Extracting evidence from forensic DNA analyses: Future molecular biology directions

BioTechniques

Volumn 46, Issue 5 SPEC. ISSUE, 2009, Pages 339-350

  Budowle, Bruce ^a   Van Daal, Angela ^b  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

^b BOND UNIVERSITY   (Australia)

Author keywords

Automation; Databases; Forensic science; Low copy number; Microbial forensics; Microfluidics; Mini STRs; Molecular biology; SNPs

Indexed keywords

DNA FRAGMENT; DNA;

DNA DETERMINATION; DNA EXTRACTION; DNA FINGERPRINTING; DNA SEQUENCE; FORENSIC GENETICS; HIGH THROUGHPUT SCREENING; POLYMERASE CHAIN REACTION; REVIEW; ROBOTICS; AUTOMATION; FORENSIC SCIENCE; GENE EXPRESSION PROFILING; GENETIC DATABASE; GENETICS; HUMAN; METHODOLOGY; MOLECULAR BIOLOGY; PHARMACOGENETICS; TISSUE MICROARRAY;

AUTOMATION; DATABASES, GENETIC; DNA; FORENSIC SCIENCES; GENE EXPRESSION PROFILING; HUMANS; MOLECULAR BIOLOGY; PHARMACOGENETICS; SEQUENCE ANALYSIS, DNA; TISSUE ARRAY ANALYSIS;

EID: 70249117523     PISSN: 07366205     EISSN: None     Source Type: Journal    
DOI: 10.2144/000113136     Document Type: Review

References (101)

