Characterization of benzoquinone - Peptide adducts by electrospray mass spectrometry

Chemical Research in Toxicology

Volumn 13, Issue 10, 2000, Pages 976-982

  Mason, D E ^a   Liebler, D C ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOQUINONE; DNA FRAGMENT; OXYTOCIN; PEPTIDE;

AMINO ACID SEQUENCE; ARTICLE; BLOOD TOXICITY; DATA ANALYSIS; ENZYME ACTIVITY; IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN ANALYSIS; RELIABILITY; TANDEM MASS SPECTROMETRY;

AMINO ACID SEQUENCE; BENZOQUINONES; MOLECULAR SEQUENCE DATA; PEPTIDES; SERUM ALBUMIN, BOVINE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TRYPSIN;

EID: 0033789364     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx0000670     Document Type: Article

References (23)

1. Metabolic basis of benzene toxicity
2. 6]benzene to rats
3. Interaction of p-Benzoquinone and p-Biphenoquinone with microtubule proteins in vitro
4. Contemporary issues in toxicology. Selective protein covalent binding and target organ toxicity
5. Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry
6. Sequencing of peptides by tandem mass spectrometry and high-energy collision-induced dissociation
7. Characterization by tandem mass spectrometry of structural modification of proteins
8. Characterization of structural xenobiotic modifications in proteins by high sensitivity tandem mass spectrometry
9. Direct analysis and identification of proteins in mixtures by LC/MS/MS and database searching at the low-femtomole level
10. Detection of modified peptides in enzymatic digests by capillary liquid chromatography/electrospray mass spectrometry and a programmable skimmer CID acquisition routine
11. A comparison of keV atom bombardment mass spectra of peptides obtained with a two-sector mass spectrometer with those from a four-sector tandem mass spectrometer
12. Refining the model for selective cleavage at acidic residues in arginine-containing protonated peptides
13. Influence of secondary structure on the fragmentation of protonated peptides
14. S-(2-Chloroacetyl)glutathione, a reactive glutathione thiolester and a putative metabolite of 1,1-dichloroethylene
15. Carbamoylation of peptides and proteins in vitro by S-(N-methylcarbamoyl)glutathione and S-(N-methylcarbamoyl)cysteine, two electrophilic S-Linked conjugates of methyl isocyanate
16. Alkylation of oxytocin by S-(2-Chloroethyl)glutathione and characterization of adducts by tandem mass-spectrometry and edman degradation
17. First direct evidence for lipid/protein conjugation in oxidized human low-density lipoprotein
18. Direct characterization of protein adducts of the lipid peroxidation product 4-Hydroxy-2-Nonenal using electrospray mass spectrometry
19. Quinone chemistry and toxicology
20. Detection of benzoquinone adducts to rat liver protein sulfhydryl groups using specific antibodies
21. Proposal for a common nomenclature for sequence ions in mass spectra of peptides