Regulation of insulin gene transcription by a Ca2+responsive pathway involving calcineurin and nuclear factor of activated T cells

Molecular Endocrinology

Volumn 15, Issue 10, 2001, Pages 1758-1767

  Lawrence, M C ^a   Bhatt, H S ^a   Watterson, J M ^a   Easom, R A ^a  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CALCIUM; INSULIN; NUCLEAR FACTOR; POTASSIUM ION; RAPAMYCIN; TACROLIMUS;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; DNA BINDING; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; RAT; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION REGULATION;

EID: 0034796114     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.15.10.0702     Document Type: Article

References (45)

1. Tacrolimus: A further update of its pharmacology and therapeutic use in the management of organ transplantation
2. Post-transplant diabetes mellitus. The role of immunosuppression
3. Transcriptional inhibition of insulin by FK506 and possible involvement of FK506 binding protein-12 in pancreatic β-cell
4. Islet cell damage associated with tacrolimus and cyclosporine: Morphological features in pancreas allograft biopsies and clinical correration
5. Inhibition of glucose-stimulated insulin release from beta TC3 celts and rodent islets by an analog of FK506
6. Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levers, and insulin secretion in HIT-T15 cells
7. Cyclosporin A stimulation of glucose-induced insulin secretion in MIN6 cells
8. Identification of carcineurin as a key signalling enzyme in T-lymphocyte activation
9. Signal transmission between the plasma membrane and nucleus of T lymphocytes
10. The mechanism of action of cycrosporin A and FK506
11. Concerted dephosphoryration of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity
12. Transcription factors of the NFAT family: Regulation and function
13. Interaction of calcineurin with a domain of the transcription factor NFAT1 that controls nuclear import
14. The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun
15. Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA
16. NF-ATp: A transcription factor required for the co-ordinate induction of several cytokine genes
17. Regulation of the calmodulin-stimulated protein phosphatase, calcineurin
18. Identification of the calmodulin-regulated protein phosphatase, calcineurin, in rat pancreatic islets
19. Characterization of a novel calcium response element in the grucagon gene
20. A mutational analysis of the insulin gene transcription control region: Expression in β cells is dependent on two related sequences within the enhancer
21. FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin
22. Site-specific phosphorylation of synapsin I by Ca2+/calmodulin-dependent protein kinase II in pancreatic betaTC3 cells: Synapsin I is not associated with insulin secretory granules
23. Regulation of insulin gene transcription
24. Involvement of the Ca(2+)-dependent phosphatase calcineurin in gene transcription that is stimulated by cAMP through cAMP response elements
25. Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin
26. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A
27. 2+, calcineurin, and NFAT
28. Calcineurin signaling and muscle remodeling
29. Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways
30. Altered function of insulin receptor substrate-1-deficient mouse islets and cultured β-cell lines
31. Glucose induces insulin gene transcription in a murine pancreatic β-cell line
32. Regulation of insulin gene expression by glucose and calcium in transfected primary islet cultures
33. Activation of serum response factor in the depolarization induction of Egr-1 transcription in pancreatic islet β-cells
34. Membrane depolarization and calcium influx induce glucagon gene transcription in pancreatic islet cells through the cyclic AMP-responsive element
35. Calcium-mobilizing insulin secretagogues stimulate transcription that is directed by the cyclic adenosine 3′,5′-monophosphate/calcium response element in a pancreatic islet β-cell line
36. Inhibition of cyclic AMP response element-binding protein/cyclic AMP response element-mediated transcription by the immunosuppressive drugs cyclosporin A and FK506 depends on the promoter context
37. Regulation of elF-4E BP1 phosphorylation by mTOR
38. PHAS-I as a link between mitogen-activated protein kinase and translation initiation
39. Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity
40. Glucagon-like peptide 1 stimulates insulin gene promoter activity by protein kinase A-independent activation of the rat insulin I gene cAMP response element
41. The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter
42. Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters
43. Pancreatic β-cell-specific repression of insulin gene transcription by CCAAT/enhancer-binding protein β. Inhibitory interactions with basic helix-loop-helix transcription factor E47
44. Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of fos and Jun
45. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen