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Volumn 12, Issue 11, 2007, Pages 4370-7383

Notch signaling and its role in breast cancer

Author keywords

Breast cancer; Notch signaling; Review; Tumorigenesis

Indexed keywords

NOTCH RECEPTOR;

EID: 34347240929     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/2394     Document Type: Article
Times cited : (49)

References (135)
  • 1
    • 0142259346 scopus 로고    scopus 로고
    • The role of Notch in tumorigenesis: Oncogene or tumour suppressor
    • Radtke, F. & K. Raj: The role of Notch in tumorigenesis: oncogene or tumour suppressor? Nat Rev Cancer, 3, 756-67 (2003) (Pubitemid 37328814)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.10 , pp. 756-767
    • Radtke, F.1    Raj, K.2
  • 2
    • 4444293744 scopus 로고    scopus 로고
    • Notch signaling in mammary development and oncogenesis
    • DOI 10.1023/B:JOMG.0000037159.63644.81, Embryonic Genes in Mammary Gland Development and Tumorigenesis
    • Callahan, R. & S. E. Egan: Notch signaling in mammary development and oncogenesis. J Mammary Gland Biol Neoplasia, 9, 145-63 (2004) (Pubitemid 39177500)
    • (2004) Journal of Mammary Gland Biology and Neoplasia , vol.9 , Issue.2 , pp. 145-163
    • Callahan, R.1    Egan, S.E.2
  • 3
    • 33748155240 scopus 로고    scopus 로고
    • Notch signaling in breast cancer and tumor angiogenesis: Cross-talk and therapeutic potentials
    • DOI 10.1007/s10911-006-9011-7
    • Shi, W. & A. L. Harris: Notch signaling in breast cancer and tumor angiogenesis: cross-talk and therapeutic potentials. J Mammary Gland Biol Neoplasia, 11, 41-52 (2006) (Pubitemid 44309188)
    • (2006) Journal of Mammary Gland Biology and Neoplasia , vol.11 , Issue.1 , pp. 41-52
    • Shi, W.1    Harris, A.L.2
  • 4
    • 27744476725 scopus 로고    scopus 로고
    • The Notch pathway in cancer: Differentiation gone awry
    • DOI 10.1016/j.ejca.2005.06.025, PII S0959804905007276
    • Sjolund, J., C. Manetopoulos, M. T. Stockhausen & H. Axelson: The Notch pathway in cancer: differentiation gone awry. Eur J Cancer, 41, 2620-9 (2005) (Pubitemid 41607552)
    • (2005) European Journal of Cancer , vol.41 , Issue.17 , pp. 2620-2629
    • Sjolund, J.1    Manetopoulos, C.2    Stockhausen, M.-T.3    Axelson, H.4
  • 5
    • 33644782668 scopus 로고    scopus 로고
    • Recent insights into the role of Notch signaling in tumorigenesis
    • DOI 10.1182/blood-2005-08-3329
    • Leong, K. G. & A. Karsan: Recent insights into the role of Notch signaling in tumorigenesis. Blood, 107, 2223-33 (2006) (Pubitemid 43345539)
    • (2006) Blood , vol.107 , Issue.6 , pp. 2223-2233
    • Leong, K.G.1    Karsan, A.2
  • 6
    • 33644752839 scopus 로고    scopus 로고
    • Notch signaling
    • DOI 10.1158/1078-0432.CCR-05-2570
    • Miele, L.: Notch signaling. Clin Cancer Res, 12, 1074-9 (2006) (Pubitemid 43342494)
    • (2006) Clinical Cancer Research , vol.12 , Issue.4 , pp. 1074-1079
    • Miele, L.1
  • 7
    • 0030877659 scopus 로고    scopus 로고
    • Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane
    • DOI 10.1016/S0092-8674(00)80336-0
    • Blaumueller, C. M., H. Qi, P. Zagouras & S. Artavanis-Tsakonas: Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. Cell, 90, 281-91 (1997) (Pubitemid 27329713)
    • (1997) Cell , vol.90 , Issue.2 , pp. 281-291
    • Blaumueller, C.M.1    Qi, H.2    Zagouras, P.3    Artavanis-Tsakonas, S.4
  • 9
    • 0032235397 scopus 로고    scopus 로고
    • Structural conservation of Notch receptors and ligands
    • Fleming, R. J.: Structural conservation of Notch receptors and ligands. Semin Cell Dev Biol, 9, 599-607 (1998) (Pubitemid 128647240)
    • (1998) Seminars in Cell and Developmental Biology , vol.9 , Issue.6 , pp. 599-607
    • Fleming, R.J.1
  • 11
    • 0033867521 scopus 로고    scopus 로고
    • A ligand-induced extracellular cleavage regulates γ-secretase-like proteolytic activation of Notch1
    • Mumm, J. S., E. H. Schroeter, M. T. Saxena, A. Griesemer, X. Tian, D. J. Pan, W. J. Ray & R. Kopan: A ligand-induced extracellular cleavage regulates gammasecretase-like proteolytic activation of Notch1. Mol Cell, 5, 197-206 (2000) (Pubitemid 30628079)
    • (2000) Molecular Cell , vol.5 , Issue.2 , pp. 197-206
    • Mumm, J.S.1    Schroeter, E.H.2    Saxena, M.T.3    Griesemer, A.4    Tian, X.5    Pan, D.J.6    Ray, W.J.7    Kopan, R.8
  • 15
    • 3342967780 scopus 로고    scopus 로고
    • Modulation of Notch signaling by mastermind-like (MAML) transcriptional co-activators and their involvement in tumorigenesis
    • DOI 10.1016/j.semcancer.2004.04.014, PII S1044579X04000318
    • Wu, L. & J. D. Griffin: Modulation of Notch signaling by mastermind-like (MAML) transcriptional co-activators and their involvement in tumorigenesis. Semin Cancer Biol, 14, 348-56 (2004) (Pubitemid 38993636)
    • (2004) Seminars in Cancer Biology , vol.14 , Issue.5 , pp. 348-356
    • Wu, L.1    Griffin, J.D.2
  • 16
    • 0033662392 scopus 로고    scopus 로고
    • MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors
    • Wu, L., J. C. Aster, S. C. Blacklow, R. Lake, S. Artavanis-Tsakonas & J. D. Griffin: MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Nat Genet, 26, 484-9 (2000)
    • (2000) Nat Genet , vol.26 , pp. 484-489
    • Wu, L.1    Aster, J.C.2    Blacklow, S.C.3    Lake, R.4    Artavanis-Tsakonas, S.5    Griffin, J.D.6
  • 17
    • 0036837899 scopus 로고    scopus 로고
    • Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors
    • Wu, L., T. Sun, K. Kobayashi, P. Gao & J. D. Griffin: Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. Mol Cell Biol, 22, 7688-700 (2002)
    • (2002) Mol Cell Biol , vol.22 , pp. 7688-7700
    • Wu, L.1    Sun, T.2    Kobayashi, K.3    Gao, P.4    Griffin, J.D.5
  • 18
    • 0037363922 scopus 로고    scopus 로고
    • HES and HERP families: Multiple effectors of the Notch signaling pathway
    • DOI 10.1002/jcp.10208
    • Iso, T., L. Kedes & Y. Hamamori: HES and HERP families: multiple effectors of the Notch signaling pathway. J Cell Physiol, 194, 237-55 (2003) (Pubitemid 36176887)
    • (2003) Journal of Cellular Physiology , vol.194 , Issue.3 , pp. 237-255
    • Iso, T.1    Kedes, L.2    Hamamori, Y.3
  • 19
    • 33845987566 scopus 로고    scopus 로고
    • Over expression of the Notch1 intracellular domain (NICD) inhibits cellular proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells
    • Kunnimalaiyaan, M., A. M. Vaccaro, M. A. Ndiaye & H. Chen: Over expression of the Notch1 intracellular domain (NICD) inhibits cellular proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells. J BiolChem (2006)
