Synthesis and biological evaluation of structurally highly modified analogues of the antimitotic natural product curacin A

Journal of Medicinal Chemistry

Volumn 45, Issue 9, 2002, Pages 1901-1917

  Wipf, Peter ^a   Reeves, Jonathan T ^a   Balachandran, Raghavan ^a   Day, Billy W ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,4,5 TRIMETHOXYBENZALDEHYDE O 8 HYDROXY 5 METHYL 8 THIOPHEN 2 YLOCTA 2,4 DIENYL OXIME; CURACIN A; CURACIN A DERIVATIVE; NATURAL PRODUCT; OXAZOLE DERIVATIVE; OXAZOLINE DERIVATIVE; THIAZOLE DERIVATIVE; TUBULIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION; TUMOR CELL;

ANTINEOPLASTIC AGENTS; BIOPOLYMERS; BLOOD PROTEINS; CELL DIVISION; CYCLOPROPANES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; OXIMES; PROTEIN BINDING; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; THIOPHENES; TUBULIN; TUMOR CELLS, CULTURED;

EID: 0037171849     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0105171     Document Type: Article

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