1. Budowle, B. and A.J. Eisenberg. 2007. Forensic Genetics, p.501-517. In D.L.Rimoin, J.M.Connor, R.E. Pyeritz, and B.R. Korf (Eds.), Emery and Rimoin's Principles and Practice of Medical Genetics, 5th ed. Vol. 1. Elsevier, Philadelphia.
2. Budowle, B., J.V. Planz, R. Campbell, and A.J. Eisenberg. 2005. Molecular diagnostic applications in forensic science, p. 267-280. In G.Patrinos and W. Ansorge (Eds.), Molecular Diagnostics. Elsevier, Amsterdam.
3. Budowle, B. and A. van Daal. 2008. Forensically relevant SNP classes. BioTechniques 44:603-610.
4. Budowle, B., H.A. Deadman, R.S. Murch, and F.S. Baechtel. 1988. An introduction to the methods of DNA analysis under investigation in the FBI Laboratory. Crime Lab. Dig. 15:8-21.
5. Scientific Working Group on DNA Analysis Methods (SWGDAM). 2004. Revised Validation Guidelines. Forensic Sci. Commun. 6 http://www.fbi.gov/hq/lab/fsc/ backissu/july2004/standards/2004-03-standards02.htm).
6. Budowle, B. and F.S. Baechtel. 1990. Modifications to improve the effectiveness of restriction fragment length polymorphism typing. Appl. Theor. Electrophor. 1:181-187.
7. Gill, P., A.J. Jeffreys, and D.J. Werrett. 1985. Forensic application of DNA fingerprints. Nature 318:577-579.
8. Jeffreys, A.J., V. Wilson, and S.L. Thein. 1985. Hypervariable minisatellite regions in human DNA. Nature 314:67-73.
9. Budowle, B., R. Chakraborty, A.M. Giusti, A.J. Eisenberg, and R.C. Allen. 1991. Analysis of the VNTR locus D1S80 by the PCR followed by high-resolution PAGE. Am. J. Hum. Genet. 48:137-144.
10. Budowle, B., J.A. Smith, T. Moretti, and J. DiZinno. 2000. DNA Typing Protocols: Molecular Biology and Forensic Analysis. Eaton Publishing Company/BioTechniques Books, Natick, MA.
11. Collins, P.J., L.K. Hennessy, C.S. Leibelt, R.K. Roby, D.J. Reeder, and P.A. Foxall. 2004. Developmental validation of a single-tube amplification of the 13 CODIS STR loci, D2S1338, D19S433, and amelogenin: the AmpFlSTR Indentifiler PCR Amplification Kit. J. Forensic Sci. 49:1265-1277.
12. Green, R.L., I.C. Roinestad, C. Boland, and L.K. Hennessy. 2005. Developmental validation of the Quantifiler Real-Time PCR Kits for the quantification of human nuclear DNA samples. J. Forensic Sci. 50:809-825. (Pubitemid 40917796)
13. Kayser, M., P. de Knijff, P. Dieltjes, M. Krawczak, M. Nagy, T. Zerjal, A. Pandya, C. Tyler-Smith, and L. Roewer. 1997. Applications of microsatellite-based Y chromosome haplotyping. Electrophoresis 18:1602-1607.
14. Kimpton, C.P., P. Gill, A. Walton, A. Urquhart, E.S. Millican, and M. Adams. 1993. Automated DNA profiling employing multiplex amplification of short tandem repeat loci. PCR Methods Appl. 3:13-22.
15. Krenke, B.E., A. Tereba, S.J. Anderson, E. Buel, S. Culhane, C.J. Finis, C.S. Tomsey, J.M. Zachetti, et al. 2002. Validation of a 16-locus fluorescent multiplex system. J. Forensic Sci. 47:773-785.
16. Moretti, T.R., A.L. Baumstark, D.A. Defenbaugh, K.M. Keys, and B. Budowle. 2001. Validation of short tandem repeats (STRs) for forensic usage: performance testing of fluorescent multiplex STR systems and analysis of authentic and simulated forensic samples. J. Forensic Sci. 46:647-660.
17. Wilson, M.R., J.A. DiZinno, D. Polanskey, J. Replogle, and B. Budowle. 1995. Validation of mitochondrial DNA sequencing for forensic casework analysis. Int. J. Legal Med. 108:68-74.