    • (2006) J BiolChem
    • Kunnimalaiyaan, M.1    Vaccaro, A.M.2    Ndiaye, M.A.3    Chen, H.4
  • 20
    • 0034902568 scopus 로고    scopus 로고
    • ic
    • DOI 10.1128/MCB.21.17.5925-5934.2001
    • Ronchini, C. & A. J. Capobianco: Induction of cyclin D1 transcription and CDK2 activity by Notch (ic): implication for cell cycle disruption in transformation by Notch (ic). Mol Cell Biol, 21, 5925-34 (2001) (Pubitemid 32737809)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.17 , pp. 5925-5934
    • Ronchini, C.1    Capobianco, A.J.2
  • 22
    • 0031594575 scopus 로고    scopus 로고
    • NF-κB2 is a putative target gene of activated Notch-1 via RBP-Jκ
    • Oswald, F., S. Liptay, G. Adler & R. M. Schmid: NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa. Mol Cell Biol, 18, 2077-88 (1998) (Pubitemid 28152657)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.4 , pp. 2077-2088
    • Oswald, F.1    Liptay, S.2    Adler, G.3    Schmid, R.M.4
  • 23
    • 0033613401 scopus 로고    scopus 로고
    • Involvement of Notch1 in the development of mouse mammary tumors
    • DOI 10.1038/sj.onc.1202991
    • Dievart, A., N. Beaulieu & P. Jolicoeur: Involvement of Notch1 in the development of mouse mammary tumors. Oncogene, 18, 5973-81 (1999) (Pubitemid 29535009)
    • (1999) Oncogene , vol.18 , Issue.44 , pp. 5973-5981
    • Dievart, A.1    Beaulieu, N.2    Jolicoeur, P.3
  • 24
    • 0030910099 scopus 로고    scopus 로고
    • Regulation of the ERBB-2 promoter by RBPJκ and NOTCH
    • DOI 10.1074/jbc.272.22.14110
    • Chen, Y., W. H. Fischer & G. N. Gill: Regulation of the ERBB-2 promoter by RBPJkappa and NOTCH. J Biol Chem, 272, 14110-4 (1997) (Pubitemid 27232816)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.22 , pp. 14110-14114
    • Chen, Y.1    Fischer, W.H.2    Gill, G.N.3
  • 25
    • 0033617522 scopus 로고    scopus 로고
    • Notch signaling: Cell fate control and signal integration in development
    • DOI 10.1126/science.284.5415.770
    • Artavanis-Tsakonas, S., M. D. Rand & R. J. Lake: Notch signaling: cell fate control and signal integration in development. Science, 284, 770-6 (1999) (Pubitemid 29291335)
    • (1999) Science , vol.284 , Issue.5415 , pp. 770-776
    • Artavanis-Tsakonas, S.1    Rand, M.D.2    Lake, R.J.3
  • 26
    • 0025856717 scopus 로고
    • TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
    • Ellisen, L. W., J. Bird, D. C. West, A. L. Soreng, T. C. Reynolds, S. D. Smith & J. Sklar: TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell, 66, 649-61 (1991) (Pubitemid 121001701)
    • (1991) Cell , vol.66 , Issue.4 , pp. 649-661
    • Ellisen, L.W.1    Bird, J.2    West, D.C.3    Soreng, A.L.4    Reynolds, T.C.5    Smith, S.D.6    Sklar, J.7
  • 28
    • 33644660241 scopus 로고    scopus 로고
    • Overexpression of activated murine Notch1 and Notch3 in transgenic mice blocks mammary gland development and induces mammary tumors
    • DOI 10.2353/ajpath.2006.050416
    • Hu, C., A. Dievart, M. Lupien, E. Calvo, G. Tremblay & P. Jolicoeur: Overexpression of activated murine Notch1 and Notch3 in transgenic mice blocks mammary gland development and induces mammary tumors. Am J Pathol, 168, 973-90 (2006) (Pubitemid 43327749)
    • (2006) American Journal of Pathology , vol.168 , Issue.3 , pp. 973-990
    • Hu, C.1    Dievart, A.2    Lupien, M.3    Calvo, E.4    Tremblay, G.5    Jolicoeur, P.6
  • 29
    • 0026517312 scopus 로고
    • Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands
    • Jhappan, C., D. Gallahan, C. Stahle, E. Chu, G. H. Smith, G. Merlino & R. Callahan: Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands. Genes Dev, 6, 345-55 (1992)
    • (1992) Genes Dev , vol.6 , pp. 345-355
    • Jhappan, C.1    Gallahan, D.2    Stahle, C.3    Chu, E.4    Smith, G.H.5    Merlino, G.6    Callahan, R.7
  • 30
    • 0029871104 scopus 로고    scopus 로고
    • Expression of a truncated Int3 gene in developing secretory mammary epithelium specifically retards lobular differentiation resulting in tumorigenesis
    • Gallahan, D., C. Jhappan, G. Robinson, L. Hennighausen, R. Sharp, E. Kordon, R. Callahan, G. Merlino & G. H. Smith: Expression of a truncated Int3 gene in developing secretory mammary epithelium specifically retards lobular differentiation resulting in tumorigenesis. Cancer Res, 56, 1775-85 (1996) (Pubitemid 26118213)
    • (1996) Cancer Research , vol.56 , Issue.8 , pp. 1775-1785
    • Gallahan, D.1    Jhappan, C.2    Robinson, G.3    Hennighausen, L.4    Sharp, R.5    Kordon, E.6    Callahan, R.7    Merlino, G.8    Smith, G.H.9
  • 31
    • 0026554890 scopus 로고
    • Mouse mammary tumor gene int-3: A member of the notch gene family transforms mammary epithelial cells
    • Robbins, J., B. J. Blondel, D. Gallahan & R. Callahan: Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells. J Virol, 66, 2594-9 (1992)
    • (1992) J Virol , vol.66 , pp. 2594-2599
    • Robbins, J.1    Blondel, B.J.2    Gallahan, D.3    Callahan, R.4
  • 32
    • 0030054646 scopus 로고    scopus 로고
    • Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene
    • Uyttendaele, H., G. Marazzi, G. Wu, Q. Yan, D. Sassoon & J. Kitajewski: Notch4/int-3, a mammary protooncogene, is an endothelial cell-specific mammalian Notch gene. Development, 122, 2251-9 (1996) (Pubitemid 26235824)
    • (1996) Development , vol.122 , Issue.7 , pp. 2251-2259
    • Uyttendaele, H.1    Marazzi, G.2    Wu, G.3    Yan, Q.4    Sassoon, D.5    Kitajewski, J.6
  • 34
    • 0030927183 scopus 로고    scopus 로고
    • The link between integration and expression of human papillomavirus type 16 genomes and cellular changes in the evolution of cervical intraepithelial neoplastic lesions
    • Daniel, B., A. Rangarajan, G. Mukherjee, E. Vallikad & S. Krishna: The link between integration and expression of human papillomavirus type 16 genomes and cellular changes in the evolution of cervical intraepithelial neoplastic lesions. J Gen Virol, 78(Pt 5), 1095-101 (1997) (Pubitemid 27207596)
    • (1997) Journal of General Virology , vol.78 , Issue.5 , pp. 1095-1101
    • Daniel, B.1    Rangarajan, A.2    Mukherjee, G.3    Vallikad, E.4    Krishna, S.5
  • 35
    • 0034729760 scopus 로고    scopus 로고
    • Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays
    • Leethanakul, C., V. Patel, J. Gillespie, M. Pallente, J. F. Ensley, S. Koontongkaew, L. A. Liotta, M. Emmert-Buck & J. S. Gutkind: Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays. Oncogene, 19, 3220-4 (2000) (Pubitemid 30455935)
    • (2000) Oncogene , vol.19 , Issue.28 , pp. 3220-3224
    • Leethanakul, C.1    Patel, V.2    Gillespie, J.3    Pallente, M.4    Ensley, J.F.5    Koontongkaew, S.6    Liotta, L.A.7    Emmert-Buck, M.8    Gutkind, J.S.9
  • 36
    • 0034544260 scopus 로고    scopus 로고
    • Imbalanced expression of TAN-1 and human Notch4 in endometrial cancers
    • Suzuki, T., D. Aoki, N. Susumu, Y. Udagawa & S. Nozawa: Imbalanced expression of TAN-1 and human Notch4 in endometrial cancers. Int J Oncol, 17, 1131-9 (2000)
    • (2000) Int J Oncol , vol.17 , pp. 1131-1139
    • Suzuki, T.1    Aoki, D.2    Susumu, N.3    Udagawa, Y.4    Nozawa, S.5
  • 37
    • 0036566557 scopus 로고    scopus 로고
    • Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma
    • DOI 10.1182/blood.V99.9.3398
    • Jundt, F., I. Anagnostopoulos, R. Forster, S. Mathas, H. Stein & B. Dorken: Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma. Blood, 99, 3398-403 (2002) (Pubitemid 34525322)
    • (2002) Blood , vol.99 , Issue.9 , pp. 3398-3403
    • Jundt, F.1    Anagnostopoulos, I.2    Forster, R.3    Mathas, S.4    Stein, H.5    Dorken, B.6
  • 38
    • 33745243418 scopus 로고    scopus 로고
    • Intracellular activated Notch1 is critical for proliferation of Kaposi's sarcoma-associated herpesvirus-associated B-lymphoma cell lines in vitro
    • DOI 10.1128/JVI.00239-06
    • Lan, K., T. Choudhuri, M. Murakami, D. A. Kuppers & E. S. Robertson: Intracellular activated Notch1 is critical for proliferation of Kaposi's sarcoma-associated herpesvirus-associated B-lymphoma cell lines in vitro. J Virol, 80, 6411-9 (2006) (Pubitemid 43927444)
    • (2006) Journal of Virology , vol.80 , Issue.13 , pp. 6411-6419
    • Lan, K.1    Choudhuri, T.2    Murakami, M.3    Kuppers, D.A.4    Robertson, E.S.5
  • 40
    • 30944467528 scopus 로고    scopus 로고
    • Notch3 signaling initiates choroid plexus tumor formation
    • DOI 10.1016/j.addr.2006.03.001, PII 1209074
    • Dang, L., X. Fan, A. Chaudhry, M. Wang, N. Gaiano & C. G. Eberhart: Notch3 signaling initiates choroid plexus tumor formation. Oncogene, 25, 487-91 (2006) (Pubitemid 43117634)
    • (2006) Oncogene , vol.25 , Issue.3 , pp. 487-491
    • Dang, L.1    Fan, X.2    Chaudhry, A.3    Wang, M.4    Gaiano, N.5    Eberhart, C.G.6
  • 41
    • 27144504699 scopus 로고    scopus 로고
    • The Notch pathway in ovarian carcinomas and adenomas
    • DOI 10.1038/sj.bjc.6602719, PII 6602719
    • Hopfer, O., D. Zwahlen, M. F. Fey & S. Aebi: The Notch pathway in ovarian carcinomas and adenomas. Br J Cancer, 93, 709-18 (2005) (Pubitemid 41486463)
    • (2005) British Journal of Cancer , vol.93 , Issue.6 , pp. 709-718
    • Hopfer, O.1    Zwahlen, D.2    Fey, M.F.3    Aebi, S.4
  • 44
    • 0034903932 scopus 로고    scopus 로고
    • Expression of Notch1 and Jagged1 proteins in acute myeloid leukemia cells
    • Tohda, S. & N. Nara: Expression of Notch1 and Jagged1 proteins in acute myeloid leukemia cells. Leuk Lymphoma, 42, 467-72 (2001) (Pubitemid 32725602)
    • (2001) Leukemia and Lymphoma , vol.42 , Issue.3 , pp. 467-472
    • Tohda, S.1    Nara, N.2
  • 45
    • 25844517958 scopus 로고    scopus 로고
    • Regulation of the Notch target gene Hes-1 by TGFα induced Ras/MAPK signaling in human neuroblastoma cells
    • DOI 10.1016/j.yexcr.2005.07.011, PII S0014482705003472
    • Stockhausen, M. T., J. Sjolund & H. Axelson: Regulation of the Notch target gene Hes-1 by TGFalpha induced Ras/MAPK signaling in human neuroblastoma cells. Exp Cell Res, 310, 218-28 (2005) (Pubitemid 41398083)
    • (2005) Experimental Cell Research , vol.310 , Issue.1 , pp. 218-228
    • Stockhausen, M.-T.1    Sjolund, J.2    Axelson, H.3
  • 48
    • 21244489623 scopus 로고    scopus 로고
    • Notch 1 oncoprotein antagonizes TGF-β/Smad-mediated cell growth suppression via sequestration of coactivator p300
    • DOI 10.1111/j.1349-7006.2005.00048.x
    • Masuda, S., K. Kumano, K. Shimizu, Y. Imai, M. Kurokawa, S. Ogawa, M. Miyagishi, K. Taira, H. Hirai & S. Chiba: Notch1 oncoprotein antagonizes TGF-beta/Smad-mediated cell growth suppression via sequestration of coactivator p300. Cancer Sci, 96, 274-82 (2005) (Pubitemid 40895075)
    • (2005) Cancer Science , vol.96 , Issue.5 , pp. 274-282
    • Masuda, S.1    Kumano, K.2    Shimizu, K.3    Imai, Y.4    Kurokawa, M.5    Ogawa, S.6    Miyagishi, M.7    Taira, K.8    Hirai, H.9    Chiba, S.10
  • 50
    • 32944470488 scopus 로고    scopus 로고
    • Aberrant activation of Notch signaling in human breast cancer
    • DOI 10.1158/0008-5472.CAN-05-3054
    • Stylianou, S., R. B. Clarke & K. Brennan: Aberrant activation of notch signaling in human breast cancer. Cancer Res, 66, 1517-25 (2006) (Pubitemid 43259933)
    • (2006) Cancer Research , vol.66 , Issue.3 , pp. 1517-1525
    • Stylianou, S.1    Clarke, R.B.2    Brennan, K.3
  • 51
    • 33645473185 scopus 로고    scopus 로고
    • Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells
    • Wang, Z., Y. Zhang, Y. Li, S. Banerjee, J. Liao & F. H. Sarkar: Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells. Mol Cancer Ther, 5, 483-93 (2006)
    • (2006) Mol Cancer Ther , vol.5 , pp. 483-493
    • Wang, Z.1    Zhang, Y.2    Li, Y.3    Banerjee, S.4    Liao, J.5    Sarkar, F.H.6
  • 52
    • 33646257783 scopus 로고    scopus 로고
    • Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase/phosphatidylinositol 3-kinase-Akt pathways and up-regulating N-cadherin expression
    • Liu, Z. J., M. Xiao, K. Balint, K. S. Smalley, P. Brafford, R. Qiu, C. C. Pinnix, X. Li & M. Herlyn: Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase/phosphatidylinositol 3-kinase-Akt pathways and up-regulating N-cadherin expression. Cancer Res, 66, 4182-90 (2006)
    • (2006) Cancer Res , vol.66 , pp. 4182-4190
    • Liu, Z.J.1    Xiao, M.2    Balint, K.3    Smalley, K.S.4    Brafford, P.5    Qiu, R.6    Pinnix, C.C.7    Li, X.8    Herlyn, M.9
  • 53
    • 33646877856 scopus 로고    scopus 로고
    • Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells
    • DOI 10.1002/cncr.21904
    • Wang, Z., Y. Zhang, S. Banerjee, Y. Li & F. H. Sarkar: Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells. Cancer, 106, 2503-13 (2006) (Pubitemid 43787677)
    • (2006) Cancer , vol.106 , Issue.11 , pp. 2503-2513
    • Wang, Z.1    Zhang, Y.2    Banerjee, S.3    Li, Y.4    Sarkar, F.H.5
  • 54
    • 23844446044 scopus 로고    scopus 로고
    • Suppression of p53 by Notch in lymphomagenesis: Implications for initiation and regression
    • DOI 10.1158/0008-5472.CAN-05-1664
