메뉴 건너뛰기




Volumn 22, Issue 5, 2010, Pages 659-676

Filamentous tropical marine cyanobacteria: A rich source of natural products for anticancer drug discovery

Author keywords

Anticancer; Drug discovery; Marine cyanobacteria; Natural products

Indexed keywords

CHLOROPHYTA; CYANOBACTERIA; EUKARYOTA; PROKARYOTA;

EID: 78650214297     PISSN: 09218971     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10811-010-9506-x     Document Type: Review
Times cited : (119)

References (107)
  • 3
    • 77955843274 scopus 로고    scopus 로고
    • Aráoz R, Molgó J, Tandeau de Marsac N (2010) Neurotoxic cyanobacterial toxins. Toxicon (in press).
  • 5
    • 34249101623 scopus 로고    scopus 로고
    • Genetic analysis of polyketide synthase and peptide synthetase genes in cyanobacteria as a mining tool for secondary metabolites
    • Barrios-Llerena ME, Burja AM, Wright PC (2007) Genetic analysis of polyketide synthase and peptide synthetase genes in cyanobacteria as a mining tool for secondary metabolites. J Ind Microbiol Biotechnol 34: 443-456.
    • (2007) J Ind Microbiol Biotechnol , vol.34 , pp. 443-456
    • Barrios-Llerena, M.E.1    Burja, A.M.2    Wright, P.C.3
  • 6
    • 0001419708 scopus 로고    scopus 로고
    • Total structure and biological properties of laxaphycins A and B, cyclic lipopeptides from the marine cyanobacterium Lyngbya majuscula
    • Bonnard I, Rolland M, Francisco C, Banaigs B (1997) Total structure and biological properties of laxaphycins A and B, cyclic lipopeptides from the marine cyanobacterium Lyngbya majuscula. Lett Pept Sci 4: 289-292.
    • (1997) Lett Pept Sci , vol.4 , pp. 289-292
    • Bonnard, I.1    Rolland, M.2    Francisco, C.3    Banaigs, B.4
  • 8
    • 50249144006 scopus 로고    scopus 로고
    • Total synthesis and biological mode of action of largazole: A potent class I histone deacetylase inhibitor
    • Bowers A, West N, Taunton J, Schreiber SL, Bradner JE, Williams RM (2008) Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor. J Am Chem Soc 130: 11219-11222.
    • (2008) J Am Chem Soc , vol.130 , pp. 11219-11222
    • Bowers, A.1    West, N.2    Taunton, J.3    Schreiber, S.L.4    Bradner, J.E.5    Williams, R.M.6
  • 9
    • 64049106355 scopus 로고    scopus 로고
    • Synthesis and histone deacetylase inhibitory activity of largazole analogs: Alteration of the zinc-binding domain and macrocyclic scaffold
    • Bowers AA, West N, Newkirk TL, Troutman-Youngman AE, Schreiber SL, Wiest O, Bradner JE, Williams RM (2009a) Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffold. Org Lett 11: 1301-1304.
    • (2009) Org Lett , vol.11 , pp. 1301-1304
    • Bowers, A.A.1    West, N.2    Newkirk, T.L.3    Troutman-Youngman, A.E.4    Schreiber, S.L.5    Wiest, O.6    Bradner, J.E.7    Williams, R.M.8
  • 11
    • 0038298134 scopus 로고    scopus 로고
    • Total synthesis of apratoxin A
    • Chen J, Forsyth CJ (2003a) Total synthesis of apratoxin A. J Am Chem Soc 125: 8734-8735.
    • (2003) J Am Chem Soc , vol.125 , pp. 8734-8735
    • Chen, J.1    Forsyth, C.J.2
  • 12
    • 0038581932 scopus 로고    scopus 로고
    • Synthesis of the apratoxin 2,4-disubstituted thiazoline via an intramolecular Aza-Wittig reaction
    • Chen J, Forsyth CJ (2003b) Synthesis of the apratoxin 2, 4-disubstituted thiazoline via an intramolecular Aza-Wittig reaction. Org Lett 8: 1281-1283.
    • (2003) Org Lett , vol.8 , pp. 1281-1283
    • Chen, J.1    Forsyth, C.J.2
  • 13
    • 4344645170 scopus 로고    scopus 로고
    • Total synthesis of the marine cyanobacterial cyclodepsipeptide apratoxin A
    • Chen J, Forsyth CJ (2004) Total synthesis of the marine cyanobacterial cyclodepsipeptide apratoxin A. Proc Natl Acad Sci USA 101: 12067-12072.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 12067-12072
    • Chen, J.1    Forsyth, C.J.2
  • 14
    • 68149161259 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of C7-demethyl largazole analogues
    • Chen F, Gao A-H, Li J, Nan F-J (2009) Synthesis and biological evaluation of C7-demethyl largazole analogues. ChemMedChem 4: 1269-1272.
    • (2009) ChemMedChem , vol.4 , pp. 1269-1272
    • Chen, F.1    Gao, A.-H.2    Li, J.3    Nan, F.-J.4
  • 16
    • 52949112287 scopus 로고    scopus 로고
    • Total synthesis of largazole
    • Dai L, Zhang H, Tan W, Xu Z, Ye T (2008) Total synthesis of largazole. Synlett 15: 2379-2383.
    • (2008) Synlett , vol.15 , pp. 2379-2383
    • Dai, L.1    Zhang, H.2    Tan, W.3    Xu, Z.4    Ye, T.5
  • 18
    • 18844444472 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of the dolastatin 10 analogue TZT-1027, given on days 1 and 8 of a 3-week cycle in patients with advanced solid tumors
    • de Jonge MJ, van der Gaast A, Planting AS, van Doorn L, Lems A, Boot I, Wanders J, Satomi M, Verweij J (2005) Phase I and pharmacokinetic study of the dolastatin 10 analogue TZT-1027, given on days 1 and 8 of a 3-week cycle in patients with advanced solid tumors. Clin Cancer Res 11: 3806-3813.
