Minireview: Lipid droplets in lipogenesis and lipolysis

Endocrinology

Volumn 149, Issue 3, 2008, Pages 942-949

  Ducharme, Nicole A ^a   Bickel, Perry E ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTE TRIGLYCERIDE LIPASE; ADIPOPHILIN; ESTERASE; FAT DROPLET; PERILIPIN; PROTEIN CGI 58; PROTEIN LSDP5; PROTEIN MLDP; PROTEIN OXPAT; PROTEIN TIP47; SNARE PROTEIN; UNCLASSIFIED DRUG; LIPID; PHOSPHOPROTEIN; TRIACYLGLYCEROL;

BIOGENESIS; CYTOPLASM; HUMAN; LIPID STORAGE; LIPOGENESIS; LIPOLYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN FUNCTION; SHORT SURVEY; ANIMAL; ENERGY METABOLISM; METABOLISM; PHYSIOLOGY; REVIEW;

ANIMALS; ENERGY METABOLISM; HUMANS; LIPIDS; LIPOGENESIS; LIPOLYSIS; PHOSPHOPROTEINS; TRIGLYCERIDES;

EID: 40849145708     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-1713     Document Type: Short Survey

References (85)

1. Brasaemle DL 2007 The perilipin family of structural lipid droplet proteins: Stabilization of lipid droplets and control of lipolysis. J Lipid Res 48:2547-2559
2. Martin S, Parton RG 2006 Lipid droplets: a unified view of a dynamic organelle. Nat Rev Mol Cell Biol 7:373-378
3. Wolins NE, Brasaemle DL, Bickel PE 2006 A proposed model of fat packaging by exchangeable lipid droplet proteins. FEBS Lett 580:5484-5491
4. Mishra R, Simonson MS 2005 Saturated free fatty acids and apoptosis in microvascular mesangial cells: palmitate activates pro-apoptotic signaling involving caspase 9 and mitochondrial release of endonuclease G. Cardiovasc Diabetol 4:2
5. Shimabukuro M, Higa M, Zhou YT, Wang MY, Newgard CB, Unger RH 1998 Lipoapoptosis in β-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression. J Biol Chem 273:32487-32490
6. Listenberger LL, Ory DS, Schaffer JE 2001 Palmitate-induced apoptosis can occur through a ceramide-independent pathway. J Biol Chem 276:14890-14895
7. Morino K, Petersen KF, Shulman GI 2006 Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction. Diabetes 55(Suppl 2):S9-S15
8. Lee Y, Wang MY, Kakuma T, Wang ZW, Babcock E, McCorkle K, Higa M, Zhou YT, Unger RH 2001 Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia. J Biol Chem 276:5629-5635
9. Listenberger LL, Han X, Lewis SE, Cases S, Farese Jr RV, Ory DS, Schaffer JE 2003 Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci USA 100:3077-3082
10. Goodpaster BH, He J, Watkins S, Kelley DE 2001 Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. J Clin Endocrinol Metab 86:5755-5761
11. Moro C, Bajpeyi S, Smith SR, Determinants of intramyocellular triglyceride turnover: implications for insulin sensitivity. Am J Physiol Endocrinol Metab, in press
12. Miura S, Gan JW, Brzostowski J, Parisi MJ, Schultz CJ, Londos C, Oliver B, Kimmel AR 2002 Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium. J Biol Chem 277:32253-32257
13. Londos C, Sztalryd C, Tansey JT, Kimmel AR 2005 Role of PAT proteins in lipid metabolism. Biochimie (Paris) 87:45-49
14. Welte MA 2007 Proteins under new management: lipid droplets deliver. Trends Cell Biol 17:363-369
15. Cermelli S, Guo Y, Gross SP, Welte MA 2006 The lipid-droplet proteome reveals that droplets are a protein-storage depot. Curr Biol 16:1783-1795
16. Brown DA 2001 Lipid droplets: proteins floating on a pool of fat. Curr Biol 11:R446-R449