18. Budowle, B., T.R. Moretti, S.J. Niezgoda, and B.L. Brown. 1998. CODIS and PCR-based short tandem repeat loci: law enforcement tools, pp. 73-88. Proceedings from the Second European Symposium on Human Identification 1998. Promega Corporation, Madison.
19. Martin, P.D., H. Schmitter, and P.M. Schneider. 2001. A brief history of the formation of DNA databases in forensic science within Europe. Forensic Sci. Int. 119:225-231.
20. CODIS - NDIS Statistics. Federal Bureau of Investigation. (http://www.fbi.gov/hq/lab/codis/clickmap.htm).
21. Budowle, B., M.W. Allard, M.R. Wilson, and R. Chakraborty. 2003. Forensics and mitochondrial DNA: applications, debates, and foundations. Annu. Rev. Genomics Hum. Genet. 4:119-141.
22. Findlay, I., R. Frazier, A. Taylor, and A. Urquhart. 1997. Single cell DNA fingerprinting for forensic applications. Nature 389:555-556.
23. van Oorschot, R.A. and M.K. Jones. 1997. DNA fingerprints from fingerprints. Nature 387:767.
24. Budowle, B., D.L. Hobson, J.B. Smerick, and J.A. Smith. L. 2001. Low copy number: consideration and caution, p. 1-9. Proceedings from the Twelfth International Symposium on Human Identification 2001, Promega Corporation, Madison. (http://www.promega.com/geneticidproc/ussymp12proc/contents/budowle. pdf).
25. Gill, P., J. Whitaker, C. Flaxman, N. Brown, and J. Buckleton. 2000. An investigation of the rigor of interpretation rules for STRs derived from less than 100 pg of DNA. Forensic Sci. Int. 112:17-40.
26. Barbaro, A., G. Falcone, and A. Barbaro. 2000. DNA typing from hair shaft. Prog. Forensic Genet. 8:523-525.
27. Kloosterman, A.D. and P. Kersbergen. 2003. Efficacy and limits of genotyping low copy number (LCN) DNA samples by multiplex PCR of STR loci. J. Soc. Biol. 197:351-359.
28. Wiegand, P. and M. Kleiber. 1997. DNA typing of epithelial cells after strangulation. Int. J. Legal Med. 110:181-183.
29. Shaw, K., I. Sesardic, N. Bristol, C. Ames, K. Dagnall, C. Ellis, F. Whittaker, and B. Daniel. 2008. Comparison of the effects of sterilization techniques on subsequent DNA profiling. Int. J. Legal Med. 122:29-33.
30. Caddy, B., D.R. Taylor, and A.M.T. Lincare. 2008. A review of the science of low template DNA analysis, p. 1-35. (http://police.homeoffice.gov.uk/ publications/operational-policing/Review-of-Low-Template-DNA-1.pdf?view=Binary).
31. Hochmeister, M.N., B. Budowle, U.V. Borer, U.T. Eggmann, C.T. Comey, and R. Dirnhofer. 1991. Typing of DNA extracted from compact bone tissue from human remains. J. Forensic Sci. 36:1649-1661.
32. Dean, F.B., S. Hosono, L. Fang, X. Wu, A.F. Faruqi, P. Bray-Ward, Z. Sun, Q. Zong, et al. 2002. Comprehensive human genome amplification using multiple displacement amplification. Proc. Natl. Acad. Sci. USA 99:5261-5266.
33. Detter, J.C., J.M. Jett, S.M. Lucas, E. Dalin, A.R. Arellano, M. Wang, J.R. Nelson, J. Chapman, et al. 2002. Isothermal strand-displacement amplification applications for high-throughput genomics. Genomics 80:691-698.
34. Polidoros, A.N., K. Pasentsis, and A.S. Tsaftaris. 2006. Rolling circle amplification-RACE: a method for simultaneous isolation of 5′ and 3′ cDNA ends from amplified cDNA templates. BioTechniques 41:35-42.
35. Nunez, A.N., M.F. Kavlick, J.M. Robertson, and B. Budowle. 2008. Application of circular ligase to provide template for rolling circle amplification of low amounts of fragmented DNA, p. 1-7. Nineteenth International Symposium on Human Identification 2008, Promega Corporation, Madison. (http://www.promega.com/geneticidproc/ussymp19proc/oralpresentations/Nunez.pdf).
