Nanomaterials for regenerative medicine

Nanomedicine

Volumn 6, Issue 1, 2011, Pages 157-181

  Verma, Shalini ^a   Domb, Abraham J ^b   Kumar, Neeraj ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

carbon nanotube; dendrimer; layer by layer; nanocomposite; nanofiber; nanomaterials; nanoparticle; nanopatterning; regenerative medicine; self assembling peptide

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; ARGINYLGLYCYLASPARTIC ACID; BIOPOLYMER; CARBON NANOTUBE; DENDRIMER; GOLD NANOPARTICLE; LIPOSOME; MAGNETIC NANOPARTICLE; MOLECULAR SCAFFOLD; MULTI WALLED NANOTUBE; NANOCARRIER; NANOCOMPOSITE; NANOFIBER; NANOMATERIAL; POLYMER; POLYMERSOME; QUANTUM DOT; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; SMALL INTERFERING RNA; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE; UNCLASSIFIED DRUG; VASCULOTROPIN;

BIOSENSOR; CELL GROWTH; CHEMICAL MODIFICATION; DIP PEN NANOLITHOGRAPHY; DRUG DELIVERY SYSTEM; HUMAN; INKJET PRINTING; NANODEVICE; NANOIMPRINTING; NANOTECHNOLOGY; NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHOTOLITHOGRAPHY; PRIORITY JOURNAL; PROTEIN ASSEMBLY; REGENERATIVE MEDICINE; REVIEW; SURFACE PROPERTY; TECHNIQUE; TISSUE REGENERATION;

ANIMALS; HUMANS; NANOMEDICINE; NANOSTRUCTURES; NANOTECHNOLOGY; REGENERATIVE MEDICINE;

EID: 78650654484     PISSN: 17435889     EISSN: None     Source Type: Journal    
DOI: 10.2217/nnm.10.146     Document Type: Review

References (216)

1. Khademhosseini A, Rajalingam B, Jinno S, Langer R: Nanoengineered systems for tissue engineering and regeneration. In: Nanotechnology. Vogel V (Ed.) Wiley-VCG Verlag GmbH and Co., KGaA, Weinheim, Germany (2009).
2. Lee SH, Shin H: Matrices and scaffolds for delivery of bioactive molecules in bone and cartilage tissue engineering. Adv. Drug Deliv. Rev. 59(4-5), 339-359 (2007).
3. Nie Z, Kumacheva E: Patterning surfaces with functional polymers. Nature Mater. 7(4), 277-290 (2008).
4. Verma S, Garkhal K, Mittal A, Kumar N: Biodegradable polymers for emerging clinical use in tissue engineering. In: Biodegradable Polymers in Clinical Use and Clinical Development. Domb A, Kumar N, Azra A (Eds). John Wiley and Sons, NJ, USA (2010) (In press).
5. Chandra R, Rustgi R: Biodegradable polymers. Prog. Polym. Sci. 23(7), 1273-1335 (1998).
6. Nair LS, Laurencin CT: Biodegradable polymers as biomaterials. Prog. Polym. Sci. 32(8-9), 762-798 (2007).
7. Stevens MM: Biomaterials for bone tissue engineering. Mater. Today 11(5), 18-25 (2008).
8. MacNeil S: Biomaterials for tissue engineering of skin. Mater. Today 11, 26-35 (2008).
9. Ma PX: Biomimetic materials for tissue engineering. Adv. Drug Deliv. Rev. 60(2), 184-198 (2008).
10. Fattal E, Barratt G: Nanotechnologies and controlled release systems for the delivery of antisense oligonucleotides and small interfering RNA. Br. J. Pharmacol. 157, 179-194 (2009).
11. Gaumet M, Gurny R, Delie F: Fluorescent biodegradable PLGA particles with narrow size distributions: preparation by means of selective centrifugation. Int. J. Pharm. 342(1-2), 222-230 (2007).
12. Lee PW, Hsu SH, Tsai JS et al.: Multifunctional core-shell polymeric nanoparticles for transdermal DNA delivery and epidermal Langerhans cells tracking. Biomaterials 31(8), 2425-2434 (2010).
13. Kundu J, Chung YI, Kim YH, Tae G, Kundu SC: Silk fbroin nanoparticles for cellular uptake and control release. Int. J. Pharm. 388(1-2), 242-250 (2010).
14. Pissuwan D, Niidome T, Cortie MB: The forthcoming applications of gold nanoparticles in drug and gene delivery systems. J. Control. Release DOI 10.1016/j.jconrel.2009.12.006 (2009) (Epub ahead of print).
15. Alivisatos AP: Semiconductor clusters, nanocrystals, and quantum dots. Science 271, 933-937 (1996).
16. Smith AM, Duan H, Mohs AM, Nie S: Bioconjugated quantum dots for in vivo molecular and cellular imaging. Adv. Drug Deliv. Rev. 60, 1226-1240 (2008).
17. Crouch D, Norager S, O'Brien P, Park JH, Pickett N: New synthetic routes for quantum dots. Philos. Transact. A Math. Phys. Eng. Sci. A 361, 297-310 (2003).
18. Hild WA, Breunig M, Goepferich A: Quantum dots - nano-sized probes for the exploration of cellular and intracellular targeting. Eur. J. Pharm. Biopharm. 68(2), 153-168 (2008).
19. Jose MV, Thomas V, Johnson KT, Dean DR, Nyairo E: Aligned PLGA/HA nanofbrous nanocomposite scaffolds for bone tissue engineering. Acta Biomater. 5(1), 305-315 (2009).
20. Armentano I, Dottori M, Fortunati E, Mattioli S, Kenny JM: Biodegradable polymer matrix nanocomposites for tissue engineering: a review. Polym. Degrad. Stab. 95(11), 2126-2146 (2010).
21. Veiseh O, Gunn JW, Zhang M: Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging. Adv. Drug Deliv. Rev. 62(3), 284-304 (2010).
22. Gupta AK, Gupta M: Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 26(18), 3995-4021 (2005).
23. Shubayev VI, Pisanic TR 2nd, Jin S: Magnetic nanoparticles for theragnostics. Adv. Drug Deliv. Rev. 61(6), 467-477 (2009).
24. Sun C, Lee JS, Zhang M: Magnetic nanoparticles in MR imaging and drug delivery. Adv. Drug Deliv. Rev. 60(11), 1252-1265 (2008).
25. Ito A, Shinkai M, Honda H, Kobayashi T: Medical application of functionalized magnetic nanoparticles. J. Biosci. Bioeng. 100(1), 1-11 (2005).
26. Dobson J: Magnetic micro- and nano-particle-based targeting for drug and gene delivery. Nanomedicine 1(1), 31-37 (2006).
27. Laurent S, Forge D, Port M et al.: Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications. Chem. Rev. 108, 2064-2110 (2008).
28. Shimizu K, Ito A, Yoshida T, Yamada Y, Ueda M, Honda H: Bone tissue engineering with human mesenchymal stem cell sheets constructed using magnetite nanoparticles and magnetic force. J. Biomed. Mater. Res. Part B App. Biomater. 82B(2), 471-480 (2007).
29. Jang JH, Castano O, Kim HW: Electrospun materials as potential platforms for bone tissue engineering. Adv. Drug Deliv. Rev. 61(12), 1065-1083 (2009).
30. Li C, Vepari C, Jin H-J, Kim HJ, Kaplan DL: Electrospun silk-BMP-2 scaffolds for bone tissue engineering. Biomaterials 27(16), 3115-3124 (2006).
31. Yoo HS, Kim TG, Park TG: Surface-functionalized electrospun nanofbers for tissue engineering and drug delivery. Adv. Drug Deliv. Rev. 61(12), 1033-1042 (2009).
32. Kim HW, Lee HH, Knowles JC: Electrospinning biomedical nanocomposite fbers of hydroxyapatite/poly(lactic acid) for bone regeneration. J. Biomed. Mater. Res. A 79A, 643-649 (2006).
33. Song JH, Kim HE, Kim HW: Electrospun fbrous web of collagen-apatite precipitated nanocomposite for bone regeneration. J. Mater. Sci. Mater. Med. 19(8), 2925-2932 (2008).
34. McCullen SD, Ramaswamy S, Clarke LI, Gorga RE: Nanofbrous composites for tissue engineering applications. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 1(4), 369-390 (2009).
35. Nam YS, Park TG: Porous biodegradable polymeric scaffolds prepared by thermally induced phase separation. J. Biomed. Mater. Res. 47, 8-17 (1999).
36. Olivas-Armendariz I, Garcia-Casillas P, Martinez-Sanchez R, Martinez-Villafane A, Martinez-Perez CA: Chitosan/MWCNT composites prepared by thermal induced phase separation. J. Alloys Compd. 495(2), 592-595 (2010).
37. Wei G, Ma PX: Nanostructured biomaterials for regeneration. Adv. Funct. Mater. 18(22), 3568-3582 (2008).
38. Zhang S, Gelain F, Zhao X: Designer self-assembling peptide nanofber scaffolds for 3D tissue cell cultures. Semin. Cancer Biol. 15(5), 413-420 (2005).
39. Zhao X, Zhang S: Self-assembling nanopeptides become a new type of biomaterial. Adv. Polym. Sci. 203, 145-170 (2006).
40. Jung JP, Nagaraj AK, Fox EK, Rudra JS, Devgun JM, Collier JH: Co-assembling peptides as defned matrices for endothelial cells. Biomaterials 30(12), 2400-2410 (2009).
41. Ying C, Luo Y, Cheung ACY et al.: Incorporation of a matrix metalloproteinase-sensitive substrate into self-assembling peptides - a model for biofunctional scaffolds. Biomaterials 29(11), 1713-1719 (2008).
42. Zhou M, Smith AM, Das AK et al.: Self-assembled peptide-based hydrogels as scaffolds for anchorage-dependent cells. Biomaterials 30(13), 2523-2530 (2009).
43. Orbach R, Adler-Abramovich L, Zigerson S, Mironi-Harpaz I, Seliktar D, Gazit E: Self-assembled Fmoc-peptides as a platform for the formation of nanostructures and hydrogels. Biomacromolecules 10(9), 2646-2651 (2009).
44. Jung JP, Jones JL, Cronier SA, Collier JH: Modulating the mechanical properties of self-assembled peptide hydrogels via native chemical ligation. Biomaterials 29(13), 2143-2151 (2008).
45. Liao SW, Yu T-B, Guan Z: De novo design of saccharide-peptide hydrogels as synthetic scaffolds for tailored cell responses. J. Am. Chem. Soc. 131(48), 17638-17646 (2009).
46. Onaca O, Enea R, Hughes DW, Meier W: Stimuli-responsive polymersomes as nanocarriers for drug and gene delivery. Macromol. Biosci. 9(2), 129-139 (2009).
47. Christian DA, Cai S, Bowen DM, Kim Y, Pajerowski JD, Discher DE: Polymersome carriers: from self-assembly to siRNA and protein therapeutics. Eur. J. Pharm. Biopharm. 71(3), 463-474 (2009).
48. Arifn DR, Palmer AF: Polymersome encapsulated hemoglobin: a novel type of oxygen carrier. Biomacromolecules 6(4), 2172-2181 (2005).
49. Katakam M, Bell LN, Banga AK: Effect of surfactants on the physical stability of recombinant human growth-hormone. J. Pharm. Sci. 84(6), 713-716 (1995).
50. Massignani M, Canton I, Sun T et al.: Enhanced fuorescence imaging of live cells by effective cytosolic delivery of probes. PLoS One 5(5), E10459 (2010).
51. Picard C, Hearnden V, Massignani M et al.: A micro-incubator for cell and tissue imaging. Biotechniques 48(2), 135-138 (2010).
52. Hearnden V, Battaglia G, Murdoch C, Thornhill M, MacNeil S: Imaging of polymersome penetration into 3D tissue engineered models of oral mucosa and head and neck cancer. Eur. Cells Mater. 16(3), 58 (2008).