    • (2005) Clin Cancer Res , vol.11 , pp. 3806-3813
    • de Jonge, M.J.1    van der Gaast, A.2    Planting, A.S.3    van Doorn, L.4    Lems, A.5    Boot, I.6    Wanders, J.7    Satomi, M.8    Verweij, J.9
  • 19
    • 27744536541 scopus 로고    scopus 로고
    • A phase I study of the dolastatin-15 analogue tasidotin (ILX651) administered intravenously daily for 5 consecutive days every 3 weeks in patients with advanced solid tumors
    • Ebbinghaus S, Rubin E, Hersh E, Cranmer LD, Bonate PL, Fram RJ, Jekunen A, Weitman S, Hammond LA (2005) A phase I study of the dolastatin-15 analogue tasidotin (ILX651) administered intravenously daily for 5 consecutive days every 3 weeks in patients with advanced solid tumors. Clin Cancer Res 11: 7807-7816.
    • (2005) Clin Cancer Res , vol.11 , pp. 7807-7816
    • Ebbinghaus, S.1    Rubin, E.2    Hersh, E.3    Cranmer, L.D.4    Bonate, P.L.5    Fram, R.J.6    Jekunen, A.7    Weitman, S.8    Hammond, L.A.9
  • 20
    • 0026754479 scopus 로고
    • Antifungal cyclic peptides from the terrestrial blue-green alga Anabeana laxa. 2. Structures of laxaphycins A, B, C, D, and E
    • Frankmolle WP, Knubel G, Moore RE, Patterson GML (1992) Antifungal cyclic peptides from the terrestrial blue-green alga Anabeana laxa. 2. Structures of laxaphycins A, B, C, D, and E. J Antibiot 45: 1458-1466.
    • (1992) J Antibiot , vol.45 , pp. 1458-1466
    • Frankmolle, W.P.1    Knubel, G.2    Moore, R.E.3    Patterson, G.M.L.4
  • 21
    • 0024598559 scopus 로고
    • Novel cytotoxic peptides from the tropical marine cyanobacterium Hormothamnion enteromorphoides. 1. Discovery, isolation and initial chemical and biological characterization of the hormothamnins from wild and cultured material
    • Gerwick WH, Mrozek C, Moghaddam MF, Agarwal SK (1989) Novel cytotoxic peptides from the tropical marine cyanobacterium Hormothamnion enteromorphoides. 1. Discovery, isolation and initial chemical and biological characterization of the hormothamnins from wild and cultured material. Experientia 45: 115-121.
    • (1989) Experientia , vol.45 , pp. 115-121
    • Gerwick, W.H.1    Mrozek, C.2    Moghaddam, M.F.3    Agarwal, S.K.4
  • 22
    • 0028258027 scopus 로고
    • Structure of curacin A, a novel antimitotic, antiproliferative, and brine shrimp toxic natural product from the marine cyanobacterium Lyngbya majuscula
    • Gerwick WH, Proteau PJ, Nagle DG, Hamel E, Blokhin A, Slate DL (1994) Structure of curacin A, a novel antimitotic, antiproliferative, and brine shrimp toxic natural product from the marine cyanobacterium Lyngbya majuscula. J Org Chem 59: 1243-1245.
    • (1994) J Org Chem , vol.59 , pp. 1243-1245
    • Gerwick, W.H.1    Proteau, P.J.2    Nagle, D.G.3    Hamel, E.4    Blokhin, A.5    Slate, D.L.6
  • 23
    • 0035225541 scopus 로고    scopus 로고
    • Nitrogen-containing metabolites from marine cyanobacteria
    • G. A. Cordell (Ed.), San Diego: Academic
    • Gerwick WH, Tan LT, Sitachitta N (2001) Nitrogen-containing metabolites from marine cyanobacteria. In: Cordell GA (ed) The alkaloids: chemistry and biology, vol 57. Academic, San Diego, pp 75-184.
    • (2001) The Alkaloids: Chemistry and Biology , vol.57 , pp. 75-184
    • Gerwick, W.H.1    Tan, L.T.2    Sitachitta, N.3
  • 25
    • 55949099039 scopus 로고    scopus 로고
    • Enantioselective total synthesis of (+)-largazole, a potent inhibitor of histone deacetylase
    • Ghosh AK, Kulkarni S (2008) Enantioselective total synthesis of (+)-largazole, a potent inhibitor of histone deacetylase. Org Lett 10: 3907-3909.
    • (2008) Org Lett , vol.10 , pp. 3907-3909
    • Ghosh, A.K.1    Kulkarni, S.2
  • 26
    • 66249094190 scopus 로고    scopus 로고
    • Supported synthesis of oxoapratoxin A
    • Gilles A, Martinez J, Cavelier F (2009) Supported synthesis of oxoapratoxin A. J Org Chem 74: 4298-4304.
    • (2009) J Org Chem , vol.74 , pp. 4298-4304
    • Gilles, A.1    Martinez, J.2    Cavelier, F.3
  • 27
    • 33747894345 scopus 로고    scopus 로고
    • A phase I study of intravenous TZT-1027 administered on day 1 and day 8 of a three-weekly cycle in combination with carboplatin given on day 1 alone in patients with advanced solid tumours
    • Greystoke A, Blagden S, Thomas AL, Scott E, Attard G, Molife R, Vidal L, Pacey S, Sarkar D, Jenner A, De-Bono JS, Steward W (2006) A phase I study of intravenous TZT-1027 administered on day 1 and day 8 of a three-weekly cycle in combination with carboplatin given on day 1 alone in patients with advanced solid tumours. Ann Oncol 17: 1313-1319.
    • (2006) Ann Oncol , vol.17 , pp. 1313-1319
    • Greystoke, A.1    Blagden, S.2    Thomas, A.L.3    Scott, E.4    Attard, G.5    Molife, R.6    Vidal, L.7    Pacey, S.8    Sarkar, D.9    Jenner, A.10    De-Bono, J.S.11    Steward, W.12
  • 28
    • 47549097980 scopus 로고    scopus 로고
    • Apratoxin D, a potent cytotoxic cyclodepsipeptide from Papua New Guinea collections of the marine cyanobacteria Lyngbya majuscula and Lyngbya sordida
    • Gutierrez M, Suyama TL, Engene N, Wingerd JS, Matainaho T, Gerwick WH (2008) Apratoxin D, a potent cytotoxic cyclodepsipeptide from Papua New Guinea collections of the marine cyanobacteria Lyngbya majuscula and Lyngbya sordida. J Nat Prod 71: 1099-1103.
