A novel approach to perform metabolite screening during the quantitative LC-MS/MS analyses of in vitro metabolic stability samples using a hybrid triple-quadrupole linear ion trap mass spectrometer

Journal of Mass Spectrometry

Volumn 40, Issue 10, 2005, Pages 1347-1356

  Shou, Wilson Z ^a   Magis, Lisa ^a   Li, Austin C ^a   Naidong, Weng ^a   Bryant, Matthew S ^a  

^a 206 Carnegie Center   (United States)

Author keywords

Drug discovery; Metabolite screening; Microsomes; Stability measurements; Time concentration profiles; Triple quadrupole linear ion trap MS

Indexed keywords

CHROMOSOMES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; REACTION KINETICS;

DRUG DISCOVERY; METABOLITE SCREENING; MICROSOMES; STABILITY MEASUREMENTS; TIME-CONCENTRATION PROFILES; TRIPLE-QUADRUPOLE LINEAR ION TRAP MS;

METABOLITES;

ARTICLE; BIOTRANSFORMATION; ION TRAP MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLIC ACTIVATION; METABOLITE; MICROSOME; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

BIOTRANSFORMATION; DRUG EVALUATION, PRECLINICAL; HUMANS; MICROSOMES, LIVER; PHARMACEUTICAL PREPARATIONS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 27644585407     PISSN: 10765174     EISSN: None     Source Type: Journal    
DOI: 10.1002/jms.917     Document Type: Article

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