Coactivators for the orphan nuclear receptor RORα

Molecular Endocrinology

Volumn 13, Issue 9, 1999, Pages 1550-1557

  Atkins, G Brandon ^a   Hu, Xiao ^a   Guenther, Matthew G ^a   Rachez, Christophe ^b   Freedman, Leonard P ^b   Lazar, Mitchell A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CELL NUCLEUS RECEPTOR; GLUCOCORTICOID RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; THYROID HORMONE; VITAMIN D RECEPTOR;

ARTICLE; CARBOXY TERMINAL SEQUENCE; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 0033305583     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.13.9.0343     Document Type: Article

References (37)

1. The nuclear receptor superfamly: The second decade
2. Disruption of the nuclear hormone receptor RORα in staggerer mice
3. Orphan nuclear receptor RORα-deficient mice display the cerebellar defects of staggerer
4. Identification of a receptor for the morphogen retinoic acid
5. Transcriptional regulation of apolipoprotein A-l agene expression by the nuclear receptor RORα
6. Orphan nuclear receptors-the first eight years
7. Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action
8. Nuclear receptor coactivators and corepressors
9. Nuclear receptor coactivators
10. Histone acetylation and transcriptional regulatory mechanisms
11. Transcriptional activation and repression by RORα, an orphan nuclear receptor required for cerebellar development
12. GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors
13. GRIP1, a novel mouse protein that serves as a transcriptional co-activator in yeast for the hormone binding domain of steroid receptors
14. TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors
15. Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor
16. A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system
17. The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion
18. Identification of RB18A, a 205 kDa new p53 regulatory protein which shares antigenic and functional properties with p53
19. The nonconserved hinge region and distinct amino-terminal domains of the RORα orphan nuclear receptor isoforms are required for proper DNA bending and RORα-DNA interactions
20. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor
21. Interaction of thyroid-hormone receptor with a conserved transcriptional mediator
22. A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein
23. The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18
24. Increasing the complexity of coactivation in nuclear receptor signaling
25. Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors
26. Nuclear receptors require the DRIP complex for ligand-dependent transactivation on chromatin complexes in vitro
27. Yeast hormone response element assays detect and characterize GRIP1 coactivator-dependent activation of transcription by thyroid and retinoid nuclear receptors
28. Differential regulation of the N-myc proto-oncogene by RORα and RVR, two orphan members of the superfamily of nuclear hormone receptors
29. Distinct steady-state nuclear receptor coregulator complexes exist in vivo
30. Competition between thyroid hormone receptor-associated protein (TRAP) 220 and transcriptional intermediary factor (TIF) 2 for binding to nuclear receptors
31. CREB-binding protein is a transcriptional coactivator for hepatocyte nuclear factor-4 and enhances apolipoprotein gene expression
32. SRC-1 and GRIP-1 coactivate transcription with hepatocyte nuclear factor 4
33. Androstane metabolites bind to and deactivate the nuclear receptor CARb
34. The monomer-binding orphan receptor Rev-Erb represses transcription as a dimer on a novel direct repeat
35. The unique C-termini of the thyroid hormone receptor variant, c-erbAa2, and the thyroid hormone receptor a1 mediate different DNA-binding and heterodimerization properties
36. Distinct stages in adipogenesis revealed by retinoid inhibition of differentiation after induction of PPARg
37. Accurate transcription initiation by RNA pol II in a soluble extract from isolated mammalian nuclei