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Volumn 8, Issue 14, 2007, Pages 2235-2245

The pharmacogenetics of analgesia

Author keywords

Analgesia; CYP2D6; Cytochrome P450 (CYP); Opioid receptor; Pharmacogenetics; Polymorphism

Indexed keywords

ANALGESIC AGENT; CATECHOL METHYLTRANSFERASE; CELECOXIB; COCODAMOL; CODEINE; CYTOCHROME P450; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; DEXTROMETHORPHAN; DICLOFENAC; IBUPROFEN; MELANOCORTIN 1 RECEPTOR; MELOXICAM; METOCLOPRAMIDE; MORPHINE; MU OPIATE RECEPTOR; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE RECEPTOR; OXYCODONE; PARACETAMOL; PHENYTOIN; PIROXICAM; TIMOLOL; TRAMADOL; TRICYCLIC ANTIDEPRESSANT AGENT; TRIMIPRAMINE; UNINDEXED DRUG; WARFARIN;

EID: 35549000170     PISSN: 14656566     EISSN: None     Source Type: Journal    
DOI: 10.1517/14656566.8.14.2235     Document Type: Review
Times cited : (62)

References (53)
  • 1
    • 0032522873 scopus 로고    scopus 로고
    • Incidence of adverse drug reactions in hospitalized patients: A meta-analysis of prospective studies
    • LAZAROU J, POMERANZ BH, COREY PN: Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. JAMA (1998):1200-1205.
    • (1998) JAMA , pp. 1200-1205
    • LAZAROU, J.1    POMERANZ, B.H.2    COREY, P.N.3
  • 2
    • 0035861049 scopus 로고    scopus 로고
    • Potential role of pharmacogenomics in reducing adverse drug reactions: A systematic review
    • PHILLIPS KA, VEENSTRA DL, OREN E, LEE JK, SADEE W: Potential role of pharmacogenomics in reducing adverse drug reactions: a systematic review. JAMA (2001) 286(18):2270-2279.
    • (2001) JAMA , vol.286 , Issue.18 , pp. 2270-2279
    • PHILLIPS, K.A.1    VEENSTRA, D.L.2    OREN, E.3    LEE, J.K.4    SADEE, W.5
  • 3
    • 0036298229 scopus 로고    scopus 로고
    • Clinically significant drug interactions with antidepressants in the elderly
    • SPINA E, SCORDO MG: Clinically significant drug interactions with antidepressants in the elderly. Drugs Aging (2002) 19:299-320.
    • (2002) Drugs Aging , vol.19 , pp. 299-320
    • SPINA, E.1    SCORDO, M.G.2
  • 5
    • 0030860004 scopus 로고    scopus 로고
    • Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: Characterization of 48 mutations and 53 alleles, their frequencies and evolution
    • MAREZ D, LEGRAND M, SABBAGH N et al.: Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution. Pharmacogenetics (1997) 7:193-202.
    • (1997) Pharmacogenetics , vol.7 , pp. 193-202
    • MAREZ, D.1    LEGRAND, M.2    SABBAGH, N.3
  • 6
    • 0031038038 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences
    • SACHSE C, BROCKMOLLER J, BAUER S, ROOTS I: Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am. J. Hum. Genet. (1997) 60:284-295.
    • (1997) Am. J. Hum. Genet , vol.60 , pp. 284-295
    • SACHSE, C.1    BROCKMOLLER, J.2    BAUER, S.3    ROOTS, I.4
  • 7
    • 0032793249 scopus 로고    scopus 로고
    • Polymorphic human cytochrome P450 enzymes: An opportunity for individualized drug treatment
    • INGELMAN-SUNDBERG M, OSCARSON M, MCLELLAN RA: Polymorphic human cytochrome P450 enzymes: an opportunity for individualized drug treatment. Trends Pharmacol. Sci. (1999) 20(8):342-349.
