Functional crosstalk of CAR-LXR and ROR-LXR in drug metabolism and lipid metabolism

Advanced Drug Delivery Reviews

Volumn 62, Issue 13, 2010, Pages 1316-1321

  Xiao, Lei ^a   Xie, Xinni ^a   Zhai, Yonggong ^a  

^a BEIJING NORMAL UNIVERSITY   (China)

Author keywords

CAR; Drug metabolism; Gene regulation; Lipid metabolism; LXR; Nuclear receptor; ROR

Indexed keywords

CAR; DRUG METABOLISMS; GENE REGULATION; LIPID METABOLISM; LXR; NUCLEAR RECEPTORS; ROR;

CATALYSTS; CHOLESTEROL; CROSSTALK; ENZYMES; GENES; LAWS AND LEGISLATION; LIVER; MAMMALS; TRANSCRIPTION FACTORS;

METABOLISM;

3 [3 [[2 CHLORO 3 (TRIFLUOROMETHYL)BENZYL](2 DIPHENYLETHYL)AMINO]PROPOXY]PHENYLACETIC ACID; 5ALPHA PREGNANE 3,20 DIONE; AMINO ACID DERIVATIVE; ANDROSTANOLONE; CAFFEINE; CARRIER PROTEIN; CELL NUCLEUS RECEPTOR; CHLORPROMAZINE; CLOTRIMAZOLE; CONSTITUTIVE ANDROSTANE RECEPTOR; DRUG METABOLIZING ENZYME; LIVER X RECEPTOR; LIVER X RECEPTOR AGONIST; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; NUCLEAR RECEPTOR COREPRESSOR; NUTRACEUTICAL; PARACETAMOL; PHENOBARBITAL; RETINOIC ACID; RETINOIC ACID DERIVATIVE; RETINOID RELATED ORPHAN RECEPTOR; RETINOID RELATED ORPHAN RECEPTOR ALPHA; RETINOID RELATED ORPHAN RECEPTOR BETA; RETINOID RELATED ORPHAN RECEPTOR GAMMA; STEROL; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UNINDEXED DRUG; XENOBIOTIC AGENT;

CHOLESTEROL METABOLISM; CHOLESTEROL TRANSPORT; DIABETES MELLITUS; DRUG METABOLISM; ENERGY METABOLISM; HUMAN; INFLAMMATION; LIPID METABOLISM; LIPOGENESIS; METABOLIC REGULATION; METABOLIC SYNDROME X; MOLECULAR CLONING; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; REVIEW;

ANIMALS; HUMANS; LIPID METABOLISM; LIVER; METABOLIC DETOXICATION, DRUG; MICE; MICE, KNOCKOUT; MOLECULAR TARGETED THERAPY; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 1; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 2; ORPHAN NUCLEAR RECEPTORS; PROTEIN ISOFORMS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; XENOBIOTICS;

EID: 78649328225     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.addr.2010.07.006     Document Type: Review

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