메뉴 건너뛰기




Volumn 203, Issue 1-3, 2010, Pages 53-62

Pharmacogenetics and forensic toxicology

Author keywords

Antidepressants; Codeine; CYP2D6; Forensic toxicology; P450; Pharmacogenetics; Polymorphism; Tramadol

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; AMITRIPTYLINE; BENZODIAZEPINE DERIVATIVE; BIOLOGICAL MARKER; CARISOPRODOL; CODEINE; DIHYDROCODEINE; ETHYLMORPHINE; FENTANYL; FLUOXETINE; METHADONE; NALOXONE; OPIATE; OXYCODONE; PARACETAMOL; PHENYTOIN; TRAMADOL; VENLAFAXINE;

EID: 78649325566     PISSN: 03790738     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.forsciint.2010.07.011     Document Type: Article
Times cited : (49)

References (111)
  • 3
    • 0037421584 scopus 로고    scopus 로고
    • Inheritance and drug response
    • Weinshilboum R. Inheritance and drug response. N. Engl. J. Med. 2003, 348:529-537.
    • (2003) N. Engl. J. Med. , vol.348 , pp. 529-537
    • Weinshilboum, R.1
  • 4
    • 0037421590 scopus 로고    scopus 로고
    • Pharmacogenomics-drug disposition, drug targets, and side effects
    • Evans W.E., McLeod H.L. Pharmacogenomics-drug disposition, drug targets, and side effects. N. Engl. J. Med. 2003, 348:538-549.
    • (2003) N. Engl. J. Med. , vol.348 , pp. 538-549
    • Evans, W.E.1    McLeod, H.L.2
  • 5
    • 2642570170 scopus 로고    scopus 로고
    • Moving towards individualized medicine with pharmacogenomics
    • Evans W.E., Relling M.V. Moving towards individualized medicine with pharmacogenomics. Nature 2004, 429:464-468.
    • (2004) Nature , vol.429 , pp. 464-468
    • Evans, W.E.1    Relling, M.V.2
  • 6
    • 33644987397 scopus 로고    scopus 로고
    • Pharmacogenomics for the forensic toxicologist
    • Kupiec T.C., Raj V., Vu N. Pharmacogenomics for the forensic toxicologist. J. Anal. Toxicol. 2006, 30:65-72.
    • (2006) J. Anal. Toxicol. , vol.30 , pp. 65-72
    • Kupiec, T.C.1    Raj, V.2    Vu, N.3
  • 8
    • 0031035007 scopus 로고    scopus 로고
    • Polymorphisms in drug-metabolizing enzymes: what is their clinical relevance and why do they exist?
    • Nebert D.W. Polymorphisms in drug-metabolizing enzymes: what is their clinical relevance and why do they exist?. Am. J. Hum. Genet. 1997, 60:265-271.
    • (1997) Am. J. Hum. Genet. , vol.60 , pp. 265-271
    • Nebert, D.W.1
  • 11
    • 0842312531 scopus 로고    scopus 로고
    • Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants
    • Nelson D.R., Zeldin D.C., Hoffman S.M., Maltais L.J., Wain H.M., Nebert D.W. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. Pharmacogenetics 2004, 14:1-18.
    • (2004) Pharmacogenetics , vol.14 , pp. 1-18
    • Nelson, D.R.1    Zeldin, D.C.2    Hoffman, S.M.3    Maltais, L.J.4    Wain, H.M.5    Nebert, D.W.6
  • 12
    • 73249132581 scopus 로고    scopus 로고
    • The cytochrome p450 homepage
    • Nelson D.R. The cytochrome p450 homepage. Hum. Genomics 2009, 4:59-65.
    • (2009) Hum. Genomics , vol.4 , pp. 59-65
    • Nelson, D.R.1
  • 13
    • 66449111462 scopus 로고    scopus 로고
    • Insights into the structure, function, and regulation of human cytochrome P450 1A2
    • Zhou S.F., Chan E., Zhou Z.W., Xue C.C., Lai X., Duan W. Insights into the structure, function, and regulation of human cytochrome P450 1A2. Curr. Drug Metab. 2009, 10:713-729.
    • (2009) Curr. Drug Metab. , vol.10 , pp. 713-729
    • Zhou, S.F.1    Chan, E.2    Zhou, Z.W.3    Xue, C.C.4    Lai, X.5    Duan, W.6
  • 14
    • 70450273286 scopus 로고    scopus 로고
    • Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development
    • Wang B., Zhou S.F. Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr. Med. Chem. 2009, 16:4066-4218.
    • (2009) Curr. Med. Chem. , vol.16 , pp. 4066-4218
    • Wang, B.1    Zhou, S.F.2
  • 15
    • 73349108767 scopus 로고    scopus 로고
    • Insights into the substrate specificity, inhibitors, regulation, and polymorphisms and the clinical impact of human cytochrome P450 1A2
    • Zhou S.F., Yang L.P., Zhou Z.W., Liu Y.H., Chan E. Insights into the substrate specificity, inhibitors, regulation, and polymorphisms and the clinical impact of human cytochrome P450 1A2. AAPS J. 2009, 11:481-494.
    • (2009) AAPS J. , vol.11 , pp. 481-494
    • Zhou, S.F.1    Yang, L.P.2    Zhou, Z.W.3    Liu, Y.H.4    Chan, E.5
  • 16
    • 77951447009 scopus 로고    scopus 로고
    • Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2
    • Zhou S.F., Wang B., Yang L.P., Liu J.P. Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2. Drug Metab. Rev. 2010, 42:268-354.
    • (2010) Drug Metab. Rev. , vol.42 , pp. 268-354
    • Zhou, S.F.1    Wang, B.2    Yang, L.P.3    Liu, J.P.4
  • 17
    • 72949119129 scopus 로고    scopus 로고
    • Structure, function, regulation and polymorphism of human cytochrome P450 2A6
    • Di Y.M., Chow V.D., Yang L.P., Zhou S.F. Structure, function, regulation and polymorphism of human cytochrome P450 2A6. Curr. Drug Metab. 2009, 10:754-780.
    • (2009) Curr. Drug Metab. , vol.10 , pp. 754-780
    • Di, Y.M.1    Chow, V.D.2    Yang, L.P.3    Zhou, S.F.4
  • 18
    • 52449133102 scopus 로고    scopus 로고
    • CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme
    • Wang H., Tompkins L.M. CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme. Curr. Drug Metab. 2008, 9:598-610.
    • (2008) Curr. Drug Metab. , vol.9 , pp. 598-610
    • Wang, H.1    Tompkins, L.M.2
  • 19
    • 72949119743 scopus 로고    scopus 로고
    • Substrate specificity, regulation, and polymorphism of human cytochrome P450 2B6
    • Mo S.L., Liu Y.H., Duan W., Wei M.Q., Kanwar J.R., Zhou S.F., Substrate specificity, regulation, and polymorphism of human cytochrome P450 2B6 Curr. Drug Metab. 2009, 10:730-753.
    • (2009) Curr. Drug Metab. , vol.10 , pp. 730-753
    • Mo, S.L.1    Liu, Y.H.2    Duan, W.3    Wei, M.Q.4    Kanwar, J.R.5    Zhou, S.F.6
  • 21
    • 70349386728 scopus 로고    scopus 로고
    • Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I
    • Zhou S.F. Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I. Clin. Pharmacokinet. 2009, 48:689-723.
    • (2009) Clin. Pharmacokinet. , vol.48 , pp. 689-723
    • Zhou, S.F.1
  • 22
    • 70449371633 scopus 로고    scopus 로고
    • Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part II
    • Zhou S.F. Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part II. Clin. Pharmacokinet. 2009, 48:761-804.
    • (2009) Clin. Pharmacokinet. , vol.48 , pp. 761-804
    • Zhou, S.F.1
  • 23
    • 70350044889 scopus 로고    scopus 로고
    • New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme
    • Wang B., Yang L.P., Zhang X.Z., Huang S.Q., Bartlam M., Zhou S.F. New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme. Drug Metab. Rev. 2009, 41:573-643.
    • (2009) Drug Metab. Rev. , vol.41 , pp. 573-643
    • Wang, B.1    Yang, L.P.2    Zhang, X.Z.3    Huang, S.Q.4    Bartlam, M.5    Zhou, S.F.6
  • 24
    • 70349387884 scopus 로고    scopus 로고
    • Substrate specificity, inhibitors and regulation of human cytochrome P450 2D6 and implications in drug development
    • Zhou S.F., Liu J.P., Lai X.S. Substrate specificity, inhibitors and regulation of human cytochrome P450 2D6 and implications in drug development. Curr. Med. Chem. 2009, 16:2661-2805.
    • (2009) Curr. Med. Chem. , vol.16 , pp. 2661-2805
    • Zhou, S.F.1    Liu, J.P.2    Lai, X.S.3
  • 26
    • 36549059303 scopus 로고    scopus 로고
    • Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring
    • Zhou S.F., Xue C.C., Yu X.Q., Li C., Wang G. Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring. Ther. Drug Monit. 2007, 29:687-710.
    • (2007) Ther. Drug Monit. , vol.29 , pp. 687-710
    • Zhou, S.F.1    Xue, C.C.2    Yu, X.Q.3    Li, C.4    Wang, G.5
  • 27
    • 45249121177 scopus 로고    scopus 로고
    • Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4
    • Zhou S.F. Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4. Curr. Drug Metab. 2008, 9:310-322.
    • (2008) Curr. Drug Metab. , vol.9 , pp. 310-322
    • Zhou, S.F.1
  • 28
    • 36148976077 scopus 로고    scopus 로고
    • Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects
    • Ingelman-Sundberg M., Sim S.C., Gomez A., Rodriguez-Antona C. Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects. Pharmacol. Ther. 2007, 116:496-526.
    • (2007) Pharmacol. Ther. , vol.116 , pp. 496-526
    • Ingelman-Sundberg, M.1    Sim, S.C.2    Gomez, A.3    Rodriguez-Antona, C.4
  • 29
    • 33644847684 scopus 로고    scopus 로고
    • Transporters as a determinant of drug clearance and tissue distribution
    • Shitara Y., Horie T., Sugiyama Y. Transporters as a determinant of drug clearance and tissue distribution. Eur. J. Pharm. Sci. 2006, 27:425-446.
    • (2006) Eur. J. Pharm. Sci. , vol.27 , pp. 425-446
    • Shitara, Y.1    Horie, T.2    Sugiyama, Y.3
  • 31
    • 56149110125 scopus 로고    scopus 로고
    • Impact of genetic polymorphisms of transporters on the pharmacokinetic, pharmacodynamic and toxicological properties of anionic drugs
    • Maeda K., Sugiyama Y. Impact of genetic polymorphisms of transporters on the pharmacokinetic, pharmacodynamic and toxicological properties of anionic drugs. Drug Metab. Pharmacokinet. 2008, 23:223-235.