    • (1999) Trends Pharmacol. Sci , vol.20 , Issue.8 , pp. 342-349
    • INGELMAN-SUNDBERG, M.1    OSCARSON, M.2    MCLELLAN, R.A.3
  • 8
    • 3543014421 scopus 로고    scopus 로고
    • A novel intronic mutation, 2988G>A, with high predictivity for impaired function of cytochrome P450 2D6 in white subjects
    • RAIMUNDO S, TOSCANO C, KLEIN K et al.: A novel intronic mutation, 2988G>A, with high predictivity for impaired function of cytochrome P450 2D6 in white subjects. Clin. Pharmacol. Ther. (2004) 76(2):128-138.
    • (2004) Clin. Pharmacol. Ther , vol.76 , Issue.2 , pp. 128-138
    • RAIMUNDO, S.1    TOSCANO, C.2    KLEIN, K.3
  • 9
    • 34250614223 scopus 로고    scopus 로고
    • Concentrations of tramadol and O-desmethyltramadol enantiomers in different CYP2D6 genotypes
    • Epub ahead of print
    • STAMER UM, MUSSHOFF F, KOBILAY M, MADEA B, HOEFT A, STÜBER F: Concentrations of tramadol and O-desmethyltramadol enantiomers in different CYP2D6 genotypes. Clin. Pharmacol. Ther. (2007) [Epub ahead of print].
    • (2007) Clin. Pharmacol. Ther
    • STAMER, U.M.1    MUSSHOFF, F.2    KOBILAY, M.3    MADEA, B.4    HOEFT, A.5    STÜBER, F.6
  • 10
    • 0030472254 scopus 로고    scopus 로고
    • Codeine and morphine in extensive and poor metabolisers of sparteine: Pharmacokinetics, analgesic effect and side effects
    • POULSEN L, BROSEN K, ARENDT-NIELSEN L, GRAM LF, ELBAEK K, SINDRUP SH: Codeine and morphine in extensive and poor metabolisers of sparteine: pharmacokinetics, analgesic effect and side effects. Eur. J. Clin. Pharmacol. (1996) 51:289-295.
    • (1996) Eur. J. Clin. Pharmacol , vol.51 , pp. 289-295
    • POULSEN, L.1    BROSEN, K.2    ARENDT-NIELSEN, L.3    GRAM, L.F.4    ELBAEK, K.5    SINDRUP, S.H.6
  • 11
    • 0031746749 scopus 로고    scopus 로고
    • Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation
    • ECKHARDT K, LI S, AMMON S, SCHANZLE G, MIKUS G, EICHELBAUM M: Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation. Pain (1998) 76:27-33.
    • (1998) Pain , vol.76 , pp. 27-33
    • ECKHARDT, K.1    LI, S.2    AMMON, S.3    SCHANZLE, G.4    MIKUS, G.5    EICHELBAUM, M.6
  • 13
    • 0036898460 scopus 로고    scopus 로고
    • Pharmacogenetics of codeine metabolism in an urban population of children and its implications for analgesic reliability
    • WILLIAMS DG, PATELA, HOWARD RF: Pharmacogenetics of codeine metabolism in an urban population of children and its implications for analgesic reliability. Br. J. Anaesth. (2002) 89:839-845.
    • (2002) Br. J. Anaesth , vol.89 , pp. 839-845
    • WILLIAMS, D.G.1    PATELA, H.R.2
  • 14
    • 0035147282 scopus 로고    scopus 로고
    • No pain relief from codeine? An introduction to pharmacogenomics
    • FAGERLUND TH, BRAATEN O: No pain relief from codeine? An introduction to pharmacogenomics. Acta Anaesthesiol. Scand. (2001) 68:140-149.
    • (2001) Acta Anaesthesiol. Scand , vol.68 , pp. 140-149
    • FAGERLUND, T.H.1    BRAATEN, O.2
  • 15
    • 11144221180 scopus 로고    scopus 로고
    • Codeine intoxication associated with ultrarapid CY52D6 metabolism
    • GASCHE Y, DAALI Y, FATHI M et al.: Codeine intoxication associated with ultrarapid CY52D6 metabolism. N. Engl. J. Med. (2004) 351 (27):2827-2831.