    • (2008) J Nat Prod , vol.71 , pp. 1099-1103
    • Gutierrez, M.1    Suyama, T.L.2    Engene, N.3    Wingerd, J.S.4    Matainaho, T.5    Gerwick, W.H.6
  • 29
    • 1842631408 scopus 로고    scopus 로고
    • Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer
    • Halkidou K, Gaughan L, Cook S, Leung HY, Neal DE, Robson CN (2004) Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer. Prostate 59: 177-189.
    • (2004) Prostate , vol.59 , pp. 177-189
    • Halkidou, K.1    Gaughan, L.2    Cook, S.3    Leung, H.Y.4    Neal, D.E.5    Robson, C.N.6
  • 30
    • 27644461429 scopus 로고    scopus 로고
    • Isolation and structure of five lyngbyabellin derivatives from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula
    • Han B, McPhail KL, Gross H, Goeger DE, Mooberry SL, Gerwick WH (2005) Isolation and structure of five lyngbyabellin derivatives from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula. Tetrahedron 61: 11723-11729.
    • (2005) Tetrahedron , vol.61 , pp. 11723-11729
    • Han, B.1    McPhail, K.L.2    Gross, H.3    Goeger, D.E.4    Mooberry, S.L.5    Gerwick, W.H.6
  • 31
    • 33744460793 scopus 로고    scopus 로고
    • Aurilides B and C, cancer cell toxins from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula
    • Han B, Gross H, Goeger DE, Mooberry SL, Gerwick WH (2006) Aurilides B and C, cancer cell toxins from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula. J Nat Prod 69: 572-575.
    • (2006) J Nat Prod , vol.69 , pp. 572-575
    • Han, B.1    Gross, H.2    Goeger, D.E.3    Mooberry, S.L.4    Gerwick, W.H.5
  • 33
    • 0036239723 scopus 로고    scopus 로고
    • Malevamide D: Isolation and structure determination of an isodolastatin H analogue from the marine cyanobacterium Symploca hydroides
    • Horgen FD, Kazmierski EB, Westenburg HE, Yoshida WY, Scheuer PJ (2002) Malevamide D: isolation and structure determination of an isodolastatin H analogue from the marine cyanobacterium Symploca hydroides. J Nat Prod 65: 487-491.
    • (2002) J Nat Prod , vol.65 , pp. 487-491
    • Horgen, F.D.1    Kazmierski, E.B.2    Westenburg, H.E.3    Yoshida, W.Y.4    Scheuer, P.J.5
  • 34
    • 42149130973 scopus 로고    scopus 로고
    • Phase I study of TZT-1027, a novel synthetic dolastatin 10 derivative, for the treatment of patients with non-small cell lung cancer
    • Horti J, Juhasz E, Monostori Z, Maeda K, Eckdardt S, Bodrogi I (2008) Phase I study of TZT-1027, a novel synthetic dolastatin 10 derivative, for the treatment of patients with non-small cell lung cancer. Can Chemother Pharmacol 62: 173-180.
    • (2008) Can Chemother Pharmacol , vol.62 , pp. 173-180
    • Horti, J.1    Juhasz, E.2    Monostori, Z.3    Maeda, K.4    Eckdardt, S.5    Bodrogi, I.6
  • 35
    • 65449160157 scopus 로고    scopus 로고
    • New tricks from ancient algae: Natural products biosynthesis in marine cyanobacteria
    • Jones AC, Gu L, Sorrels CM, Sherman DH, Gerwick WH (2009) New tricks from ancient algae: natural products biosynthesis in marine cyanobacteria. Curr Opin Chem Biol 13: 216-123.
    • (2009) Curr Opin Chem Biol , vol.13 , pp. 216-123
    • Jones, A.C.1    Gu, L.2    Sorrels, C.M.3    Sherman, D.H.4    Gerwick, W.H.5
  • 36
    • 0032006059 scopus 로고    scopus 로고
    • Microtubules and actin filaments: Dynamic targets for cancer chemotherapy
    • Jordan MA, Wilson L (1998) Microtubules and actin filaments: dynamic targets for cancer chemotherapy. Curr Opin Cell Biol 10: 123-130.
    • (1998) Curr Opin Cell Biol , vol.10 , pp. 123-130
    • Jordan, M.A.1    Wilson, L.2
  • 37
    • 34247109540 scopus 로고    scopus 로고
    • Venturamides A and B: Antimalarial constituents of the Panamanian marine cyanobacterium Oscillatoria sp
    • Linington RG, Gonzalez J, Urena L, Romero LI, Ortega-Barria E, Gerwick WH (2007) Venturamides A and B: antimalarial constituents of the Panamanian marine cyanobacterium Oscillatoria sp. J Nat Prod 70: 397-401.
    • (2007) J Nat Prod , vol.70 , pp. 397-401
    • Linington, R.G.1    Gonzalez, J.2    Urena, L.3    Romero, L.I.4    Ortega-Barria, E.5    Gerwick, W.H.6
  • 38
    • 39049108641 scopus 로고    scopus 로고
    • Symplocamide A, a potent cytotoxin and chymotrypsin inhibitor from the marine cyanobacterium Symploca sp
    • Linington RG, Edwards DJ, Shuman CF, McPhail KL, Matainaho T, Gerwick WH (2008) Symplocamide A, a potent cytotoxin and chymotrypsin inhibitor from the marine cyanobacterium Symploca sp. J Nat Prod 71: 22-27.
    • (2008) J Nat Prod , vol.71 , pp. 22-27
    • Linington, R.G.1    Edwards, D.J.2    Shuman, C.F.3    McPhail, K.L.4    Matainaho, T.5    Gerwick, W.H.6
  • 40
    • 67649861838 scopus 로고    scopus 로고
    • Apratoxin A reversibly inhibits the secretory pathway by preventing cotranslational translocation
    • Liu Y, Law BK, Luesch H (2009) Apratoxin A reversibly inhibits the secretory pathway by preventing cotranslational translocation. Mol Pharmacol 76: 91-104.
    • (2009) Mol Pharmacol , vol.76 , pp. 91-104
    • Liu, Y.1    Law, B.K.2    Luesch, H.3
  • 41
    • 0034092263 scopus 로고    scopus 로고
    • Isolation, structure determination, and biological activity of lyngbyabellin A from the marine cyanobacterium Lyngbya majuscula
    • Luesch H, Yoshida WY, Moore RE, Paul VJ, Mooberry SL (2000) Isolation, structure determination, and biological activity of lyngbyabellin A from the marine cyanobacterium Lyngbya majuscula. J Nat Prod 63: 611-615.