17. Tauchi-Sato K, Ozeki S, Houjou T, Taguchi R, Fujimoto T 2002 The surface of lipid droplets is a phospholipid monolayer with a unique fatty acid composition. J Biol Chem 277:44507-44512
18. Blanchette-Mackie EJ, Dwyer NK, Barber T, Coxey RA, Takeda T, Rondinone CM, Theodorakis JL, Greenberg AS, Londos C 1995 Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes. J. Lipid Res. 36:1211-1226
19. Robenek H, Hofnagel O, Buers I, Robenek MJ, Troyer D, Severs NJ 2006 Adipophilin-enriched domains in the ER membrane are sites of lipid droplet biogenesis. J Cell Sci 119:4215-4224
20. Wan H-C, Melo RCN, Jin Z, Dvorak AM, Weller PF 2007 Roles and origins of leukocyte lipid bodies: proteomic and ultrastructural studies. FASEB J 21:167-178
21. Brasaemle DL, Dolios G, Shapiro L, Wang R 2004 Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes. J Biol Chem 279:46835-46842
22. Liu P, Ying Y, Zhao Y, Mundy DI, Zhu M, Anderson RG 2004 Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane traffic. J Biol Chem 279:3787-3792
23. Wolins NE, Skinner JR, Schoenfish MJ, Tzekov A, Bensch KG, Bickel PE 2003 Adipocyte protein S3-12 coats nascent lipid droplets. J Biol Chem 278:37713-37721
24. Wolins NE, Quaynor BK, Skinner JR, Schoenfish MJ, Tzekov A, Bickel PE 2005 S3-12, adipophilin, and TIP47 package lipid in adipocytes. J Biol Chem 280:19146-19155
25. Yamaguchi T, Matsushita S, Motojima K, Hirose F, Osumi T 2006 MLDP, a novel PAT family protein localized to lipid droplets and enriched in the heart, is regulated by peroxisome proliferator-activated receptor α. J Biol Chem 281:14232-14240
26. Wolins NE, Quaynor BK, Skinner JR, Tzekov A, Croce MA, Gropler MC, Varma V, Yao-Borengasser A, Rasouli N, Kern PA, Finck BN, Bickel PE 2006 OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilization. Diabetes 55:3418-3428
27. Dalen KT, Dahl T, Holter E, Arntsen B, Londos C, Sztalryd C, Nebb HI 2007 LSDP5 is a PAT protein specifically expressed in fatty acid oxidizing tissues. Biochim Biophys Acta 1771:210-227
28. Beller M, Riedel D, Jansch L, Dieterich G, Wehland J, Jackle H, Kuhnlein RP 2006 Characterization of the Drosophila lipid droplet subproteome. Mol Cell Proteomics 5:1082-1094
29. Ackerman WE, Robinson JM, Kniss DA 2007 Association of PAT proteins with lipid storage droplets in term fetal membranes. Placenta 28:465-476
30. Lu X, Gruia-Gray J, Copeland NG, Gilbert DJ, Jenkins NA, Londos C, Kimmel AR 2001 The murine perilipin gene: the lipid droplet-associated perilipins derive from tissue-specific, mRNA splice variants and define a gene family of ancient origin. Mamm Genome 12:741-749
31. Forcheron F, Legedz L, Chinetti G, Feugier P, Letexier D, Bricca G, Beylot M 2005 Genes of cholesterol metabolism in human atheroma: overexpression of perilipin and genes promoting cholesterol storage and repression of ABCA1 expression. Arterioscler Thromb Vasc Biol 25:1711-1717
32. Scherer PE, Bickel PE, Kotler M, Lodish HF 1998 Cloning of cell-specific secreted and surface proteins by subtractive antibody screening. Nat Biotechnol 16:581-586
33. Dalen KT, Schoonjans K, Ulven SM, Weedon-Fekjaer MS, Bentzen TG, Koutnikova H, Auwerx J, Nebb HI 2004 Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-α. Diabetes 53:1243-1252
34. Greenberg AS, Egan JJ, Wek SA, Garty NB, Blanchette-Mackie EJ, Londos C 1991 Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. J Biol Chem 266:11341-11346