53. Rajagopal K, Christian DA, Harada T, Tian A, Discher DE: Polymersomes and wormlike micelles made fuorescent by direct modifcations of block copolymer amphiphiles. Int. J. Polym. Sci. 2010, 1-10 (2010).
54. Ghoroghchian PP, Frail PR, Susumu K et al.: Near-infrared-emissive polymersomes: self-assembled soft matter for in vivo optical imaging. Proc Natl Acad. Sci. USA 102(8), 2922-2927 (2005).
55. Tran PA, Zhang L, Webster TJ: Carbon nanofbers and carbon nanotubes in regenerative medicine. Adv. Drug Deliv. Rev. 61(12), 1097-1114 (2009).
56. Harrison BS, Atala A: Carbon nanotube applications for tissue engineering. Biomaterials 28(2), 344-353 (2007).
57. Dai H: Carbon nanotubes: Synthesis, integration, and properties. Acc. Chem. Res. 35(12), 1035-1044 (2002).
58. Zhang Y, Bai Y, Yan B: Functionalized carbon nanotubes for potential medicinal applications. Drug Discov. Today 15(11-12), 428-435 (2010).
59. Oliveira JM, Salgado AJ, Sousa N, Mano JF, Reis RL: Dendrimers and derivatives as a potential therapeutic tool in regenerative medicine strategies - a review. Prog. Polym. Sci. 35(9), 1163-1194 (2010).
60. Calderon M, Quadir MA, Sharma SK, Haag R: Dendritic polyglycerols for biomedical applications. Adv. Mater. 22(2), 190-218 (2010).
61. Menjoge AR, Kannan RM, Tomalia DA: Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications. Drug Discov. Today 15(5-6), 171-185 (2010).
62. Wan AC, Ying JY: Nanomaterials for in situ cell delivery and tissue regeneration. Adv. Drug Deliv. Rev. 62(7-8), 731-740 (2010).
63. Wong JE, Richtering W: Layer-by-layer assembly on stimuli-responsive microgels. Curr. Opin. Colloid Interface Sci. 13 403-412 (2008).
64. Takahashi H, Niidome T, Kawano T, Yamada S, Niidome Y: Surface modifcation of gold nanorods using layer-by-layer technique for cellular uptake. J. Nanopart. Res. 10(1), 221-228 (2008).
65. Yamauchi F, Koyamatsu Y, Kato K, Iwata H: Layer-by-layer assembly of cationic lipid and plasmid DNA onto gold surface for stent-assisted gene transfer. Biomaterials 27, 3497-3504 (2006).
66. Cai K, Rechtenbach A, Hao J, Bossert Jr, JKD: Polysaccharide-protein surface modifcation of titanium via a layer-by-layer technique: Characterization and cell behaviour aspects. Biomaterials 26, 5960-5971 (2005).
67. Feng Z, Yan F: Preparation and tribological studies of nanocomposite flms fabricated using spin-assisted layer-by-layer assembly. Surf. Coat. Tech. 202, 3290-3297 (2008).
68. Salditt T, Schubert US: Layer-by-layer self-assembly of supramolecular and biomolecular flms. Rev. Mol. Biotech. 90, 55-70 (2002).
69. Wang C, Ye W, Zheng Y, Liu X, Tong Z: Fabrication of drug-loaded biodegradable microcapsules for controlled release by combination of solvent evaporation and layer-by-layer self-assembly. Int. J. Pharm. 338, 165-173 (2007).
70. Zhang Z, Zhu Y, Yang X, Li C: Preparation of azithromycin microcapsules by a layer-by-layer self-assembly approach and release behaviors of azithromycin. Colloids Surf. A Physicochem. Eng. Asp. 362, 135-139 (2010).
71. 2 sensors by layer-by-layer self-assembly of multi-walled carbon nanotubes and their gas sensing properties. Sens. Actuators B: Chemical 139, 488-493 (2009).
72. Kim JH, Kim SH, Shiratori S: Fabrication of nanoporous and hetero structure thin flm via a layer-by-layer self assembly method for a gas sensor. Sens. Actuators A 102, 241-247 (2004).
73. Tang Q, Wu J, Li Q, Lin J: High conducting multilayer flms from poly(sodium styrenesulfonate) and graphite nanoplatelets by layer-by-layer self-assembly. Polymer 49, 5329-5335 (2008).
74. Tang Q, Wu J, Sun X, Li Q, Lin J: Layer-by-layer self-assembly of conducting multilayer flm from poly (sodium styrenesulfonate) and polyaniline. J. Coll. Interface Sci. 337, 155-161 (2009).
75. Shekaran A, Garcia AJ: Nanoscale engineering of extracellular matrix-mimetic bioadhesive surfaces and implants for tissue engineering. Biochim. Biophys. Acta DOI: 10.1016/j.bbagen.2010.04.006 (2010) (Epub ahead of print).
76. Biggs MJ, Richards RG, Dalby MJ: Nanotopographical modifcation: a regulator of cellular function through focal adhesions. Nanomedicine 6(5), 619-633 (2010).
77. Huo F, Zheng Z, Zheng G, Giam LR, Zhang H, Mirkin CA: Polymer pen lithography. Science 321(5896), 1658-1660 (2008).
78. Salaita K, Wang Y, Mirkin CA: Applications of dip-pen nanolithography Nature Nanotechnol. 2(3), 145-155 (2007).
79. Braunschweig AB, Huo F, Mirkin CA: Molecular printing. Nature Chem. 1, 353-358 (2009).
80. Tormen M, Businaro L, Altissimo M et al.: 3D patterning by means of nanoimprinting, X-ray and two-photon lithography Microelectronic Eng. 73-74, 535-541 (2004).
81. Liberski AR, Zhang R, Bradley M: In situ nanoliter-scale polymer fabrication for fexible cell patterning. JALA 14, 285-293 (2009).
