Death of a 10-month-old boy after exposure to ethylmorphine

Journal of Forensic Sciences

Volumn 55, Issue 2, 2010, Pages 551-553

  Helland, Arne ^a   Isaksen, Christina V ^a,b   Slørdal, Lars ^a,b  

^a TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

Blood concentration; Child; Death; Ethylmorphine; Forensic science; Forensic toxicology; Infant; Morphine; Postmortem

Indexed keywords

CYTOCHROME P450 2D6; ETHYLMORPHINE; MORPHINE; NARCOTIC ANALGESIC AGENT;

AIRWAY OBSTRUCTION; ARTICLE; BLOOD; BODY POSTURE; BREATHING; CASE REPORT; DRUG EFFECT; FORENSIC TOXICOLOGY; GENETICS; GENOTYPE; HUMAN; INFANT; MALE; MASS FRAGMENTOGRAPHY; RESPIRATORY TRACT INFECTION; SLEEP;

AIRWAY OBSTRUCTION; ANALGESICS, OPIOID; CYTOCHROME P-450 CYP2D6; ETHYLMORPHINE; FORENSIC TOXICOLOGY; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GENOTYPE; HUMANS; INFANT; MALE; MORPHINE; POSTURE; RESPIRATION; RESPIRATORY TRACT INFECTIONS; SLEEP;

EID: 77649258025     PISSN: 00221198     EISSN: 15564029     Source Type: Journal    
DOI: 10.1111/j.1556-4029.2009.01294.x     Document Type: Article

References (12)

1. Chen ZR, Irvine RJ, Somogyi AA, Bochner F. Mu receptor binding of some commonly used opioids and their metabolites. Life Sci 1991 48 (22 2165 2171.
2. Aasmundstad TA, Xu BQ, Johansson I, Ripel A, Bjørneboe A, Christophersen AS, et al. Biotransformation and pharmacokinetics of ethylmorphine after a single oral dose. Br J Clin Pharmacol 1995 39 (6 611 620.
3. Kintz P, Jamey C, Mangin P. Ethylmorphine concentrations in human samples in an overdose case. Arch Toxicol 1994 68 (3 210 211.
4. Jonasson B, Jonasson U, Holmgren P, Saldeen T. Fatal poisonings where ethylmorphine from antitussive medications contributed to death. Int J Legal Med 1999 112 (5 299 302.
5. Koren G, Cairns J, Chitayat D, Gaedigk A, Leeder SJ. Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother. Lancet 2006 368 (9536 704.
6. Gourlay GK, Boas RA. Fatal outcome with use of rectal morphine for postoperative pain control in an infant. BMJ (Clinical research ed.) 1992 304 (6829 766 767.
7. Poklis A, Edinboro LE, Wohler AS, Presswalla F, Barron D. Fatal morphine poisoning in a child due to accidental oral ingestion. Forensic Sci Int 1995 76 (1 55 9.
8. Lynn AM, Nespeca MK, Opheim KE, Slattery JT. Respiratory effects of intravenous morphine infusions in neonates, infants, and children after cardiac surgery. Anesth Analg 1993 77 (4 695 701.
9. Bouwmeester NJ, Anderson BJ, Tibboel D, Holford NH. Developmental pharmacokinetics of morphine and its metabolites in neonates, infants and young children. Br J Anaesth 2004 92 (2 208 217.
10. Kearns GL, Abdel-Rahman SM, Alander SW, Blowey DL, Leeder JS, Kauffman RE. Developmental pharmacology - drug disposition, action, and therapy in infants and children. N Engl J Med 2003 349 (12 1157 1167.
11. Gerostamoulos J, Drummer OH. Postmortem redistribution of morphine and its metabolites. J Forensic Sci 2000 45 (4 843 845.
12. Logan BK, Smirnow D. Postmortem distribution and redistribution of morphine in man. J Forensic Sci 1996 41 (2 221 229.