In vitro microsomal metabolic studies on a selective mGluR5 antagonist MTEP: Characterization of in vitro metabolites and identification of a novel thiazole ring opening aldehyde metabolite

Xenobiotica

Volumn 35, Issue 8, 2005, Pages 797-809

  Yang, X ^a,b   Chen, W ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b VERTEX PHARMACEUTICALS   (United States)

Author keywords

In vitro; Metabolites; Structure elucidation

Indexed keywords

3 [(2 METHYL 4 THIAZOLYL)ETHYNYL]PYRIDINE; ALDEHYDE; GLUTAMATE RECEPTOR 5 ANTAGONIST; PYRIDINE 1 OXIDE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOG; DRUG STRUCTURE; HUMAN; HUMAN CELL; IN VITRO STUDY; INCUBATION TIME; LIQUID CHROMATOGRAPHY; LIVER METABOLISM; LIVER MICROSOME; MALE; MASS SPECTROMETRY; MONKEY; MOUSE; NONHUMAN; OXIDATION KINETICS; OXIDATIVE STRESS; QUADRUPOLE MASS SPECTROMETRY; RAT; RING OPENING; SPECIES DIFFERENCE; SULFATION; XENOBIOTIC METABOLISM;

ALDEHYDES; ANIMALS; HUMANS; MICROSOMES, LIVER; PYRIDINES; RECEPTORS, METABOTROPIC GLUTAMATE; THIAZOLES;

ANIMALIA; CANIS FAMILIARIS;

EID: 27944450385     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.1080/00498250500230412     Document Type: Article

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