메뉴 건너뛰기




Volumn 33, Issue 5, 2010, Pages 262-271

Helper T cell paradigm: Th17 and regulatory T cells involved in autoimmune inflammatory disorders, pathogen defense and allergic diseases

Author keywords

(ROR) t; Allergic diseases; Autoimmune inflammatory disorders; CCR6; Crohn disease; FOXP3; GATA 3; Helper T cell paradigm; Hyper IgE syndrome; IFN ; IL 1 ; IL 10; IL 12; IL 17; IL 17F; IL 21; IL 22; IL 23; IL 4; IL 6; IPEX syndrome; Neutrophilia; Pathogen defense; Regulatory T cells; RORC2; STAT3; T cell differentiation; T bet; TGF ; Th1 cells; Th17 cells; Th2 cells

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 17F; INTERLEUKIN 21; INTERLEUKIN 22; INTERLEUKIN 23; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; STAT3 PROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

EID: 78049486778     PISSN: 09114300     EISSN: 13497413     Source Type: Journal    
DOI: 10.2177/jsci.33.262     Document Type: Review
Times cited : (11)

References (69)
  • 1
    • 0024353079 scopus 로고
    • TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
    • Mosmann TR, Coffman RL. : TH1 and TH2 cells : different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7 : 145-173, 1989.
    • (1989) Annu Rev Immunol , vol.7 , pp. 145-173
    • Mosmann, T.R.1    Coffman, R.L.2
  • 2
    • 0029839059 scopus 로고    scopus 로고
    • Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell level
    • Sornasse T., Larenas P. V., Davis K. A., de Vries J. E., Yssel H. : Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell level. J Exp Med 184 : 473-483, 1996.
    • (1996) J Exp Med , vol.184 , pp. 473-483
    • Sornasse, T.1    Larenas, P.V.2    Davis, K.A.3    De Vries, J.E.4    Yssel, H.5
  • 3
    • 0032960198 scopus 로고    scopus 로고
    • IL-4 enhances IL-10 gene expression in murine Th2 cells in the absence of TCR engagement
    • Schmidt-Weber C. B., Alexander S. I., Henault L. E., James L., Lichtman A. H. : IL-4 enhances IL-10 gene expression in murine Th2 cells in the absence of TCR engagement. J Immunol 162 : 238-244, 1999.
    • (1999) J Immunol , vol.162 , pp. 238-244
    • Schmidt-Weber, C.B.1    Alexander, S.I.2    Henault, L.E.3    James, L.4    Lichtman, A.H.5
  • 4
    • 0031066654 scopus 로고    scopus 로고
    • Polarization of IL-4-and IFN-gamma-producing CD4+ T cells following activation of naive CD4+ T cells
    • Nakamura T., Kamogawa Y., Bottomly K., Flavell R. A. : Polarization of IL-4-and IFN-gamma-producing CD4+ T cells following activation of naive CD4+ T cells. J Immunol 158 : 1085-1094, 1997.
    • (1997) J Immunol , vol.158 , pp. 1085-1094
    • Nakamura, T.1    Kamogawa, Y.2    Bottomly, K.3    Flavell, R.A.4
  • 5
    • 8044250881 scopus 로고    scopus 로고
    • Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells
    • Szabo S. J., Dighe A. S., Gubler U., Murphy K. M. : Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J Exp Med 185 : 817-824. 1997.
    • (1997) J Exp Med , vol.185 , pp. 817-824
    • Szabo, S.J.1    Dighe, A.S.2    Gubler, U.3    Murphy, K.M.4
  • 6
    • 12344269852 scopus 로고    scopus 로고
    • T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3
    • Hwang E. S., Szabo S. J., Schwartzberg P. L., Glimcher L. H. : T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science 307 : 430-433, 2005.
    • (2005) Science , vol.307 , pp. 430-433
    • Hwang, E.S.1    Szabo, S.J.2    Schwartzberg, P.L.3    Glimcher, L.H.4
  • 7
    • 0029555301 scopus 로고
    • Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor
    • Yao Z, Fanslow WC, Seldin MF, Rousseau AM, Painter SL, Comeau MR, et al. : Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity 3 : 811-821, 1995.
