Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction

PLoS ONE

Volumn 5, Issue 12, 2010, Pages

  Oshiumi, Hiroyuki ^a   Ikeda, Masanori ^b   Matsumoto, Misako ^a   Watanabe, Ayako ^a   Takeuchi, Osamu ^c   Akira, Shizuo ^c   Kato, Nobuyuki ^b   Shimotohno, Kunitada ^d   Seya, Tsukasa ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d CHIBA INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CORE PROTEIN; DEAD BOX PROTEIN; FAT DROPLET; MITOCHONDRIAL PROTEIN; PROTEIN DDX3; PROTEIN IPS 1; UNCLASSIFIED DRUG; DDX3X PROTEIN, HUMAN; NUCLEOCAPSID PROTEIN, HEPATITIS C VIRUS; SIGNAL TRANSDUCING ADAPTOR PROTEIN; VISA PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; CELL STRAIN HEK293; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LOCALIZATION; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; INTERFERON INDUCTION; LIVER CELL; MITOCHONDRION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; VIRUS REPLICATION; CONFOCAL MICROSCOPY; CYTOLOGY; CYTOPLASM; GENE EXPRESSION REGULATION; HEPATITIS C; METABOLISM; PROTEIN TERTIARY STRUCTURE; RNA INTERFERENCE;

HEPATITIS C VIRUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CYTOPLASM; DEAD-BOX RNA HELICASES; GENE EXPRESSION REGULATION, VIRAL; HEPACIVIRUS; HEPATITIS C; HEPATOCYTES; HUMANS; INTERFERON-BETA; MICROSCOPY, CONFOCAL; MITOCHONDRIA; PROTEIN STRUCTURE, TERTIARY; RNA INTERFERENCE; SIGNAL TRANSDUCTION; VIRAL CORE PROTEINS;

EID: 78650127763     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0014258     Document Type: Article

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