    • (2008) Drug Metab. Pharmacokinet. , vol.23 , pp. 223-235
    • Maeda, K.1    Sugiyama, Y.2
  • 32
    • 77949458095 scopus 로고    scopus 로고
    • Pharmacogenetics of drug transporters
    • see also (accessed 31.03.10)
    • Franke R.M., Gardner E.R., Sparreboom A. Pharmacogenetics of drug transporters. Curr. Pharm. Des. 2010, 16(2):220-230. see also http://www.membranetransport.org/ (accessed 31.03.10).
    • (2010) Curr. Pharm. Des. , vol.16 , Issue.2 , pp. 220-230
    • Franke, R.M.1    Gardner, E.R.2    Sparreboom, A.3
  • 33
    • 72849150876 scopus 로고    scopus 로고
    • The pharmacogenomics of membrane transporters project: research at the interface of genomics and transporter pharmacology
    • Kroetz D.L., Yee S.W., Giacomini K.M. The pharmacogenomics of membrane transporters project: research at the interface of genomics and transporter pharmacology. Clin. Pharmacol. Ther. 2010, 87:109-116.
    • (2010) Clin. Pharmacol. Ther. , vol.87 , pp. 109-116
    • Kroetz, D.L.1    Yee, S.W.2    Giacomini, K.M.3
  • 37
    • 85168049709 scopus 로고    scopus 로고
    • Cytochrome P450 Drug Interaction Table. Version 5.0 (accessed 31.03.10)
    • D.A. Flockhart, Cytochrome P450 Drug Interaction Table. Version 5.0 (2009) (accessed 31.03.10). http://medicine.iupui.edu/clinpharm/ddis/table.asp.
    • (2009)
    • Flockhart, D.A.1
  • 38
  • 40
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints: preferred definitions and conceptual framework
    • Biomarkers Definitions Working Group
    • Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin. Pharmacol. Ther. 2001, 69:89-95. Biomarkers Definitions Working Group.
    • (2001) Clin. Pharmacol. Ther. , vol.69 , pp. 89-95
  • 41
    • 77949410471 scopus 로고    scopus 로고
    • Impact of biomarker development on drug safety assessment
    • Marrer E., Dieterle F. Impact of biomarker development on drug safety assessment. Toxicol. Appl. Pharmacol. 2010, 243:167-179.
    • (2010) Toxicol. Appl. Pharmacol. , vol.243 , pp. 167-179
    • Marrer, E.1    Dieterle, F.2
  • 44
    • 39649111940 scopus 로고    scopus 로고
    • Genomic and genetic biomarkers of toxicity
    • Mendrick D.L. Genomic and genetic biomarkers of toxicity. Toxicology 2008, 245:175-181.
    • (2008) Toxicology , vol.245 , pp. 175-181
    • Mendrick, D.L.1
  • 45
    • 77952552373 scopus 로고    scopus 로고
    • The discovery and development of proteomic safety biomarkers for the detection of drug-induced liver toxicity
    • Amacher D.E. The discovery and development of proteomic safety biomarkers for the detection of drug-induced liver toxicity. Toxicol. Appl. Pharmacol. 2010.
    • (2010) Toxicol. Appl. Pharmacol.
    • Amacher, D.E.1
  • 46
    • 0032299995 scopus 로고    scopus 로고
    • High frequency of CYP2D6 poor and " intermediate" metabolizers in black populations: a review and preliminary data
    • Bradford L.D., Gaedigk A., Leeder J.S. High frequency of CYP2D6 poor and " intermediate" metabolizers in black populations: a review and preliminary data. Psychopharmacol. Bull. 1998, 34:797-804.
    • (1998) Psychopharmacol. Bull. , vol.34 , pp. 797-804
    • Bradford, L.D.1    Gaedigk, A.2    Leeder, J.S.3
  • 47
    • 0036124107 scopus 로고    scopus 로고
    • CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants
    • Bradford L.D. CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants. Pharmacogenomics 2002, 3:229-243.
    • (2002) Pharmacogenomics , vol.3 , pp. 229-243
    • Bradford, L.D.1
  • 48
    • 0042357440 scopus 로고    scopus 로고
    • PM frequencies of major CYPs in Asians and Caucasians
    • Mizutani T. PM frequencies of major CYPs in Asians and Caucasians. Drug Metab. Rev. 2003, 35:99-106.
    • (2003) Drug Metab. Rev. , vol.35 , pp. 99-106
    • Mizutani, T.1
  • 50
    • 31044442759 scopus 로고    scopus 로고
    • Pharmacogenetics in drug regulation: promise, potential and pitfalls
    • Shah R.R. Pharmacogenetics in drug regulation: promise, potential and pitfalls. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 2005, 360:1617-1638.
    • (2005) Philos. Trans. R. Soc. Lond. B: Biol. Sci. , vol.360 , pp. 1617-1638
    • Shah, R.R.1
  • 51
    • 0032692297 scopus 로고    scopus 로고
    • High and variable frequencies of CYP2C19 mutations: medical consequences of poor drug metabolism in Vanuatu and other Pacific islands
    • Kaneko A., Lum J.K., Yaviong L., Takahashi N., Ishizaki T., Bertilsson L., Kobayakawa T., Bjorkman A. High and variable frequencies of CYP2C19 mutations: medical consequences of poor drug metabolism in Vanuatu and other Pacific islands. Pharmacogenetics 1999, 9:581-590.
    • (1999) Pharmacogenetics , vol.9 , pp. 581-590
    • Kaneko, A.1    Lum, J.K.2    Yaviong, L.3    Takahashi, N.4    Ishizaki, T.5    Bertilsson, L.6    Kobayakawa, T.7    Bjorkman, A.8
  • 52
    • 0037131892 scopus 로고    scopus 로고
    • CYP2C9 allelic variants: ethnic distribution and functional significance
    • Xie H.G., Prasad H.C., Kim R.B., Stein C.M. CYP2C9 allelic variants: ethnic distribution and functional significance. Adv. Drug Deliv. Rev. 2002, 54:1257-1270.
    • (2002) Adv. Drug Deliv. Rev. , vol.54 , pp. 1257-1270
    • Xie, H.G.1    Prasad, H.C.2    Kim, R.B.3    Stein, C.M.4
  • 53
    • 0036263813 scopus 로고    scopus 로고
    • Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data
    • Lee C.R., Goldstein J.A., Pieper J.A. Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data. Pharmacogenetics 2002, 12:251-263.
    • (2002) Pharmacogenetics , vol.12 , pp. 251-263
    • Lee, C.R.1    Goldstein, J.A.2    Pieper, J.A.3
  • 55
    • 0028270681 scopus 로고
    • Ethnic distribution of slow acetylator mutations in the polymorphic N-acetyltransferase (NAT2) gene
    • Lin H.J., Han C.Y., Lin B.K., Hardy S. Ethnic distribution of slow acetylator mutations in the polymorphic N-acetyltransferase (NAT2) gene. Pharmacogenetics 1994, 4:125-134.
    • (1994) Pharmacogenetics , vol.4 , pp. 125-134
    • Lin, H.J.1    Han, C.Y.2    Lin, B.K.3    Hardy, S.4
  • 58
    • 0037330517 scopus 로고    scopus 로고
    • Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporin disposition in heart transplant recipients
    • Chowbay B., Cumaraswamy S., Cheung Y.B., Zhou Q., Lee E.J. Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporin disposition in heart transplant recipients. Pharmacogenetics 2003, 13:89-95.
    • (2003) Pharmacogenetics , vol.13 , pp. 89-95
    • Chowbay, B.1    Cumaraswamy, S.2    Cheung, Y.B.3    Zhou, Q.4    Lee, E.J.5
  • 61
    • 0038014055 scopus 로고    scopus 로고
    • Serotonin transporter promoter polymorphism in African Americans: allele frequencies and implications for treatment
    • Lotrich F.E., Pollock B.G., Ferrell R.E. Serotonin transporter promoter polymorphism in African Americans: allele frequencies and implications for treatment. Am. J. Pharmacogenomics 2003, 3:145-147.
    • (2003) Am. J. Pharmacogenomics , vol.3 , pp. 145-147
    • Lotrich, F.E.1    Pollock, B.G.2    Ferrell, R.E.3
  • 62
    • 67649339183 scopus 로고    scopus 로고
    • Pharmacogenomics for forensic toxicology: Swedish experience
    • AACC Press, Washington, DC, S.H. Wong, M. Linder, R. Valdes (Eds.)
    • Holmgren P., Ahlner J. Pharmacogenomics for forensic toxicology: Swedish experience. Pharmacogenomics and Proteomics 2006, 295-299. AACC Press, Washington, DC. S.H. Wong, M. Linder, R. Valdes (Eds.).
    • (2006) Pharmacogenomics and Proteomics , pp. 295-299
    • Holmgren, P.1    Ahlner, J.2
  • 63
    • 2542503653 scopus 로고    scopus 로고
    • Preanalytic aspects in postmortem toxicology
    • Skopp G. Preanalytic aspects in postmortem toxicology. Forensic Sci. Int. 2004, 142:75-100.
    • (2004) Forensic Sci. Int. , vol.142 , pp. 75-100
    • Skopp, G.1
  • 64
    • 2542507165 scopus 로고    scopus 로고
    • Postmortem toxicology of drugs of abuse
    • Drummer O.H. Postmortem toxicology of drugs of abuse. Forensic Sci. Int. 2004, 142:101-113.
    • (2004) Forensic Sci. Int. , vol.142 , pp. 101-113
    • Drummer, O.H.1
  • 65
    • 33846060715 scopus 로고    scopus 로고
    • Post-mortem toxicology
    • Drummer O.H. Post-mortem toxicology. Forensic Sci. Int. 2007, 165:199-203.
    • (2007) Forensic Sci. Int. , vol.165 , pp. 199-203
    • Drummer, O.H.1
  • 66
    • 49649100492 scopus 로고    scopus 로고
    • Post-mortem clinical pharmacology
    • Ferner R.E. Post-mortem clinical pharmacology. Br. J. Clin. Pharmacol. 2008, 66:430-443.
    • (2008) Br. J. Clin. Pharmacol. , vol.66 , pp. 430-443
    • Ferner, R.E.1
  • 67
    • 77956876794 scopus 로고    scopus 로고
    • Postmortem toxicology
    • (Epub ahead of print)
    • Skopp G. Postmortem toxicology. Forensic Sci. Med. Pathol. 2010, (Epub ahead of print).
    • (2010) Forensic Sci. Med. Pathol.