82. Roth EA, Xu T, Das M, Gregory C, Hickman J J, Boland T: Inkjet printing for high-throughput cell patterning. Biomaterials 25(17), 3707-3715 (2004).
83. Kim JD, Choi JS, Kim BS, Choi YC, Cho YW: Piezoelectric inkjet printing of polymers: stem cell patterning on polymer substrates. Polymer 51, 2147-2154 (2010).
84. Sakamoto JH, van De Ven AL, Godin B et al.: Enabling individualized therapy through nanotechnology Pharmacol. Res. 62(2), 57-89 (2010).
85. Solanki A, Kim JD, Lee KB: Nanotechnology for regenerative medicine: nanomaterials for stem cell imaging. Nanomedicine 3(4), 567-578 (2008).
86. Khang D, Carpenter J, Chun YW, Pareta R, Webster TJ: Nanotechnology for regenerative medicine. Biomed. Microdevices 12(4), 575-587 (2010).
87. Zhang L, Webster TJ: Nanotechnology and nanomaterials: promises for improved tissue regeneration. Nano Today 4, 66-80 (2009).
88. Engel E, Michiardi A, Navarro M, Lacroix D, Planell JA: Nanotechnology in regenerative medicine: the materials side. Trends Biotechnol. 26(1), 39-47 (2008).
89. Sokolsky Papkov M, Agashi K, Olaye A, Shakesheff K, Domb AJ: Polymer carriers for drug delivery in tissue engineering. Adv. Drug Deliv. Rev. 59(4-5), 187-206 (2007).
90. Willerth SM, Sakiyama-Elbert SE: Approaches to neural tissue engineering using scaffolds for drug delivery Adv. Drug Deliv. Rev. 59(4-5), 325-338 (2007).
91. Yao X, Yao H, Li Y, Chen G: Preparation of honeycomb scaffold with hierarchical porous structures by core-crosslinked core-corona nanoparticles. J. Colloid Interface Sci. 332(1), 165-172 (2009).
92. Couto DS, Hong Z, Mano JF: Development of bioactive and biodegradable chitosan-based injectable systems containing bioactive glass nanoparticles. Acta Biomater. 5(1), 115-123 (2009).
93. Tautzenberger A, Lorenz S, Kreja L et al.: Effect of functionalised fuorescence-labelled nanoparticles on mesenchymal stem cell differentiation. Biomaterials 31(8), 2064-2071 (2010).
94. Chao T-I, Xiang S, Chen C-S et al.: Carbon nanotubes promote neuron differentiation from human embryonic stem cells. Biochem. Biophys. Res. Commun. 384(4), 426-430 (2009).
95. Kannarkat JT, Battogtokh J, Philip J, Wilson OC, Mehl PM: Embedding of magnetic nanoparticles in polycaprolactone nanofber scaffolds to facilitate bone healing and regeneration. J. Appl. Phys. 107(9, Pt 2), 09B307/301- 309B307/303 (2010).
96. Kalfa D, Bel A, Chen-Tournoux A et al.: A polydioxanone electrospun valved patch to replace the right ventricular outfow tract in a growing lamb model. Biomaterials 31(14), 4056-4063 (2010).
97. Yang F, Murugan R, Wang S, Ramakrishna S: Electrospinning of nano/micro scale poly(L-lactic acid) aligned fbers and their potential in neural tissue engineering. Biomaterials 26(15), 2603-2610 (2005).
98. Meng J, Han Z, Kong H et al.: Electrospun aligned nanofbrous composite of MWCNT/ polyurethane to enhance vascular endothelium cells proliferation and function. J. Biomed. Mater. Res. Part A 95A(1), 312-320 (2010).
99. Edwards SL, Church JS, Werkmeister JA, Ramshaw JA: Tubular micro-scale multiwalled carbon nanotube-based scaffolds for tissue engineering. Biomaterials 30(9), 1725-1731 (2009).
100. Balani K, Anderson R, Laha T et al.: Plasma-sprayed carbon nanotube reinforced hydroxyapatite coatings and their interaction with human osteoblasts in vitro. Biomaterials 28(4), 618-624 (2007).
101. Niu L, Kua H, Chua DHC: Bonelike apatite formation utilizing carbon nanotubes as template. Langmuir 26(6), 4069-4073 (2009).
102. Smith-Freshwater AP, Bowlin GL, Yang H: A novel electrospun dendrimer-gelatin hybrid nanofber scaffold for tissue regeneration and drug delivery Mater. Res. Soc. Symp. Proc. 1094E, 1094-DD1009-1007 (2008).
103. Duan X, Sheardown H: Dendrimer crosslinked collagen as a corneal tissue engineering scaffold: mechanical properties and corneal epithelial cell interactions. Biomaterials 27(26), 4608-4617 (2006).
104. Duan X, McLaughlin C, Griffth M, Sheardown H: Biofunctionalization of collagen for improved biological response: scaffolds for corneal tissue engineering. Biomaterials 28(1), 78-88 (2007).
105. Zhao D, Ong S-M, Yue Z et al.: Dendrimer hydrazides as multivalent transient intercellular linkers. Biomaterials 29(27), 3693-3702 (2008).
106. 2 nanoparticles in PLGA scaffolds with improved bioactivity for regenerative medicine. Adv. Funct. Mater. 20(10), 1617-1624 (2010).
107. Verma S, Kumar N: Effect of biomimetic 3D environment of an injectable polymeric scaffold on MG-63 osteoblastic-cell response. Mater. Sci. Eng. C 30, 1118-1128 (2010).
108. Dalby MJ, McCloy D, Robertson M, Wilkinson CD, Oreffo RO: Osteoprogenitor response to defned topographies with nanoscale depths. Biomaterials 27(8), 1306-1315 (2006).
109. Lenhert S, Meier MB, Meyer U, Chi L, Wiesmann HP: Osteoblast alignment, elongation and migration on grooved polystyrene surfaces patterned by Langmuir-Blodgett lithography. Biomaterials 26(5), 563-570 (2005).
