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Volumn 429, Issue 6990, 2004, Pages 464-468

Moving towards individualized medicine with pharmacogenomics

Author keywords

[No Author keywords available]

Indexed keywords

DNA SEQUENCES; DRUG PRODUCTS; DRUG THERAPY; GENES; MOLECULAR DYNAMICS; OPTIMIZATION; PROTEINS;

EID: 2642570170     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02626     Document Type: Review
Times cited : (646)

References (30)
  • 1
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenomics: Translating functional genomics into rational therapeutics
    • Evans, W. E. & Relling, M. V. Pharmacogenomics: translating functional genomics into rational therapeutics. Science 286, 487-491 (1999).
    • (1999) Science , vol.286 , pp. 487-491
    • Evans, W.E.1    Relling, M.V.2
  • 2
    • 0024523831 scopus 로고
    • Pharmacogenetic perspectives gained from twin and family studies
    • Vesell, E. S. Pharmacogenetic perspectives gained from twin and family studies. Pharmacol. Ther. 41, 535-552 (1989).
    • (1989) Pharmacol. Ther. , vol.41 , pp. 535-552
    • Vesell, E.S.1
  • 3
    • 0032416603 scopus 로고    scopus 로고
    • Twenty years of biochemistry of human P450s: Purification, expression, mechanism, and relevance to drugs
    • Guengerich F. P. et al. Twenty years of biochemistry of human P450s: purification, expression, mechanism, and relevance to drugs. Drug Metab. Dispos. 26, 1175-1178 (1998).
    • (1998) Drug Metab. Dispos. , vol.26 , pp. 1175-1178
    • Guengerich, F.P.1
  • 4
    • 0030995879 scopus 로고    scopus 로고
    • Molecular mechanisms of genetic polymorphisms of drug metabolism
    • Meyer, U. A. & Zanger, U. M. Molecular mechanisms of genetic polymorphisms of drug metabolism. Annu. Rev. Pharmacol. Toxicol. 37, 269-296 (1997).
    • (1997) Annu. Rev. Pharmacol. Toxicol. , vol.37 , pp. 269-296
    • Meyer, U.A.1    Zanger, U.M.2
  • 5
    • 0023854270 scopus 로고
    • Characterization of the common genetic defect in humans deficient in debrisoquine metabolism
    • Gonzalez, F. J. et al. Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. Nature 331, 442-446 (1988).
    • (1988) Nature , vol.331 , pp. 442-446
    • Gonzalez, F.J.1
  • 6
    • 0035775486 scopus 로고    scopus 로고
    • Pharmacogenomics: The inherited basis for interindividual differences in drug response
    • Evans, W. E. & Johnson, J. A. Pharmacogenomics: the inherited basis for interindividual differences in drug response. Annu. Rev. Genomics Hum. Genet. 2, 9-39 (2001).
    • (2001) Annu. Rev. Genomics Hum. Genet. , vol.2 , pp. 9-39
    • Evans, W.E.1    Johnson, J.A.2
  • 7
    • 0037421584 scopus 로고    scopus 로고
    • Inheritance and drug response
    • Weinshilboum, R. Inheritance and drug response. N. Engl. J. Med. 348, 529-537 (2003).
    • (2003) N. Engl. J. Med. , vol.348 , pp. 529-537
    • Weinshilboum, R.1
  • 8
    • 0037421590 scopus 로고    scopus 로고
    • Pharmacogenomics-drug disposition, drug targets, and side effects
    • Evans, W. E. & McLeod, H. L. Pharmacogenomics-drug disposition, drug targets, and side effects. N. Engl. J. Med. 348, 538-549 (2003).
    • (2003) N. Engl. J. Med. , vol.348 , pp. 538-549
    • Evans, W.E.1    McLeod, H.L.2
  • 9
    • 0035871560 scopus 로고    scopus 로고
    • Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine
    • Evans W. E. et al. Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine. J. Clin. Oncol. 19, 2293-2301 (2001).
    • (2001) J. Clin. Oncol. , vol.19 , pp. 2293-2301
    • Evans, W.E.1
  • 10
    • 0025837127 scopus 로고
    • Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyl transferase-deficient child with acute lymphocytic leukemia
    • Evans, W. E., Horner, M., Chu, Y. Q., Kalwinsky, D. & Roberts, W. M. Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyl transferase-deficient child with acute lymphocytic leukemia. J. Pediatr. 119, 985-989 (1991).
    • (1991) J. Pediatr. , vol.119 , pp. 985-989
    • Evans, W.E.1    Horner, M.2    Chu, Y.Q.3    Kalwinsky, D.4    Roberts, W.M.5
  • 11
    • 0142240380 scopus 로고    scopus 로고
    • Preventing toxicity with a gene test
    • Marshall, E. Preventing toxicity with a gene test. Science 302, 588-590 (2003).
    • (2003) Science , vol.302 , pp. 588-590
    • Marshall, E.1
  • 12
    • 0242363251 scopus 로고    scopus 로고
    • With your genes? Take one of these, three times a day
    • Abbott, A. With your genes? Take one of these, three times a day. Nature 425, 760-762 (2003).
    • (2003) Nature , vol.425 , pp. 760-762
    • Abbott, A.1
  • 13
    • 0035861049 scopus 로고    scopus 로고
    • Potential role of pharmacogenomics in reducing adverse drug reactions: A Systematic review
    • Phillips, K. A., Veenstra, D. L., Oren, E., Lee, J. K. & Sadee, W. Potential role of pharmacogenomics in reducing adverse drug reactions: a Systematic review. J. Am. Med. Assoc. 286, 2270-2279 (2001).