36. Hellmann, A., U. Rohleder, H. Schmitter, and M. Wittig. 2001. STR typing of human telogen hairs: a new approach. Int. J. Legal Med. 114:269-273.
37. Mulero, J.J., C.W. Chang, R.E. Lagacé, D.Y. Wang, J.L. Bas, T.P. McMahon, and L.K. Hennessy. 2008. Development and validation of the AmpFlSTR MiniFiler PCR Amplification Kit: a MiniSTR multiplex for the analysis of degraded and/or PCR inhibited DNA. J. Forensic Sci. 53:838-852.
38. Gill, P., L. Fereday, N. Morling, and P.M. Schneider. 2006. The evolution of DNA databases - recommendations for new European STR loci. Forensic Sci. Int. 156:242-244.
39. Ecker, D.J., R. Sampath, C. Massire, L.B. Blyn, T.A. Hall, M.W. Eshoo, and S.A. Hofstadler. 2008. Ibis T5000: a universal biosensor approach for microbiology. Nat. Rev. Microbiol. 6:553-558.
40. Hall, T.A., B. Budowle, Y. Jiang, L. Blyn, M. Eshoo, K.A. Sannes-Lowery, R. Sampath, J.J. Drader, et al. 2005. Base composition analysis of human mitochondrial DNA using electrospray ionization mass spectrometry: a novel tool for the identification and differentiation of humans. Anal. Biochem. 344:53-69.
41. Honisch, C., Y. Chen, C. Mortimer, C. Arnold, O. Schmidt, D. van den Boom, C.R. Cantor, H.N. Shah, and S.E. Gharbia. 2007. Automated comparative sequence analysis by base-specific cleavage and mass spectrometry for nucleic acid-based microbial typing. Proc. Natl. Acad. Sci. USA 104:10649-10654.
42. Köster, H., K. Tang, D.J. Fu, A. Braun, D. van den Boom, C.L. Smith, R.J. Cotter, and C.R. Cantor. 1996. A strategy for rapid and efficient DNA sequencing by mass spectrometry. Nat. Biotechnol. 14:1123-1128.
43. Sampath, R., T.A. Hall, C. Massire, F. Li, L.B. Blyn, M.W. Eshoo, S.A. Hofstadler, and D.J. Ecker. 2007. Rapid identification of emerging infectious agents using PCR and electrospray ionization mass spectrometry. Ann. N. Y. Acad. Sci. 1102:109-120.
44. Lunetta, P., A. Levo, A. Mannikko, A. Pentilla, and A. Sajantila. 2002. Death in a bathtub revisited with molecular genetics: a victim with suicidal traits and a LQTS gene mutation. Forensic Sci. Int. 130:122-124.
45. Sistonen, J., S. Fuselli, J.U. Palo, N. Chauhan, H. Padh, and A. Sajantila. 2009. Pharmacogenetic variation at CYP2C9, CYP2C19, and CYP2D6 at global and microgeographic scales. Pharmacogenet. Genomics 19:170-179.
46. Dixon, L.A., C.M. Murray, E.J. Archer, A.E. Dobbins, P. Koumi, and P. Gill. 2005. Validation of a 21-locus autosomal SNP multiplex for forensic identification purposes. Forensic Sci. Int. 154:62-77.
47. Kidd, K.K., A.J. Pakstis, W.C. Speed, E.L. Grigorenko, S.L. Kajuna, N.J. Karoma, S. Kungulilo, J.J. Kim, et al. 2006. Developing a SNP panel for forensic identification of individuals. Forensic Sci. Int. 164:20-32.
48. Pakstis, A.J., W.C. Speed, J.R. Kidd, and K.K. Kidd. 2007. Candidate SNPs for a universal individual identification panel. Hum. Genet. 121:305-317.
49. Sanchez, J.J., C. Phillips, C. Børsting, K. Balogh, M. Bogus, M. Fondevila, C.D. Harrison, E. Musgrave-Brown, et al. 2006. A multiplex assay with 52 single nucleotide polymorphisms for human identification. Electrophoresis 27:1713-1724.
50. Daly, M.J., J.D. Rioux, S.F. Schaffner, T.J. Hudson, and E.S. Lander. 2001. High-resolution haplotype structure in the human genome. Nat. Genet. 29:229-232.