35. Brasaemle DL, Rubin B, Harten IA, Gruia-Gray J, Kimmel AR, Londos C 2000 Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysis. J Biol Chem 275:38486-38493
36. Martinez-Botas J, Anderson JB, Tessier D, Lapillonne A, Chang BH, Quast MJ, Gorenstein D, Chen KH, Chan L 2000 Absence of perilipin results in leanness and reverses obesity in Lepr(db/db) mice. Nat Genet 26:474-479
37. Tansey JT, Sztalryd C, Gruia-Gray J, Roush DL, Zee JV, Gavrilova O, Reitman ML, Deng CX, Li C, Kimmel AR, Londos C 2001 Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc Natl Acad Sci USA 98:6494-6499
38. Imamura M, Inoguchi T, Ikuyama S, Taniguchi S, Kobayashi K, Nakashima N, Nawata H 2002 ADRP stimulates lipid accumulation and lipid droplet formation in murine fibroblasts. Am J Physiol Endocrinol Metab 283:E775-E783
39. Fukushima M, Enjoji M, Kohjima M, Sugimoto R, Ohta S, Kotoh K, Kuniyoshi M, Kobayashi K, Imamura M, Inoguchi T, Nakamuta M, Nawata H 2005 Adipose differentiation related protein induces lipid accumulation and lipid droplet formation in hepatic stellate cells. In Vitro Cell Dev Biol Anim 41:321-324
40. Larigauderie G, Furman C, Jaye M, Lasselin C, Copin C, Fruchart JC, Castro G, Rouis M 2004 Adipophilin enhances lipid accumulation and prevents lipid efflux from THP-1 macrophages: potential role in atherogenesis. Arterioscler Thromb Vasc Biol 24:504-510
41. Larigauderie G, Cuaz-Perolin C, Younes AB, Furman C, Lasselin C, Copin C, Jaye M, Fruchart JC, Rouis M 2006 Adipophilin increases triglyceride storage in human macrophages by stimulation of biosynthesis and inhibition of β-oxidation. FEBS J 273:3498-3510
42. Chang BH, Li L, Paul A, Taniguchi S, Nannegari V, Heird WC, Chan L 2006 Protection against fatty liver but normal adipogenesis in mice lacking adipose differentiation-related protein. Mol Cell Biol 26:1063-1076
43. Russell TD, Palmer CA, Orlicky DJ, Bales ES, Chang BH, Chan L, McManaman JL 2007 Mammary glands of adipophilin-null mice produce an N-terminally truncated form of adipophilin that mediates milk lipid formation and secretion. J Lipid Res 49:206-216
44. Sztalryd C, Bell M, Lu X, Mertz P, Hickenbottom S, Chang BH, Chan L, Kimmel AR, Londos C 2006 Functional compensation for adipose differentiation-related protein (ADFP) by Tip47 in an ADFP null embryonic cell line. J Biol Chem 281:34341-34348
45. Nagayama M, Uchida T, Gohara K 2007 Temporal and spatial variations of lipid droplets during adipocyte division and differentiation. J Lipid Res 48:9-18
46. Bartz R, Zehmer JK, Zhu M, Chen Y, Serrero G, Zhao Y, Liu P 2007 Dynamic activity of lipid droplets: protein phosphorylation and GTP-mediated protein translocation. J Proteome Res 6:3256-3265
47. Ozeki S, Cheng J, Tauchi-Sato K, Hatano N, Taniguchi H, Fujimoto T 2005 Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane. J Cell Sci 118:2601-2611
48. Martin S, Driessen K, Nixon SJ, Zerial M, Parton RG 2005 Regulated localization of Rab18 to lipid droplets: effects of lipolytic stimulation and inhibition of lipid droplet catabolism. J Biol Chem 280:42325-42335
49. Bartz R, Li WH, Venables B, Zehmer JK, Roth MR, Welti R, Anderson RG, Liu P, Chapman KD 2007 Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic. J Lipid Res 48:837-847