    • (2000) J Nat Prod , vol.63 , pp. 611-615
    • Luesch, H.1    Yoshida, W.Y.2    Moore, R.E.3    Paul, V.J.4    Mooberry, S.L.5
  • 42
    • 0034898713 scopus 로고    scopus 로고
    • Isolation of dolastatin 10 from the marine cyanobacterium Symploca species VP642 and total stereochemistry and biological evaluation of its analogue symplostatin 1
    • Luesch H, Moore RE, Paul VJ, Mooberry SL, Corbett TH (2001a) Isolation of dolastatin 10 from the marine cyanobacterium Symploca species VP642 and total stereochemistry and biological evaluation of its analogue symplostatin 1. J Nat Prod 64: 907-910.
    • (2001) J Nat Prod , vol.64 , pp. 907-910
    • Luesch, H.1    Moore, R.E.2    Paul, V.J.3    Mooberry, S.L.4    Corbett, T.H.5
  • 43
    • 0034833620 scopus 로고    scopus 로고
    • Total structure determination of apratoxin A, a potent novel cytotoxin from the marine cyanobacterium Lyngbya majuscula
    • Luesch H, Yoshida WY, Moore RE, Paul VJ, Corbett TH (2001b) Total structure determination of apratoxin A, a potent novel cytotoxin from the marine cyanobacterium Lyngbya majuscula. J Am Chem Soc 123: 5418-5423.
    • (2001) J Am Chem Soc , vol.123 , pp. 5418-5423
    • Luesch, H.1    Yoshida, W.Y.2    Moore, R.E.3    Paul, V.J.4    Corbett, T.H.5
  • 44
    • 0036383653 scopus 로고    scopus 로고
    • The cyanobacterial origin of potent anticancer agents originally isolated from sea hares
    • Luesch H, Harrigan GG, Goetz G, Horgen FD (2002a) The cyanobacterial origin of potent anticancer agents originally isolated from sea hares. Curr Med Chem 9: 1791-1806.
    • (2002) Curr Med Chem , vol.9 , pp. 1791-1806
    • Luesch, H.1    Harrigan, G.G.2    Goetz, G.3    Horgen, F.D.4
  • 45
    • 0036009896 scopus 로고    scopus 로고
    • New apratoxins of marine cyanobacterial origin from Guam and Palau
    • Luesch H, Yoshida WY, Moore RE, Paul VJ (2002b) New apratoxins of marine cyanobacterial origin from Guam and Palau. Bioorg Med Chem 10: 1973-1978.
    • (2002) Bioorg Med Chem , vol.10 , pp. 1973-1978
    • Luesch, H.1    Yoshida, W.Y.2    Moore, R.E.3    Paul, V.J.4
  • 46
    • 0036165655 scopus 로고    scopus 로고
    • Symplostatin 3, a new dolastatin 10 analogue from the marine cyanobacterium Symploca sp. VP452
    • Luesch H, Yoshida WY, Moore RE, Paul VJ, Mooberry SL, Corbett TH (2002c) Symplostatin 3, a new dolastatin 10 analogue from the marine cyanobacterium Symploca sp. VP452. J Nat Prod 65: 16-20.
    • (2002) J Nat Prod , vol.65 , pp. 16-20
    • Luesch, H.1    Yoshida, W.Y.2    Moore, R.E.3    Paul, V.J.4    Mooberry, S.L.5    Corbett, T.H.6
  • 48
    • 33750012824 scopus 로고    scopus 로고
    • Total synthesis of the cyclodepsipeptide apratoxin A and its analogues and assessment of their biological activities
    • Ma D, Zou B, Cai G, Hu X, Liu JO (2006) Total synthesis of the cyclodepsipeptide apratoxin A and its analogues and assessment of their biological activities. Chem Eur J 12: 7615-7626.
    • (2006) Chem Eur J , vol.12 , pp. 7615-7626
    • Ma, D.1    Zou, B.2    Cai, G.3    Hu, X.4    Liu, J.O.5
  • 51
    • 33847063427 scopus 로고    scopus 로고
    • Lyngbyastatin 4, a dolastatin 13 analogue with elastase and chymotrypsin inhibitory activity from the marine cyanobacterium Lyngbya confervoides
    • Matthew S, Ross C, Rocca JR, Paul VJ, Luesch H (2007) Lyngbyastatin 4, a dolastatin 13 analogue with elastase and chymotrypsin inhibitory activity from the marine cyanobacterium Lyngbya confervoides. J Nat Prod 70: 124-127.
    • (2007) J Nat Prod , vol.70 , pp. 124-127
    • Matthew, S.1    Ross, C.2    Rocca, J.R.3    Paul, V.J.4    Luesch, H.5
  • 52
    • 47549102471 scopus 로고    scopus 로고
    • Apratoxin E, a cytotoxic peptolide from a Guamanian collection of the marine cyanobacterium Lyngbya bouillonii
    • Matthew S, Schupp PJ, Luesch H (2008a) Apratoxin E, a cytotoxic peptolide from a Guamanian collection of the marine cyanobacterium Lyngbya bouillonii. J Nat Prod 71: 1113-1116.
    • (2008) J Nat Prod , vol.71 , pp. 1113-1116
    • Matthew, S.1    Schupp, P.J.2    Luesch, H.3
  • 53
    • 40849117988 scopus 로고    scopus 로고
    • Pompenopeptins A and B, new cyclic peptides from the marine cyanobacterium Lyngbya confervoides
    • Matthew S, Ross C, Paul VJ, Luesch H (2008b) Pompenopeptins A and B, new cyclic peptides from the marine cyanobacterium Lyngbya confervoides. Tetrahedron 64: 4081-4089.
    • (2008) Tetrahedron , vol.64 , pp. 4081-4089
    • Matthew, S.1    Ross, C.2    Paul, V.J.3    Luesch, H.4
  • 54
    • 65949106959 scopus 로고    scopus 로고
    • Largamides A-C, tiglic acid-containing cyclodepsipeptides with elastase-inhibitory activity from the marine cyanobacterium Lyngbya confervoides
    • Matthew S, Paul VJ, Luesch H (2009) Largamides A-C, tiglic acid-containing cyclodepsipeptides with elastase-inhibitory activity from the marine cyanobacterium Lyngbya confervoides. Planta Med 75: 528-533.