    • Beverly, L. J., D. W. Felsher & A. J. Capobianco: Suppression of p53 by Notch in lymphomagenesis: implications for initiation and regression. Cancer Res, 65, 7159-68 (2005) (Pubitemid 41161246)
    • (2005) Cancer Research , vol.65 , Issue.16 , pp. 7159-7168
    • Beverly, L.J.1    Felsher, D.W.2    Capobianco, A.J.3
  • 55
    • 33646415906 scopus 로고    scopus 로고
    • Survival signaling by Notch1: Mammalian target of rapamycin (mTOR)-dependent inhibition of p53
    • Mungamuri, S. K., X. Yang, A. D. Thor & K. Somasundaram: Survival signaling by Notch1: mammalian target of rapamycin (mTOR)-dependent inhibition of p53. Cancer Res, 66, 4715-24 (2006)
    • (2006) Cancer Res , vol.66 , pp. 4715-4724
    • Mungamuri, S.K.1    Yang, X.2    Thor, A.D.3    Somasundaram, K.4
  • 56
    • 22244461524 scopus 로고    scopus 로고
    • Notch signaling from tumor cells: A new mechanism of angiogenesis
    • DOI 10.1016/j.ccr.2005.06.013, PII S1535610805001996
    • Li, J. L. & A. L. Harris: Notch signaling from tumor cells: a new mechanismofangiogenesis. Cancer Cell, 8, 1-3 (2005) (Pubitemid 40991807)
    • (2005) Cancer Cell , vol.8 , Issue.1 , pp. 1-3
    • Li, J.-L.1    Harris, A.L.2
  • 57
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • DOI 10.1038/nrc1093
    • Bergers, G. & L. E. Benjamin: Tumorigenesis and the angiogenic switch. Nat RevCancer, 3, 401-10 (2003) (Pubitemid 37328844)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.6 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 58
    • 0037216703 scopus 로고    scopus 로고
    • Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: Implications for modulating arteriogenesis and angiogenesis
    • DOI 10.1128/MCB.23.1.14-25.2003
    • Liu, Z. J., T. Shirakawa, Y. Li, A. Soma, M. Oka, G. P. Dotto, R. M. Fairman, O. C. Velazquez & M. Herlyn: Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. Mol Cell Biol, 23, 14-25 (2003) (Pubitemid 36008497)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.1 , pp. 14-25
    • Liu, Z.-J.1    Shirakawa, T.2    Li, Y.3    Soma, A.4    Oka, M.5    Dotto, G.P.6    Fairman, R.M.7    Velazquez, O.C.8    Herlyn, M.9
  • 59
    • 25444506836 scopus 로고    scopus 로고
    • Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function
    • DOI 10.1158/0008-5472.CAN-05-1208
    • Patel, N. S., J. L. Li, D. Generali, R. Poulsom, D. W. Cranston & A. L. Harris: Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function. Cancer Res, 65, 8690-7 (2005) (Pubitemid 41377356)
    • (2005) Cancer Research , vol.65 , Issue.19 , pp. 8690-8697
    • Patel, N.S.1    Li, J.-L.2    Generali, D.3    Poulsom, R.4    Cranston, D.W.5    Harris, A.L.6
  • 60
    • 0035753241 scopus 로고    scopus 로고
    • Delta4, an endothelial specific Notch ligand expressed at sites of physiological and tumor angiogenesis
    • Mailhos, C., U. Modlich, J. Lewis, A. Harris, R. Bicknell & D. Ish-Horowicz: Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis. Differentiation, 69, 135-44 (2001) (Pubitemid 33755062)
    • (2001) Differentiation , vol.69 , Issue.2-3 , pp. 135-144
    • Mailhos, C.1    Modlich, U.2    Lewis, J.3    Harris, A.4    Bicknell, R.5    Ish-Horowicz, D.6
  • 61
    • 22244460522 scopus 로고    scopus 로고
    • Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling
    • DOI 10.1016/j.ccr.2005.06.004, PII S1535610805001923
    • Zeng, Q., S. Li, D. B. Chepeha, T. J. Giordano, J. Li, H. Zhang, P. J. Polverini, J. Nor, J. Kitajewski & C. Y. Wang: Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling. Cancer Cell, 8, 13-23 (2005) (Pubitemid 40991811)
    • (2005) Cancer Cell , vol.8 , Issue.1 , pp. 13-23
    • Zeng, Q.1    Li, S.2    Chepeha, D.B.3    Giordano, T.J.4    Li, J.5    Zhang, H.6    Polverini, P.J.7    Nor, J.8    Kitajewski, J.9    Wang, C.-Y.10
  • 62
    • 33645049305 scopus 로고    scopus 로고
    • Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factorkappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells
    • Wang, Z., S. Banerjee, Y. Li, K. M. Rahman, Y. Zhang & F. H. Sarkar: Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factorkappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells. Cancer Res, 66, 2778-84 (2006)
    • (2006) Cancer Res , vol.66 , pp. 2778-2784
    • Wang, Z.1    Banerjee, S.2    Li, Y.3    Rahman, K.M.4    Zhang, Y.5    Sarkar, F.H.6
  • 63
    • 0033624445 scopus 로고    scopus 로고
    • Matrix metalloproteinasesmolecular aspects of their roles in tumour invasion and metastasis
    • DOI 10.1016/S0959-8049(00)00156-8, PII S0959804900001568
    • Curran, S. & G. I. Murray: Matrix metalloproteinases: molecular aspects of their roles in tumour invasion and metastasis. Eur J Cancer, 36, 1621-30 (2000) (Pubitemid 30616366)
    • (2000) European Journal of Cancer , vol.36 , Issue.13 , pp. 1621-1630
    • Curran, S.1    Murray, G.I.2
  • 64
    • 0034956272 scopus 로고    scopus 로고
    • The role of matrix metalloproteinases in tumor angiogenesis and tumor metastasis
    • John, A. & G. Tuszynski: The role of matrix metalloproteinases in tumor angiogenesis and tumor metastasis. Pathol Oncol Res, 7, 14-23 (2001) (Pubitemid 32591662)
    • (2001) Pathology Oncology Research , vol.7 , Issue.1 , pp. 14-23
    • John, A.1    Tuszynski, G.2
  • 65
    • 0348012946 scopus 로고    scopus 로고
    • NF-κB activity blockade impairs the angiogenic potential of human pancreatic cancer cells
    • DOI 10.1002/ijc.11562
    • Xiong, H. Q., J. L. Abbruzzese, E. Lin, L. Wang, L. Zheng & K. Xie: NF-kappaB activity blockade impairs the angiogenic potential of human pancreatic cancer cells. Int J Cancer, 108, 181-8 (2004) (Pubitemid 37541768)
    • (2004) International Journal of Cancer , vol.108 , Issue.2 , pp. 181-188
    • Xiong, H.Q.1    Abbruzzese, J.L.2    Lin, E.3    Wang, L.4    Zheng, L.5    Xie, K.6
  • 66
    • 0037470435 scopus 로고    scopus 로고
    • Requirement of different signaling pathways mediated by insulin-like growth factor-I receptor for proliferation, invasion, and VPF/VEGF expression in a pancreatic carcinoma cell line
    • DOI 10.1016/S0006-291X(03)00107-4
    • Zeng, H., K. Datta, M. Neid, J. Li, S. Parangi & D. Mukhopadhyay: Requirement of different signaling pathways mediated by insulin-like growth factor-I receptor for proliferation, invasion, and VPF/VEGF expression in a pancreatic carcinoma cell line. Biochem Biophys Res Commun, 302, 46-55 (2003) (Pubitemid 36268917)
    • (2003) Biochemical and Biophysical Research Communications , vol.302 , Issue.1 , pp. 46-55
    • Zeng, H.1    Datta, K.2    Neid, M.3    Li, J.4    Parangi, S.5    Mukhopadhyay, D.6
  • 67
    • 33645064160 scopus 로고    scopus 로고