    • Skopp, G.1
  • 68
    • 10044297116 scopus 로고    scopus 로고
    • Genetic predictors of the clinical response to opioid analgesics: clinical utility and future perspectives
    • Lotsch J., Skarke C., Liefhold J., Geisslinger G. Genetic predictors of the clinical response to opioid analgesics: clinical utility and future perspectives. Clin. Pharmacokinet. 2004, 43:983-1013.
    • (2004) Clin. Pharmacokinet. , vol.43 , pp. 983-1013
    • Lotsch, J.1    Skarke, C.2    Liefhold, J.3    Geisslinger, G.4
  • 69
  • 70
    • 38349163777 scopus 로고    scopus 로고
    • Effects of the CYP2D6 gene duplication on the pharmacokinetics and pharmacodynamics of tramadol
    • Kirchheiner J., Keulen J.T., Bauer S., Roots I., Brockmoller J. Effects of the CYP2D6 gene duplication on the pharmacokinetics and pharmacodynamics of tramadol. J. Clin. Psychopharmacol. 2008, 28:78-83.
    • (2008) J. Clin. Psychopharmacol. , vol.28 , pp. 78-83
    • Kirchheiner, J.1    Keulen, J.T.2    Bauer, S.3    Roots, I.4    Brockmoller, J.5
  • 71
    • 51449102329 scopus 로고    scopus 로고
    • Respiratory depression with tramadol in a patient with renal impairment and CYP2D6 gene duplication
    • Stamer U.M., Stuber F., Muders T., Musshoff F. Respiratory depression with tramadol in a patient with renal impairment and CYP2D6 gene duplication. Anesth. Analg. 2008, 107:926-929.
    • (2008) Anesth. Analg. , vol.107 , pp. 926-929
    • Stamer, U.M.1    Stuber, F.2    Muders, T.3    Musshoff, F.4
  • 72
    • 0043127371 scopus 로고    scopus 로고
    • SNP analysis of CYP2D6 gene reveals correlation between genotype and opioid drug (tramadol) metabolite ratios in blood
    • Post-mortem
    • Levo A., Koski A., Ojanpera I., Vuori E., Sajantila A., Post-mortem SNP analysis of CYP2D6 gene reveals correlation between genotype and opioid drug (tramadol) metabolite ratios in blood. Forensic Sci. Int. 2003, 135:9-15.
    • (2003) Forensic Sci. Int. , vol.135 , pp. 9-15
    • Levo, A.1    Koski, A.2    Ojanpera, I.3    Vuori, E.4    Sajantila, A.5
  • 73
    • 0030472254 scopus 로고    scopus 로고
    • Codeine and morphine in extensive and poor metabolizers of sparteine: pharmacokinetics, analgesic effect and side effects
    • Poulsen L., Brosen K., Rendt-Nielsen L., Gram L.F., Elbaek K., Sindrup S.H. Codeine and morphine in extensive and poor metabolizers of sparteine: pharmacokinetics, analgesic effect and side effects. Eur. J. Clin. Pharmacol. 1996, 51:289-295.
    • (1996) Eur. J. Clin. Pharmacol. , vol.51 , pp. 289-295
    • Poulsen, L.1    Brosen, K.2    Rendt-Nielsen, L.3    Gram, L.F.4    Elbaek, K.5    Sindrup, S.H.6
  • 74
    • 0031679974 scopus 로고    scopus 로고
    • Codeine in post-operative pain. Study of the influence of sparteine phenotype and serum concentrations of morphine and morphine-6-glucuronide
    • Poulsen L., Riishede L., Brosen K., Clemensen S., Sindrup S.H. Codeine in post-operative pain. Study of the influence of sparteine phenotype and serum concentrations of morphine and morphine-6-glucuronide. Eur. J. Clin. Pharmacol. 1998, 54:451-454.
    • (1998) Eur. J. Clin. Pharmacol. , vol.54 , pp. 451-454
    • Poulsen, L.1    Riishede, L.2    Brosen, K.3    Clemensen, S.4    Sindrup, S.H.5
  • 75
    • 0031746749 scopus 로고    scopus 로고
    • Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation
    • Eckhardt K., Li S., Ammon S., Schanzle G., Mikus G., Eichelbaum M. Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation. Pain 1998, 76:27-33.
    • (1998) Pain , vol.76 , pp. 27-33
    • Eckhardt, K.1    Li, S.2    Ammon, S.3    Schanzle, G.4    Mikus, G.5    Eichelbaum, M.6
  • 77
    • 33747134323 scopus 로고    scopus 로고
    • Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother
    • Koren G., Cairns J., Chitayat D., Gaedigk A., Leeder S.J. Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother. Lancet 2006, 368:704.
    • (2006) Lancet , vol.368 , pp. 704
    • Koren, G.1    Cairns, J.2    Chitayat, D.3    Gaedigk, A.4    Leeder, S.J.5
  • 78
    • 34250345279 scopus 로고    scopus 로고
    • Apnea in a child after oral codeine: a genetic variant-an ultra-rapid metabolizer
    • Voronov P., Przybylo H.J., Jagannathan N. Apnea in a child after oral codeine: a genetic variant-an ultra-rapid metabolizer. Paediatr. Anaesth. 2007, 17:684-687.