    • (2004) N. Engl. J. Med , vol.351 , Issue.27 , pp. 2827-2831
    • GASCHE, Y.1    DAALI, Y.2    FATHI, M.3
  • 16
    • 34547644659 scopus 로고    scopus 로고
    • Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolisers due to CYP2D6 duplication
    • KIRCHHEINER J, SCHMIDT H, TZVETKOV M et al.: Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolisers due to CYP2D6 duplication. Pharmacogenom. J. (2006) 7(4):257-265.
    • (2006) Pharmacogenom. J , vol.7 , Issue.4 , pp. 257-265
    • KIRCHHEINER, J.1    SCHMIDT, H.2    TZVETKOV, M.3
  • 17
    • 0027429714 scopus 로고
    • Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol
    • RAFFA RB, FRIDERICHS E, REIMANN W et al.: Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol. J. Pharmacol. Exp. Ther. (1993) 267:331-340.
    • (1993) J. Pharmacol. Exp. Ther , vol.267 , pp. 331-340
    • RAFFA, R.B.1    FRIDERICHS, E.2    REIMANN, W.3
  • 19
    • 0141626841 scopus 로고    scopus 로고
    • Impact of CYP2D6 genotype on postoperative tramadol analgesia
    • STAMER UM, LEHNEN K, HÖTHKER F et al.: Impact of CYP2D6 genotype on postoperative tramadol analgesia. Pain (2003) 105:231-238.
    • (2003) Pain , vol.105 , pp. 231-238
    • STAMER, U.M.1    LEHNEN, K.2    HÖTHKER, F.3
  • 20
    • 33750492934 scopus 로고    scopus 로고
    • Effect of the CYP2D6*10 C188T polymorphism on postoperative tramadol analgesia in a Chinese population
    • WANG G, ZHANG H, HE F. FANG X: Effect of the CYP2D6*10 C188T polymorphism on postoperative tramadol analgesia in a Chinese population. Eur. J. Clin. Pharmacol. (2006) 62(11):927-931.
    • (2006) Eur. J. Clin. Pharmacol , vol.62 , Issue.11 , pp. 927-931
    • WANG, G.1    ZHANG, H.2    HE, F.F.X.3
  • 21
    • 0035100677 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 genotype and methadone steady-state concentrations
    • EAP CB, BROLY F, MINO A et al.: Cytochrome P450 2D6 genotype and methadone steady-state concentrations. J. Clin. Psychopharmacol. (2001) 21:229-234.
    • (2001) J. Clin. Psychopharmacol , vol.21 , pp. 229-234
    • EAP, C.B.1    BROLY, F.2    MINO, A.3
  • 22
    • 0042530185 scopus 로고    scopus 로고
    • A discordance between cytochrome P450 2D6 genotype and phenotype in patients undergoing methadone maintenance treatment
    • SHIRAN MR, CHOWDRY J, ROSTAMI-HODJEGAN A et al.: A discordance between cytochrome P450 2D6 genotype and phenotype in patients undergoing methadone maintenance treatment. Br. J. Clin. Pharmacol. (2003) 56:220-224.
    • (2003) Br. J. Clin. Pharmacol , vol.56 , pp. 220-224
    • SHIRAN, M.R.1    CHOWDRY, J.2    ROSTAMI-HODJEGAN, A.3
  • 23
    • 0029944684 scopus 로고    scopus 로고
    • Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes
    • IRIBARNE C, BERTHOU F, BAIRD S et al.: Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes. Chem. Res. Toxicol. (1996) 9:365-373.
    • (1996) Chem. Res. Toxicol , vol.9 , pp. 365-373
    • IRIBARNE, C.1    BERTHOU, F.2    BAIRD, S.3
  • 24
    • 0025983863 scopus 로고
    • Genetic influences in opioid analgesic sensitivity in mice
    • PICK CG, CHENG J, PAUL D, PASTERNAK GW: Genetic influences in opioid analgesic sensitivity in mice. Brain Res. (1991) 556:295-298.
