The type of responder T-cell has a significant impact in a human in vitro suppression assay

PLoS ONE

Volumn 5, Issue 12, 2010, Pages

  Jana, Srikanta ^a,e   Campbell, Hope ^c   Woodliff, Jeffrey ^d   Waukau, Jill ^a   Jailwala, Parthav ^a   Ghorai, Jugal ^b   Ghosh, Soumitra ^a   Glisic, Sanja ^a  

^a Medical College and Children's Hospital of Wisconsin ^*  (United States)

^b UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^c BLOOD RESEARCH INSTITUTE   (United States)

^d MEDICAL COLLEGE OF WISCONSIN   (United States)

^e UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA;

ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL KINETICS; CELL STIMULATION; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE EXACERBATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOASSAY; IMMUNOREACTIVITY; IN VITRO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTE CULTURE; LYMPHOCYTE PROLIFERATION; REGULATORY T LYMPHOCYTE; SENSITIVITY AND SPECIFICITY; AUTOIMMUNE DISEASE; BIOSYNTHESIS; CD4+ T LYMPHOCYTE; CELL SEPARATION; CYTOLOGY; FLOW CYTOMETRY; IMMUNOLOGY; KINETICS; METABOLISM; MONONUCLEAR CELL; PANCREAS ISLET BETA CELL; RISK; T LYMPHOCYTE;

AUTOIMMUNE DISEASES; CD4-POSITIVE T-LYMPHOCYTES; CELL SEPARATION; COCULTURE TECHNIQUES; DIABETES MELLITUS, TYPE 1; FLOW CYTOMETRY; HUMANS; INSULIN-SECRETING CELLS; INTERLEUKIN-2; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; KINETICS; LEUKOCYTES, MONONUCLEAR; RISK; T-LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY;

EID: 78649938754     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015154     Document Type: Article

References (51)