51. Gabriel, S.B., S.F. Schaffner, H. Nguyen, J.M. Moore, J. Roy, B. Blumenstiel, J. Higgins, M. DeFelice, et al. 2002. The structure of haplotype blocks in the human genome. Science 296:2225-2229.
52. International HapMap Consortium. 2003. The International HapMap Project. Nature 426:789-796.
53. McVean, G.A., S.R. Myers, S. Hunt, P. Deloukas, D.R. Bentley, and P. Donnelly. 2004. The fine-scale structure of recombination rate variation in the human genome. Science 304:581-584. (Pubitemid 38541915)
54. Patil, N., A.J. Berno, D.A. Hinds, W.A. Barrett, J.M. Doshi, C.R. Hacker, C.R. Kautzer, D.H. Lee, et al. 2001. Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21. Science 294:1719-1723.
55. Ge, J., H. Xi, B. Budowle, and R. Chakraborty. 2008. Haplotype block: a new type of forensic DNA markers. Poster presented at the Eighteenth Meeting of the International Association of Forensic Sciences, New Orleans, LA.
56. Baudhuin, L.M., L.J. Langman, and D.J. O'Kane. 2007. Translation of pharmacogenetics into clinically relevant testing modalities. Clin. Pharmacol. Ther. 82:373-376.
57. Smith, G., M.J. Stubbins, L.W. Harries, and C.R. Wolf. 1998. Molecular genetics of the human cytochrome P450 monooxygenase superfamily. Xenobiotica 28:1129-1165. (Pubitemid 29017139)
58. Zhou, S.F., Y.M. Di, E. Chan, Y.M. Du, V.D. Chow, C.C. Xue, X. Lai, J.C. Wang, et al. 2008. Clinical pharmacogenetics and potential application in personalized medicine. Curr. Drug Metab. 9:738-784.
59. Rodríguez-Calvo, M.S., M. Brion, C. Allegue, L. Concheiro, and A. Carracedo. 2008. Molecular genetics of sudden cardiac death. Forensic Sci. Int. 182:1-12.
60. Juusola, J. and J. Ballantyne. 2005. Multiplex mRNA profiling for the identification of body fluids. Forensic Sci. Int. 152:1-12.
61. Zubakov, D., M. Kokshoorn, A. Kloosterman, and M. Kayser. 2009. New markers for old stains: stable mRNA markers for blood and saliva identification from up to 16-year-old stains. Int. J. Legal Med. 123:71-74.
62. Bieber, F.R., C.H. Brenner, and D. Lazer. 2006. Human genetics. Finding criminals through DNA of their relatives. Science 312:1315-1316.
63. Budowle, B., J.V. Planz, R. Chakraborty, T.F. Callaghan, and A.J. Eisenberg. 2006 Clarification of statistical issues related to the operation of CODIS, p. 1-20. Seventeenth International Symposium on Human Identification 2006, Promega Corporation, Madison. (http://www.promega.com/geneticidproc/ ussymp17proc/oralpresentations/budowle.pdf).
64. Breeze, R.G., B. Budowle, and S. Schutzer. 2005. Microbial Forensics, p. 1-425. Academic Press, Amsterdam.
65. Budowle, B., S.E. Schutzer, A. Einseln, L.C. Kelley, A.C. Walsh, J.A.L. Smith, B.L. Marrone, J. Robertson, and J. Campos. 2003. Building microbial forensics as a response to bioterrorism. Science 301:1852-1853. (Pubitemid 37221374)
66. Morse, S.A. and B. Budowle. 2006. Microbial forensics-application to bioterrorism preparedness and response. Infect. Dis. Clin. North Am. 20:455-473.
67. Morse, S.A. and A.S. Khan. 2006. Epidemiologic investigation for public health, biodefense, and forensic microbiology, p. 157-171. In R.G. Breeze, B. Budowle, and S. Schutzer (Eds.) Microbial Forensics. Academic Press, Amsterdam.
68. Budowle, B., M.D. Johnson, C.M. Fraser, T.J. Leighton, R.S. Murch, and R. Chakraborty. 2005. Genetic analysis and attribution of microbial forensics evidence. Crit. Rev. Microbiol. 31:233-254.