110. Yim EK, Pang SW, Leong KW: Synthetic nanostructures inducing differentiation of human mesenchymal stem cells into neuronal lineage. Exp. Cell Res. 313(9), 1820-1829 (2007).
111. Yim EK, Reano RM, Pang SW, Yee AF, Chen CS, Leong KW: Nanopattern-induced changes in morphology and motility of smooth muscle cells. Biomaterials 26(26), 5405-5413 (2005).
112. Tessmar JK, Gopferich AM: Matrices and scaffolds for protein delivery in tissue engineering. Adv. Drug Deliv. Rev. 59(4-5), 274-291 (2007).
113. Mercado AE, Ma J, He X, Jabbari E: Release characteristics and osteogenic activity of recombinant human bone morphogenetic protein-2 grafted to novel self-assembled poly(lactide-co-glycolide fumarate) nanoparticles. J. Control. Release 140(2), 148-156 (2009).
114. Bessa PC, Machado R, Nurnberger S et al.: Thermoresponsive self-assembled elastin-based nanoparticles for delivery of BMPs. J. Control. Release 142(3), 312-318 (2010).
115. Oh KS, Song JY, Yoon SJ, Park Y, Kim D, Yuk SH: Temperature-induced gel formation of core/shell nanoparticles for the regeneration of ischemic heart. J. Control. Release 146(2), 207-211 (2010).
116. Thomas TP, Shukla R, Kotlyar A, Kukowska-Latallo J, Baker JR Jr: Dendrimer-based tumor cell targeting of fbroblast growth factor-1. Bioorg. Medic. Chem. Lett. 20(2), 700-703 (2010).
117. Park JH, Kwon S, Nam JO et al.: Self-assembled nanoparticles based on glycol chitosan bearing 5b-cholanic acid for RGD peptide delivery. J. Control. Release 95(3), 579-588 (2004).
118. Bonoiu AC, Mahajan SD, Ding H et al.: Nanotechnology approach for drug addiction therapy: gene silencing using delivery of gold nanorod-siRNA nanoplex in dopaminergic neurons. PNAS 106(14), 5546-5550 (2009).
119. Klein S, Zolk O, Fromm MF, Schrödl F, Neuhuber W, Kryschi C: Functionalized silicon quantum dots tailored for targeted siRNA delivery. Biochem. Biophys. Res. Commun. 387(1), 164-168 (2009).
120. Kim Y, Tewari M, Pajerowski JD et al.: Polymersome delivery of siRNA and antisense oligonucleotides. J. Control. Release 134(2), 132-140 (2009).
121. Liao IC, Chen S, Liu JB, Leong KW: Sustained viral gene delivery through core-shell fbers. J. Control. Release 139(1), 48-55 (2009).
122. Lee H, Mok H, Lee S, Oh YK, Park TG: Target-specifc intracellular delivery of siRNA using degradable hyaluronic acid nanogels. J. Control. Release 119(2), 245-252 (2007).
123. Santos JL, Oliveira H, Pandita D et al.: Functionalization of poly(amidoamine) dendrimers with hydrophobic chains for improved gene delivery in mesenchymal stem cells. J. Control. Release 144(1), 55-64 (2010).
124. Peng SF, Su CJ, Wei MC et al.: Effects of the nanostructure of dendrimer/DNA complexes on their endocytosis and gene expression. Biomaterials 31(21), 5660-5670 (2010).
125. Kim TI, Baek JU, Zhe Bai C, Park JS: Arginine-conjugated polypropylenimine dendrimer as a non-toxic and effcient gene delivery carrier. Biomaterials 28(11), 2061-2067 (2007).
126. Hussain M, Shchepinov M, Sohail M et al.: A novel anionic dendrimer for improved cellular delivery of antisense oligonucleotides. J. Control. Release 99(1), 139-155 (2004).
127. Jewell CM, Lynn DM: Multilayered polyelectrolyte assemblies as platforms for the delivery of DNA and other nucleic acid-based therapeutics. Adv. Drug Deliv. Rev. 60, 979-999 (2008).
128. Wang F, Wang J, Zhai Y, Li G, Li D, Dong S: Layer-by-layer assembly of biologically inert inorganic ions/DNA multilayer flms for tunable DNA release by chelation. J. Control. Release 132, 65-73 (2008).
129. Sheyn D, Mizrahi O, Benjamin S, Gazit Z, Pelled G, Gazit D: Genetically modifed cells in regenerative medicine and tissue engineering. Adv. Drug Deliv. Rev. 62(7-8), 683-698 (2010).
130. Weissleder R, Pittet MJ: Imaging in the era of molecular oncology. Nature 452, 580-589 (2008).
131. Fang C, Zhang M: Nanoparticle-based theragnostics: integrating diagnostic and therapeutic potentials in nanomedicine. J. Control. Release 146(1), 2-5 (2010).
132. Xie J, Lee S, Chen X: Nanoparticle-based theranostic agents. Adv. Drug Deliv. Rev. 62(11), 1064-1079 (2010).
133. Kobayashi H, Brechbiel MW: Nano-sized MRI contrast agents with dendrimer cores. Adv. Drug Deliv. Rev. 57(15), 2271-2286 (2005).
134. Oliveira JM, Kotobuki N, Marques AP et al.: Surface engineered carboxymethylchitosan/ poly(amidoamine) dendrimer nanoparticles for intracellular targeting. Adv. Funct. Mater. 18(12), 1840-1853 (2008).
135. Tallheden T, Nannmark U, Lorentzon M et al.: In vivo MR imaging of magnetically labeled human embryonic stem cells. Life Sci. 79(10), 999-1006 (2006).
136. Wang HH, Xiang Y, Wang J et al.: Durable mesenchymal stem cell labeling by using polyhedral superparamagnetic iron oxide nanoparticles. Chemistry 15(45), 12417-12425 (2009).
137. Lee PW, Hsu SH, Wang JJ et al.: The characteristics, biodistribution, magnetic resonance imaging and biodegradability of superparamagnetic core-shell nanoparticles. Biomaterials 31(6), 1316-1324 (2010).