    • (2009) Planta Med , vol.75 , pp. 528-533
    • Matthew, S.1    Paul, V.J.2    Luesch, H.3
  • 56
    • 33748991177 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of tasidotin hydrochloride (ILX651), a third-generation dolastatin-15 analogue, administered weekly for 3 weeks every 28 days in patients with advanced solid tumors
    • Mita AC, Hammond LA, Bonate PL, Weiss G, McCreery H, Syed S, Garrison M, Chu QSC, DeBono JS, Jones CB, Weitman S, Rowinsky EK (2006) Phase I and pharmacokinetic study of tasidotin hydrochloride (ILX651), a third-generation dolastatin-15 analogue, administered weekly for 3 weeks every 28 days in patients with advanced solid tumors. Clin Cancer Res 12: 5207-5215.
    • (2006) Clin Cancer Res , vol.12 , pp. 5207-5215
    • Mita, A.C.1    Hammond, L.A.2    Bonate, P.L.3    Weiss, G.4    McCreery, H.5    Syed, S.6    Garrison, M.7    Chu, Q.S.C.8    Debono, J.S.9    Jones, C.B.10    Weitman, S.11    Rowinsky, E.K.12
  • 58
  • 59
    • 54049152858 scopus 로고    scopus 로고
    • A concise total synthesis of largazole, solution structure, and some preliminary structure activity relationships
    • Nasveschuk CG, Ungermannova D, Liu X, Phillips AJ (2008) A concise total synthesis of largazole, solution structure, and some preliminary structure activity relationships. Org Lett 10: 3595-3598.
    • (2008) Org Lett , vol.10 , pp. 3595-3598
    • Nasveschuk, C.G.1    Ungermannova, D.2    Liu, X.3    Phillips, A.J.4
  • 60
    • 0037018448 scopus 로고    scopus 로고
    • Somocystinamide A, a novel cytotoxic disulfide dimer from a Fijian marine cyanobacterial mixed assemblage
    • Nogle LM, Gerwick WH (2002) Somocystinamide A, a novel cytotoxic disulfide dimer from a Fijian marine cyanobacterial mixed assemblage. Org Lett 4: 1095-1098.
    • (2002) Org Lett , vol.4 , pp. 1095-1098
    • Nogle, L.M.1    Gerwick, W.H.2
  • 61
    • 58149178729 scopus 로고    scopus 로고
    • Total synthesis of (-)-apratoxin A, 34-epimer, and its oxazoline analogue
    • Numajiri Y, Takahashi T, Doi T (2009) Total synthesis of (-)-apratoxin A, 34-epimer, and its oxazoline analogue. Chem Asian J 4: 111-125.
    • (2009) Chem Asian J , vol.4 , pp. 111-125
    • Numajiri, Y.1    Takahashi, T.2    Doi, T.3
  • 62
    • 0037466288 scopus 로고    scopus 로고
    • Dolastatin 11 connects two long-pitch strands in F-actin to stabilize microfilaments
    • Oda T, Crane ZD, Dicus CW, Sufi BA, Bates RB (2003) Dolastatin 11 connects two long-pitch strands in F-actin to stabilize microfilaments. J Mol Biol 328: 319-324.
    • (2003) J Mol Biol , vol.328 , pp. 319-324
    • Oda, T.1    Crane, Z.D.2    Dicus, C.W.3    Sufi, B.A.4    Bates, R.B.5
  • 63
    • 33845582571 scopus 로고    scopus 로고
    • Phase II study of intavenous TZT-1027 in patients with advanced or metastatic soft-tissue sarcomas with prior exposure to anthracycline-based chemotherapy
    • Patel S, Keohan ML, Saif MW, Rushing D, Baez L, Feit K, DeJager R, Anderson S (2006) Phase II study of intavenous TZT-1027 in patients with advanced or metastatic soft-tissue sarcomas with prior exposure to anthracycline-based chemotherapy. Cancer 107: 2881-2887.
    • (2006) Cancer , vol.107 , pp. 2881-2887
    • Patel, S.1    Keohan, M.L.2    Saif, M.W.3    Rushing, D.4    Baez, L.5    Feit, K.6    Dejager, R.7    Anderson, S.8
  • 64
    • 69049091880 scopus 로고    scopus 로고
    • Hoiamide A, a sodium channel activator of unusual architecture from a consortium of two Papua New Guinea cyanobacteria
    • Pereira A, Cao Z, Murray TF, Gerwick WH (2009) Hoiamide A, a sodium channel activator of unusual architecture from a consortium of two Papua New Guinea cyanobacteria. Chem Biol 16: 893-906.
    • (2009) Chem Biol , vol.16 , pp. 893-906
    • Pereira, A.1    Cao, Z.2    Murray, T.F.3    Gerwick, W.H.4
  • 65
    • 33750446641 scopus 로고    scopus 로고
    • Largamides A-H, unusual cyclic peptides from the marine cyanobacterium Oscillatoria sp
    • Plaza A, Bewley CA (2006) Largamides A-H, unusual cyclic peptides from the marine cyanobacterium Oscillatoria sp. J Org Chem 71: 6898-6907.
    • (2006) J Org Chem , vol.71 , pp. 6898-6907
    • Plaza, A.1    Bewley, C.A.2
  • 66
    • 0033857767 scopus 로고    scopus 로고
    • Serine protease inhibiting cyanopeptides
    • Radau G (2000) Serine protease inhibiting cyanopeptides. Pharmazie 55: 555-560.
    • (2000) Pharmazie , vol.55 , pp. 555-560
    • Radau, G.1
  • 67
    • 33846041131 scopus 로고    scopus 로고
    • A phase 2 study of TZT1027, administered weekly to patients with advanced non-small cell lung cancer following treatment with platinum-based chemotherapy
    • Riely GJ, Gadgeel S, Rothman I, Saidman B, Sabbath K, Feit K, Kris MG, Rizvi NA (2007) A phase 2 study of TZT1027, administered weekly to patients with advanced non-small cell lung cancer following treatment with platinum-based chemotherapy. Lung Cancer 55: 181-185.