    • (2007) Paediatr. Anaesth. , vol.17 , pp. 684-687
    • Voronov, P.1    Przybylo, H.J.2    Jagannathan, N.3
  • 81
    • 0028862793 scopus 로고
    • Dihydrocodeine: a new opioid substrate for the polymorphic CYP2D6 in humans
    • Fromm M.F., Hofmann U., Griese E.U., Mikus G. Dihydrocodeine: a new opioid substrate for the polymorphic CYP2D6 in humans. Clin. Pharmacol. Ther. 1995, 58:374-382.
    • (1995) Clin. Pharmacol. Ther. , vol.58 , pp. 374-382
    • Fromm, M.F.1    Hofmann, U.2    Griese, E.U.3    Mikus, G.4
  • 82
    • 0031839871 scopus 로고    scopus 로고
    • The visceral and somatic antinociceptive effects of dihydrocodeine and its metabolite, dihydromorphine. A cross-over study with extensive and quinidine-induced poor metabolizers
    • Wilder-Smith C.H., Hufschmid E., Thormann W. The visceral and somatic antinociceptive effects of dihydrocodeine and its metabolite, dihydromorphine. A cross-over study with extensive and quinidine-induced poor metabolizers. Br. J. Clin. Pharmacol. 1998, 45:575-581.
    • (1998) Br. J. Clin. Pharmacol. , vol.45 , pp. 575-581
    • Wilder-Smith, C.H.1    Hufschmid, E.2    Thormann, W.3
  • 84
    • 0036825844 scopus 로고    scopus 로고
    • Pharmacogenomics as molecular autopsy for postmortem forensic toxicology: genotyping cytochrome P450 2D6 for oxycodone cases
    • Jannetto P.J., Wong S.H., Gock S.B., Laleli-Sahin E., Schur B.C., Jentzen J.M. Pharmacogenomics as molecular autopsy for postmortem forensic toxicology: genotyping cytochrome P450 2D6 for oxycodone cases. J. Anal. Toxicol. 2002, 26:438-447.
    • (2002) J. Anal. Toxicol. , vol.26 , pp. 438-447
    • Jannetto, P.J.1    Wong, S.H.2    Gock, S.B.3    Laleli-Sahin, E.4    Schur, B.C.5    Jentzen, J.M.6
  • 85
    • 0032917451 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 (CYP2D6) genotyping on postmortem blood as a supplementary tool for interpretation of forensic toxicological results
    • Druid H., Holmgren P., Carlsson B., Ahlner J. Cytochrome P450 2D6 (CYP2D6) genotyping on postmortem blood as a supplementary tool for interpretation of forensic toxicological results. Forensic Sci. Int. 1999, 99:25-34.
    • (1999) Forensic Sci. Int. , vol.99 , pp. 25-34
    • Druid, H.1    Holmgren, P.2    Carlsson, B.3    Ahlner, J.4
  • 86
    • 77649258025 scopus 로고    scopus 로고
    • Death of a 10-month-old boy after exposure to ethylmorphine
    • Helland A., Isaksen C.V., Slordal L. Death of a 10-month-old boy after exposure to ethylmorphine. J. Forensic Sci. 2010, 55:551-553.
    • (2010) J. Forensic Sci. , vol.55 , pp. 551-553
    • Helland, A.1    Isaksen, C.V.2    Slordal, L.3
  • 87
    • 0242526177 scopus 로고    scopus 로고
    • Pharmacogenomics as an aspect of molecular autopsy for forensic pathology/toxicology: does genotyping CYP 2D6 serve as an adjunct for certifying methadone toxicity?
    • Wong S.H., Wagner M.A., Jentzen J.M., Schur C., Bjerke J., Gock S.B., Chang C.C. Pharmacogenomics as an aspect of molecular autopsy for forensic pathology/toxicology: does genotyping CYP 2D6 serve as an adjunct for certifying methadone toxicity?. J. Forensic Sci. 2003, 48:1406-1415.
    • (2003) J. Forensic Sci. , vol.48 , pp. 1406-1415
    • Wong, S.H.1    Wagner, M.A.2    Jentzen, J.M.3    Schur, C.4    Bjerke, J.5    Gock, S.B.6    Chang, C.C.7
  • 89
    • 0030739468 scopus 로고    scopus 로고
    • Possible involvement of multiple cytochrome P450S in fentanyl and sufentanil metabolism as opposed to alfentanil
    • Guitton J., Buronfosse T., Desage M., Lepape A., Brazier J.L., Beaune P. Possible involvement of multiple cytochrome P450S in fentanyl and sufentanil metabolism as opposed to alfentanil. Biochem. Pharmacol. 1997, 53:1613-1619.
    • (1997) Biochem. Pharmacol. , vol.53 , pp. 1613-1619
    • Guitton, J.1    Buronfosse, T.2    Desage, M.3    Lepape, A.4    Brazier, J.L.5    Beaune, P.6
  • 90
    • 29144447977 scopus 로고    scopus 로고
    • Pharmacogenomics as molecular autopsy for forensic toxicology: genotyping cytochrome P450 3A4*1B and 3A5*3 for 25 fentanyl cases
    • Jin M., Gock S.B., Jannetto P.J., Jentzen J.M., Wong S.H. Pharmacogenomics as molecular autopsy for forensic toxicology: genotyping cytochrome P450 3A4*1B and 3A5*3 for 25 fentanyl cases. J. Anal. Toxicol. 2005, 29:590-598.