    • (1991) Brain Res , vol.556 , pp. 295-298
    • PICK, C.G.1    CHENG, J.2    PAUL, D.3    PASTERNAK, G.W.4
  • 25
    • 0033030271 scopus 로고    scopus 로고
    • Heritability of nociception I: Responses of 11 inbred mouse strains on 12 measures of nociception
    • MOGIL JS, WILSON SG, BON K et al.: Heritability of nociception I: responses of 11 inbred mouse strains on 12 measures of nociception. Pain (1999) 80:67-82.
    • (1999) Pain , vol.80 , pp. 67-82
    • MOGIL, J.S.1    WILSON, S.G.2    BON, K.3
  • 26
    • 0041381141 scopus 로고    scopus 로고
    • Influence of CYP2C9 genetic polymorphisms on pharmacokinetics of celecoxib and its metabotites
    • KIRCHHEINER J, STÖRMER E, MEISEL C, STEINBACH N, ROOTS I, BROCKMOLLER J: Influence of CYP2C9 genetic polymorphisms on pharmacokinetics of celecoxib and its metabotites. Pharmacogenetics (2003) 13(8):473-480.
    • (2003) Pharmacogenetics , vol.13 , Issue.8 , pp. 473-480
    • KIRCHHEINER, J.1    STÖRMER, E.2    MEISEL, C.3    STEINBACH, N.4    ROOTS, I.5    BROCKMOLLER, J.6
  • 27
    • 0035052562 scopus 로고    scopus 로고
    • In-vitro metabolism of celecoxib, a cyclooxygenase-2 inhibitor, by allelic variant forms of human liver microsomal cytochrome P450 2C9: Correlation with CYP2C9 genotype and in vivo pharmacokinetics
    • TANG C, SHOU M, RUSHMORE TH et al.: In-vitro metabolism of celecoxib, a cyclooxygenase-2 inhibitor, by allelic variant forms of human liver microsomal cytochrome P450 2C9: correlation with CYP2C9 genotype and in vivo pharmacokinetics. Pharmacogenetics (2001) 11:223-235.
    • (2001) Pharmacogenetics , vol.11 , pp. 223-235
    • TANG, C.1    SHOU, M.2    RUSHMORE, T.H.3
  • 28
    • 0036336114 scopus 로고    scopus 로고
    • Enantiospecific effects of cytochrome P450 2C9 amino acid variants on ibuprofen pharmacokinetics and on the inhibition of cyclooxygenases 1 and 2
    • KIRCHHEINER J, MEINEKE I, FREYTAG G, MEISEL C, ROOTS I, BROCKMOLLER J: Enantiospecific effects of cytochrome P450 2C9 amino acid variants on ibuprofen pharmacokinetics and on the inhibition of cyclooxygenases 1 and 2. Clin. Pharmacol. Ther. (2002) 72(1):62-75.
    • (2002) Clin. Pharmacol. Ther , vol.72 , Issue.1 , pp. 62-75
    • KIRCHHEINER, J.1    MEINEKE, I.2    FREYTAG, G.3    MEISEL, C.4    ROOTS, I.5    BROCKMOLLER, J.6
  • 29
    • 1842506233 scopus 로고    scopus 로고
    • Trimipramine pharmacogenetics after intravenous and oral administration in cariiers of CYP2D6 genotypes predicting poor, extensive and ultrahigh activity
    • KIRCHHEINER J, SASSE J, MEINEKE I, ROOTS I, BROCKMOLLER J: Trimipramine pharmacogenetics after intravenous and oral administration in cariiers of CYP2D6 genotypes predicting poor, extensive and ultrahigh activity. Pharmacogenetics (2004) 13(12):721-728.