    • (2007) Lung Cancer , vol.55 , pp. 181-185
    • Riely, G.J.1    Gadgeel, S.2    Rothman, I.3    Saidman, B.4    Sabbath, K.5    Feit, K.6    Kris, M.G.7    Rizvi, N.A.8
  • 69
    • 18144432660 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of TZT-1027, a novel synthetic dolastatin 10 derivative, administered as a 1-hour intravenous infusion every 3 weeks in patients with advanced refractory cancer
    • Schoffski P, Thate B, Beutel G, Bolte O, Otto D, Hofmann M, Ganser A, Jenner A, Cheverton P, Wanders J, Oguma T, Atsumi R, Satomi M (2004) Phase I and pharmacokinetic study of TZT-1027, a novel synthetic dolastatin 10 derivative, administered as a 1-hour intravenous infusion every 3 weeks in patients with advanced refractory cancer. Ann Oncol 15: 671-679.
    • (2004) Ann Oncol , vol.15 , pp. 671-679
    • Schoffski, P.1    Thate, B.2    Beutel, G.3    Bolte, O.4    Otto, D.5    Hofmann, M.6    Ganser, A.7    Jenner, A.8    Cheverton, P.9    Wanders, J.10    Oguma, T.11    Atsumi, R.12    Satomi, M.13
  • 70
    • 52049119362 scopus 로고    scopus 로고
    • Synthesis and biological activity of largazole and derivatives
    • Seiser T, Kamena F, Cramer N (2008) Synthesis and biological activity of largazole and derivatives. Angew Chem Int Ed 47: 6483-6485.
    • (2008) Angew Chem Int Ed , vol.47 , pp. 6483-6485
    • Seiser, T.1    Kamena, F.2    Cramer, N.3
  • 71
    • 67649886201 scopus 로고    scopus 로고
    • Potent antibody drug conjugates for cancer therapy
    • Senter PD (2009) Potent antibody drug conjugates for cancer therapy. Curr Opin Chem Biol 13: 1-10.
    • (2009) Curr Opin Chem Biol , vol.13 , pp. 1-10
    • Senter, P.D.1
  • 72
    • 66149128366 scopus 로고    scopus 로고
    • Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy
    • Shen S, Zhang P, Lovchik MA, Li Y, Tang L, Chen Z, Zeng R, Ma D, Yuan J, Yu Q (2009) Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy. J Cell Biol 185: 629-639.
    • (2009) J Cell Biol , vol.185 , pp. 629-639
    • Shen, S.1    Zhang, P.2    Lovchik, M.A.3    Li, Y.4    Tang, L.5    Chen, Z.6    Zeng, R.7    Ma, D.8    Yuan, J.9    Yu, Q.10
  • 73
  • 74
    • 45349086318 scopus 로고    scopus 로고
    • Anticancer drugs of marine origin
    • P. Walsh, S. Smith, L. Fleming, H. Solo-Gabriele, and W. H. Gerwick (Eds.), New York: Academic
    • Simmons TL, Gerwick WH (2008) Anticancer drugs of marine origin. In: Walsh P, Smith S, Fleming L, Solo-Gabriele H, Gerwick WH (eds) Oceans and human health: risks and remedies from the seas. Academic, New York, pp 431-452.
    • (2008) Oceans and Human Health: Risks and Remedies from the Seas , pp. 431-452
    • Simmons, T.L.1    Gerwick, W.H.2
  • 75
    • 67650225531 scopus 로고    scopus 로고
    • Desmethoxymajusculamide C, a cyanobacterial depsipeptide with potent cytotoxicity in both cyclic and ring-opened forms
    • Simmons TL, Nogle LM, Media J, Valeriote FA, Mooberry SL, Gerwick WH (2009) Desmethoxymajusculamide C, a cyanobacterial depsipeptide with potent cytotoxicity in both cyclic and ring-opened forms. J Nat Prod 72: 1011-1016.
    • (2009) J Nat Prod , vol.72 , pp. 1011-1016
    • Simmons, T.L.1    Nogle, L.M.2    Media, J.3    Valeriote, F.A.4    Mooberry, S.L.5    Gerwick, W.H.6
  • 76
    • 70349934410 scopus 로고    scopus 로고
    • Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii
    • Soria-Mercado IE, Pereira A, Cao Z, Murray TF, Gerwick WH (2009) Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii. Org Lett 11: 4704-4707.
    • (2009) Org Lett , vol.11 , pp. 4704-4707
    • Soria-Mercado, I.E.1    Pereira, A.2    Cao, Z.3    Murray, T.F.4    Gerwick, W.H.5
  • 77
    • 0030576999 scopus 로고    scopus 로고
    • Isolation and stereostructure of aurilide, a novel cyclodepsipeptide from the Japanese sea hare Dolabella auricularia
    • Suenaga K, Mutou T, Shibata T, Itoh T, Kigoshi H, Yamada K (1996) Isolation and stereostructure of aurilide, a novel cyclodepsipeptide from the Japanese sea hare Dolabella auricularia. Tet Lett 37: 6771-6774.
    • (1996) Tet Lett , vol.37 , pp. 6771-6774
    • Suenaga, K.1    Mutou, T.2    Shibata, T.3    Itoh, T.4    Kigoshi, H.5    Yamada, K.6
  • 80
    • 58149147063 scopus 로고    scopus 로고
    • Stereospecific total synthesis of somocystinamide A
    • Suyama TL, Gerwick WH (2008) Stereospecific total synthesis of somocystinamide A. Org Lett 10: 4449-4452.
    • (2008) Org Lett , vol.10 , pp. 4449-4452
    • Suyama, T.L.1    Gerwick, W.H.2
  • 81
    • 34548833003 scopus 로고    scopus 로고
    • Reinvestigation of the stereochemistry of kulokekahilide-2
    • Takada Y, Mori E, Umehara M, Nakao Y, Kimura J (2007) Reinvestigation of the stereochemistry of kulokekahilide-2. Tet Lett 48: 7653-7656.
    • (2007) Tet Lett , vol.48 , pp. 7653-7656
    • Takada, Y.1    Mori, E.2    Umehara, M.3    Nakao, Y.4    Kimura, J.5
  • 82
    • 38349141838 scopus 로고    scopus 로고
    • Revised absolute stereochemistry of natural kulokekahilide-2
    • Takada Y, Umehara M, Nakao Y, Kimura J (2008) Revised absolute stereochemistry of natural kulokekahilide-2. Tet Lett 49: 1163-1165.
