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Volumn 158, Issue 2-3, 2006, Pages 177-183

CYP2D6 and CYP2C19 genotypes and amitriptyline metabolite ratios in a series of medicolegal autopsies

Author keywords

Amitriptyline; CYP2C19 gene; CYP2D6 gene; Forensic; Pharmacogenetics; Toxicology

Indexed keywords

AMITRIPTYLINE; CYTOCHROME P450 2C19; CYTOCHROME P450 2D6; DRUG METABOLITE;

EID: 33645034693     PISSN: 03790738     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.forsciint.2005.05.032     Document Type: Article
Times cited : (47)

References (31)
  • 1
    • 0035137253 scopus 로고    scopus 로고
    • Amitriptyline v. the rest: Still the leading antidepressant after 40 years of randomised controlled trials
    • C. Barbui, and M. Hotopf Amitriptyline v. the rest: still the leading antidepressant after 40 years of randomised controlled trials Br. J. Psychiatry 178 2001 129 144
    • (2001) Br. J. Psychiatry , vol.178 , pp. 129-144
    • Barbui, C.1    Hotopf, M.2
  • 3
    • 0030735733 scopus 로고    scopus 로고
    • Metabolism of the tricyclic antidepressant amitriptyline by cDNA-expressed human cytochrome P450 enzymes
    • O.V. Olesen, and K. Linnet Metabolism of the tricyclic antidepressant amitriptyline by cDNA-expressed human cytochrome P450 enzymes Pharmacology 55 5 1997 235 243
    • (1997) Pharmacology , vol.55 , Issue.5 , pp. 235-243
    • Olesen, O.V.1    Linnet, K.2
  • 5
    • 0036327723 scopus 로고    scopus 로고
    • The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients
    • K. Shimoda, T. Someya, A. Yokono, S. Morita, G. Hirokane, S. Takahashi, and M. Okawa The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients J. Clin. Psychopharmacol. 22 4 2002 371 378
    • (2002) J. Clin. Psychopharmacol. , vol.22 , Issue.4 , pp. 371-378
    • Shimoda, K.1    Someya, T.2    Yokono, A.3    Morita, S.4    Hirokane, G.5    Takahashi, S.6    Okawa, M.7
  • 6
    • 0019449455 scopus 로고
    • E- and Z-10-hydroxylation of nortriptyline: Relationship to polymorphic debrisoquine hydroxylation
    • B. Mellström, L. Bertilsson, J. Sawe, H.U. Schulz, and F. Sjöqvist E- and Z-10-hydroxylation of nortriptyline: relationship to polymorphic debrisoquine hydroxylation Clin. Pharmacol. Ther. 30 2 1981 189 193
    • (1981) Clin. Pharmacol. Ther. , vol.30 , Issue.2 , pp. 189-193
    • Mellström, B.1    Bertilsson, L.2    Sawe, J.3    Schulz, H.U.4    Sjöqvist, F.5
  • 7
    • 0020309115 scopus 로고
    • Steady-state plasma concentrations of cis- and trans-10-OH amitriptyline metabolites
    • J.L. Bock, E. Giller, S. Gray, and P. Jatlow Steady-state plasma concentrations of cis- and trans-10-OH amitriptyline metabolites Clin. Pharmacol. Ther. 31 5 1982 609 616
    • (1982) Clin. Pharmacol. Ther. , vol.31 , Issue.5 , pp. 609-616
    • Bock, J.L.1    Giller, E.2    Gray, S.3    Jatlow, P.4
  • 8
    • 0020287098 scopus 로고
    • Simultaneous determination of amitriptyline, nortriptyline and their respective isomeric 10-hydroxy metabolites in plasma by liquid chromatography
    • R.F. Suckow, and T.B. Cooper Simultaneous determination of amitriptyline, nortriptyline and their respective isomeric 10-hydroxy metabolites in plasma by liquid chromatography J. Chromatogr. 230 2 1982 391 400
    • (1982) J. Chromatogr. , vol.230 , Issue.2 , pp. 391-400
    • Suckow, R.F.1    Cooper, T.B.2
  • 9
    • 0025341399 scopus 로고
    • Enantiomer analysis of E- and Z-10-hydroxyamitriptyline in human urine
    • E. Nusser, K. Nill, and U. Breyer-Pfaff Enantiomer analysis of E- and Z-10-hydroxyamitriptyline in human urine J. Chromatogr. 528 1 1990 163 171
    • (1990) J. Chromatogr. , vol.528 , Issue.1 , pp. 163-171
    • Nusser, E.1    Nill, K.2    Breyer-Pfaff, U.3
  • 10
    • 2942674322 scopus 로고    scopus 로고
    • Some aspects of genetic polymorphism in the biotransformation of antidepressants