    • Inhibition of nuclear factor kappab activity by genistein is mediated via Notch-1 signaling pathway in pancreatic cancer cells
    • Wang, Z., Y. Zhang, S. Banerjee, Y. Li & F. H. Sarkar: Inhibition of nuclear factor kappab activity by genistein is mediated via Notch-1 signaling pathway in pancreatic cancer cells. Int J Cancer, 118, 1930-6 (2006)
    • (2006) Int J Cancer , vol.118 , pp. 1930-1936
    • Wang, Z.1    Zhang, Y.2    Banerjee, S.3    Li, Y.4    Sarkar, F.H.5
  • 68
    • 0035200379 scopus 로고    scopus 로고
    • EBNA2 and Notch signalling in Epstein-Barr virus mediated immortalization of B lymphocytes
    • DOI 10.1006/scbi.2001.0409
    • Zimber-Strobl, U. & L. J. Strobl: EBNA2 and Notch signalling in Epstein-Barr virus mediated immortalization of B lymphocytes. Semin Cancer Biol, 11, 423-34 (2001) (Pubitemid 33105021)
    • (2001) Seminars in Cancer Biology , vol.11 , Issue.6 , pp. 423-434
    • Zimber-Strobl, U.1    Strobl, L.J.2
  • 69
    • 0343517577 scopus 로고    scopus 로고
    • Activated Notch1 modulates gene expression in B cells similarly to Epstein-Barr viral nuclear antigen 2
    • DOI 10.1128/JVI.74.4.1727-1735.2000
    • Strobl, L. J., H. Hofelmayr, G. Marschall, M. Brielmeier, G. W. Bornkamm & U. Zimber-Strobl: Activated Notch1 modulates gene expression in B cells similarly to Epstein-Barr viral nuclear antigen 2. J Virol, 74, 1727-35 (2000) (Pubitemid 30434029)
    • (2000) Journal of Virology , vol.74 , Issue.4 , pp. 1727-1735
    • Strobl, L.J.1    Hofelmayr, H.2    Marschall, G.3    Brielmeier, M.4    Bornkamm, G.W.5    Zimber-Strobl, U.6
  • 70
    • 0030063909 scopus 로고    scopus 로고
    • Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2
    • Hsieh, J. J., T. Henkel, P. Salmon, E. Robey, M. G. Peterson & S. D. Hayward: Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2. Mol Cell Biol, 16, 952-9 (1996) (Pubitemid 26061666)
    • (1996) Molecular and Cellular Biology , vol.16 , Issue.3 , pp. 952-959
    • Hsieh, J.J.-D.1    Henkel, T.2    Salmon, P.3    Robey, E.4    Peterson, M.G.5    Hayward, S.D.6
  • 71
    • 0035135322 scopus 로고    scopus 로고
    • Activated Notch1 can transiently substitute for EBNA2 in the maintenance of proliferation of LMP1-expressing immortalized B cells
    • DOI 10.1128/JVI.75.5.2033-2040.2001
    • Hofelmayr, H., L. J. Strobl, G. Marschall, G. W. Bornkamm & U. Zimber-Strobl: Activated Notch1 can transiently substitute for EBNA2 in the maintenance of proliferation of LMP1-expressing immortalized B cells. J Virol, 75, 2033-40 (2001) (Pubitemid 32147542)
    • (2001) Journal of Virology , vol.75 , Issue.5 , pp. 2033-2040
    • Hofelmayr, H.1    Strobl, L.J.2    Marschall, G.3    Bornkamm, G.W.4    Zimber-Strobl, U.5
  • 72
    • 0034977362 scopus 로고    scopus 로고
    • Notch1IC partially replaces EBNA2 function in B cells immortalized by Epstein-Barr virus
    • DOI 10.1128/JVI.75.13.5899-5912.2001
    • Gordadze, A. V., R. Peng, J. Tan, G. Liu, R. Sutton, B. Kempkes, G. W. Bornkamm & P. D. Ling: Notch1IC partially replaces EBNA2 function in B cells immortalized by Epstein-Barr virus. J Virol, 75, 5899-912 (2001) (Pubitemid 32553120)
    • (2001) Journal of Virology , vol.75 , Issue.13 , pp. 5899-5912
    • Gordadze, A.V.1    Peng, R.2    Tan, J.3    Liu, G.4    Sutton, R.5    Kempkes, B.6    Bornkamm, G.W.7    Ling, P.D.8
  • 74
    • 0025639158 scopus 로고
    • The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
    • Scheffner, M., B. A. Werness, J. M. Huibregtse, A. J. Levine & P. M. Howley: The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell, 63, 1129-36 (1990) (Pubitemid 120035062)
    • (1990) Cell , vol.63 , Issue.6 , pp. 1129-1136
    • Scheffner, M.1    Werness, B.A.2    Huibregtse, J.M.3    Levine, A.J.4    Howley, P.M.5
  • 75
    • 0024535228 scopus 로고
    • The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product
    • Dyson, N., P. M. Howley, K. Munger & E. Harlow: The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science, 243, 934-7 (1989) (Pubitemid 19066153)
    • (1989) Science , vol.243 , Issue.4893 , pp. 934-937
    • Dyson, N.1    Howley, P.M.2    Munger, K.3    Harlow, E.4
  • 76
    • 0037362373 scopus 로고    scopus 로고
    • HPV16 E6 and E7 oncoproteins regulate Notch-1 expression and cooperate to induce transformation
    • DOI 10.1002/jcp.10217
    • Weijzen, S., A. Zlobin, M. Braid, L. Miele & W. M. Kast: HPV16 E6 and E7 oncoproteins regulate Notch-1 expression and cooperate to induce transformation. J Cell Physiol, 194, 356-62 (2003) (Pubitemid 36176896)
    • (2003) Journal of Cellular Physiology , vol.194 , Issue.3 , pp. 356-362
    • Weijzen, S.1    Zlobin, A.2    Braid, M.3    Miele, L.4    Kast, W.M.5
  • 77
    • 0035919676 scopus 로고    scopus 로고
    • Activated Notch1 signaling cooperates with papillomavirus oncogenes in transformation and generates resistance to apoptosis on matrix withdrawal through PKB/Akt
    • DOI 10.1006/viro.2001.0867
    • Rangarajan, A., R. Syal, S. Selvarajah, O. Chakrabarti, A. Sarin & S. Krishna: Activated Notch1 signaling cooperates with papillomavirus oncogenes in transformation and generates resistance to apoptosis on matrix withdrawal through PKB/Akt. Virology, 286, 23-30 (2001) (Pubitemid 32675462)
    • (2001) Virology , vol.286 , Issue.1 , pp. 23-30
    • Rangarajan, A.1    Syal, R.2    Selvarajah, S.3    Chakrabarti, O.4    Sarin, A.5    Krishna, S.6
  • 78
    • 0037941645 scopus 로고    scopus 로고
    • Activated Notch1 inhibits p53-induced apoptosis and sustains transformation by human papillomavirus type 16 E6 and E7 oncogenes through a PI3K-PKB/Akt-dependent pathway
    • DOI 10.1128/JVI.77.12.7106-7112.2003
    • Nair, P., K. Somasundaram & S. Krishna: Activated Notch1 inhibits p53-induced apoptosis and sustains transformation by human papillomavirus type 16 E6 and E7 oncogenes through a PI3K-PKB/Akt-dependent pathway. J Virol, 77, 7106-12 (2003) (Pubitemid 36666904)
    • (2003) Journal of Virology , vol.77 , Issue.12 , pp. 7106-7112
    • Nair, P.1    Somasundaram, K.2    Krishna, S.3
  • 79
    • 30544452875 scopus 로고    scopus 로고
    • Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation
    • DOI 10.1016/j.ydbio.2005.11.009, PII S0012160605007864
    • Wang, X. D., C. C. Leow, J. Zha, Z. Tang, Z. Modrusan, F. Radtke, M. Aguet, F. J. de Sauvage & W. Q. Gao: Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation. Dev Biol, 290, 66-80 (2006) (Pubitemid 43083604)
    • (2006) Developmental Biology , vol.290 , Issue.1 , pp. 66-80