138. Heng BC, Cowan CM, Davalian D et al.: Electrostatic binding of nanoparticles to mesenchymal stem cells via high molecular weight polyelectrolyte chains. J. Tissue Eng. Regener. Med. 3(4), 243-254 (2009).
139. Willner I, Baron R, Willner B: Integrated nanoparticle-biomolecule systems for biosensing and bioelectronics. Biosens. Bioelectron. 22(9-10), 1841-1852 (2007).
140. Vaddiraju S, Tomazos I, Burgess DJ, Jain FC, Papadimitrakopoulos F: Emerging synergy between nanotechnology and implantable biosensors: a review. Biosens. Bioelectron. 25, 1553-1565 (2010).
141. He B, Morrow TJ, Keating CD: Nanowire sensors for multiplexed detection of biomolecules. Curr. Opin. Chem. Biol. 12(5), 522-528 (2008).
142. Roy S, Gao Z: Nanostructure-based electrical biosensors. Nano Today 4, 318-334 (2009).
143. Dahint R, Trileva E, Acunman H et al.: Optically responsive nanoparticle layers for the label-free ana lysis of biospecifc interactions in array formats. Biosens. Bioelectron. 22(12), 3174-3181 (2007).
144. Merkoçi A, Pumera M, Llopis X, Pérez B, Valle MD, Alegret S: New materials for electrochemical sensing VI: Carbon nanotubes. Trends Anal. Chem. 24(9), 826-838 (2005). (Pubitemid 41429295)
145. Yang M, Jiang J, Lu Y, He Y, Shen G, Yu R: Functional histidine/nickel hexacyanoferrate nanotube assembly for biosensor applications. Biomaterials 28(23), 3408-3417 (2007).
146. Li CA, Han KN, Bui M-PN, Pham X-H, Seong GH: Development of hydrogel microstructures on single-walled carbon nanotube flms. Appl. Surf. Sci. 256, 7428-7433 (2010).
147. Arumugam PU, Chen H, Siddiqui S et al.: Wafer-scale fabrication of patterned carbon nanofber nanoelectrode arrays: a route for development of multiplexed, ultrasensitive disposable biosensors. Biosens. Bioelectron. 24(9), 2818-2824 (2009).
148. Hou X, Yang F, Li L, Song Y, Jiang L, Zhu D: A biomimetic asymmetric responsive single nanochannel. J. Am. Chem. Soc. 132(33), 11736-11742 (2010).
149. Peng H, Zhang L, Soeller C, Travas-Sejdic J: Conducting polymers for electrochemical DNA sensing. Biomaterials 30(11), 2132-2148 (2009).
150. Morel AL, Volmant RM, Methivier C, Krafft JM, Boujday S, Pradier CM: Optimized immobilization of gold nanoparticles on planar surfaces through alkyldithiols and their use to build 3D biosensors. Colloids Surf. B 81(1), 304-312 (2010).
151. Park H, Park TJ, Huh YS et al.: Immobilization of genetically engineered fusion proteins on gold-decorated carbon nanotube hybrid flms for the fabrication of biosensor platforms. J. Colloid Interface Sci. 350(2), 453-458 (2010).
152. Park M, Cella LN, Chen W, Myung NV, Mulchandani A: Carbon nanotubes-based chemiresistive immunosensor for small molecules: detection of nitroaromatic explosives. Biosens. Bioelectron. 26(4), 1297-1301 (2010).
153. Liu Y, Erdman AG, Cui T: Acetylcholine biosensors based on layer-by-layer self-assembled polymer/nanoparticle ion-sensitive feld-effect transistors. Sens. Actuators A 136, 540-545 (2007).
154. Medintz IL, Clapp AR, Mattoussi H, Goldman ER, Fisher B, Mauro JM: Self-assembled nanoscale biosensors based on quantum dot FRET donors. Nature Mater. 2, 630-638 (2003).
155. Medintz IL, Stewart MH, Trammell SA et al.: Quantum-dot/dopamine bioconjugates function as redox coupled assemblies for in vitro and intracellular pH sensing. Nature Mater. 9, 676-684 (2010).
156. Rousserie G, Sukhanova A, Even- Desrumeaux K et al.: Semiconductor quantum dots for multiplexed bio-detection on solid-state microarrays. Crit. Rev. Oncol. Hematol. 74(1), 1-15 (2010).
157. Setti L, Fraleoni-Morgera A, Mencarelli I, Filippini A, Ballarin B, Biase MD: An HRP-based amperometric biosensor fabricated by thermal inkjet printing. Sens. Actuators B 126, 252-257 (2007).
158. Tang Q, Shi SQ: Preparation of gas sensors via dip-pen nanolithography. Sens. Actuators B: Chemical 131, 379-383 (2008).
159. Roy D, Munz M, Colombi P et al.: Directly writing with nanoparticles at the nanoscale using dip-pen nanolithography. Appl. Surf. Sci. 254, 1394-1398 (2007).
160. Choi HJ, Kim NH, Chung BH, Seong GH: Micropatterning of biomolecules on glass surfaces modifed with various functional groups using photoactivatable biotin. Anal. Biochem. 347(1), 60-66 (2005).
161. Montelius L, Heidari B, Graczyk M, Maximov I, Sarwe E-L, Ling TGI: Nanoimprint- and UV-lithography: mix&match process for fabrication of interdigitated nanobiosensors. Microelectronic Eng. 53, 521-524 (2000).
162. Lee W, Choi D, Lee Y, Kim D-N, Park J, Koh W-G: Preparation of micropatterned hydrogel substrate via surface graft polymerization combined with photolithography for biosensor application. Sens. Actuators A 129, 841-849 (2008).
163. Stern ST, McNeil SE: Nanotechnology safety concerns revisited. Toxicol. Sci. 101(1), 4-21 (2008).
164. Garnett MC, Kallinteri P: Nanomedicines and nanotoxicology: some physiological principles. Occup. Med. 56(5), 307-311 (2006).