    • K. Brøsen Some aspects of genetic polymorphism in the biotransformation of antidepressants Thérapie 59 1 2004 5 12
    • (2004) Thérapie , vol.59 , Issue.1 , pp. 5-12
    • Brøsen, K.1
  • 11
    • 3142519666 scopus 로고    scopus 로고
    • Pharmacogenetics of antidepressants and antipsychotics: The contribution of allelic variations to the phenotype of drug response
    • J. Kirchheiner, K. Nickchen, M. Bauer, M.L. Wong, J. Licinio, I. Roots, and J. Brockmoller Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response Mol. Psychiatry 9 5 2004 442 473
    • (2004) Mol. Psychiatry , vol.9 , Issue.5 , pp. 442-473
    • Kirchheiner, J.1    Nickchen, K.2    Bauer, M.3    Wong, M.L.4    Licinio, J.5    Roots, I.6    Brockmoller, J.7
  • 14
    • 0034059585 scopus 로고    scopus 로고
    • Fluoxetine-related death in a child with cytochrome P-450 2D6 genetic deficiency
    • F.R. Sallee, C.L. DeVane, and R.E. Ferrell Fluoxetine-related death in a child with cytochrome P-450 2D6 genetic deficiency J. Child. Adolesc. Psychopharmacol. 10 1 2000 27 34
    • (2000) J. Child. Adolesc. Psychopharmacol. , vol.10 , Issue.1 , pp. 27-34
    • Sallee, F.R.1    Devane, C.L.2    Ferrell, R.E.3
  • 15
    • 0032917451 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 (CYP2D6) genotyping on postmortem blood as a supplementary tool for interpretation of forensic toxicological results
    • H. Druid, P. Holmgren, B. Carlsson, and J. Ahlner Cytochrome P450 2D6 (CYP2D6) genotyping on postmortem blood as a supplementary tool for interpretation of forensic toxicological results Forensic Sci. Int. 99 1 1999 25 34
    • (1999) Forensic Sci. Int. , vol.99 , Issue.1 , pp. 25-34
    • Druid, H.1    Holmgren, P.2    Carlsson, B.3    Ahlner, J.4
  • 18
    • 0036825844 scopus 로고    scopus 로고
    • Pharmacogenomics as molecular autopsy for postmortem forensic toxicology: Genotyping cytochrome P450 2D6 for oxycodone cases
    • P.J. Jannetto, S.H. Wong, S.B. Gock, E. Laleli-Sahin, B.C. Schur, and J.M. Jentzen Pharmacogenomics as molecular autopsy for postmortem forensic toxicology: genotyping cytochrome P450 2D6 for oxycodone cases J. Anal. Toxicol. 26 7 2002 438 447
    • (2002) J. Anal. Toxicol. , vol.26 , Issue.7 , pp. 438-447
    • Jannetto, P.J.1    Wong, S.H.2    Gock, S.B.3    Laleli-Sahin, E.4    Schur, B.C.5    Jentzen, J.M.6
  • 19
    • 0043127371 scopus 로고    scopus 로고
    • Postmortem SNP analysis of CYP2D6 gene reveals correlation between genotype and opioid drug (tramadol) metabolite ratios in blood
    • A. Levo, A. Koski, I. Ojanperä, E. Vuori, and A. Sajantila Postmortem SNP analysis of CYP2D6 gene reveals correlation between genotype and opioid drug (tramadol) metabolite ratios in blood Forensic Sci. Int. 135 1 2003 9 15
    • (2003) Forensic Sci. Int. , vol.135 , Issue.1 , pp. 9-15
    • Levo, A.1    Koski, A.2    Ojanperä, I.3    Vuori, E.4    Sajantila, A.5
  • 20
    • 0242526177 scopus 로고    scopus 로고
    • Pharmacogenomics as an aspect of molecular autopsy for forensic pathology/toxicology: Does genotyping CYP 2D6 serve as an adjunct for certifying methadone toxicity?
    • S.H. Wong, M.A. Wagner, J.M. Jentzen, C. Schur, J. Bjerke, S.B. Gock, and C.C. Chang Pharmacogenomics as an aspect of molecular autopsy for forensic pathology/toxicology: does genotyping CYP 2D6 serve as an adjunct for certifying methadone toxicity? J. Forensic. Sci. 48 6 2003 1406 1415
    • (2003) J. Forensic. Sci. , vol.48 , Issue.6 , pp. 1406-1415
    • Wong, S.H.1    Wagner, M.A.2    Jentzen, J.M.3    Schur, C.4    Bjerke, J.5    Gock, S.B.6    Chang, C.C.7
  • 21
    • 0033590590 scopus 로고    scopus 로고
    • Genetic mechanisms for duplication and multiduplication of the human CYP2D6 gene and methods for detection of duplicated CYP2D6 genes
    • E. Lundqvist, I. Johansson, and M. Ingelman-Sundberg Genetic mechanisms for duplication and multiduplication of the human CYP2D6 gene and methods for detection of duplicated CYP2D6 genes Gene 226 2 1999 327 338