    • Wang, X.-D.1    Leow, C.C.2    Zha, J.3    Tang, Z.4    Modrusan, Z.5    Radtke, F.6    Aguet, M.7    De Sauvage, F.J.8    Gao, W.-Q.9
  • 80
    • 33747014859 scopus 로고    scopus 로고
    • Growth suppression induced by Notch1 activation involves Wnt - β-catenin down-regulation in human tongue carcinoma cells
    • DOI 10.1042/BC20060020
    • Duan, L., J. Yao, X. Wu & M. Fan: Growth suppression induced by Notch1 activation involves Wnt-beta-catenin down-regulation in human tongue carcinoma cells. Biol Cell, 98, 479-90 (2006) (Pubitemid 44203907)
    • (2006) Biology of the Cell , vol.98 , Issue.8 , pp. 479-490
    • Duan, L.1    Yao, J.2    Wu, X.3    Fan, M.4
  • 81
    • 16244418366 scopus 로고    scopus 로고
    • Constitutively active Notch1 induces growth arrest of HPV-positive cervical cancer cells via separate signaling pathways
    • DOI 10.1016/j.yexcr.2005.01.015
    • Talora, C., S. Cialfi, O. Segatto, S. Morrone, J. Kim Choi, L. Frati, G. Paolo Dotto, A. Gulino & I. Screpanti: Constitutively active Notch1 induces growth arrest of HPV-positive cervical cancer cells via separate signaling pathways. Exp Cell Res, 305, 343-54 (2005) (Pubitemid 40462545)
    • (2005) Experimental Cell Research , vol.305 , Issue.2 , pp. 343-354
    • Talora, C.1    Cialfi, S.2    Segatto, O.3    Morrone, S.4    Kim Choi, J.5    Frati, L.6    Dotto, G.P.7    Gulino, A.8    Screpanti, I.9
  • 82
    • 0036713311 scopus 로고    scopus 로고
    • Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation
    • DOI 10.1101/gad.988902
    • Talora, C., D. C. Sgroi, C. P. Crum & G. P. Dotto: Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation. Genes Dev, 16, 2252-63 (2002) (Pubitemid 35013088)
    • (2002) Genes and Development , vol.16 , Issue.17 , pp. 2252-2263
    • Talora, C.1    Sgroi, D.C.2    Crum, C.P.3    Paolo Dotto, G.4
  • 84
    • 1042278765 scopus 로고    scopus 로고
    • The history of cancer epigenetics
    • Feinberg, A. P. & B. Tycko: The history of cancer epigenetics. Nat Rev Cancer, 4, 143-53 (2004) (Pubitemid 38198742)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.2 , pp. 143-153
    • Feinberg, A.P.1    Tycko, B.2
  • 85
    • 17444417521 scopus 로고    scopus 로고
    • Cancer epigenetics
    • DOI 10.1093/hmg/ddi113
    • Laird, P. W.: Cancer epigenetics. Hum Mol Genet, 14 Spec No 1, R65-76 (2005) (Pubitemid 40542622)
    • (2005) Human Molecular Genetics , vol.14 , Issue.SPEC. ISS. 1
    • Laird, P.W.1
  • 86
    • 31444452060 scopus 로고    scopus 로고
    • Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing
    • DOI 10.1038/nature04376, PII NATURE04376
    • Ferres-Marco, D., I. Gutierrez-Garcia, D. M. Vallejo, J. Bolivar, F. J. Gutierrez-Avino & M. Dominguez: Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing. Nature, 439, 430-6 (2006) (Pubitemid 43152828)
    • (2006) Nature , vol.439 , Issue.7075 , pp. 430-436
    • Ferres-Marco, D.1    Gutierrez-Garcia, I.2    Vallejo, D.M.3    Bolivar, J.4    Gutierrez-Avino, F.J.5    Dominguez, M.6
  • 87
    • 33749461057 scopus 로고    scopus 로고
    • Interplay between notch signaling and epigenetic silencers in cancer
    • DOI 10.1158/0008-5472.CAN-06-1858
    • Dominguez, M.: Interplay between Notch signaling and epigenetic silencers in cancer. Cancer Res, 66, 8931-4 (2006) (Pubitemid 44521106)
    • (2006) Cancer Research , vol.66 , Issue.18 , pp. 8931-8934
    • Dominguez, M.1
  • 88
    • 0035222855 scopus 로고    scopus 로고
    • The Ras Signaling Pathway in Mammary Tumorigenesis and Metastasis
    • DOI 10.1023/A:1009572700317
    • Malaney, S. & R. J. Daly: The ras signaling pathway in mammary tumorigenesis and metastasis. J Mammary Gland Biol Neoplasia, 6, 101-13 (2001) (Pubitemid 33640649)
    • (2001) Journal of Mammary Gland Biology and Neoplasia , vol.6 , Issue.1 , pp. 101-113
    • Malaney, S.1    Daly, R.J.2
  • 89
    • 0344759138 scopus 로고    scopus 로고
    • Immunohistochemical detection of H-ras protooncoprotein p21 indicates favorable prognosis in node-negative breast cancer patients
    • DOI 10.1159/000030061
    • Gohring, U. J., T. Schondorf, V. R. Kiecker, M. Becker, C. Kurbacher & A. Scharl: Immunohistochemical detection of H-ras protooncoprotein p21 indicates favorable prognosis in node-negative breast cancer patients. Tumour Biol, 20, 173-83 (1999) (Pubitemid 29287473)
    • (1999) Tumor Biology , vol.20 , Issue.4 , pp. 173-183
    • Gohring, U.-J.1    Schondorf, T.2    Kiecker, V.R.3    Becker, M.4    Kurbacher, C.5    Scharl, A.6
  • 91
    • 0034738965 scopus 로고    scopus 로고
    • Ras pathway signals are required for notch-mediated oncogenesis
    • Fitzgerald, K., A. Harrington & P. Leder: Ras pathway signals are required for notch-mediated oncogenesis. Oncogene, 19, 4191-8 (2000)
    • (2000) Oncogene , vol.19 , pp. 4191-4198
    • Fitzgerald, K.1    Harrington, A.2    Leder, P.3
  • 92
    • 18144426777 scopus 로고    scopus 로고
    • Dominant-negative Notch3 receptor inhibits mitogen-activated protein kinase pathway and the growth of human lung cancers
    • DOI 10.1158/0008-5472.CAN-04-3132
    • Haruki, N., K. S. Kawaguchi, S. Eichenberger, P. P. Massion, S. Olson, A. Gonzalez, D. P. Carbone & T. P. Dang: Dominant-negative Notch3 receptor inhibits mitogen-activated protein kinase pathway and the growth of human lung cancers. Cancer Res, 65, 3555-61 (2005) (Pubitemid 40616330)
    • (2005) Cancer Research , vol.65 , Issue.9 , pp. 3555-3561
    • Haruki, N.1    Kawaguchi, K.S.2    Eichenberger, S.3    Massion, P.P.4    Olson, S.5    Gonzalez, A.6    Carbone, D.P.7    Dang, T.P.8
  • 94
    • 0022399581 scopus 로고
    • Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene
    • Coussens, L., T. L. Yang-Feng, Y. C. Liao, E. Chen, A. Gray, J. McGrath, P. H. Seeburg, T. A. Libermann, J. Schlessinger, U. Francke & et al.: Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. Science, 230, 1132-9 (1985) (Pubitemid 16169997)
    • (1985) Science , vol.230 , Issue.4730 , pp. 1132-1139
    • Coussens, L.1    Yang-Feng, T.L.2    Liao, Y.-C.3
  • 95
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon, D. J., G. M. Clark, S. G. Wong, W. J. Levin, A. Ullrich & W. L. McGuire: Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science, 235, 177-82 (1987) (Pubitemid 17231334)
    • (1987) Science , vol.235 , Issue.4785 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 97
    • 0023301170 scopus 로고
    • Overexpression of the EGF receptor-related protooncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms
    • Kraus, M. H., N. C. Popescu, S. C. Amsbaugh & C. R. King: Overexpression of the EGF receptor-related protooncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms. Embo J, 6, 605-10 (1987)
    • (1987) Embo J , vol.6 , pp. 605-610
    • Kraus, M.H.1    Popescu, N.C.2    Amsbaugh, S.C.3    King, C.R.4
  • 99
    • 0345166971 scopus 로고    scopus 로고
    • Cross-talk between the Notch and TGF-β signaling pathways mediated by interaction of the Notch intracellular domain with Smad3
    • DOI 10.1083/jcb.200305112
    • Blokzijl, A., C. Dahlqvist, E. Reissmann, A. Falk, A. Moliner, U. Lendahl & C. F. Ibanez: Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3. J Cell Biol, 163, 723-8 (2003) (Pubitemid 37517880)
    • (2003) Journal of Cell Biology , vol.163 , Issue.4 , pp. 723-728
    • Blokzijl, A.1    Dahlqvist, C.2    Reissmann, E.3    Falk, A.4    Moliner, A.5    Lendahl, U.6    Ibanez, C.F.7
  • 100
    • 1842524153 scopus 로고    scopus 로고
    • Integration of TGF-β/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition
    • DOI 10.1038/sj.emboj.7600069
    • Zavadil, J., L. Cermak, N. Soto-Nieves & E. P. Bottinger: Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition. Embo J, 23, 1155-65 (2004) (Pubitemid 38436879)
    • (2004) EMBO Journal , vol.23 , Issue.5 , pp. 1155-1165
    • Zavadil, J.1    Cermak, L.2    Soto-Nieves, N.3    Bottinger, E.P.4
  • 101
    • 0021270667 scopus 로고
    • Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15
    • Nusse, R., A. van Ooyen, D. Cox, Y. K. Fung & H. Varmus: Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15. Nature, 307, 131-6 (1984) (Pubitemid 14132897)
    • (1984) Nature , vol.307 , Issue.5947 , pp. 131-136
    • Nusse, R.1    Van Ooyen, A.2    Cox, D.3
  • 102
    • 0034696341 scopus 로고    scopus 로고
    • MMTV-induced mammary tumorigenesis: Gene discovery, progression to malignancy and cellular pathways
    • Callahan, R. & G. H. Smith: MMTV-induced mammary tumorigenesis: gene discovery, progression to malignancy and cellular pathways. Oncogene, 19, 992-1001 (2000) (Pubitemid 30153782)
    • (2000) Oncogene , vol.19 , Issue.8 , pp. 992-1001
    • Callahan, R.1    Smith, G.H.2
  • 103
    • 0024162530 scopus 로고
    • Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice
    • Tsukamoto, A. S., R. Grosschedl, R. C. Guzman, T. Parslow & H. E. Varmus: Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. Cell, 55, 619-25 (1988)
    • (1988) Cell , vol.55 , pp. 619-625
    • Tsukamoto, A.S.1    Grosschedl, R.2    Guzman, R.C.3    Parslow, T.4    Varmus, H.E.5
  • 104
    • 3142590865 scopus 로고    scopus 로고
    • Wnt signaling and breast cancer
    • Howe, L. R. & A. M. Brown: Wnt signaling and breast cancer. Cancer Biol Ther, 3, 36-41 (2004)
    • (2004) Cancer Biol Ther , vol.3 , pp. 36-41
    • Howe, L.R.1    Brown, A.M.2
  • 105
    • 0033545570 scopus 로고    scopus 로고
    • Differential expression assay of chromosome arm 8p genes identifies Frizzled-related (FRP1/FRZB) and fibroblast growth factor receptor 1 (FGFR1) as candidate breast cancer genes
    • Ugolini, F., J. Adelaide, E. Charafe-Jauffret, C. Nguyen, J. Jacquemier, B. Jordan, D. Birnbaum & M. J. Pebusque: Differential expression assay of chromosome arm 8p genes identifies Frizzled-related (FRP1/FRZB) and Fibroblast Growth Factor Receptor 1 (FGFR1) as candidate breast cancer genes. Oncogene, 18, 1903-10 (1999) (Pubitemid 29145858)
    • (1999) Oncogene , vol.18 , Issue.10 , pp. 1903-1910
    • Ugolini, F.1    Adelaide, J.2    Charafe-Jauffret, E.3    Nguyen, C.4    Jacquemier, J.5    Jordan, B.6    Birnbaum, D.7    Pebusque, M.-J.8
  • 107
    • 0038301969 scopus 로고    scopus 로고
    • Amplification, up-regulation and over-expression of DVL-1, the human counterpart of the Drosophila disheveled gene, in primary breast cancers
    • Nagahata, T., T. Shimada, A. Harada, H. Nagai, M. Onda, S. Yokoyama, T. Shiba, E. Jin, O. Kawanami & M. Emi: Amplification, up-regulation and over-expression of DVL-1, the human counterpart of the Drosophila disheveled gene, in primary breast cancers. Cancer Sci, 94, 515-8 (2003) (Pubitemid 36849715)
    • (2003) Cancer Science , vol.94 , Issue.6 , pp. 515-518
    • Nagahata, T.1    Shimada, T.2    Harada, A.3    Nagai, H.4    Onda, M.5    Yokoyama, S.6    Shiba, T.7    Jin, E.8    Kawanami, O.9    Emi, M.10
  • 108
    • 0033895709 scopus 로고    scopus 로고
    • Wnt signaling and cancer
    • Polakis, P.: Wnt signaling and cancer. Genes Dev, 14, 1837-51 (2000) (Pubitemid 30639518)
    • (2000) Genes and Development , vol.14 , Issue.15 , pp. 1837-1851
    • Polakis, P.1
  • 109
    • 0029781509 scopus 로고    scopus 로고
    • Functional interaction of β-catenin with the transcription factor LEF- 1
    • DOI 10.1038/382638a0
    • Behrens, J., J. P. von Kries, M. Kuhl, L. Bruhn, D. Wedlich, R. Grosschedl & W. Birchmeier: Functional interaction of beta-catenin with the transcription factor LEF-1. Nature, 382, 638-42 (1996) (Pubitemid 26268958)
    • (1996) Nature , vol.382 , Issue.6592 , pp. 638-642
    • Behrens, J.1    Von Kries, J.P.2    Kuhl, M.3    Bruhn, L.4    Wedlich, D.5    Grosschedl, R.6    Birchmeier, W.7
  • 111
    • 0041856097 scopus 로고    scopus 로고
    • Phosphorylation by glycogen synthase kinase-3β down-regulates Notch activity, a link for Notch and Wnt pathways
    • DOI 10.1074/jbc.M304001200
    • Espinosa, L., J. Ingles-Esteve, C. Aguilera & A. Bigas: Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways. J Biol Chem, 278, 32227-35 (2003) (Pubitemid 37048415)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.34 , pp. 32227-32235
    • Espinosa, L.1    Ingles-Esteve, J.2    Aguilera, C.3    Bigas, A.4
  • 112
    • 0032522992 scopus 로고    scopus 로고
    • Notch4 and Wnt-1 proteins function to regulate branching morphogenesis of mammary epithelial cells in an opposing fashion
    • DOI 10.1006/dbio.1998.8863
    • Uyttendaele, H., J. V. Soriano, R. Montesano & J. Kitajewski: Notch4 and Wnt-1 proteins function to regulate branching morphogenesis of mammary epithelial cells in an opposing fashion. Dev Biol, 196, 204-17 (1998) (Pubitemid 28198847)
    • (1998) Developmental Biology , vol.196 , Issue.2 , pp. 204-217
    • Uyttendaele, H.1    Soriano, J.V.2    Montesano, R.3    Kitajewski, J.4
  • 113
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - A key regulatory factor in tumour growth
    • Harris, A. L.: Hypoxia-a key regulatory factor in tumour growth. Nat Rev Cancer, 2, 38-47 (2002) (Pubitemid 37328806)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.1 , pp. 38-47
    • Harris, A.L.1
  • 118
    • 4544326176 scopus 로고    scopus 로고