    • (2008) Tet Lett , vol.49 , pp. 1163-1165
    • Takada, Y.1    Umehara, M.2    Nakao, Y.3    Kimura, J.4
  • 83
    • 0141675075 scopus 로고    scopus 로고
    • Solid phase library synthesis of cyclic depsipeptides: Aurilide and aurilide analogues
    • Takahashi T, Nagamiya H, Doi T, Griffiths PG, Bray AM (2003) Solid phase library synthesis of cyclic depsipeptides: aurilide and aurilide analogues. J Comb Chem 5: 414-428.
    • (2003) J Comb Chem , vol.5 , pp. 414-428
    • Takahashi, T.1    Nagamiya, H.2    Doi, T.3    Griffiths, P.G.4    Bray, A.M.5
  • 84
    • 54149114729 scopus 로고    scopus 로고
    • Total synthesis of largazole and its biological evaluation
    • Takahashi T, Takagi M, Shin-ya K, Doi T (2008) Total synthesis of largazole and its biological evaluation. Synlett 16: 2483-2486.
    • (2008) Synlett , vol.16 , pp. 2483-2486
    • Takahashi, T.1    Takagi, M.2    Shin-Ya, K.3    Doi, T.4
  • 85
    • 34248374465 scopus 로고    scopus 로고
    • Phase I study of TZT-1027, a novel synthetic dolastatin 10 derivative and inhibitor of tubulin polymerization, which was administered to patients with advanced solid tumors on days 1 and 8 in 3-week courses
    • Tamura K, Nakagawa K, Kurata T, Satoh T, Nogami T, Takeda K, Mitsuoka S, Yoshimura N, Kudoh S, Negoro S, Fukuoka M (2007) Phase I study of TZT-1027, a novel synthetic dolastatin 10 derivative and inhibitor of tubulin polymerization, which was administered to patients with advanced solid tumors on days 1 and 8 in 3-week courses. Cancer Chemother Pharmacol 60: 285-293.
    • (2007) Cancer Chemother Pharmacol , vol.60 , pp. 285-293
    • Tamura, K.1    Nakagawa, K.2    Kurata, T.3    Satoh, T.4    Nogami, T.5    Takeda, K.6    Mitsuoka, S.7    Yoshimura, N.8    Kudoh, S.9    Negoro, S.10    Fukuoka, M.11
  • 86
    • 33947104489 scopus 로고    scopus 로고
    • Bioactive natural products from marine cyanobacteria for drug discovery
    • Tan LT (2007) Bioactive natural products from marine cyanobacteria for drug discovery. Phytochemistry 68: 954-979.
    • (2007) Phytochemistry , vol.68 , pp. 954-979
    • Tan, L.T.1
  • 87
    • 77950416522 scopus 로고    scopus 로고
    • Taniguchi M, Nunnery JK, Engene N, Esquenazi E, Byrum T, Dorrestein P, Gerwick WH (2010) Palmyramide A, a cyclic depsipeptide from a Palmyra atoll collection of the marine cyanobacterium Lyngbya majuscula. J Nat Prod (in press).
  • 88
    • 36348972843 scopus 로고    scopus 로고
    • Lyngbyastatins 5-7, potent elastase inhibitors from Floridian marine cyanobacteria, Lyngbya spp
    • Taori K, Matthew S, Rocca JR, Paul VJ, Luesch H (2007) Lyngbyastatins 5-7, potent elastase inhibitors from Floridian marine cyanobacteria, Lyngbya spp. J Nat Prod 70: 1593-1600.
    • (2007) J Nat Prod , vol.70 , pp. 1593-1600
    • Taori, K.1    Matthew, S.2    Rocca, J.R.3    Paul, V.J.4    Luesch, H.5
  • 89
    • 39049135494 scopus 로고    scopus 로고
    • Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp
    • Taori K, Paul VJ, Luesch H (2008a) Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp. J Am Chem Soc 130: 1806-1807.
    • (2008) J Am Chem Soc , vol.130 , pp. 1806-1807
    • Taori, K.1    Paul, V.J.2    Luesch, H.3
  • 90
    • 54149108953 scopus 로고    scopus 로고
    • Kempopetins A and B, serine protease inhibitors with different selectivity profiles from a marine cyanobacterium, Lyngbya sp
    • Taori K, Paul VJ, Luesch H (2008b) Kempopetins A and B, serine protease inhibitors with different selectivity profiles from a marine cyanobacterium, Lyngbya sp. J Nat Prod 71: 1625-1629.
    • (2008) J Nat Prod , vol.71 , pp. 1625-1629
    • Taori, K.1    Paul, V.J.2    Luesch, H.3
  • 91
    • 70349554391 scopus 로고    scopus 로고
    • Combinatorial strategies by marine cyanobacteria: Symplostatin 4, an antimitotic natural dolastatin 10/15 hybrid that synergizes with the coproduced HDAC inhibitor largazole
    • Taori K, Liu Y, Paul VJ, Luesch H (2009) Combinatorial strategies by marine cyanobacteria: symplostatin 4, an antimitotic natural dolastatin 10/15 hybrid that synergizes with the coproduced HDAC inhibitor largazole. ChemBioChem 10: 1634-1639.
    • (2009) ChemBioChem , vol.10 , pp. 1634-1639
    • Taori, K.1    Liu, Y.2    Paul, V.J.3    Luesch, H.4
  • 92
    • 70350637641 scopus 로고    scopus 로고
    • Bisebromoamide, a potent cytotoxic peptide from the marine cyanobacterium Lyngbya sp.: Isolation, stereostructure, and biological activity
    • Teruya T, Sasaki H, Fukazawa H, Suenaga K (2009) Bisebromoamide, a potent cytotoxic peptide from the marine cyanobacterium Lyngbya sp.: isolation, stereostructure, and biological activity. Org Lett 11: 5062-5065.
    • (2009) Org Lett , vol.11 , pp. 5062-5065
    • Teruya, T.1    Sasaki, H.2    Fukazawa, H.3    Suenaga, K.4
  • 93
    • 77956526969 scopus 로고    scopus 로고
    • Tidgewell K, Clark BR, Gerwick WH (2010) The natural products chemistry of cyanobacteria. In: Mander LN, Liu HW (eds) Comprehensive natural products chemistry II, vol 8. Pergamon (in press).
