Persistent activation of CD8+ T-cells characterizes prediabetic twins

Diabetes Care

Volumn 19, Issue 11, 1996, Pages 1177-1184

  Peakman, Mark ^a   Leslie, R David G ^b   Alviggi, Lorenzo ^a   Hawa, Mohammed ^b   Vergani, Diego ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; HLA DR ANTIGEN; INTERLEUKIN 2 RECEPTOR;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC VALUE; FEMALE; HELPER CELL; HUMAN; HUMAN CELL; IMPAIRED GLUCOSE TOLERANCE; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MONOZYGOTIC TWINS; PROSPECTIVE STUDY; SCHOOL CHILD; SUPPRESSOR CELL; T LYMPHOCYTE ACTIVATION;

EID: 0029854418     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.19.11.1177     Document Type: Article

References (28)

1. Castano L, Eisenbarth GS: Type I diabetes: a chronic autoimmune disease of human, mouse and rat. Annu Rev Immunol 8:647-649, 1990
2. Bottazzo GF, Dean BM, McNally JM, Mackay EH, Swift PGF Gamble R: In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. N Engl J Med 313:353-360, 1985
3. Alviggi L, Johnston C, Hoskins PJ, Tee DEH, Pyke DA, Leslie RDG, Vergani D: Pathogenesis of insulin dependent diabetes: a role for activated T lymphocytes. Lancet ii:4-5, 1984
4. Jackson RA, Morris MA, Haynes BF, Eisenbarth GS: Increased circulating Ia- antigen bearing T cells in type 1 diabetes mellitus. N Engl J Med 306:785-788, 1982
5. Peakman M, Hussain MJ, Millward BA, Leslie RDG, Vergani D: Effect of initiation of insulin therapy on T-lymphocyte activation in type 1 (insulin dependent) diabetes. Diabetic Med 7:327-330, 1990
6. Pozzilli P, Zuccarini O, Iavicoli M, Andreani D, Sensi M, Spencer KM, Bottazzo GF, Beverley PCL, Kyner JL, Cudworth AG: Monoclonal antibodies defined abnormalities of T-lymphocytes in type 1 (insulin-dependent) diabetes. Diabetes 32:91-94, 1993
7. Tun RYM, Peakman M, Alviggi L, Hussain MJ, Lo SSS, Shattock M, Pyke DA, Bottazzo GF, Vergani D, Leslie RDG: The importance of persistent cellular and humoral immune changes in the prediabetic period: a prospective identical twin study. Brit Med J 308:1063-1068, 1994
8. Lo SSS, Tun RYM, Hawa M, Leslie RDG: Studies of diabetic twins. Diabetes Metab Rev 7:223-238, 1991
9. Olmos P, A'Hern R, Heaton DA, Millward BA, Risley D, Pyke DA, Leslie RDG: The significance of the concordance rate for Type 1 (insulin-dependent) diabetes in identical twins. Diabetologia 31:747-750, 1988
10. Peakman M, Wen L, McNab GL, Watkins PJ, Tan KC, Vergani D: T cell clones generated from patients with Type 1 diabetes using interleukin-2 proliferate to human islet antigens. Autoimmunity 17:31-39, 1994
11. Sibley RK, Sutherland DER, Goetz F, Michael AF: Recurrent diabetes mellitus in the pancreas iso and allograft: a light and electron microscopic and immunohistochemical analysis of four cases. Lab Invest 53:132-144, 1985
12. Hänninen A, Jalkanen S, Salmi M, Toikannen S, Nikolakaros G, Simell O: Macrophages, T cell receptor usage, and endothelial cell activation in the pancreas at the onset of insulin dependent diabetes mellitus. J Clin Invest 90:1901-1910, 1992
13. De Berardinis P, Londei M, James RFL, Lake SP, Wise PH, Feldmann M: Do CD4-positive cytotoxic T cells damage β cells in type 1 diabetes? Lancet ii:823-824, 1988
14. Peakman M, Alviggi L, Hussain MJ, Lo SSS, Hawa M, Leslie RDG, Vergani D: Increased expression of T cell markers of immunological memory associated with protection from type 1 diabetes: a study of identical twins. Diabetes 43:712-717, 1994
15. National Diabetes Data Group: Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28:1039-1057, 1979
16. Bonifacio E, Bingley P, Shattock M, Dean BM, Dunger D, Gale EAM, Bottazzo GF: Quantification of islet-cell antibodies and prediction of insulin-dependent diabetes. Lancet 335:147-149, 1990
17. Christie MR, Tun RYM, Lo SSS, Cassidy D, Brown TJ, Hollands J, Shattock M, Bottazzo GF, Leslie RDG: Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM. Diabetes 41:782-787, 1992
18. Kurtz AB, DiSilvio L, Bosi E: The determination of detection limits for insulin antibody assays. Diabelotogia 31:395-399, 1988
19. Smerdon KA, Peakman M, Hussain MJ, Alviggi L, Watkins PJ, Leslie RDG, Vergani D: Increase in simultaneous co-expression of naive and memory lymphocyte markers at diagnosis of insulin dependent diabetes mellitus. Diabetes 42:127-133, 1993
20. Roep BO, Kallan AA, Hazenbos WL, Bruining GJ, Bailyes WM, Aarden SD, Hutton JC, De Vries RR: T-cell reactivity to 38 kD insulin-secretory granule protein in patients with recent-onset type 1 diabetes. Lancet 337:1439-1441, 1991
21. Atkinson MA, Kaufman DL, Campbell L, Gibbs KA, Shah SC, Bu D-F, Erlander MG, Tobin AJ, Maclaren NK: Response of peripheral blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes. Lancet 339:458-459, 1992
22. Roep BO, Aarden SD, De Vries RRP, Hutton JC: T-cell clones from a type-1 diabetes patient respond to insulin secretory granule proteins. Nature 345:632-634, 1990
23. Kontiainen S, James RFL, Feldmann M: Human islet cell induced T cell lines and clones from diabetic children. Autoimmunity 8:193-197, 1991
24. Beavis AJ, Pennline KJ: Tracking of murine spleen cells in vivo: detection of PKH26-labelled cells in the pancreas of non-obese diabetic (NOD) mice. J Immunol Methods 170:57-65, 1994
25. Peakman M, Warnock T, Vats A, McNab GL, Underhill JA, Donaldson PT, Vergani D: Lymphocyte subset abnormalities, autoantibodies and their relationship with HLA DR types in children with type 1 diabetes and their first degree relatives. Diabetologia 37:155-165, 1994
26. H2 subsets: doubt no more. Immunol Today 12:256-257, 1991
27. Harrison LC, Honeyman MC, DeAizpura HJ, Schmidli RS, Colman PG, Tait BD, Cram DS: Inverse relationship between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes. Lancet 341:1365-1368, 1993
28. De Berardinis P, Londei M, Kahan M, Balsano F, Kontianen S, Gale EAM, Bottazzo GF, Feldmann M: The majority of the activated T cells in the blood of insulin-dependent diabetes mellitus (IDDM) patients are CD4+. Clin Exp Immunol 73:255-259, 1988