A study of the aneugenic activity of trichlorfon detected by centromere-specific probes in human lymphoblastoid cell lines

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 372, Issue 2, 1996, Pages 221-231

  Doherty, Ann T ^a   Ellard, Sian ^a   Parry, Elizabeth M ^a   Parry, James M ^a  

^a SWANSEA UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

METRIFONATE;

ANEUPLOIDY; CENTROMERE; CHROMOSOME DAMAGE; CHROMOSOME LOSS; CONFERENCE PAPER; CONTROLLED STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; GENOTOXICITY; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL LINE; MICRONUCLEUS; PRIORITY JOURNAL;

ANEUPLOIDY; B-LYMPHOCYTES; CELL LINE; CENTROMERE; DNA PROBES; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INSECTICIDES; MICRONUCLEUS TESTS; NONDISJUNCTION, GENETIC; TRICHLORFON;

EID: 0030474094     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(96)00142-X     Document Type: Conference Paper

References (20)

1. Adbi, Y.A. and Villén, T. (1991) Pharmacokinetics of metrifonate and its rearrangement product dichlorvos in whole blood, Pharmacol. Toxicol., 68, 137-142.
2. Chaganti, R.S., Rodriguez, E. and Bosl, G.J. (1993) Cytogenetics of male germ-cell tumors. Urol. Clin. N. Am., 20. 55-66.
3. Crespi, C.L., Gonzalez, F.J., Steimel, D.T., Turner, T.R., Gelboin, H.Y., Penman, B.W. and Langenbach, R. (1991) A metabolically competent human cell line expressing five cDNA's encoding procarcinogen-activating enzymes: application to mutagenicity testing, Chem. Res. Toxicol., 4, 566-572.
4. Crofton-Sleigh, C., Doherty, A.T., Ellard, S., Parry, E.M. and Venitt, S. (1993) Micronucleus assays using cytochalasinblocked MCL-5 cells, a proprietary human cell line expressing five human cytochromes P-450 and microsomal epoxide hydrolase, Mutagenesis, 8, 363-372.
5. Czeizel, A.E. (1994) Phenotypic and cytogenetic studies in self-poisoned patients. Mutation Res., 313, 175-181.
6. Czeizel, A.E., Elek, C., Gundy, S., Metneki, J., Nemes, E., Reis, A., Sperling, K., Timos, L., Tusnady, G. and Viragh, Z. (1993) Environmental trichlorfon and cluster of congenital abnormalities, Lancet. 341, 539-542.
7. Doherty, A.T., Ellard, S., Parry, E.M. and Parry, J.M. (1996) An investigation into the activation and deactivation of chlorinated hydrocarbons to genotoxins in metabolically competent human cells, Mutagenesis. 11, 247-274.
8. Ellard, S., Mohammad, Y., Dogra, S., Wölfel, C., Doehmer, J. and Parry. J.M. (1991) The use of genetically engineered V79 Chinese hamster cultures expressing rat liver CYP1A1,1A2 and 2B1 cDNA's in micronucleus assays, Mutagenesis, 6, 461-470.
9. Enviromental Health Criteria (1993) Trichlorfon, 132, 14.
10. Fenech, M. and Morley, A.A. (1985b) Measurement of micronuclei in lymphocytes, Mutation Res., 147, 29-36.
11. Haesen, S., Timmermans, M. and Kirsch, V.M. (1993) Induction of micronuclei and karyotype aberrations during in vivo mouse skin carcinogenesis, Carcinogenesis, 14, 2319-2327.
12. Howe, G.E., Marking. L.L., Bills, T.D., Rach. J.J. and Mayer, F.L. (1994) Effects of water temperature and pH of terbufos, trichlorfon, 4-nitrophenol and 2,4-nitrophenol to the amphipod Gammarus pseudolimnaeus and rainbow trout (Oncorhynchus mykiss), Environ. Toxicol. Chem., 13, 51-66.
13. Langenbach, R., Smith, P.B. and Crespi, C.L. (1992) Recombinant DNA approaches for the development of metabolic systems used in in vitro toxicology, Mutation Res., 277, 251-275.
14. Madrigal-Bujaidar, E., Cadena, S.R., Trujillo-Valdés, V.M. and Cassini, M. (1993) Sister-chromatid exchange frequencies induced by metrifonate in mammalian in vivo and in vitro systems. Mutation Res., 300, 135-140.
15. Pachecka, J., Sulinski, A. and Traczykiewicz, K. (1977) The effect of acute intoxication by dichlorvos and trichlorfon on the activites of some rat brain esterases, Neuropathol. Pol., 15, 85-90.
16. Parry, J.M. and Sors, A. (1993) The detection and assessment of the aneugenic potential of environmental chemicals: the European Community Aneuploidy Project, Mutation Res., 287, 3-15.
17. Sandberg, A.A. (1992) Chromosome changes in early bladder neoplasms, J. Cell Biochem. Suppl., 161, 76-79.
18. Scott, D., Galloway, S.M., Marshall, R.R., Ishidate, M., Brusick, D., Ashby, J. and Myhr. B.C. (1991) Genotoxicity under extreme culture conditions. Mutation Res., 257, 147-205.
19. Yamano, T. and Morita, S. (1992) Hepatotoxicity of trichlrofon and dichlorvos in isolated rat hepatocytes, Toxicology, 76, 69-77.
20. Zijno, A., Marcon, F., Leopardi, P. and Crebelli, R. (1994) Simultaneous detection of X-chromosome loss and non-disjunction in cytokinesis-blocked human lymphocytes by in situ hybridization with a centromeric DNA probe; implications for the human lymphocyte in vitro micronucleus assay using cytochalasin B, Mutagenesis, 9, 225-232.