    • (2004) Pharmacogenetics , vol.13 , Issue.12 , pp. 721-728
    • KIRCHHEINER, J.1    SASSE, J.2    MEINEKE, I.3    ROOTS, I.4    BROCKMOLLER, J.5
  • 30
    • 3142519666 scopus 로고    scopus 로고
    • Pharmacogenetics of antidepressants and antipsychotics: The contribution of allelic variations to the phenotype of drug response
    • KIRCHHEINER J, NICKCHEN K, BAUER M et al.: Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response. Mol. Psychiatry (2004) 9(5):442-473.
    • (2004) Mol. Psychiatry , vol.9 , Issue.5 , pp. 442-473
    • KIRCHHEINER, J.1    NICKCHEN, K.2    BAUER, M.3
  • 31
    • 0033944519 scopus 로고    scopus 로고
    • Allelic variation S268P of the human μ-opioid receptor affects both desensitization and G protein coupling
    • KOCH T, KROSLAK T, AVERBECK M et al.: Allelic variation S268P of the human μ-opioid receptor affects both desensitization and G protein coupling. Mol. Pharmacol. (2000) 58:328-334.
    • (2000) Mol. Pharmacol , vol.58 , pp. 328-334
    • KOCH, T.1    KROSLAK, T.2    AVERBECK, M.3
  • 32
    • 0035793631 scopus 로고    scopus 로고
    • A single nucleotide polymorphic mutation in the human μ-opioid receptor severely impairs receptor signalling
    • BEFORT K, FILLIOL D, DECAILLOT FM, GAVERIAUX-RUFF C, HOEHE MR, KIEFFER BL: A single nucleotide polymorphic mutation in the human μ-opioid receptor severely impairs receptor signalling. J. Biol. Chem. (2001) 276:3130-3137.
    • (2001) J. Biol. Chem , vol.276 , pp. 3130-3137
    • BEFORT, K.1    FILLIOL, D.2    DECAILLOT, F.M.3    GAVERIAUX-RUFF, C.4    HOEHE, M.R.5    KIEFFER, B.L.6
  • 33
    • 0036152705 scopus 로고    scopus 로고
    • L TSCH J, SKARKE C, GROSCH S, DARIMONT J, SCHMIDT H, GEISSLINGER G: The polymorphism A118G of the human μ-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine. Pharmacogenetics (2002) 12:3-9.
    • L TSCH J, SKARKE C, GROSCH S, DARIMONT J, SCHMIDT H, GEISSLINGER G: The polymorphism A118G of the human μ-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine. Pharmacogenetics (2002) 12:3-9.
  • 34
    • 0036792226 scopus 로고    scopus 로고
    • Does the A118G polymorphism at the μ-opioid receptor gene protect against morphine-6-glucuronide toxicity?
    • LÖTSCH J, ZIMMERMANN M, DARIMONT J et al.: Does the A118G polymorphism at the μ-opioid receptor gene protect against morphine-6-glucuronide toxicity? Anesthesiology (2002) 97:814-819.
    • (2002) Anesthesiology , vol.97 , pp. 814-819
    • LÖTSCH, J.1    ZIMMERMANN, M.2    DARIMONT, J.3
  • 35
    • 8544257029 scopus 로고    scopus 로고
    • The 118 A > G polymorphism in the human μ-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease
    • KLEPSTAD P, RAKVAG TT, KAASA S et al.: The 118 A > G polymorphism in the human μ-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease. Acta Anaesthesiol. Scand. (2004) 48:1232-1239.
    • (2004) Acta Anaesthesiol. Scand , vol.48 , pp. 1232-1239
    • KLEPSTAD, P.1    RAKVAG, T.T.2    KAASA, S.3
  • 36
    • 33745813212 scopus 로고    scopus 로고
    • Association of μ-opioid receptor gene polymorphism (A118G) with variations in morphine consumption for analgesia after total knee arthroplasty
    • CHOU WY, YANG LC, LU HF et al.: Association of μ-opioid receptor gene polymorphism (A118G) with variations in morphine consumption for analgesia after total knee arthroplasty. Acta Anaesthesiol. Scand. (2006) 50(7):787-792.