    • (1995) Immunity , vol.3 , pp. 811-821
    • Yao, Z.1    Fanslow, W.C.2    Seldin, M.F.3    Rousseau, A.M.4    Painter, S.L.5    Comeau, M.R.6
  • 8
    • 15844402155 scopus 로고    scopus 로고
    • T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
    • Fossiez F, Djossou O, Chomarat P, Flores-Romo L, Ait-Yahia S, Maat C, et al. : T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J Exp Med 183 : 2593-2603, 1996.
    • (1996) J Exp Med , vol.183 , pp. 2593-2603
    • Fossiez, F.1    Djossou, O.2    Chomarat, P.3    Flores-Romo, L.4    Ait-Yahia, S.5    Maat, C.6
  • 9
    • 37549030879 scopus 로고    scopus 로고
    • Interleukin-17 as an effector molecule of innate and acquired immunity against infections
    • Matsuzaki G, Umemura M. : Interleukin-17 as an effector molecule of innate and acquired immunity against infections. Microbiol Immunol 51 : 1139-1147, 2007.
    • (2007) Microbiol Immunol , vol.51 , pp. 1139-1147
    • Matsuzaki, G.1    Umemura, M.2
  • 10
    • 44049104564 scopus 로고    scopus 로고
    • The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat
    • Manel N, Unutmaz D, Littman DR. : The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol 9 : 641-649, 2008.
    • (2008) Nat Immunol , vol.9 , pp. 641-649
    • Manel, N.1    Unutmaz, D.2    Littman, D.R.3
  • 11
    • 39449101603 scopus 로고    scopus 로고
    • Transcriptional regulation of Th17 cell differentiation
    • Ivanov II, Zhou L, Littman DR. : Transcriptional regulation of Th17 cell differentiation. Semin Immunol 19 : 409-417, 2007.
    • (2007) Semin Immunol , vol.19 , pp. 409-417
    • Ivanov, I.I.1    Zhou, L.2    Littman, D.R.3
  • 12
    • 41449110468 scopus 로고    scopus 로고
    • Impaired T (H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
    • Milner JD, Brenchley JM, Laurence A, Freeman AF, Hill BJ, Elias KM, et al. : Impaired T (H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature 452 : 773-776, 2008.
    • (2008) Nature , vol.452 , pp. 773-776
    • Milner, J.D.1    Brenchley, J.M.2    Laurence, A.3    Freeman, A.F.4    Hill, B.J.5    Elias, K.M.6
  • 13
    • 46949089128 scopus 로고    scopus 로고
    • Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3
    • Ma CS, Chew GY, Simpson N, Priyadarshi A, Wong M, Grimbacher B, et al. : Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3. J Exp Med 205 : 1551-1557. 2008.
    • (2008) J Exp Med , vol.205 , pp. 1551-1557
    • Ma, C.S.1    Chew, G.Y.2    Simpson, N.3    Priyadarshi, A.4    Wong, M.5    Grimbacher, B.6
  • 14
    • 34548125305 scopus 로고    scopus 로고
    • Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
    • Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F. : Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 8 : 942-949, 2007.
    • (2007) Nat Immunol , vol.8 , pp. 942-949
    • Acosta-Rodriguez, E.V.1    Napolitani, G.2    Lanzavecchia, A.3    Sallusto, F.4
  • 16
    • 0037449737 scopus 로고    scopus 로고
    • Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
    • Aggarwal S, Ghilardi N, Xie MH, de Sauvage FJ, Gurney AL. : Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem 278 : 1910-1914, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 1910-1914
    • Aggarwal, S.1    Ghilardi, N.2    Xie, M.H.3    De Sauvage, F.J.4    Gurney, A.L.5
  • 18
    • 33646397611 scopus 로고    scopus 로고
    • IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
    • Yen D, Cheung J, Scheerens H, Poulet F, McClanahan T, McKenzie B, et al. : IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest 116 : 1310-1316, 2006.
    • (2006) J Clin Invest , vol.116 , pp. 1310-1316
    • Yen, D.1    Cheung, J.2    Scheerens, H.3    Poulet, F.4    McClanahan, T.5    McKenzie, B.6
  • 19
    • 44049102724 scopus 로고    scopus 로고
    • A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses
    • Volpe E, Servant N, Zollinger R, Bogiatzi SI, Hupe P, Barillot E, et al. : A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat Immunol 9 : 650-657, 2008.
