Concordance analysis of an in vitro micronucleus screening assay and the regulatory chromosome aberration assay using pharmaceutical drug candidates

Environmental and Molecular Mutagenesis

Volumn 51, Issue 1, 2010, Pages 39-47

  Homiski, Michael L ^a   Muehlbauer, Paula A ^a   Dobo, Krista L ^a   Schuler, Maik J ^a   Aubrecht, Jiri ^a  

^a PFIZER INC   (United States)

Author keywords

Chromosome aberration; Concordance; Cytotoxicity; In vitro assays; Micronucleus

Indexed keywords

CHEMICAL COMPOUND; CLASTOGEN; CYCLOPHOSPHAMIDE; MITOMYCIN C;

ACCURACY; ANIMAL CELL; ARTICLE; CHO CELL; CHROMOSOME ABERRATION; CONTROLLED STUDY; CYTOKINESIS; CYTOTOXICITY; GENOTOXICITY; IN VITRO STUDY; INTERMETHOD COMPARISON; LYMPHOCYTE; MICRONUCLEUS TEST; NONHUMAN; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; TOXICITY TESTING;

ANIMALS; CHO CELLS; CHROMOSOME ABERRATIONS; CRICETINAE; CRICETULUS; DRUG TOXICITY; HUMANS; MICRONUCLEUS TESTS; MUTAGENICITY TESTS; RETROSPECTIVE STUDIES;

EID: 75149188915     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.20507     Document Type: Article

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