  • 94
    • 60549092554 scopus 로고    scopus 로고
    • Hantupeptin A, a cytotoxic cyclic depsipeptide from a Singapore collection of Lyngbya majuscula
    • Tripathi A, Puddick J, Prinsep MR, Lee PPF, Tan LT (2009) Hantupeptin A, a cytotoxic cyclic depsipeptide from a Singapore collection of Lyngbya majuscula. J Nat Prod 72: 29-32.
    • (2009) J Nat Prod , vol.72 , pp. 29-32
    • Tripathi, A.1    Puddick, J.2    Prinsep, M.R.3    Lee, P.P.F.4    Tan, L.T.5
  • 95
    • 33748308883 scopus 로고    scopus 로고
    • Targeting proteases: Successes, failures and future prospects
    • Turk B (2006) Targeting proteases: successes, failures and future prospects. Nat Rev Drug Discovery 5: 785-799.
    • (2006) Nat Rev Drug Discovery , vol.5 , pp. 785-799
    • Turk, B.1
  • 96
    • 58049134569 scopus 로고    scopus 로고
    • Intramolecular ester exchange of potent cytotoxic kulokekahilide-2
    • Umehara M, Takada Y, Nakao Y, Kimura J (2009) Intramolecular ester exchange of potent cytotoxic kulokekahilide-2. Tet Lett 50: 840-843.
    • (2009) Tet Lett , vol.50 , pp. 840-843
    • Umehara, M.1    Takada, Y.2    Nakao, Y.3    Kimura, J.4
  • 97
    • 34547685818 scopus 로고    scopus 로고
    • Comparison of the antivascular and cytotoxic activities of TZT-1027 (soblidotin) with those of other anticancer agents
    • Watanabe J, Natsume T, Kobayashi M (2007a) Comparison of the antivascular and cytotoxic activities of TZT-1027 (soblidotin) with those of other anticancer agents. Anticancer Drugs 18: 905-911.
    • (2007) Anticancer Drugs , vol.18 , pp. 905-911
    • Watanabe, J.1    Natsume, T.2    Kobayashi, M.3
  • 98
    • 34047212221 scopus 로고    scopus 로고
    • Antiangiogenic activity of TZT-1027 (soblidotin) on chick chorioallantoic membrane and human umbilical vein endothelial cells
    • Watanabe J, Endo Y, Shimada N, Natsume T, Sasaki T, Kobayashi M (2007b) Antiangiogenic activity of TZT-1027 (soblidotin) on chick chorioallantoic membrane and human umbilical vein endothelial cells. In Vivo 21: 297-304.
    • (2007) In Vivo , vol.21 , pp. 297-304
    • Watanabe, J.1    Endo, Y.2    Shimada, N.3    Natsume, T.4    Sasaki, T.5    Kobayashi, M.6
  • 99
    • 0346396114 scopus 로고    scopus 로고
    • The structure of palau'amide, a potent cytotoxin from a species of the marine cyanobacterium Lyngbya
    • Williams PG, Yoshida WY, Quon MK, Moore RE, Paul VJ (2003) The structure of palau'amide, a potent cytotoxin from a species of the marine cyanobacterium Lyngbya. J Nat Prod 66: 1545-1549.
    • (2003) J Nat Prod , vol.66 , pp. 1545-1549
    • Williams, P.G.1    Yoshida, W.Y.2    Quon, M.K.3    Moore, R.E.4    Paul, V.J.5
  • 101
    • 0037171849 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of structurally highly modified analogues of the antimitotic natural product curacin A
    • Wipf P, Reeves JT, Balachandran R, Day BW (2002) Synthesis and biological evaluation of structurally highly modified analogues of the antimitotic natural product curacin A. J Med Chem 45: 1901-1917.
    • (2002) J Med Chem , vol.45 , pp. 1901-1917
    • Wipf, P.1    Reeves, J.T.2    Balachandran, R.3    Day, B.W.4
  • 104
    • 58549093199 scopus 로고    scopus 로고
    • Phase I study of TZT-1027, a novel synthetic dolastatin 10 derivative and inhibitor of tubulin polymerization, given weekly to advanced solid tumor patients for 3 weeks
    • Yamamoto N, Andoh M, Kawahara M, Fukuoka M, Niitani H (2009) Phase I study of TZT-1027, a novel synthetic dolastatin 10 derivative and inhibitor of tubulin polymerization, given weekly to advanced solid tumor patients for 3 weeks. Cancer Sci 100: 316-321.
    • (2009) Cancer Sci , vol.100 , pp. 316-321
    • Yamamoto, N.1    Andoh, M.2    Kawahara, M.3    Fukuoka, M.4    Niitani, H.5
  • 105
    • 46049100010 scopus 로고    scopus 로고
    • Total synthesis and molecular target of largazole, a histone deacetylase inhibitor
    • Ying Y, Taori K, Kim H, Hong J, Luesch H (2008a) Total synthesis and molecular target of largazole, a histone deacetylase inhibitor. J Am Chem Soc 130: 8455-8459.
    • (2008) J Am Chem Soc , vol.130 , pp. 8455-8459
    • Ying, Y.1    Taori, K.2    Kim, H.3    Hong, J.4    Luesch, H.5
  • 106
    • 55949094932 scopus 로고    scopus 로고
    • Synthesis and activity of largazole analogues with linker and macrocycle modification
    • Ying Y, Liu Y, Byeon SR, Kim H, Luesch H, Hong J (2008b) Synthesis and activity of largazole analogues with linker and macrocycle modification. Org Lett 10: 4021-4024.
    • (2008) Org Lett , vol.10 , pp. 4021-4024
    • Ying, Y.1    Liu, Y.2    Byeon, S.R.3    Kim, H.4    Luesch, H.5    Hong, J.6
  • 107
    • 0345255657 scopus 로고    scopus 로고
    • Synthesis of an oxazoline analogue of apratoxin A
    • Zou B, Wei J, Cai G, Ma D (2003) Synthesis of an oxazoline analogue of apratoxin A. Org Lett 5: 3503-3506.
    • (2003) Org Lett , vol.5 , pp. 3503-3506
    • Zou, B.1    Wei, J.2    Cai, G.3    Ma, D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.