neu oncogene in pancreatic adenocarcinoma. Am J Clin Oncol 2001;24:496-9.
-
(2001)
Am J Clin Oncol
, vol.24
, pp. 496-499
-
-
Safran, H.1
Steinhoff, M.2
Mangray, S.3
Rathore, R.4
King, T.C.5
Chai, L.6
-
29
-
-
0035415663
-
SH2 domain inhibition: A problem solved?
-
Shakespeare WC. SH2 domain inhibition: A problem solved? Curr Opin Chem Biol 2001;5:409-15.
-
(2001)
Curr Opin Chem Biol
, vol.5
, pp. 409-415
-
-
Shakespeare, W.C.1
-
30
-
-
0027957389
-
Prokaryotic expression cloning of a novel human tyrosine kinase
-
Beeler JF, LaRochelle WJ, Chedid M, Tronick SR, Aaronson SA. Prokaryotic expression cloning of a novel human tyrosine kinase. Mol Cell Biol 1994;14:982-8.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 982-988
-
-
Beeler, J.F.1
LaRochelle, W.J.2
Chedid, M.3
Tronick, S.R.4
Aaronson, S.A.5
-
31
-
-
0242270878
-
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
-
Thayer SP, di Magliano MP, Heiser PW, Nielsen CM, Roberts DJ, Lauwers GY, et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 2003;425:851-6.
-
(2003)
Nature
, vol.425
, pp. 851-856
-
-
Thayer, S.P.1
di Magliano, M.P.2
Heiser, P.W.3
Nielsen, C.M.4
Roberts, D.J.5
Lauwers, G.Y.6
-
32
-
-
24944572259
-
Pten constrains centroacinar cell expansion and malignant transformation in the pancreas
-
Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, Wang Y, et al. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell 2005;8:185-95.
-
(2005)
Cancer Cell
, vol.8
, pp. 185-195
-
-
Stanger, B.Z.1
Stiles, B.2
Lauwers, G.Y.3
Bardeesy, N.4
Mendoza, M.5
Wang, Y.6
-
33
-
-
4344590997
-
Etuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multicenter phase II trial
-
Xiong HQ, Rosenberg A, LoBuglio A, Schmidt W, Wolff RA, Deutsch J, et al. Etuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multicenter phase II trial. J Clin Oncol 2004;22:2610-6.
-
(2004)
J Clin Oncol
, vol.22
, pp. 2610-2616
-
-
Xiong, H.Q.1
Rosenberg, A.2
LoBuglio, A.3
Schmidt, W.4
Wolff, R.A.5
Deutsch, J.6
-
34
-
-
19944429073
-
Herceptin and gemcitabine for metastatic pancreatic cancers that overexpress HER-2/neu
-
Safran H, Iannitti D, Ramanathan R, Schwartz JD, Steinhoff M, Nauman C, et al. Herceptin and gemcitabine for metastatic pancreatic cancers that overexpress HER-2/neu. Cancer Invest 2004;22:706-12.
-
(2004)
Cancer Invest
, vol.22
, pp. 706-712
-
-
Safran, H.1
Iannitti, D.2
Ramanathan, R.3
Schwartz, J.D.4
Steinhoff, M.5
Nauman, C.6
-
35
-
-
0037389850
-
Expression of molecular targets for tyrosine kinase receptor antagonists in malignant endocrine pancreatic tumors
-
Fjallskog ML, Lejonklou MH, Oberg KE, Eriksson BK, Janson ET. Expression of molecular targets for tyrosine kinase receptor antagonists in malignant endocrine pancreatic tumors. Clin Cancer Res 2003;9:1469-73.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 1469-1473
-
-
Fjallskog, M.L.1
Lejonklou, M.H.2
Oberg, K.E.3
Eriksson, B.K.4
Janson, E.T.5
-
36
-
-
29044433659
-
Erlotinib and chemoradiation followed by maintenance erlotinib for locally advanced pancreatic cancer: A phase I study
-
Iannitti D, Dipetrillo T, Akerman P, Barnett JM, Maia-Acuna C, Cruff D, et al. Erlotinib and chemoradiation followed by maintenance erlotinib for locally advanced pancreatic cancer: A phase I study. Am J Clin Oncol 2005;28:570-5.
-
(2005)
Am J Clin Oncol
, vol.28
, pp. 570-575
-
-
Iannitti, D.1
Dipetrillo, T.2
Akerman, P.3
Barnett, J.M.4
Maia-Acuna, C.5
Cruff, D.6
-
37
-
-
0037047324
-
Association of Grb7 with phosphoinositides and its role in the regulation of cell migration
-
Shen TL, Han CH, Guan JL. Association of Grb7 with phosphoinositides and its role in the regulation of cell migration. J Biol Chem 2002;277: 29069-77.
-
(2002)
J Biol Chem
, vol.277
, pp. 29069-29077
-
-
Shen, T.L.1
Han, C.H.2
Guan, J.L.3
-
38
-
-
11844291360
-
PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins
-
Jenzora A, Behrendt B, Small JV, Wehland J, Stradal TE. PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins. FEBS Lett 2005;579:455-63.
-
(2005)
FEBS Lett
, vol.579
, pp. 455-463
-
-
Jenzora, A.1
Behrendt, B.2
Small, J.V.3
Wehland, J.4
Stradal, T.E.5
|