    • Evidence for the notch signaling pathway on the role of estrogen in angiogenesis
    • DOI 10.1210/me.2003-0362
    • Soares, R., G. Balogh, S. Guo, F. Gartner, J. Russo & F. Schmitt: Evidence for the notch signaling pathway on the role of estrogen in angiogenesis. Mol Endocrinol, 18, 2333-43 (2004) (Pubitemid 39215261)
    • (2004) Molecular Endocrinology , vol.18 , Issue.9 , pp. 2333-2343
    • Soares, R.1    Balogh, G.2    Guo, S.3    Gartner, F.4    Russo, J.5    Schmitt, F.6
  • 119
    • 14244269366 scopus 로고    scopus 로고
    • The possible correlation of Notch-1 and Notch-2 with clinical outcome and tumour clinicopathological parameters in human breast cancer
    • Parr, C., G. Watkins & W. G. Jiang: The possible correlation of Notch-1 and Notch-2 with clinical outcome and tumour clinicopathological parameters in human breast cancer. Int J Mol Med, 14, 779-86 (2004)
    • (2004) Int J Mol Med , vol.14 , pp. 779-786
    • Parr, C.1    Watkins, G.2    Jiang, W.G.3
  • 120
    • 24944506696 scopus 로고    scopus 로고
    • High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival
    • DOI 10.1158/0008-5472.CAN-05-1069
    • Reedijk, M., S. Odorcic, L. Chang, H. Zhang, N. Miller, D. R. McCready, G. Lockwood & S. E. Egan: Highlevel coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Res, 65, 8530-7 (2005) (Pubitemid 41330622)
    • (2005) Cancer Research , vol.65 , Issue.18 , pp. 8530-8537
    • Reedijk, M.1    Odorcic, S.2    Chang, L.3    Zhang, H.4    Miller, N.5    McCready, D.R.6    Lockwood, G.7    Sean, E.8
  • 122
    • 33745168977 scopus 로고    scopus 로고
    • Functional characterization of novel presenilin-2 variants identified in human breast cancers
    • DOI 10.1038/sj.onc.1209397, PII 1209397
    • To, M. D., N. Gokgoz, T. G. Doyle, D. B. Donoviel, J. A. Knight, P. S. Hyslop, A. Bernstein & I. L. Andrulis: Functional characterization of novel presenilin-2 variants identified in human breast cancers. Oncogene, 25, 3557-64 (2006) (Pubitemid 43901677)
    • (2006) Oncogene , vol.25 , Issue.25 , pp. 3557-3564
    • To, M.D.1    Gokgoz, N.2    Doyle, T.G.3    Donoviel, D.B.4    Knight, J.A.5    Hyslop, P.S.6    Bernstein, A.7    Andrulis, I.L.8
  • 123
    • 33745509199 scopus 로고    scopus 로고
    • NOTCH signaling as a novel cancer therapeutic target
    • DOI 10.2174/156800906777441771
    • Miele, L., H. Miao & B. J. Nickoloff: NOTCH signaling as a novel cancer therapeutic target. Curr Cancer Drug Targets, 6, 313-23 (2006) (Pubitemid 43961866)
    • (2006) Current Cancer Drug Targets , vol.6 , Issue.4 , pp. 313-323
    • Miele, L.1    Miao, H.2    Nickoloff, B.J.3
  • 124
    • 27144512725 scopus 로고    scopus 로고
    • Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells
    • DOI 10.1038/sj.onc.1208783, PII 1208783
    • Curry, C. L., L. L. Reed, T. E. Golde, L. Miele, B. J. Nickoloff & K. E. Foreman: Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells. Oncogene, 24, 6333-44 (2005) (Pubitemid 41486467)
    • (2005) Oncogene , vol.24 , Issue.42 , pp. 6333-6344
    • Curry, C.L.1    Reed, L.L.2    Golde, T.E.3    Miele, L.4    Nickoloff, B.J.5    Foreman, K.E.6
  • 125
    • 18844386841 scopus 로고    scopus 로고
    • Inhibition of angiogenesis and tumor growth by β and γ-secretase inhibitors
    • DOI 10.1016/j.ejphar.2005.02.050, PII S0014299905002438
    • Paris, D., A. Quadros, N. Patel, A. DelleDonne, J. Humphrey & M. Mullan: Inhibition of angiogenesis and tumor growth by beta and gamma-secretase inhibitors. Eur J Pharmacol, 514, 1-15 (2005) (Pubitemid 40692758)
    • (2005) European Journal of Pharmacology , vol.514 , Issue.1 , pp. 1-15
    • Paris, D.1    Quadros, A.2    Patel, N.3    DelleDonne, A.4    Humphrey, J.5    Mullan, M.6
  • 126
  • 128
    • 24644458638 scopus 로고    scopus 로고
    • The role of TGF-β and Wnt signaling in gastrointestinal stem cells and cancer
    • DOI 10.1038/sj.onc.1208924, PII 1208924
    • Mishra, L., K. Shetty, Y. Tang, A. Stuart & S. W. Byers: The role of TGF-beta and Wnt signaling in gastrointestinal stem cells and cancer. Oncogene, 24, 5775-89 (2005) (Pubitemid 43086137)
    • (2005) Oncogene , vol.24 , Issue.37 , pp. 5775-5789
    • Mishra, L.1    Shetty, K.2    Tang, Y.3    Stuart, A.4    Byers, S.W.5
  • 129
    • 6044221204 scopus 로고    scopus 로고
    • Cancer stem cells in nervous system tumors
    • DOI 10.1038/sj.onc.1207946
    • Singh, S. K., I. D. Clarke, T. Hide & P. B. Dirks: Cancer stem cells in nervous system tumors. Oncogene, 23, 7267-73 (2004) (Pubitemid 39382160)
    • (2004) Oncogene , vol.23 , Issue.43 REV. ISS. 6 , pp. 7267-7273
    • Singh, S.K.1    Clarke, I.D.2    Hide, T.3    Dirks, P.B.4
  • 130
    • 34247843997 scopus 로고    scopus 로고
    • Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review)
    • Katoh, Y. & M. Katoh: Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review). Int J Mol Med, 18, 1019-23 (2006)
    • (2006) Int J Mol Med , vol.18 , pp. 1019-1023
    • Katoh, Y.1    Katoh, M.2
  • 131
    • 18944407603 scopus 로고    scopus 로고
    • Mammary stem cells, self-renewal pathways, and carcinogenesis
    • DOI 10.1186/bcr1021, 86
    • Liu, S., G. Dontu & M. S. Wicha: Mammary stem cells, self-renewal pathways, and carcinogenesis. Breast Cancer Res, 7, 86-95 (2005) (Pubitemid 40704127)
    • (2005) Breast Cancer Research , vol.7 , Issue.3 , pp. 86-95
    • Liu, S.1    Dontu, G.2    Wicha, M.S.3
  • 133
    • 0029002597 scopus 로고
    • Constitutive expression of a truncated INT3 gene in mouse mammary epithelium impairs differentiation and functional development
    • Smith, G. H., D. Gallahan, F. Diella, C. Jhappan, G. Merlino & R. Callahan: Constitutive expression of a truncated INT3 gene in mouse mammary epithelium impairs differentiation and functional development. Cell Growth Differ, 6, 563-77 (1995)
    • (1995) Cell Growth Differ , vol.6 , pp. 563-577
    • Smith, G.H.1    Gallahan, D.2    Diella, F.3    Jhappan, C.4    Merlino, G.5    Callahan, R.6
  • 135
    • 22244433866 scopus 로고    scopus 로고
    • - cancer cells are similarly tumorigenic
    • DOI 10.1158/0008-5472.CAN-05-0592
    • Patrawala, L., T. Calhoun, R. Schneider-Broussard, J. Zhou, K. Claypool & D. G. Tang: Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2-cancer cells are similarly tumorigenic. Cancer Res, 65, 6207-19 (2005) (Pubitemid 40994406)
    • (2005) Cancer Research , vol.65 , Issue.14 , pp. 6207-6219
    • Patrawala, L.1    Calhoun, T.2    Schneider-Broussard, R.3    Zhou, J.4    Claypool, K.5    Tang, D.G.6


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