    • (2008) Nat Immunol , vol.9 , pp. 650-657
    • Volpe, E.1    Servant, N.2    Zollinger, R.3    Bogiatzi, S.I.4    Hupe, P.5    Barillot, E.6
  • 20
    • 51349111163 scopus 로고    scopus 로고
    • An overview of IL-17 function and signaling
    • Gaffen SL. : An overview of IL-17 function and signaling. Cytokine 43 : 402-407, 2008.
    • (2008) Cytokine , vol.43 , pp. 402-407
    • Gaffen, S.L.1
  • 21
    • 0025877075 scopus 로고
    • Antibody responses to protein, polysaccharide, and phi X174 antigens in the hyperimmunoglobulinemia E (hyper-IgE) syndrome
    • Sheerin KA, Buckley RH. : Antibody responses to protein, polysaccharide, and phi X174 antigens in the hyperimmunoglobulinemia E (hyper-IgE) syndrome. J Allergy Clin Immunol 87 : 803-811, 1991.
    • (1991) J Allergy Clin Immunol , vol.87 , pp. 803-811
    • Sheerin, K.A.1    Buckley, R.H.2
  • 22
    • 34848855805 scopus 로고    scopus 로고
    • Human CD4+ central and effector memory T cells produce IL-21: Effect on cytokinedriven proliferation of CD41 T cell subsets
    • Onoda T, Rahman M, Nara H, Araki A, Makabe K, Tsumoto K, et al. : Human CD4+ central and effector memory T cells produce IL-21 : effect on cytokinedriven proliferation of CD41 T cell subsets. Int Immunol 19 : 1191-1199, 2007.
    • (2007) Int Immunol , vol.19 , pp. 1191-1199
    • Onoda, T.1    Rahman, M.2    Nara, H.3    Araki, A.4    Makabe, K.5    Tsumoto, K.6
  • 23
    • 33846196712 scopus 로고    scopus 로고
    • IL-21 counteracts the regulatory T cell-mediated suppression of human CD4+ T lymphocytes
    • Peluso I, Fantini MC, Fina D, Caruso R, Boirivant M, MacDonald TT, et al. : IL-21 counteracts the regulatory T cell-mediated suppression of human CD4+ T lymphocytes. J Immunol 178 : 732-739, 2007.
    • (2007) J Immunol , vol.178 , pp. 732-739
    • Peluso, I.1    Fantini, M.C.2    Fina, D.3    Caruso, R.4    Boirivant, M.5    MacDonald, T.T.6
  • 24
    • 41549135632 scopus 로고    scopus 로고
    • The biological functions of T helper 17 cell effector cytokines in inflammation
    • Ouyang W, Kolls JK, Zheng Y. : The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 28 : 454-467, 2008.
    • (2008) Immunity , vol.28 , pp. 454-467
    • Ouyang, W.1    Kolls, J.K.2    Zheng, Y.3
  • 25
    • 33646552450 scopus 로고    scopus 로고
    • IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: A potential role in psoriasis
    • Wolk K, Witte E, Wallace E, Docke WD, Kunz S, Asadullah K, et al. : IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes : a potential role in psoriasis. Eur J Immunol 36 : 1309-1323, 2006.
    • (2006) Eur J Immunol , vol.36 , pp. 1309-1323
    • Wolk, K.1    Witte, E.2    Wallace, E.3    Docke, W.D.4    Kunz, S.5    Asadullah, K.6
  • 26
    • 51349111163 scopus 로고    scopus 로고
    • An overview of IL-17 function and signaling
    • Gaffen SL. : An overview of IL-17 function and signaling. Cytokine 43 : 402-407, 2008.
    • (2008) Cytokine , vol.43 , pp. 402-407
    • Gaffen, S.L.1
  • 27
    • 33645995745 scopus 로고    scopus 로고
    • The multiple personalities of the chemokine receptor CCR7 in dendritic cells
    • Sanchez-Sanchez N, Riol-Blanco L, Rodriguez-Fernandez JL. : The multiple personalities of the chemokine receptor CCR7 in dendritic cells. J Immunol 176 : 5153-5159, 2006.
    • (2006) J Immunol , vol.176 , pp. 5153-5159
    • Sanchez-Sanchez, N.1    Riol-Blanco, L.2    Rodriguez-Fernandez, J.L.3
  • 29
    • 36549019912 scopus 로고    scopus 로고
    • Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model
    • Hirota K, Yoshitomi H, Hashimoto M, Maeda S, Teradaira S, Sugimoto N, et al. : Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J Exp Med 204 : 2803-2812, 2007.
