Alpha-tocopherol quinone inhibits beta-amyloid aggregation and cytotoxicity, disaggregates preformed fibrils and decreases the production of reactive oxygen species, NO and inflammatory cytokines

Neurochemistry International

Volumn 57, Issue 8, 2010, Pages 914-922

  Yang, Shi Gao ^a   Wang, Wei Yun ^b   Ling, Tie Jun ^b   Feng, Ying ^a   Du, Xue Ting ^a   Zhang, Xi ^a   Sun, Xiao Xia ^a   Zhao, Min ^a   Xue, Di ^a   Yang, Yang ^a   Liu, Rui Tian ^a  

^a Tsinghua University   (China)

^b ANHUI AGRICULTURAL UNIVERSITY   (China)

Author keywords

Aggregation; Alzheimer's disease; Amyloid protein; Cytotoxicity; Inflammatory cytokines; RRR tocopherol quinine

Indexed keywords

1,4 BENZOQUINONE; ALPHA TOCOPHEROL; ALPHA TOCOPHERYLQUINONE; AMYLOID BETA PROTEIN[1-42]; ANTHRAQUINONE; INTERLEUKIN 1BETA; INTERLEUKIN 4; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA; UBIDECARENONE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG ACTIVITY; DRUG SYNTHESIS; FEMALE; MICROGLIA; NEUROBLASTOMA CELL; NEUROFILAMENT; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION;

AMYLOID; AMYLOID BETA-PEPTIDES; ANIMALS; ANTIOXIDANTS; CELL LINE, TUMOR; CHO CELLS; CRICETINAE; CRICETULUS; CYTOKINES; DOWN-REGULATION; HUMANS; INFLAMMATION MEDIATORS; NEURONS; NITRIC OXIDE; REACTIVE OXYGEN SPECIES; VITAMIN E;

EID: 78649634550     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2010.09.011     Document Type: Article

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