165. Sahay G, Alakhova DY, Kabanov AV: Endocytosis of nanomedicines. J. Control. Release 145(3), 182-195 (2010).
166. Oberdörster G, Maynard A, Donaldson K. et al.; ILSI Research Foundation/Risk Science Institute Nanomaterial Toxicity Screening Working Group: Principles for characterizing the potential human health effects from exposure to nanomaterial: elements of a screening strategy. Particle Fibre Toxicol. 2, 1-35 (2005).
167. Chan VSW: Nanomedicine: an unresolved regulatory issue. Regulatory Tox. Pharmacol 46, 218-224 (2006).
168. Rozenberga BA, Tenne R: Polymer-assisted fabrication of nanoparticles and nanocomposites. Prog. Polym. Sci. 33, 40-112 (2008).
169. Mazzola L: Commercializing nanotechnology. Nature Biotech. 21(10), 1137-1143 (2003).
170. Tan WB, Jiang S, Zhang Y: Quantum-dot based nanoparticles for targeted silencing of HER2/neu gene via RNA interference. Biomaterials 28(8), 1565-1571 (2007).
171. 2 biosensor based on horseradish peroxidase-labeled Au nanoparticles self-assembled to hollow porous polymeric nanospheres. Biosens. Bioelectron. 22(8), 1807-1810 (2007).
172. 4 magnetic nanoparticle dispersed multiwalled carbon nanotubes based amperometric glucose biosensor. Talanta 80(5), 2016- 2022 (2010).
173. Li J, Wei X, Yuan Y: Synthesis of magnetic nanoparticles composed by prussian blue and glucose oxidase for preparing highly sensitive and selective glucose biosensor. Sens. Actuators B: Chemical 139(2), 400-406 (2009).
174. Nikitin PI, Vetoshko PM, Ksenevich TI: New type of biosensor based on magnetic nanoparticle detection. J. Magnet. Mag. Mater. 311, 445-449 (2007).
175. Nejati E, Mirzadeh H, Zandi M: Synthesis and characterization of nano-hydroxyapatite rods/poly(L-lactide acid) composite scaffolds for bone tissue engineering. Composites A 39A(10), 1589-1596 (2008).
176. Gay S, Arostegui S, Lemaitre J: Preparation and characterization of dense nanohydroxyapatite/PLLA composites. Mater. Sci. Eng. C 29(1), 172-177 (2009).
177. Kong L-J, Ao Q, Xi J et al.: Proliferation and differentiation of MC 3T3-E1 cells cultured on nanohydroxyapatite/chitosan composite scaffolds. Shengwu Gongcheng Xuebao 23(2), 262-267 (2007).
178. Degirmenbasi N, Kalyon DM, Birinci E: Biocomposites of nanohydroxyapatite with collagen and poly (vinyl alcohol). Colloids Surf. B 48(1), 42-49 (2006).
179. Lee SH, Bae KH, Kim SH, Lee KR, Park TG: Amine-functionalized gold nanoparticles as non-cytotoxic and effcient intracellular siRNA delivery carriers. Int. J. Pharm. 364(1), 94-101 (2008).
180. Noh SM, Kim WK, Kim SJ, Kim JM, Baek KH, Oh YK: Enhanced cellular delivery and transfection effciency of plasmid DNA using positively charged biocompatible colloidal gold nanoparticles. Biochim. Biophys. Acta 1770(5), 747-752 (2007).
181. Persson S, Havton LA: Retrogradely transported fuorogold accumulates in lysosomes of neurons and is detectable ultrastructurally using post-embedding immuno-gold methods. J. Neurosci. Meth. 184(1), 42-47 (2009).
182. Grieshaber P, Lagrèze WA, Noack C, Boehringer D, Biermann J: Staining of fuorogold-prelabeled retinal ganglion cells with calcein-AM: a new method for assessing cell vitality. J. Neurosci. Meth. 192(2), 233-239 (2010).
183. Pettersson J, Lobov S, Novikova LN: Labeling of olfactory ensheathing glial cells with fuorescent tracers for neurotransplantation. Brain Res. Bull. 81(1), 125-132 (2010).
184. Tang L, Zhu Y, Yang X, Li C: An enhanced biosensor for glutamate based on self-assembled carbon nanotubes and dendrimer-encapsulated platinum nanobiocomposites-doped polypyrrole flm. Anal. Chim. Acta 597(1), 145-150 (2007). (Pubitemid 47068389)
185. Liu Y, Zhang D, Alocilja EC, Chakrabartty S: Biomolecules detection using a silver-enhanced gold nanoparticle-based biochip. Nanoscale Res. Lett. 5(3), 533-538 (2010).
186. Tian D, Duan C, Wang W et al.: Sandwich-type electrochemiluminescence immunosensor based on N-(aminobutyl)-N-ethylisoluminol labeling and gold nanoparticle amplifcation. Talanta 78(2), 399-404 (2009).
187. Kim H-W, Song J-H, Kim H-E: Bioactive glass nanofber-collagen nanocomposite as a novel bone regeneration matrix. J. Biomed. Mater. Res. Part A 79A(3), 698-705 (2006).
188. Arsat R, Yu XF, Li YX, Wlodarski W, Kalantar-zadeh K: Hydrogen gas sensor based on highly ordered polyaniline nanofbers. Sens. Actuators B: Chemical 137(2), 529-532 (2009).
189. Li Z-F, Blum FD, Bertino MF, Kim C-S, Pillalamarri SK: One-step fabrication of a polyaniline nanofber vapor sensor. Sens. Actuators B: Chemical 134(1), 31-35 (2008).
190. Ji S, Li Y, Yang M: Gas sensing properties of a composite composed of electrospun poly(methyl methacrylate) nanofbers and in situ polymerized polyaniline. Sens. Actuators B: Chemical 133(2), 644-649 (2008).
191. Krajcik R, Jung A, Hirsch A, Neuhuber W, Zolk O: Functionalization of carbon nanotubes enables non-covalent binding and intracellular delivery of small interfering RNA for effcient knock-down of genes. Biochem. Biophys. Res. Commun. 369(2), 595-602 (2008).