    • (2001) J. Am. Med. Assoc. , vol.286 , pp. 2270-2279
    • Phillips, K.A.1    Veenstra, D.L.2    Oren, E.3    Lee, J.K.4    Sadee, W.5
  • 16
    • 0032793249 scopus 로고    scopus 로고
    • Polymorphic human cytochrome P450 enzymes: An opportunity for individualized drug treatment
    • Ingelman-Sundberg, M., Oscarson, M. & McLellan, R. A. Polymorphic human cytochrome P450 enzymes: an opportunity for individualized drug treatment. Trends Pharmacol. Sci. 20, 342-349 (1999).
    • (1999) Trends Pharmacol. Sci. , vol.20 , pp. 342-349
    • Ingelman-Sundberg, M.1    Oscarson, M.2    McLellan, R.A.3
  • 17
    • 0037738513 scopus 로고    scopus 로고
    • Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells
    • Cheok, M. H. et al. Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells. Nature Genet. 34, 85-90 (2003).
    • (2003) Nature Genet. , vol.34 , pp. 85-90
    • Cheok, M.H.1
  • 18
    • 0035895258 scopus 로고    scopus 로고
    • High-throughput development and characterization of a genomewide collection of gene-based single nucleotide polymorphism markers by chip-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
    • Buetow, K. H. et al. High-throughput development and characterization of a genomewide collection of gene-based single nucleotide polymorphism markers by chip-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Proc. Natl Acad. Sci. USA 98, 581-584 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 581-584
    • Buetow, K.H.1
  • 19
    • 0035860969 scopus 로고    scopus 로고
    • Clinical proteomics: Personalized molecular medicine
    • Liotta, L. A., Kohn, E. C. & Petricoin, E. F. Clinical proteomics: personalized molecular medicine. J. Am. Med. Assoc. 286, 2211-2214 (2001).
    • (2001) J. Am. Med. Assoc. , vol.286 , pp. 2211-2214
    • Liotta, L.A.1    Kohn, E.C.2    Petricoin, E.F.3
  • 20
    • 0038239933 scopus 로고    scopus 로고
    • Mining the genome for combination therapies
    • Golub, T. R. Mining the genome for combination therapies. Nature Med. 9, 510-511 (2003).
    • (2003) Nature Med. , vol.9 , pp. 510-511
    • Golub, T.R.1
  • 21
    • 1442335997 scopus 로고    scopus 로고
    • Gene expression-based high-throughput screening (GE-HTS) and application to leukemia differentiation
    • Stegmaier, K. et al. Gene expression-based high-throughput screening (GE-HTS) and application to leukemia differentiation. Nature Genet. 36, 257-263 (2004).
    • (2004) Nature Genet. , vol.36 , pp. 257-263
    • Stegmaier, K.1
  • 22
    • 1442311573 scopus 로고    scopus 로고
    • Gene expression as a drug discovery tool
    • Evans, W. E. & Guy, R. K. Gene expression as a drug discovery tool. Nature Genet. 36, 214-215 (2004).
    • (2004) Nature Genet. , vol.36 , pp. 214-215
    • Evans, W.E.1    Guy, R.K.2
  • 23
    • 0037006623 scopus 로고    scopus 로고
    • Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir
    • Mallal, S. et al. Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir. Lancet 359, 727-732 (2002).
    • (2002) Lancet , vol.359 , pp. 727-732
    • Mallal, S.1
  • 24
    • 0035071598 scopus 로고    scopus 로고
    • Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
    • Kuehl, P. et al. Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nature Genet. 27, 393-391 (2001).
    • (2001) Nature Genet. , vol.27 , pp. 393-391
    • Kuehl, P.1
  • 25
    • 0142209382 scopus 로고    scopus 로고
    • Race and medicine
    • Holden, C. Race and medicine. Science 302, 594-596 (2003).
    • (2003) Science , vol.302 , pp. 594-596
    • Holden, C.1
  • 26
    • 2642516920 scopus 로고    scopus 로고
    • Genetic structure of human populations
    • Rosenberg, N. A. et al. Genetic structure of human populations. Science 299, 2391-2395 (2002).
    • (2002) Science , vol.299 , pp. 2391-2395
    • Rosenberg, N.A.1
  • 27
    • 0037456772 scopus 로고    scopus 로고
    • The importance of race and ethnic background in biomedical research and clinical practice
    • Burchard, E. G. et al. The importance of race and ethnic background in biomedical research and clinical practice. N. Engl. J Med. 348, 1170-1175 (2003).
    • (2003) N. Engl. J Med. , vol.348 , pp. 1170-1175
    • Burchard, E.G.1
  • 28
    • 85046979445 scopus 로고    scopus 로고
    • Genetic testing for BRCA1 mutation in the UK
    • Eccles, D. M. Genetic testing for BRCA1 mutation in the UK. Lancet 361, 178-179 (2003).
    • (2003) Lancet , vol.361 , pp. 178-179
    • Eccles, D.M.1
  • 29
    • 0037246618 scopus 로고    scopus 로고
    • Indexing pharmacogenetic knowledge on the World Wide Web
    • Altman, R. B. et al. Indexing pharmacogenetic knowledge on the World Wide Web. Pharmacogenetics 13, 3-5 (2003).
    • (2003) Pharmacogenetics , vol.13 , pp. 3-5
    • Altman, R.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.