    • (2005) J. Anal. Toxicol. , vol.29 , pp. 590-598
    • Jin, M.1    Gock, S.B.2    Jannetto, P.J.3    Jentzen, J.M.4    Wong, S.H.5
  • 92
    • 0036965857 scopus 로고    scopus 로고
    • CYP2D6 deficiency, a factor in ecstasy related deaths?
    • Gilhooly T.C., Daly A.K. CYP2D6 deficiency, a factor in ecstasy related deaths?. Br. J. Clin. Pharmacol. 2002, 54:69-70.
    • (2002) Br. J. Clin. Pharmacol. , vol.54 , pp. 69-70
    • Gilhooly, T.C.1    Daly, A.K.2
  • 93
    • 0034092057 scopus 로고    scopus 로고
    • Identification of the human cytochromes P450 involved in the oxidative metabolism of " Ecstasy" -related designer drugs
    • Kreth K., Kovar K., Schwab M., Zanger U.M. Identification of the human cytochromes P450 involved in the oxidative metabolism of " Ecstasy" -related designer drugs. Biochem. Pharmacol. 2000, 59:1563-1571.
    • (2000) Biochem. Pharmacol. , vol.59 , pp. 1563-1571
    • Kreth, K.1    Kovar, K.2    Schwab, M.3    Zanger, U.M.4
  • 94
    • 0036129441 scopus 로고    scopus 로고
    • Toxicokinetics of amphetamines: metabolism and toxicokinetic data of designer drugs, amphetamine, methamphetamine, and their N-alkyl derivatives
    • Kraemer T., Maurer H.H. Toxicokinetics of amphetamines: metabolism and toxicokinetic data of designer drugs, amphetamine, methamphetamine, and their N-alkyl derivatives. Ther. Drug Monit. 2002, 24:277-289.
    • (2002) Ther. Drug Monit. , vol.24 , pp. 277-289
    • Kraemer, T.1    Maurer, H.H.2
  • 95
    • 0034059585 scopus 로고    scopus 로고
    • Fluoxetine-related death in a child with cytochrome P-450 2D6 genetic deficiency
    • Salle F.R., DeVane C.L., Ferrell R.E. Fluoxetine-related death in a child with cytochrome P-450 2D6 genetic deficiency. J. Child Adolesc. Psychopharmacol. 2000, 10(1):27-34.
    • (2000) J. Child Adolesc. Psychopharmacol. , vol.10 , Issue.1 , pp. 27-34
    • Salle, F.R.1    DeVane, C.L.2    Ferrell, R.E.3
  • 96
    • 33645034693 scopus 로고    scopus 로고
    • CYP2D6 and CYP2C19 genotypes and amitriptyline metabolite ratios in a series of medicolegal autopsies
    • Koski A., Sistonen J., Ojanpera I., Gergov M., Vuori E., Sajantila A. CYP2D6 and CYP2C19 genotypes and amitriptyline metabolite ratios in a series of medicolegal autopsies. Forensic Sci. Int. 2006, 158:177-183.
    • (2006) Forensic Sci. Int. , vol.158 , pp. 177-183
    • Koski, A.1    Sistonen, J.2    Ojanpera, I.3    Gergov, M.4    Vuori, E.5    Sajantila, A.6
  • 97
    • 38649126903 scopus 로고    scopus 로고
    • Correlation of inter-individual variations of amitriptyline metabolism examined in hairs with CYP2C19 and CYP2D6 polymorphisms
    • Thieme D., Rolf B., Sachs H., Schmid D. Correlation of inter-individual variations of amitriptyline metabolism examined in hairs with CYP2C19 and CYP2D6 polymorphisms. Int. J. Legal Med. 2008, 122:149-155.
    • (2008) Int. J. Legal Med. , vol.122 , pp. 149-155
    • Thieme, D.1    Rolf, B.2    Sachs, H.3    Schmid, D.4
  • 99
    • 73449113301 scopus 로고    scopus 로고
    • Depressive effect of an antidepressant: therapeutic failure of venlafaxine in a case lacking CYP2D6 activity
    • Wijnen P.A., Limantoro I., Drent M., Bekers O., Kuijpers P.M., Koek G.H. Depressive effect of an antidepressant: therapeutic failure of venlafaxine in a case lacking CYP2D6 activity. Ann. Clin. Biochem. 2009, 46:527-530.
    • (2009) Ann. Clin. Biochem. , vol.46 , pp. 527-530
    • Wijnen, P.A.1    Limantoro, I.2    Drent, M.3    Bekers, O.4    Kuijpers, P.M.5    Koek, G.H.6
  • 100
    • 79956140697 scopus 로고    scopus 로고
    • Fatal venlafaxine poisonings are associated with a high prevalence of drug interactions
    • (Epub ahead of print)
    • Launiainen T., Rasanen I., Vuori E., Ojanperä I. Fatal venlafaxine poisonings are associated with a high prevalence of drug interactions. Int. J. Legal Med. 2010, (Epub ahead of print).
    • (2010) Int. J. Legal Med.
    • Launiainen, T.1    Rasanen, I.2    Vuori, E.3    Ojanperä, I.4
  • 101
    • 47249097440 scopus 로고    scopus 로고
    • The impact of CYP2D6 and CYP2C19 polymorphisms on suicidal behavior and substance abuse disorder among patients with schizophrenia: a retrospective study
    • Kobylecki C.J., Hansen T., Timm S., Wang A., Jakobsen K.D., Sorensen H.J., Rasmussen H.B., Werge T. The impact of CYP2D6 and CYP2C19 polymorphisms on suicidal behavior and substance abuse disorder among patients with schizophrenia: a retrospective study. Ther. Drug Monit. 2008, 30:265-270.