1. Jonuleit H, Schmitt E (2003) The regulatory T cell family: distinct subsets and their interrelations. J Immunol 171: 6323-6327.
2. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M (1995) Immunologic selftolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155: 1151-1164.
3. Salomon B, Lenschow DJ, Rhee L, Ashourian N, Singh B, et al. (2000) B7/ CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity 12: 431-440.
4. Read S, Malmstrom V, Powrie F (2000) Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J Exp Med 192: 295-302.
5. Suri-Payer E, Amar AZ, Thornton AM, Shevach EM (1998) CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J Immunol 160: 1212-1218.
6. Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA (2001) CD4+CD25high regulatory cells in human peripheral blood. J Immunol 167: 1245-1253.
7. Miyara M, Yoshioka Y, Kitoh A, Shima T, Wing K, et al. (2009) Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity 30: 899-911.
8. Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, et al. (2006) CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 203: 1701-1711.
9. Ehst BD, Ingulli E, Jenkins MK (2003) Development of a novel transgenic mouse for the study of interactions between CD4 and CD8 T cells during graft rejection. Am J Transplant 3: 1355-1362.
10. Tran DQ, Glass DD, Uzel G, Darnell DA, Spalding C, et al. (2009) Analysis of adhesion molecules, target cells, and role of IL-2 in human FOXP3+ regulatory T cell suppressor function. J Immunol 182: 2929-2938.
11. Liu MF, Wang CR, Fung LL, Wu CR (2004) Decreased CD4+CD25+ T cells in peripheral blood of patients with systemic lupus erythematosus. Scand J Immunol 59: 198-202.
12. Cao D, Malmstrom V, Baecher-Allan C, Hafler D, Klareskog L, et al. (2003) Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis. Eur J Immunol 33: 215-223.
13. Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA (2004) Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med 199: 971-979.
14. Lindley S, Dayan CM, Bishop A, Roep BO, Peakman M, et al. (2005) Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes 54: 92-99.
15. D'Alise AM, Auyeung V, Feuerer M, Nishio J, Fontenot J, et al. (2008) The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors. Proc Natl Acad Sci U S A 105: 19857-19862.
16. Venigalla RK, Tretter T, Krienke S, Max R, Eckstein V, et al. (2008) Reduced CD4+,CD25- T cell sensitivity to the suppressive function of CD4+,CD25high,CD127-/low regulatory T cells in patients with active systemic lupus erythematosus. Arthritis Rheum 58: 2120-2130.
17. Lawson JM, Tremble J, Dayan C, Beyan H, Leslie RD, et al. (2008) Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes. Clin Exp Immunol 154: 353-359.
18. Jin Y, Chen X, Podolsky R, Hopkins D, Makala LH, et al. (2009) APC dysfunction is correlated with defective suppression of T cell proliferation in human type 1 diabetes. Clin Immunol 130: 272-279.
19. Herman AE, Freeman GJ, Mathis D, Benoist C (2004) CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. J Exp Med 199: 1479-1489.
20. Kumanogoh A, Wang X, Lee I, Watanabe C, Kamanaka M, et al. (2001) Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: a role of CD40 in regulatory T cell development. J Immunol 166: 353-360.
21. Hansen JD, Du Pasquier L, Lefranc MP, Lopez V, Benmansour A, et al. (2009) The B7 family of immunoregulatory receptors: a comparative and evolutionary perspective. Mol Immunol 46: 457-472.
22. Dieckmann D, Plottner H, Berchtold S, Berger T, Schuler G (2001) Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood. J Exp Med 193: 1303-1310.
23. Cantrell DA, Smith KA (1984) The interleukin-2 T-cell system: a new cell growth model. Science 224: 1312-1316.
24. Shevach EM, McHugh RS, Piccirillo CA, Thornton AM (2001) Control of Tcell activation by CD4+ CD25+ suppressor T cells. Immunol Rev 182: 58-67.
25. Gondek DC, Lu LF, Quezada SA, Sakaguchi S, Noelle RJ (2005) Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism. J Immunol 174: 1783-1786.
26. Lundgren A, Suri-Payer E, Enarsson K, Svennerholm AM, Lundin BS (2003) Helicobacter pylori-specific CD4+ CD25high regulatory T cells suppress memory T-cell responses to H. pylori in infected individuals. Infect Immun 71: 1755-1762.
27. Khoury SJ, Guttmann CR, Orav EJ, Kikinis R, Jolesz FA, et al. (2000) Changes in activated T cells in the blood correlate with disease activity in multiple sclerosis. Arch Neurol 57: 1183-1189.
28. Jensen J, Langkilde AR, Fenst C, Nicolaisen MS, Roed HG, et al. (2004) CD4 T cell activation and disease activity at onset of multiple sclerosis. J Neuroimmunol 149: 202-209.
29. Peakman M, Leslie RD, Alviggi L, Hawa M, Vergani D (1996) Persistent activation of CD8+ T-cells characterizes prediabetic twins. Diabetes Care 19: 1177-1184.
30. Iezzi G, Karjalainen K, Lanzavecchia A (1998) The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity 8: 89-95.
31. Strauss L, Bergmann C, Whiteside TL (2009) Human circulating CD4+CD25highFoxp3+ regulatory T cells kill autologous CD8+ but not CD4+ responder cells by Fas-mediated apoptosis. J Immunol 182: 1469-1480.
32. Croft M, Bradley LM, Swain SL (1994) Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells. J Immunol 152: 2675-2685.
33. Baecher-Allan C, Viglietta V, Hafler DA (2002) Inhibition of human CD4(+)CD25(+high) regulatory T cell function. J Immunol 169: 6210-6217.
34. Setoguchi R, Hori S, Takahashi T, Sakaguchi S (2005) Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J Exp Med 201: 723-735.
35. Thornton AM, Donovan EE, Piccirillo CA, Shevach EM (2004) Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function. J Immunol 172: 6519-6523.
36. May T, Eccleston L, Herrmann S, Hauser H, Goncalves J, et al. (2008) Bimodal and hysteretic expression in mammalian cells from a synthetic gene circuit. PLoS One 3: e2372.
37. Busse D, de la Rosa M, Hobiger K, Thurley K, Flossdorf M, et al. (2010) Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments. Proc Natl Acad Sci U S A 107: 3058-3063.
38. Podtschaske M, Benary U, Zwinger S, Hofer T, Radbruch A, et al. (2007) Digital NFATc2 activation per cell transforms graded T cell receptor activation into an all-or-none IL-2 expression. PLoS One 2: e935.
39. Bijl M, Horst G, Limburg PC, Kallenberg CG (2001) Fas expression on peripheral blood lymphocytes in systemic lupus erythematosus (SLE): relation to lymphocyte activation and disease activity. Lupus 10: 866-872.
40. Crispin JC, Martinez A, Alcocer-Varela J (2003) Quantification of regulatory T cells in patients with systemic lupus erythematosus. J Autoimmun 21: 273-276.
41. Amasaki Y, Kobayashi S, Takeda T, Ogura N, Jodo S, et al. (1995) Upregulated expression of Fas antigen (CD95) by peripheral naive and memory T cell subsets in patients with systemic lupus erythematosus (SLE): a possible mechanism for lymphopenia. Clin Exp Immunol 99: 245-250.
42. Black AP, Bhayani H, Ryder CA, Gardner-Medwin JM, Southwood TR (2002) T-cell activation without proliferation in juvenile idiopathic arthritis. Arthritis Res 4: 177-183.
43. Hidaka T, Suzuki K, Matsuki Y, Takamizawa-Matsumoto M, Okada M, et al. (1999) Changes in CD4+ T lymphocyte subsets in circulating blood and synovial fluid following filtration leukocytapheresis therapy in patients with rheumatoid arthritis. Ther Apher 3: 178-185.
44. Salazar-Fontana LI, Sanz E,Merida I, Zea A, Sanchez-Atrio A, et al. (2001) Cell surface CD28 levels define four CD4+ T cell subsets: abnormal expression in rheumatoid arthritis. Clin Immunol 99: 253-265.
45. Glisic-Milosavljevic S, Waukau J, Jailwala P, Jana S, Khoo HJ, et al. (2007) Atrisk and recent-onset type 1 diabetic subjects have increased apoptosis in the CD4+CD25+ T-cell fraction. PLoS One 2: e146.
46. van Amelsfort JM, Jacobs KM, Bijlsma JW, Lafeber FP, Taams LS (2004) CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid. Arthritis Rheum 50: 2775-2785.
47. Klein S, Kretz CC, Krammer PH, Kuhn A CD127(low/-) and FoxP3(+) expression levels characterize different regulatory T-cell populations in human peripheral blood. J Invest Dermatol 130: 492-499.
48. Long SA, Cerosaletti K, Bollyky PL, Tatum M, Shilling H, et al. Defects in IL- 2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects. Diabetes 59: 407-415.
49. high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. Blood 108: 4260-4267.
50. Jailwala P, Waukau J, Glisic S, Jana S, Ehlenbach S, et al. (2009) Apoptosis of CD4+ CD25(high) T cells in type 1 diabetes may be partially mediated by IL-2 deprivation. PLoS One 4: e6527.
51. De Boer RJ, Perelson AS (2005) Estimating division and death rates from CFSE data. Journal of Computational and Applied Mathematics Special Issue on Mathematics Applied to Immunology 184: 140-164.