Codeine in post-operative pain. Study of the influence of sparteine phenotype and serum concentrations of morphine and morphine-6-glucuronide

European Journal of Clinical Pharmacology

Volumn 54, Issue 6, 1998, Pages 451-454

  Poulsen, L ^a   Riishede, L ^b   Brosen, K ^a   Clemensen, S ^b   Sindrup, S H ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b Department of Anaesthesiology   (Denmark)

Author keywords

Codeine; Post operative pain

Indexed keywords

CODEINE; DRUG METABOLITE; MORPHINE; MORPHINE 6 GLUCURONIDE; SPARTEINE;

ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG URINE LEVEL; ELECTROCHEMICAL DETECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; ORAL DRUG ADMINISTRATION; PHENOTYPE; POSTOPERATIVE PAIN; PRIORITY JOURNAL; SPINAL ANESTHESIA;

ADULT; AGED; AGED, 80 AND OVER; ANALGESICS, OPIOID; CODEINE; FEMALE; HUMANS; MALE; MIDDLE AGED; MORPHINE; MORPHINE DERIVATIVES; PAIN, POSTOPERATIVE; PHENOTYPE; SPARTEINE;

EID: 0031679974     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002280050491     Document Type: Article

References (19)

1. Alván G, Bechtel P, Iselius L, Gundert-Remy U (1990) Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations. Eur J Clin Pharmacol 39: 533-537
2. Brosen K (1993) The pharmacogenetics of the selective serotonin reuptake inhibitors. Clin Investig 71: 1002-1009
3. Brøsen K, Gram LF (1989) Clinical significance of the sparteine/ debrisoquine oxidation polymorphism. Eur J Clin Pharmacol 36: 537-547
4. Brøsen K, Otton SV, Gram LF (1985) Sparteine oxidation polymorphism in Denmark. Acta Pharmacol Toxicol 57: 357-360
5. Desmeules J, Gascon M-P, Dayer P, Magistris M (1991) Impact of environmental and genetic factors on codeine analgesia. Eur J Clin Pharmacol 41: 23-26
6. Eichelbaum M, Spannbrucker N, Steincke B, Dengler HJ (1979) Defective N-oxidation of sparteine in man: a new pharmacogenetic defect. Eur J Clin Pharmacol 16: 183-187
7. Honig S, Murray KA (1984) An appraisal of codeine as an analgesic: single-dose analysis. J Clin Pharmacol 24: 96-102
8. Jochimsen PR, Noyes R (1978) Appraisal of codeine as an analgesic in older patients. J Am Geriatr Soc 26: 521-523
9. Persson K, Sjöström S, Sigurdardottir I, Molnar V, Hammarlund-Udenaes M, Rane A (1995) Patient-controlled analgesia (PCA) with codeine for postoperative pain relief in ten extensive and one poor metaboliser of dextromethorphan. Br J Clin Pharmacol 39: 182-186
10. Pert CB, Snyder SH (1973) Properties of opiate-receptor binding in rat brain. Proc Natl Acad Sci USA 70: 2243-2247
11. Poulsen L, Brøsen K, Arendt-Nielsen L, Gram LF, Elbæk K, Sindrup SH (1996) Codeine and morphine in extensive and poor metabolisers of sparteine: pharmacokinetics, analgesic effect and side effects. Eur J Clin Pharmacol 51: 289-295
12. Quiding H, Anderson P, Bondesson U, Boréus LO, Hynning P-A (1986) Plasma concentrations of codeine and its metabolite, morphine, after single and repeated oral administration. Eur J Clin Pharmacol 30: 673-677
13. Quiding H, Lundqvist G, Boréus LO, Bondesson U, Öhrvik J (1993) Analgesic effect and plasma concentrations of codeine and morphine after two dose levels of codeine following oral surgery. Eur J Clin Pharmacol 44: 319-323
14. Sanfilippo G (1948) Contributo sperimentale all'ipotesi della smetilazione della codeina nell'organismo.I. Influenza della dose sull'assuefazione alla codeina.II. Assuefazione alla codeina ottenuta con somministazione prolungata di morfina. Boll Soc Ital Biol Sper 24: 723-726
15. Sindrup SH, Brøsen K, Bjerring P, Arendt-Nielsen L, Larsen U, Angelo HR, Gram LF (1990) Codeine increases pain thresholds to copper vapor laser stimuli in extensive but not poor metabolizers of sparteine. Clin Pharmacol Ther 48: 686-693
16. Sindrup SH, Arendt-Nielsen L, Broøsen K, Bjerring P, Angelo HR, Eriksen B, Gram LF (1992) The effect of quinidine on the analgesic effect of codeine. Eur J Clin Pharmacol 42: 587-592
17. Yue QY, Svensson J-O, Alm C, Sjöqvist F, Säwe J (1989) Codeine O-demethylation co-segregates with polymorphic debrisoquine hydroxylation. Br J Clin Pharmacol 28: 639-645
18. Yue QY, Hasselström J, Svensson J-O, Säwe J (1991) Pharmacokinetics of codeine and its metabolites in Caucasian healthy volunteers: comparisons between extensive and poor hydroxylators of debrisoquine. Br J Clin Pharmacol 31: 635-642
19. Zanger UM, Vilbois F, Hardwick JP, Meyer UA (1988) Absence of hepatic cytochrome P450bufl causes genetically deficient debrisoquine oxidation in man. Biochemistry 27: 5447-5454