50. Liu P, Bartz R, Zehmer JK, Ying YS, Zhu M, Serrero G, Anderson RG 2007 Rab-regulated interaction of early endosomes with lipid droplets. Biochim Biophys Acta 1773:784-793
51. Jahn R, Scheller RH 2006 SNAREs-engines for membrane fusion. Nat Rev Mol Cell Biol 7:631-643
52. Bonifacino JS, Glick BS 2004 The mechanisms of vesicle budding and fusion. Cell 116:153-166
53. Boström P, Andersson L, Rutberg M, Perman J, Lidberg U, Johansson BR, Fernandez-Rodriguez J, Ericson J, Nilsson T, Boren J, Olofsson SO 2007 SNARE proteins mediate fusion between cytosolic lipid droplets and are implicated in insulin sensitivity. Nat Cell Biol 9:1286-1293
54. Bostrom P, Rutberg M, Ericsson J, Holmdahl P, Andersson L, Frohman MA, Boren J, Olofsson SO 2005 Cytosolic lipid droplets increase in size by microtubule-dependent complex formation. Arterioscler Thromb Vasc Biol 25:1945-1951
55. Gross SP, Welte MA, Block SM, Wieschaus EF 2000 Dynein-mediated cargo transport in vivo: a switch controls travel distance. J Cell Biol 148:945-956
56. Andersson L, Bostrom P, Ericson J, Rutberg M, Magnusson B, Marchesan D, Ruiz M, Asp L, Huang P, Frohman MA, Boren J, Olofsson SO 2006 PLD1 and ERK2 regulate cytosolic lipid droplet formation. J Cell Sci 119:2246-2257
57. Zechner R, Strauss JG, Haemmerle G, Lass A, Zimmermann R 2005 Lipolysis: pathway under construction. Curr Opin Lipidol 16:333-340
58. Carmen GY, Victor SM 2006 Signalling mechanisms regulating lipolysis. Cell Signal 18:401-408
59. Langin D 2006 Adipose tissue lipolysis as a metabolic pathway to define pharmacological strategies against obesity and the metabolic syndrome. Pharmacol Res 53:482-491
60. Duncan RE, Ahmadian M, Jaworski K, Sarkadi-Nagy E, Sul HS 2007 Regulation of lipolysis in adipocytes. Annu Rev Nutr 27:79-101
61. Brasaemle DL, Levin DM, Adler-Wailes DC, Londos C 2000 The lipolytic stimulation of 3T3-L1 adipocytes promotes the translocation of hormone-sensitive lipase to the surfaces of lipid storage droplets. Biochim Biophys Acta 1483:251-262
62. Marcinkiewicz A, Gauthier D, Garcia A, Brasaemle DL 2006 The phosphorylation of serine 492 of perilipin a directs lipid droplet fragmentation and dispersion. J Biol Chem 281:11901-11909
63. Osuga J, Ishibashi S, Oka T, Yagyu H, Tozawa R, Fujimoto A, Shionoiri F, Yahagi N, Kraemer FB, Tsutsumi O, Yamada N 2000 Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity. Proc Natl Acad Sci USA 97:787-792
64. Wang SP, Laurin N, Himms-Hagen J, Rudnicki MA, Levy E, Robert MF, Pan L, Oligny L, Mitchell GA 2001 The adipose tissue phenotype of hormone-sensitive lipase deficiency in mice. Obes Res 9:119-128
65. Haemmerle G, Zimmermann R, Hayn M, Theussl C, Waeg G, Wagner E, Sattler W, Magin TM, Wagner EF, Zechner R 2002 Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis. J Biol Chem 277:4806-4815
66. Villena JA, Roy S, Sarkadi-Nagy E, Kim KH, Sul HS 2004 Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis. J Biol Chem 279:47066-47075
67. Zimmermann R, Strauss JG, Haemmerle G, Schoiswohl G, Birner-Gruenberger R, Riederer M, Lass A, Neuberger G, Eisenhaber F, Hermetter A, Zechner R 2004 Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 306:1383-1386
68. Jenkins CM, Mancuso DJ, Yan W, Sims HF, Gibson B, Gross RW 2004 Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J Biol Chem 279:48968-48975