    • (2007) J Exp Med , vol.204 , pp. 2803-2812
    • Hirota, K.1    Yoshitomi, H.2    Hashimoto, M.3    Maeda, S.4    Teradaira, S.5    Sugimoto, N.6
  • 31
  • 32
    • 55149087226 scopus 로고    scopus 로고
    • From interleukin-23 to T-helper 17 cells: Human T-helper cell differentiation revisited
    • Boniface K., Blom B., Liu Y. J., de Waal Malefyt R. : From interleukin-23 to T-helper 17 cells : human T-helper cell differentiation revisited. Immunol Rev 226 : 132-146, 2008.
    • (2008) Immunol Rev , vol.226 , pp. 132-146
    • Boniface, K.1    Blom, B.2    Liu, Y.J.3    De Waal Malefyt, R.4
  • 33
    • 34548133583 scopus 로고    scopus 로고
    • Development, cytokine profile and function of human interleukin 17-producing helper T cells
    • Wilson N. J., Boniface K., Chan J. R., McKenzie B. S., Blumenschein W. M., Mattson J. D., et al : Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol 8 : 950-957, 2007.
    • (2007) Nat Immunol , vol.8 , pp. 950-957
    • Wilson, N.J.1    Boniface, K.2    Chan, J.R.3    McKenzie, B.S.4    Blumenschein, W.M.5    Mattson, J.D.6
  • 34
    • 0036188478 scopus 로고    scopus 로고
    • Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein
    • Bush K. A., Farmer K. M., Walker J. S., Kirkham B. W. : Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein. Arthritis Rheum 46 : 802-805, 2002.
    • (2002) Arthritis Rheum , vol.46 , pp. 802-805
    • Bush, K.A.1    Farmer, K.M.2    Walker, J.S.3    Kirkham, B.W.4
  • 35
    • 0037216818 scopus 로고    scopus 로고
    • Interleukin -17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma
    • Hellings P. W., Kasran A., Liu Z., Vandekerckhove P., Wuyts A., Overbergh L., et al. : Interleukin -17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma. Am J Respir Cell Mol Biol 28 : 42-50, 2003.
    • (2003) Am J Respir Cell Mol Biol , vol.28 , pp. 42-50
    • Hellings, P.W.1    Kasran, A.2    Liu, Z.3    Vandekerckhove, P.4    Wuyts, A.5    Overbergh, L.6
  • 37
    • 0031066654 scopus 로고    scopus 로고
    • Polarization of IL-4- and IFN-gamma-producing CD4+ T cells following activation of naive CD4+ T cells
    • Nakamura T., Kamogawa Y., Bottomly K., Flavell R. A. : Polarization of IL-4- and IFN-gamma-producing CD4+ T cells following activation of naive CD4+ T cells. J Immunol 158 : 1085-1094, 1997.
    • (1997) J Immunol , vol.158 , pp. 1085-1094
    • Nakamura, T.1    Kamogawa, Y.2    Bottomly, K.3    Flavell, R.A.4
  • 38
    • 33746863277 scopus 로고    scopus 로고
    • T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17
    • Rangachari M., Mauermann N., Marty R. R., Dirnhofer S., Kurrer M. O., Komnenovic V., et al. : T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17. J Exp Med 203 : 2009-2019, 2006.
    • (2006) J Exp Med , vol.203 , pp. 2009-2019
    • Rangachari, M.1    Mauermann, N.2    Marty, R.R.3    Dirnhofer, S.4    Kurrer, M.O.5    Komnenovic, V.6
  • 39
    • 0034677646 scopus 로고    scopus 로고
    • A novel transcription factor, T-bet, directs Th1 lineage commitment
    • Szabo S. J., Kim S. T., Costa G. L., Zhang X., Fathman C. G., Glimcher L. H. : A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100 : 655-669, 2000.
    • (2000) Cell , vol.100 , pp. 655-669
    • Szabo, S.J.1    Kim, S.T.2    Costa, G.L.3    Zhang, X.4    Fathman, C.G.5    Glimcher, L.H.6
  • 40
    • 3042598052 scopus 로고    scopus 로고
    • Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci
    • Yamashita M., Ukai-Tadenuma M., Miyamoto T., Sugaya K., Hosokawa H., Hasegawa A., et al. : Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci. J Biol Chem 279 : 26983-26990, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 26983-26990
    • Yamashita, M.1    Ukai-Tadenuma, M.2    Miyamoto, T.3    Sugaya, K.4    Hosokawa, H.5    Hasegawa, A.6
  • 41
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for Scurfin in CD4+CD25 + T regulatory cells
    • Khattri R., Cox T., Yasayko S. A., Ramsdell F. : An essential role for Scurfin in CD4+CD25 + T regulatory cells. Nat Immunol 4 : 337-342, 2003.