    • (2006) Acta Anaesthesiol. Scand , vol.50 , Issue.7 , pp. 787-792
    • CHOU, W.Y.1    YANG, L.C.2    LU, H.F.3
  • 37
    • 33746608902 scopus 로고    scopus 로고
    • Human opioid receptor A118G polymorphism affects intravenous patient-controlled analgesia morphine consumption after total abdominal hysterectomy
    • CHOU WY, WANG CH, LIU PH, LIU CC, TSENG CC, JAWAN B: Human opioid receptor A118G polymorphism affects intravenous patient-controlled analgesia morphine consumption after total abdominal hysterectomy. Anesthesiology (2006) 105(2):334-337.
    • (2006) Anesthesiology , vol.105 , Issue.2 , pp. 334-337
    • CHOU, W.Y.1    WANG, C.H.2    LIU, P.H.3    LIU, C.C.4    TSENG, C.C.5    JAWAN, B.6
  • 38
    • 33746603524 scopus 로고    scopus 로고
    • One size does not fit all: Genetic variability of μ-opioid receptor and postoperative morphine consumption
    • LANDAU R: One size does not fit all: genetic variability of μ-opioid receptor and postoperative morphine consumption. Anesthesiology (2006) 105(2):235-237.
    • (2006) Anesthesiology , vol.105 , Issue.2 , pp. 235-237
    • LANDAU, R.1
  • 40
    • 2542424501 scopus 로고    scopus 로고
    • Fishing for genes: Practical ways to study polymorphisms for pain
    • EISENACH JC: Fishing for genes: Practical ways to study polymorphisms for pain. Anesthesiology (2004) 100:1343-1344.
    • (2004) Anesthesiology , vol.100 , pp. 1343-1344
    • EISENACH, J.C.1
  • 41
    • 1842685390 scopus 로고    scopus 로고
    • Assessing pain candidate gene studies
    • MAX MB: Assessing pain candidate gene studies. Pain (2004) 109:1-3.
    • (2004) Pain , vol.109 , pp. 1-3
    • MAX, M.B.1
  • 43
    • 0032882252 scopus 로고    scopus 로고
    • The κ opioid nalbuphine produces gender- and dose-dependent analgesia and antianalgesia in patients with postoperative pain
    • GEAR RW, MIASKOWSKI C, GORDON NC, PAUL SM, HELLER PH, LEVINE JD: The κ opioid nalbuphine produces gender- and dose-dependent analgesia and antianalgesia in patients with postoperative pain. Pain (1999) 83:339-345.
    • (1999) Pain , vol.83 , pp. 339-345
    • GEAR, R.W.1    MIASKOWSKI, C.2    GORDON, N.C.3    PAUL, S.M.4    HELLER, P.H.5    LEVINE, J.D.6
  • 44
    • 0344341625 scopus 로고    scopus 로고
    • The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans
    • MOGIL JS, WILSON SG, CHESLER EJ et al.: The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans. Proc. Natl. Acad. Sci. USA (2003) 100(8):4867-4872.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , Issue.8 , pp. 4867-4872
    • MOGIL, J.S.1    WILSON, S.G.2    CHESLER, E.J.3
  • 45
    • 22244492308 scopus 로고    scopus 로고
    • Melanocortin-1 receptor gene variants affect pain and μ-opioid analgesia in mice and humans
    • MOGIL JS, RITCHIE J, SMITH SB et al.: Melanocortin-1 receptor gene variants affect pain and μ-opioid analgesia in mice and humans. J. Med. Genet. (2005) 42(7):583-587.
    • (2005) J. Med. Genet , vol.42 , Issue.7 , pp. 583-587
    • MOGIL, J.S.1    RITCHIE, J.2    SMITH, S.B.3
  • 46
    • 3342919012 scopus 로고    scopus 로고
    • Anesthetic requirement is increased in redheads
    • LIEM EB, LIN CM, SULEMAN MI et al.: Anesthetic requirement is increased in redheads. Anesthesiology (2004) 101:279-283.
