Dolastatin 11 conformations, analogues and pharmacophore

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 13, 2005, Pages 4138-4152

  Ali, Md Ahad ^a   Bates, Robert B ^a   Crane, Zackary D ^a   Dicus, Christopher W ^a   Gramme, Michelle R ^a   Hamel, Ernest ^b   Marcischak, Jacob ^a   Martinez, David S ^a   McClure, Kelly J ^a   Nakkiew, Pichaya ^a   Pettit, George R ^c   Stessman, Chad C ^a   Sufi, Bilal A ^a   Yarick, Gayle V ^a  

^a University of Arizona   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c ARIZONA STATE UNIVERSITY   (United States)

Author keywords

Anticancer; Depsipeptide; Dolastatin 11; Pharmacophore

Indexed keywords

10 NORDOLASTATIN 11; 10,10 DINORDOLASTATIN 11; 12 EPI 7 NORDOLASTATIN; 12 EPIDOLASTATIN 11; 3 NORDOLASTATIN 11; 3,4 DINORDOLASTATIN 11; 3,4,7 TRINORDOLASTATIN 11; 57 NORDOLASTATIN 11; 7 EPIDOLOASTATIN 11; 7 NORDOLASTATIN 11; ALCOHOL DERIVATIVE; AMIDE; ANTINEOPLASTIC AGENT; DOLASTATIN; DOLASTATIN 11 DERIVATIVE; MAJUSCULAMIDE C; UNCLASSIFIED DRUG;

ACTIN POLYMERIZATION; ARTICLE; CANCER CELL; CELL WALL; CHEMICAL BOND; CIS ISOMER; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG CONFORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHARMACOPHORE; STRUCTURE ANALYSIS; TRANS ISOMER;

ACTINS; ANIMALS; CELL SURVIVAL; DEPSIPEPTIDES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LEUKEMIA P388; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 20344386229     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.04.040     Document Type: Article

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