    • (2003) Nat Immunol , vol.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.A.3    Ramsdell, F.4
  • 42
    • 33748588423 scopus 로고    scopus 로고
    • The orphan nuclear receptor RORgammat directs the differentiation program of proin- flammatory IL-17+ T helper cells
    • Ivanov, II, II, McKenzie B. S., Zhou L., Tadokoro C. E., Lepelley A., Lafaille J. J., et al. : The orphan nuclear receptor RORgammat directs the differentiation program of proin- flammatory IL-17+ T helper cells. Cell 126 : 1121-1133, 2006.
    • (2006) Cell , vol.126 , pp. 1121-1133
    • Ivanov II, I.I.1    McKenzie, B.S.2    Zhou, L.3    Tadokoro, C.E.4    Lepelley, A.5    Lafaille, J.J.6
  • 43
    • 12344269852 scopus 로고    scopus 로고
    • T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3
    • Hwang E. S., Szabo S. J., Schwartzberg P. L., Glimcher L. H. : T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science 307 : 430-433, 2005.
    • (2005) Science , vol.307 , pp. 430-433
    • Hwang, E.S.1    Szabo, S.J.2    Schwartzberg, P.L.3    Glimcher, L.H.4
  • 44
    • 34147138648 scopus 로고    scopus 로고
    • Chromatin remodeling of interleukin-17 (IL- 17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation
    • Akimzhanov A. M., Yang X. O., Dong C. : Chromatin remodeling of interleukin-17 (IL- 17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation. J Biol Chem 282 : 5969-5972, 2007.
    • (2007) J Biol Chem , vol.282 , pp. 5969-5972
    • Akimzhanov, A.M.1    Yang, X.O.2    Dong, C.3
  • 45
    • 3042598052 scopus 로고    scopus 로고
    • Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci
    • Yamashita M., Ukai-Tadenuma M., Miyamoto T., Sugaya K., Hosokawa H., Hasegawa A., et al. : ? Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci. J Biol Chem 279 : 26983-26990, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 26983-26990
    • Yamashita, M.1    Ukai-Tadenuma, M.2    Miyamoto, T.3    Sugaya, K.4    Hosokawa, H.5    Hasegawa, A.6
  • 46
    • 33947177232 scopus 로고    scopus 로고
    • Chromatin remodeling by the SWI/SNF-like BAF complex and STAT4 activation synergistically induce IL-12Rbeta2 expression during human Th1 cell differentiation
    • Letimier F. A., Passini N., Gasparian S., Bianchi E., Rogge L. : Chromatin remodeling by the SWI/SNF-like BAF complex and STAT4 activation synergistically induce IL-12Rbeta2 expression during human Th1 cell differentiation. EMBO J 26 : 1292-1302, 2007.
    • (2007) EMBO J , vol.26 , pp. 1292-1302
    • Letimier, F.A.1    Passini, N.2    Gasparian, S.3    Bianchi, E.4    Rogge, L.5
  • 47
    • 33646196946 scopus 로고    scopus 로고
    • Regulation of Th2 differentiation and Il4 locus accessibility
    • Ansel K. M., Djuretic I., Tanasa B., Rao A. : Regulation of Th2 differentiation and Il4 locus accessibility. Annu Rev Immunol 24 : 607-656, 2006.
    • (2006) Annu Rev Immunol , vol.24 , pp. 607-656
    • Ansel, K.M.1    Djuretic, I.2    Tanasa, B.3    Rao, A.4
  • 48
    • 0034327176 scopus 로고    scopus 로고
    • Cutting edge: TGF-beta inhibits Th type 2 development through inhibition of GATA-3 expression
    • Gorelik L., Fields P. E., Flavell R. A. : Cutting edge : TGF-beta inhibits Th type 2 development through inhibition of GATA-3 expression. J Immunol 165 : 4773-4777, 2000.