    • (2004) Anesthesiology , vol.101 , pp. 279-283
    • LIEM, E.B.1    LIN, C.M.2    SULEMAN, M.I.3
  • 47
    • 14644436410 scopus 로고    scopus 로고
    • Increased sensitivity to thermal pain and reduced subcutaneous lidocaine efficacy in redheads
    • LIEM EB, JOINER TV, TSUEDA K, SESSLER DI: Increased sensitivity to thermal pain and reduced subcutaneous lidocaine efficacy in redheads. Anesthesiology (2005) 102:509-514.
    • (2005) Anesthesiology , vol.102 , pp. 509-514
    • LIEM, E.B.1    JOINER, T.V.2    TSUEDA, K.3    SESSLER, D.I.4
  • 48
    • 0037458277 scopus 로고    scopus 로고
    • Val158met genotype affects μ-opioid neurotransmitter responses to a pain stressor
    • ZUBIETA JK, HEITZEG MM, SMITH YR et al.: Val158met genotype affects μ-opioid neurotransmitter responses to a pain stressor. Science (2003) 299(5610):1240-1243.
    • (2003) Science , vol.299 , Issue.5610 , pp. 1240-1243
    • ZUBIETA, J.K.1    HEITZEG, M.M.2    SMITH, Y.R.3
  • 49
    • 20444451123 scopus 로고    scopus 로고
    • The Val158 Met polymorphism of the human catechol O-methyltransferase (COMT) gene may influence morphine requirements in cancer patients
    • RAKVAG TT, KLEPSTAD P, BAAR C et al: The Val158 Met polymorphism of the human catechol O-methyltransferase (COMT) gene may influence morphine requirements in cancer patients. Pain (2005) 116:73-78.
    • (2005) Pain , vol.116 , pp. 73-78
    • RAKVAG, T.T.1    KLEPSTAD, P.2    BAAR, C.3
  • 50
    • 34249794271 scopus 로고    scopus 로고
    • Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene
    • REYES-GIBBY CC, SHETE S, RAKVAG T et al.: Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene. Pain (2006) 130(1-2):25-30.
    • (2006) Pain , vol.130 , Issue.1-2 , pp. 25-30
    • REYES-GIBBY, C.C.1    SHETE, S.2    RAKVAG, T.3
  • 51
    • 33747357980 scopus 로고    scopus 로고
    • Genetic polymorphisms in monoamine neurotransmitter systems show only weak association with acute post-surgical pain in humans
    • KIM H, LEE H, ROWAN J, BRAHIM J, DIONNE RA: Genetic polymorphisms in monoamine neurotransmitter systems show only weak association with acute post-surgical pain in humans. Mol. Pain (2006) 2:24.
    • (2006) Mol. Pain , vol.2 , pp. 24
    • KIM, H.1    LEE, H.2    ROWAN, J.3    BRAHIM, J.4    DIONNE, R.A.5
  • 52
    • 0042126736 scopus 로고    scopus 로고
    • Celecoxib inhibits metabolism of cytochrome P450 2D6 substrate metoprolol in humans
    • WERNER U, WERNER D, RAU T, FROMM ME HINZ B, BRUNE K: Celecoxib inhibits metabolism of cytochrome P450 2D6 substrate metoprolol in humans. Clin. Pharmacol. Ther. (2003) 74(2):130-137,
    • (2003) Clin. Pharmacol. Ther , vol.74 , Issue.2 , pp. 130-137
    • WERNER, U.1    WERNER, D.2    RAU, T.3    FROMM, M.H.B.4    BRUNE, K.5
  • 53
    • 7944238518 scopus 로고    scopus 로고
    • Effect of amiodarone on the plasma levels of metoprolol
    • WERNER D, WUTTKE H, FROMM MF et al.: Effect of amiodarone on the plasma levels of metoprolol. Am. J. Cardiol. (2004) 94(10):1319-1321.
    • (2004) Am. J. Cardiol , vol.94 , Issue.10 , pp. 1319-1321
    • WERNER, D.1    WUTTKE, H.2    FROMM, M.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.