69. Read, T.D., S.N. Peterson, N. Tourasse, L.W. Baillie, I.T. Paulsen, K.E. Nelson, H. Tettelin, D.E. Fouts, et al. 2003. The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria. Nature 423:81-86.
70. Sanger, F., S. Nicklen, and A.R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463-5468.
71. Lipshutz, R.J., D. Morris, M. Chee, E. Hubbell, M.J. Kozal, N. Shah, N. Shen, R. Yang, and S.P. Fodor. 1995. Using oligonucleotide probe arrays to access genetic diversity. BioTechniques 19:442-447.
72. Cutler, D.J., M.E. Zwick, M.M. Carrasquillo, C.T. Yohn, K.P. Tobin, C. Kashuk, D.J. Mathews, N.A. Shah, et al. 2001. High-throughput variation detection and genotyping using microarrays. Genome Res. 11:1913-1925.
73. Drmanac, S., D. Kita, I. Labat, B. Hauser, C. Schmidt, J.D. Burczak, and R. Drmanac. 1998. Accurate sequencing by hybridization for DNA diagnostics and individual genomics. Nat. Biotechnol. 16:54-58.
74. Adessi, C., G. Matton, G. Ayala, G. Turcatti, J.J. Mermod, P. Mayer, and E. Kawashima. 2000. Solid phase DNA amplification: characterisation of primer attachment and amplification mechanisms. Nucleic Acids Res. 28:E87.
75. Brenner, S., M. Johnson, J. Bridgham, G. Golda, D.H. Lloyd, D. Johnson, S. Luo, S. McCurdy, et al. 2000. Gene expression analysis by massively parallel signature sequencing (MPSS) on microbead arrays. Nat. Biotechnol. 18:630-634.
76. Brenner, S., S.R. Williams, E.H. Vermaas, T. Storck, K. Moon, C. McCollum, J.I. Mao, S. Luo, et al. 2000. In vitro cloning of complex mixtures of DNA on microbeads: physical separation of differentially expressed cDNAs. Proc. Natl. Acad. Sci. USA 97:1665-1670.
77. Holt, K.E., J. Parkhill, C.J. Mazzoni, P. Roumagnac, F.X. Weill, I. Goodhead, R. Rance, S. Baker, et al. 2008. High-throughput sequencing provides insights into genome variation and evolution in Salmonella Typhi. Nat. Genet. 40:987-993.
78. Margulies, M., M. Egholm, W.E. Altman, S. Attiya, J.S. Bader, L.A. Bemben, J. Berka, M.S. Braverman, et al. 2005. Genome sequencing in microfabricated high-density picolitre reactors. Nature 437:376-380.
79. Oh, J.D., H. Kling-Bäckhed, M. Giannakis, J. Xu, R.S. Fulton, L.A. Fulton, H.S. Cordum, C. Wang, et al. 2006. The complete genome sequence of a chronic atrophic gastritis Helicobacter pylori strain: evolution during disease progression. Proc. Natl. Acad. Sci. USA 103:9999-10004.
80. Quail, M.A., I. Kozarewa, F. Smith, A. Scally, P.J. Stephens, R. Durbin, H. Swerdlow, and D.J. Turner. 2008. A large genome center's improvements to the Illumina sequencing system. Nat. Methods 5:1005-1010.
81. Van Tassell, C.P., T.P. Smith, L.K. Matukumalli, J.F. Taylor, R.D. Schnabel, C.T. Lawley, C.D. Haudenschild, S.S. Moore, et al. 2008. SNP discovery and allele frequency estimation by deep sequencing of reduced representation libraries. Nat. Methods 5:247-252.
82. Wheeler, D.A., M. Srinivasan, M. Egholm, Y. Shen, L. Chen, A. McGuire, W. He, Y.J. Chen, et al. 2008. The complete genome of an individual by massively parallel DNA sequencing. Nature 452:872-876.
83. Wicker, T., E. Schlagenhauf, A. Graner, T.J. Close, B. Keller, and N. Stein. 2006. 454 sequencing put to the test using the complex genome of barley. BMC Genomics 7:275. (Pubitemid 44697663)
84. Braslavsky, I., B. Hebert, E. Kartalov, and S.R. Quake. 2003. Sequence information can be obtained from single DNA molecules. Proc. Natl. Acad. Sci. USA 100:3960-3964.