    • (2000) J Immunol , vol.165 , pp. 4773-4777
    • Gorelik, L.1    Fields, P.E.2    Flavell, R.A.3
  • 49
    • 0033623339 scopus 로고    scopus 로고
    • TGF-beta1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression
    • Heath V. L., Murphy E. E., Crain C., Tomlinson M. G., O'Garra A. : TGF-beta1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression. Eur J Immunol 30 : 2639-2649, 2000.
    • (2000) Eur J Immunol , vol.30 , pp. 2639-2649
    • Heath, V.L.1    Murphy, E.E.2    Crain, C.3    Tomlinson, M.G.4    O'Garra, A.5
  • 50
    • 34248592104 scopus 로고    scopus 로고
    • T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1-and Th17-cell differentiation
    • Li M. O., Wan Y. Y., Flavell R. A. : T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1-and Th17-cell differentiation. Immunity 26 : 579-591, 2007.
    • (2007) Immunity , vol.26 , pp. 579-591
    • Li, M.O.1    Wan, Y.Y.2    Flavell, R.A.3
  • 51
    • 33846906224 scopus 로고    scopus 로고
    • Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
    • Zheng Y., Danilenko D. M., Valdez P., Kasman I., Eastham-Anderson J., Wu J., et al. : Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 445 : 648-651, 2007.
    • (2007) Nature , vol.445 , pp. 648-651
    • Zheng, Y.1    Danilenko, D.M.2    Valdez, P.3    Kasman, I.4    Eastham-Anderson, J.5    Wu, J.6
  • 52
    • 33845576001 scopus 로고    scopus 로고
    • Up-regulation of IL-23p19 expression in rheumatoid arthritis synovial fibroblasts by IL-17 through PI3-kinase-, NF-kappaB-and p38 MAPK-dependent signalling pathways
    • Oxford
    • Kim H. R., Cho M. L., Kim K. W., Juhn J. Y., Hwang S. Y., Yoon C. H., et al. : Up-regulation of IL-23p19 expression in rheumatoid arthritis synovial fibroblasts by IL-17 through PI3-kinase-, NF-kappaB-and p38 MAPK-dependent signalling pathways. Rheumatology (Oxford) 46 : 57-64, 2007.
    • (2007) Rheumatology , vol.46 , pp. 57-64
    • Kim, H.R.1    Cho, M.L.2    Kim, K.W.3    Juhn, J.Y.4    Hwang, S.Y.5    Yoon, C.H.6
  • 53
    • 33744996730 scopus 로고    scopus 로고
    • + regulatory T cells in self-tolerance and autoimmune disease
    • Current Concepts in Autoimmunity and Chronic Inflammation
    • Sakaguchi S, Setoguchi R, Yagi H, Nomura T. : Naturally arising Foxp3-expressing CD251CD41 regulatory T cells in self-tolerance and autoimmune disease. Curr Top Microbiol Immunol 305 : 51-66, 2006. (Pubitemid 47400264)
    • (2006) Current Topics in Microbiology and Immunology , vol.305 , pp. 51-66
    • Sakaguchi, S.1    Setoguchi, R.2    Yagi, H.3    Nomura, T.4
  • 54
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, et al. : Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441 : 235-238, 2006.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6
  • 55
    • 34247564147 scopus 로고    scopus 로고
    • Nonredundant roles for Stat5a/b in directly regulating Foxp3
    • Yao Z, Kanno Y, Kerenyi M, Stephens G, Durant L, Watford WT, et al. : Nonredundant roles for Stat5a/b in directly regulating Foxp3. Blood 109 : 4368-4375, 2007.
    • (2007) Blood , vol.109 , pp. 4368-4375
    • Yao, Z.1    Kanno, Y.2    Kerenyi, M.3    Stephens, G.4    Durant, L.5    Watford, W.T.6
  • 56
    • 33845935950 scopus 로고    scopus 로고
    • IL-2 receptor betadependent STAT5 activation is required for the development of Foxp31 regulatory T cells
    • Burchill MA, Yang J, Vogtenhuber C, Blazar BR, Farrar MA. : IL-2 receptor betadependent STAT5 activation is required for the development of Foxp31 regulatory T cells. J Immunol 178 : 280-290, 2007.
    • (2007) J Immunol , vol.178 , pp. 280-290
    • Burchill, M.A.1    Yang, J.2    Vogtenhuber, C.3    Blazar, B.R.4    Farrar, M.A.5
  • 57
    • 53149137849 scopus 로고    scopus 로고
    • Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression
    • Xiao S, Jin H, Korn T, Liu SM, Oukka M, Lim B, et al. : Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression. J Immunol 181 : 2277-2284, 2008.