    • (1999) Gene , vol.226 , Issue.2 , pp. 327-338
    • Lundqvist, E.1    Johansson, I.2    Ingelman-Sundberg, M.3
  • 22
    • 0007293059 scopus 로고    scopus 로고
    • Ultrarapid metabolizers of debrisoquine: Characterization and PCR-based detection of alleles with duplication of the CYP2D6 gene
    • R. Løvlie, A.K. Daly, A. Molven, J.R. Idle, and V.M. Steen Ultrarapid metabolizers of debrisoquine: characterization and PCR-based detection of alleles with duplication of the CYP2D6 gene FEBS Lett. 392 1996 30 34
    • (1996) FEBS Lett. , vol.392 , pp. 30-34
    • Løvlie, R.1    Daly, A.K.2    Molven, A.3    Idle, J.R.4    Steen, V.M.5
  • 25
    • 23444450271 scopus 로고    scopus 로고
    • CYP2D6 genotyping by a multiplex primer extension reaction
    • doi:10.1373/clinchem.2004.046466.
    • J. Sistonen, S. Fuselli, A. Levo, A. Sajantila, CYP2D6 genotyping by a multiplex primer extension reaction. Clin. Chem. (2005), doi:10.1373/clinchem. 2004.046466.
    • (2005) Clin. Chem.
    • Sistonen, J.1    Fuselli, S.2    Levo, A.3    Sajantila, A.4
  • 26
    • 0347767428 scopus 로고    scopus 로고
    • The advantage of dual-column approach and retention indices combined with refined reporting in gas chromatographic drug screening
    • I. Rasanen, I. Ojanperä, J. Vartiovaara, E. Vuori, and P. Sunila The advantage of dual-column approach and retention indices combined with refined reporting in gas chromatographic drug screening J. High Resolut. Chromatogr. 19 6 1996 313 321
    • (1996) J. High Resolut. Chromatogr. , vol.19 , Issue.6 , pp. 313-321
    • Rasanen, I.1    Ojanperä, I.2    Vartiovaara, J.3    Vuori, E.4    Sunila, P.5
  • 27
    • 0030860004 scopus 로고    scopus 로고
    • Polymorphism of the P450 CYP2D6 gene in a European population: Characterization of 48 mutations and 53 alleles, their frequencies and evolution
    • D. Marez, M. Legrand, N. Sabbagh, J.M. Guidice, C. Spire, J.J. Lafitte, U.A. Meyer, and F. Broly Polymorphism of the P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution Pharmacogenetics 7 3 1997 193 202
    • (1997) Pharmacogenetics , vol.7 , Issue.3 , pp. 193-202
    • Marez, D.1    Legrand, M.2    Sabbagh, N.3    Guidice, J.M.4    Spire, C.5    Lafitte, J.J.6    Meyer, U.A.7    Broly, F.8
  • 28
    • 0031038038 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences
    • C. Sachse, J. Brockmöller, S. Bauer, and I. Roots Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences Am. J. Hum. Genet. 60 2 1997 284 295
    • (1997) Am. J. Hum. Genet. , vol.60 , Issue.2 , pp. 284-295
    • Sachse, C.1    Brockmöller, J.2    Bauer, S.3    Roots, I.4
  • 30
    • 0036223831 scopus 로고    scopus 로고
    • Summary of information on human CYP enzymes: Human P450 metabolism data
    • S. Rendic Summary of information on human CYP enzymes: human P450 metabolism data Drug Metab. Rev. 34 1-2 2002 83 448
    • (2002) Drug Metab. Rev. , vol.34 , Issue.1-2 , pp. 83-448
    • Rendic, S.1
  • 31
    • 4344613464 scopus 로고    scopus 로고
    • Allele-specific change of concentration and functional gene dose for the prediction of steady-state serum concentrations of amitriptyline and nortriptyline in CYP2C19 and CYP2D6 extensive and intermediate metabolizers
    • W. Steimer, K. Zopf, S. von Amelunxen, H. Pfeiffer, J. Bachofer, J. Popp, B. Messner, W. Kissling, and S. Leucht Allele-specific change of concentration and functional gene dose for the prediction of steady-state serum concentrations of amitriptyline and nortriptyline in CYP2C19 and CYP2D6 extensive and intermediate metabolizers Clin. Chem. 50 9 2004 1623 1633
    • (2004) Clin. Chem. , vol.50 , Issue.9 , pp. 1623-1633
    • Steimer, W.1    Zopf, K.2    Von Amelunxen, S.3    Pfeiffer, H.4    Bachofer, J.5    Popp, J.6    Messner, B.7    Kissling, W.8    Leucht, S.9


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