192. Sung J, Barone PW, Kong H, Strano MS: Sequential delivery of dexamethasone and VEGF to control local tissue response for carbon nanotube fuorescence based micro-capillary implantable sensors. Biomaterials 30(4), 622-631 (2009).
193. Zeinali M, Jammalan M, Ardestani SK, Mosaveri N: Immunological and cytotoxicological characterization of tuberculin purifed protein derivative (PPD) conjugated to single-walled carbon nanotubes. Immunol. Lett. 126(1-2), 48-53 (2009).
194. Zheng D, Li X, Ye J: Adsorption and release behavior of bare and DNA-wrapped-carbon nanotubes on self-assembled monolayer surface. Bioelectrochemistry 74(2), 240-245 (2009).
195. Awasthi K, Singh DP, Singh SK, Dash D, Srivastava ON: Attachment of biomolecules (protein and DNA) to amino-functionalized carbon nanotubes. New Carbon Mater. 24(4), 301-306 (2009).
196. Xu Z, Hu P, Wang S, Wang X: Biological functionalization and fuorescent imaging of carbon nanotubes. Appl. Surf. Sci. 254, 1915-1918 (2008).
197. Wang CH, Chiou SH, Chou CP, Chen YC, Huang YJ, Peng CA: Photothermolysis of glioblastoma stem-like cells targeted by carbon nanotubes conjugated with CD133 monoclonal antibody. Nanomedicine DOI: 10.1016/j.nano.2010.06.010 (2010) (Epub ahead of print).
198. Arima H, Yamashita S, Mori Y et al.: In vitro and in vivo gene delivery mediated by Lactosylated dendrimer/a-cyclodextrin conjugates (G2) into hepatocytes. J. Control. Release 146(1), 106-117 (2010).
199. Sato N, Park CW, Kim HS et al.: Synthesis of dendrimer-based biotin radiopharmaceuticals to enhance whole-body clearance. Nucl. Med. Biol. 30(6), 617-625 (2003).
200. Kim MH, Kino-oka M, Saito A, Sawa Y, Taya M: Myogenic induction of human mesenchymal stem cells by culture on dendrimer-immobilized surface with d-glucose display. J. Biosci. Bioeng. 109(1), 55-61 (2010).
201. Oliveira JM, Sousa RA, Kotobuki N et al.: The osteogenic differentiation of rat bone marrow stromal cells cultured with dexamethasone-loaded carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles. Biomaterials 30(5), 804-813 (2009).
202. Yao K, Zhu Y, Yang X, Li C: ENFET glucose biosensor produced with dendrimer encapsulated Pt nanoparticles. Mater. Sci. Eng. C 28(8), 1236-1241 (2008).
203. Xu L, Zhu Y, Yang X, Li C: Amperometric biosensor based on carbon nanotubes coated with polyaniline/dendrimer-encapsulated Pt nanoparticles for glucose detection. Mater. Sci. Eng. C 29(4), 1306-1310 (2009).
204. Zhu N, Gao H, Xu Q, Lin Y, Su L, Mao L: Sensitive impedimetric DNA biosensor with poly(amidoamine) dendrimer covalently attached onto carbon nanotube electronic transducers as the tether for surface confnement of probe DNA. Biosens. Bioelectron. 25(6), 1498-1503 (2010).
205. Martinovic J, Wyk Jv, Mapolie S, Jahed N, Baker P, Iwuoha E: Electrochemical and spectroscopic properties of dendritic cobalto- salicylaldiimine DNA biosensor. Electrochim. Acta 55(14), 4296-4302 (2010).
206. Zhang P, Liu W: ZnO QD@PMAA-co-PDMAEMA nonviral vector for plasmid DNA delivery and bioimaging. Biomaterials 31(11), 3087-3094 (2010).
207. Fu RH, Liu SP, Ou CW, Huang CM, Wang YC: Spatial control of cells, peptide delivery and dynamic monitoring of cellular physiology with chitosan-assisted dual color quantum dot FRET peptides. Acta Biomater. 6(9), 3621-3629 (2010).
208. Kim JH, Kim SH, Shiratori S: Fabrication of nanoporous and hetero structure thin flm via a layer-by-layer self assembly method for a gas sensor. Sens. Actuators B: Chemical 102(2), 241-247 (2004).
209. Kramer MA, Park HC, Ivanisevic A: Dip-pen nanolithography on SiOx and tissue-derived substrates: comparison with multiple biological inks. Scanning 32, 30-34 (2010).
210. Zhou H, Li Z, Wu A, Wei G, Liu Z: Direct patterning of rhodamine 6G molecules on mica by dip-pen nanolithography. Appl. Surf. Sci. 236(1-4), 18-24 (2004).
211. Wang G-J, Hsu Y-F, Hsu S-H, Horng RH: JSR photolithography based microvessel scaffold fabrication and cell seeding. Biomed. Microdevices 8(1), 17-23 (2006).
212. Hsieh TM, Benjamin Ng CW, Narayanan K, Wan AC, Ying JY: Three-dimensional microstructured tissue scaffolds fabricated by two-photon laser scanning photolithography. Biomaterials 31(30), 7648-7652 (2010).
213. Zhang W, Han L-H, Chen S: Integrated two-photon polymerization with nanoimprinting for direct digital nanomanufacturing. J. Manuf. Sci. Eng. 132(3), 030907 (2010).
214. Glangchai LC, Caldorera-Moore M, Shi L, Roy K: Nanoimprint lithography based fabrication of shape-specifc, enzymatically-triggered smart nanoparticles. J. Control. Release 125(3), 263-272 (2008).
215. Ofr Y, Moran IW, Subramani C, Carter KR, Rotello VM: Nanoimprint lithography for functional three-dimensional patterns. Adv. Mater. 22(32), 3608-3614 (2010).
216. Nishiyama Y, Nakamura M, Henmi C et al.: Development of a three-dimensional bioprinter: construction of cell supporting structures using hydrogel and state-of-the-art inkjet technology. J. Biomech. Eng. 131(3), 035001 (2009).