    • (2008) Ther. Drug Monit. , vol.30 , pp. 265-270
    • Kobylecki, C.J.1    Hansen, T.2    Timm, S.3    Wang, A.4    Jakobsen, K.D.5    Sorensen, H.J.6    Rasmussen, H.B.7    Werge, T.8
  • 102
    • 42049090602 scopus 로고    scopus 로고
    • Pharmacokinetic, pharmacodynamic, and pharmacogenetic targeted therapy of antiepileptic drugs
    • Anderson G.D. Pharmacokinetic, pharmacodynamic, and pharmacogenetic targeted therapy of antiepileptic drugs. Ther. Drug Monit. 2008, 30:173-180.
    • (2008) Ther. Drug Monit. , vol.30 , pp. 173-180
    • Anderson, G.D.1
  • 103
    • 0346639205 scopus 로고    scopus 로고
    • Individualized medicine-implementation of pharmacogenetic diagnostics in antidepressant drug treatment of major depressive disorders
    • Kirchheiner J., Bertilsson L., Bruus H., Wolff A., Roots I., Bauer M. Individualized medicine-implementation of pharmacogenetic diagnostics in antidepressant drug treatment of major depressive disorders. Pharmacopsychiatry 2003, 3(36 Suppl.):S235-S243.
    • (2003) Pharmacopsychiatry , vol.3 , Issue.36 SUPPL.
    • Kirchheiner, J.1    Bertilsson, L.2    Bruus, H.3    Wolff, A.4    Roots, I.5    Bauer, M.6
  • 104
    • 48549093980 scopus 로고    scopus 로고
    • Clinically relevant pharmacokinetic drug interactions with second-generation antidepressants: an update
    • Spina E., Santoro V., D'Arrigo C. Clinically relevant pharmacokinetic drug interactions with second-generation antidepressants: an update. Clin. Ther. 2008, 30:1206-1227.
    • (2008) Clin. Ther. , vol.30 , pp. 1206-1227
    • Spina, E.1    Santoro, V.2    D'Arrigo, C.3
  • 105
    • 77949461421 scopus 로고    scopus 로고
    • Pharmacogenetics in psychiatry-a useful clinical tool or wishful thinking for the future?
    • Kirchheiner J., Seeringer A., Viviani R. Pharmacogenetics in psychiatry-a useful clinical tool or wishful thinking for the future?. Curr. Pharm. Des. 2010, 16:136-144.
    • (2010) Curr. Pharm. Des. , vol.16 , pp. 136-144
    • Kirchheiner, J.1    Seeringer, A.2    Viviani, R.3
  • 107
    • 70449503599 scopus 로고    scopus 로고
    • Utilization of pharmacogenomics and therapeutic drug monitoring for opioid pain management
    • Jannetto P.J., Bratanow N.C. Utilization of pharmacogenomics and therapeutic drug monitoring for opioid pain management. Pharmacogenomics 2009, 10(7):1157-1167.
    • (2009) Pharmacogenomics , vol.10 , Issue.7 , pp. 1157-1167
    • Jannetto, P.J.1    Bratanow, N.C.2
  • 108
    • 77952908167 scopus 로고    scopus 로고
    • Personalized therapy in pain management: where do we stand?
    • Stamer U.M., Zhang L., Stuber F. Personalized therapy in pain management: where do we stand?. Pharmacogenomics 2010, 11(6):843-864.
    • (2010) Pharmacogenomics , vol.11 , Issue.6 , pp. 843-864
    • Stamer, U.M.1    Zhang, L.2    Stuber, F.3
  • 109
    • 0042367335 scopus 로고    scopus 로고
    • Association between blood carisoprodol:meprobamate concentration ratios and CYP2C19 genotype in carisoprodol-drugged drivers: decreased metabolic capacity in heterozygous CYP2C19*1/CYP2C19*2 subjects?
    • Bramness J.G., Skurtveit S., Fauske L., Grung M., Molven A., Morland J., Steen V.M. Association between blood carisoprodol:meprobamate concentration ratios and CYP2C19 genotype in carisoprodol-drugged drivers: decreased metabolic capacity in heterozygous CYP2C19*1/CYP2C19*2 subjects?. Pharmacogenetics 2003, 13:383-388.
    • (2003) Pharmacogenetics , vol.13 , pp. 383-388
    • Bramness, J.G.1    Skurtveit, S.2    Fauske, L.3    Grung, M.4    Molven, A.5    Morland, J.6    Steen, V.M.7
  • 110
    • 34548140526 scopus 로고    scopus 로고
    • Changing times: DNA resequencing and the " nearly normal autopsy"
    • Karch S.B. Changing times: DNA resequencing and the " nearly normal autopsy" J. Forensic Leg. Med. 2007, 14:389-397.
    • (2007) J. Forensic Leg. Med. , vol.14 , pp. 389-397
    • Karch, S.B.1
  • 111
    • 70249117523 scopus 로고    scopus 로고
    • Extracting evidence from forensic DNA analyses: future molecular biology directions
    • Budowle B., van D.A. Extracting evidence from forensic DNA analyses: future molecular biology directions. Biotechniques 2009, 46:339-350.
    • (2009) Biotechniques , vol.46 , pp. 339-350
    • Budowle, B.1    van, D.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.