D-Isomer of gly-tyr-pro-cys-pro-his-pro peptide: A novel and sensitive in vitro trapping agent to detect reactive metabolites by electrospray mass spectrometry

Toxicology in Vitro

Volumn 25, Issue 1, 2011, Pages 411-425

  Laine, Jaana E ^a   Auriola, Seppo ^a   Pasanen, Markku ^a   Juvonen, Risto O ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Bioactivation; Covalent binding; LC MS liquid chromatography mass spectrometry; Peptide d isomer and peptide adducts; Reactive metabolites

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; CIPROFLOXACIN; CLOPIDOGREL; CLOZAPINE; CYTOCHROME P450 3A4; DICLOFENAC; ELECTROPHILE; GLUTATHIONE; GLYCYLTYROSYLPROLYLCYSTYLPROLYLHISTIDYLPROLINE; IMIPRAMINE; KETOCONAZOLE; MENTHOFURAN; NICOTINE; NIMESULIDE; PARACETAMOL; PROPRANOLOL; PROTEINASE; PULEGONE; RECOMBINANT ENZYME; SYNTHETIC PEPTIDE; TICLOPIDINE; TOLCAPONE; UNCLASSIFIED DRUG; VERAPAMIL; XENOBIOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL ADDUCTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; IN VITRO STUDY; INCUBATION TIME; ION TRAP MASS SPECTROMETRY; ISOMER; LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY ION TRAP MASS SPECTROMETRY; LIVER MICROSOME; METABOLISM; METABOLITE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PROTEIN HYDROLYSIS; PROTEIN STABILITY; RAT;

ANALYTIC SAMPLE PREPARATION METHODS; ANIMALS; BIOTRANSFORMATION; CYTOCHROME P-450 CYP3A; DRUG EVALUATION, PRECLINICAL; GLUTATHIONE; HUMANS; INDICATORS AND REAGENTS; ISOMERISM; MICE; MICE, INBRED DBA; MICROSOMES, LIVER; OLIGOPEPTIDES; PROTEIN STABILITY; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; XENOBIOTICS;

EID: 78650520382     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2010.11.002     Document Type: Article

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