85. Anslinger, K., B. Bayer, B. Rolf, W. Keil, and W. Eisenmenger. 2005. Application of the BioRobot EZ1 in a forensic laboratory. Leg. Med. 7:164-168.
86. Frégeau, C.J., C.M. Lett, J. Elliott, C. Yensen, and R.M. Fourney. 2008. Automated processing of forensic casework samples using robotic workstations equipped with nondisposable tips: contamination prevention. J. Forensic Sci. 53:632-651.
87. Greenspoon, S.A., K.L. Sykes, J.D. Ban, A. Pollard, M. Baisden, M. Farr, N. Graham, B.L. Collins, et al. 2006. Automated PCR setup for forensic casework samples using the Normalization Wizard and PCR Setup robotic methods. Forensic Sci. Int. 164:240-248.
88. Greenspoon, S.A., J.D. Ban, K. Sykes, E.J. Ballard, S.S. Edler, M. Baisden, and B.L. Covington. 2004. Application of the BioMek 2000 Laboratory Automation Workstation and the DNA IQ System to the extraction of forensic casework samples. J. Forensic Sci. 49:29-39.
89. Hanselle, T., M. Otte, T. Schnibbe, E. Smythe, and F. Krieg-Schneider. 2003. Isolation of genomic DNA from buccal swabs for forensic analysis, using fully automated silica-membrane purification technology. Leg. Med. 5:S145-S149.
90. Parson, W. and M. Steinlechner. 2001. Efficient DNA database laboratory strategy for high through-put STR typing of reference samples. Forensic Sci. Int. 122:1-6.
91. Tereba, A., L. Flanagan, P. Mandrekar, and R. Olson. 2004. A new, rapid method to separate sperm and epithelial cells. Profiles in DNA 7:8-10.
92. Mandrekar, P., B.E. Krenke, and A. Tereba. 2001. DNA IQ: the intelligent way to purify DNA. Profiles in DNA 4:16.
93. Kadash, K., B.E. Kozlowski, L.A. Biega, and B.W. Duceman. 2004. Validation study of the TrueAllele automated data review system. J. Forensic Sci. 49:1-8. (Pubitemid 38924198)
94. Roby, R.K. and A.D. Cristen. 2007. Validating expert systems: Examples with the FSS-i3 expert systems software. Profiles in DNA 10:13-15.
95. Pendleton, J. and T.W. Wang. Gilbert, k., and Lucas, C. 2004. Probability distribution of allele bands for multi-person STR mixtures. Proceedings from the Fifteenth International Symposium on Human Identification 2004, Promega Corporation, Madison. (http://www.promega.com/geneticidproc/ussymp15proc/ posterpresentations/12Wang.pdf)
96. Horsman, K.M., J.M. Bienvenue, K.R. Blasier, and J.P. Landers. 2007. Forensic DNA analysis on microfluidic devices: a review. J. Forensic Sci. 52:784-799. (Pubitemid 46918579)
97. Easley, C.J., J.M. Karlinsey, J.M. Bienvenue, L.A. Legendre, M.G. Roper, S.H. Feldman, M.A. Hughes, E.L. Hewlett, et al. 2006. A fully integrated microfluidic genetic analysis system with sample-in-answer-out capability. Proc. Natl. Acad. Sci. USA 103:19272-19277.
98. Yeung, S.H., P. Liu, N. Del Bueno, S.A. Green-spoon, and R.A. Mathies. 2009. Integrated sample cleanup-capillary electrophoresis microchip for high-performance short tandem repeat genetic analysis. Anal. Chem. 81:210-217.
99. Norris, J.V., K. Manning, S.J. Linke, J.P. Ferrance, and J.P. Landers. 2007. Expedited, chemically enhanced sperm cell recovery from cotton swabs for rape kit analysis. J. Forensic Sci. 52:800-805.
100. Wen, J., C. Guillo, J.P. Ferrance, and J.P. Landers. 2007. Microfluidic-based DNA purification in a two-stage, dual-phase microchip containing a reversed-phase and a photopolymerized monolith. Anal. Chem. 79:6135-6142.
101. Wen, J., L.A. Legendre, J.M. Bienvenue, and J.P. Landers. 2008. Purification of nucleic acids in microfluidic devices. Anal. Chem. 80:6472-6479.