69. Haemmerle G, Lass A, Zimmermann R, Gorkiewicz G, Meyer C, Rozman J, Heldmaier G, Maier R, Theussl C, Eder S, Kratky D, Wagner EF, Klingenspor M, Hoefler G, Zechner R 2006 Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science 312:734-737
70. Arner P, Langin D 2007 The role of neutral lipases in human adipose tissue lipolysis. Curr Opin Lipidol 18:246-250
71. Akiyama M, Sakai K, Ogawa M, McMillan JR, Sawamura D, Shimizu H 2007 Novel duplication mutation in the patatin domain of adipose triglyceride lipase (PNPLA2) in neutral lipid storage disease with severe myopathy. Muscle Nerve 36:856-859
72. Fischer J, Lefevre C, Morava E, Mussini JM, Laforet P, Negre-Salvayre A, Lathrop M, Salvayre R 2007 The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy. Nat Genet 39:28-30
73. Lass A, Zimmermann R, Haemmerle G, Riederer M, Schoiswohl G, Schweiger M, Kienesberger P, Strauss JG, Gorkiewicz G, Zechner R 2006 Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome. Cell Metab 3:309-319
74. Granneman JG, Moore HP, Granneman RL, Greenberg AS, Obin MS, Zhu Z 2007 Analysis of lipolytic protein trafficking and interactions in adipocytes. J Biol Chem 282:5726-5735
75. Lefevre C, Jobard F, Caux F, Bouadjar B, Karaduman A, Heilig R, Lakhdar H, Wollenberg A, Verret JL, Weissenbach J, Ozguc M, Lathrop M, Prud'homme JF, Fischer J 2001 Mutations in CGI-58, the gene encoding a new protein of the esterase/lipase/thioesterase subfamily, in Chanarin-Dorfman syndrome. Am J Hum Genet 69:1002-1012
76. Gronke S, Beller M, Fellert S, Ramakrishnan H, Jackle H, Kuhnlein RP 2003 Control of fat storage by a Drosophila PAT domain protein. Curr Biol 13:603-606
77. Welte MA, Cermelli S, Griner J, Viera A, Guo Y, Kim DH, Gindhart JG, Gross SP 2005 Regulation of lipid-droplet transport by the perilipin homolog LSD2. Curr Biol 15:1266-1275
78. Gronke S, Mildner A, Fellert S, Tennagels N, Petry S, Muller G, Jackle H, Kuhnlein RP 2005 Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila. Cell Metab 1:323-330
79. Ashrafi K, Chang FY, Watts JL, Fraser AG, Kamath RS, Ahringer J, Ruvkun G 2003 Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature 421:268-272
80. Daum G, Wagner A, Czabany T, Athenstaedt K 2007 Dynamics of neutral lipid storage and mobilization in yeast. Biochimie (Paris) 89:243-248
81. Czabany T, Athenstaedt K, Daum G 2007 Synthesis, storage and degradation of neutral lipids in yeast. Biochim Biophys Acta 1771:299-309
82. Qi L, Corella D, Sorli JV, Portoles O, Shen H, Coltell O, Godoy D, Greenberg AS, Ordovas JM 2004 Genetic variation at the perilipin (PLIN) locus is associated with obesity-related phenotypes in White women. Clin Genet 66:299-310
83. Qi L, Shen H, Larson I, Schaefer EJ, Greenberg AS, Tregouet DA, Corella D, Ordovas JM 2004 Gender-specific association of a perilipin gene haplotype with obesity risk in a white population. Obes Res 12:1758-1765
84. Qi L, Tai ES, Tan CE, Shen H, Chew SK, Greenberg AS, Corella D, Ordovas JM 2005 Intragenic linkage disequilibrium structure of the human perilipin gene (PLIN) and haplotype association with increased obesity risk in a multiethnic Asian population. J Mol Med 83:448-456
85. Mottagui-Tabar S, Ryden M, Lofgren P, Faulds G, Hoffstedt J, Brookes AJ, Andersson I, Arner P 2003 Evidence for an important role of perilipin in the regulation of human adipocyte lipolysis. Diabetologia 46:789-797