Self-assembly of β-amyloid 42 is retarded by small molecular ligands at the stage of structural intermediates

Journal of Structural Biology

Volumn 130, Issue 2-3, 2000, Pages 232-246

  Bohrmann, Bernd ^a   Adrian, Marc ^b   Dubochet, Jacques ^b   Kuner, Pascal ^a   Müller, Francis ^a   Huber, Walter ^a   Nordstedt, Christer ^a   Döbeli, Heinz ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Amyloid; A 42; Electron cryomicroscopy; Fibril formation; Inhibitor; Intermediate; Nonfibrillar; Retardation; Self as sembly

Indexed keywords

AMYLOID BETA PROTEIN; CHELATING AGENT; RO 01 6150; RO 02 4009; RO 02 4025; RO 90 7501; RO 91 4714; RO 91 4949; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CRYOELECTRON MICROSCOPY; DRUG PROTEIN BINDING; DRUG SCREENING; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN PROTEIN INTERACTION;

EID: 0033855433     PISSN: 10478477     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsbi.2000.4241     Document Type: Article

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