    • (2008) J Immunol , vol.181 , pp. 2277-2284
    • Xiao, S.1    Jin, H.2    Korn, T.3    Liu, S.M.4    Oukka, M.5    Lim, B.6
  • 58
    • 7044284788 scopus 로고    scopus 로고
    • Regulation and role of transforming growth factor-beta in immune tolerance induction and inflammation
    • Schmidt-Weber C. B., Blaser K. : Regulation and role of transforming growth factor-beta in immune tolerance induction and inflammation. Curr Opin Immunol 16 : 709-716, 2004.
    • (2004) Curr Opin Immunol , vol.16 , pp. 709-716
    • Schmidt-Weber, C.B.1    Blaser, K.2
  • 59
    • 33846005781 scopus 로고    scopus 로고
    • IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin
    • Clark R. A., Kupper T. S. : IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin. Blood 109 : 194-202, 2007.
    • (2007) Blood , vol.109 , pp. 194-202
    • Clark, R.A.1    Kupper, T.S.2
  • 60
    • 51049101255 scopus 로고    scopus 로고
    • CD41 FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner
    • Andersson J, Tran DQ, Pesu M, Davidson TS, Ramsey H, O'Shea JJ, et al. : CD41 FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner. J Exp Med 205 : 1975-1981, 2008.
    • (2008) J Exp Med , vol.205 , pp. 1975-1981
    • Andersson, J.1    Tran, D.Q.2    Pesu, M.3    Davidson, T.S.4    Ramsey, H.5    O'Shea, J.J.6
  • 61
    • 35948964817 scopus 로고    scopus 로고
    • Regulatory T cells in primary immunodeficiency diseases
    • Torgerson TR, Ochs HD. : Regulatory T cells in primary immunodeficiency diseases. Curr Opin Allergy Clin Immunol 7 : 515-521, 2007.
    • (2007) Curr Opin Allergy Clin Immunol , vol.7 , pp. 515-521
    • Torgerson, T.R.1    Ochs, H.D.2
  • 62
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD41CD251 regulatory T cells
    • Fontenot JD, Gavin MA, Rudensky AY. : Foxp3 programs the development and function of CD41CD251 regulatory T cells. Nat Immunol 4 : 330-336, 2003.
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 63
    • 0035576221 scopus 로고    scopus 로고
    • The amount of scurfin protein determines peripheral T cell number and responsiveness
    • Khattri R, Kasprowicz D, Cox T, Mortrud M, Appleby MW, Brunkow ME, et al. : The amount of scurfin protein determines peripheral T cell number and responsiveness. J Immunol 167 : 6312-6320, 2001.
    • (2001) J Immunol , vol.167 , pp. 6312-6320
    • Khattri, R.1    Kasprowicz, D.2    Cox, T.3    Mortrud, M.4    Appleby, M.W.5    Brunkow, M.E.6
  • 65
    • 33746933828 scopus 로고    scopus 로고
    • TGF-beta-mediated suppression by CD4+CD25+ T cells is facilitated by CTLA-4 signaling
    • Oida T., Xu L., Weiner H.L., Kitani A., Strober W. : TGF-beta-mediated suppression by CD4+CD25+ T cells is facilitated by CTLA-4 signaling. J Immunol 177 : 2331-2339, 2006.
    • (2006) J Immunol , vol.177 , pp. 2331-2339
    • Oida, T.1    Xu, L.2    Weiner, H.L.3    Kitani, A.4    Strober, W.5
  • 66
    • 46949111560 scopus 로고    scopus 로고
    • Foxp31 regulatory T cells maintain immune homeostasis in the skin
    • Dudda JC, Perdue N, Bachtanian E, Campbell DJ. : Foxp31 regulatory T cells maintain immune homeostasis in the skin. J Exp Med 205 : 1559-1565, 2008.
    • (2008) J Exp Med , vol.205 , pp. 1559-1565
    • Dudda, J.C.1    Perdue, N.2    Bachtanian, E.3    Campbell, D.J.4
  • 67
    • 0034077559 scopus 로고    scopus 로고
    • CD4+ CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells
    • Cederbom L., Hall H., Ivars F. : CD4+ CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells. Eur J Immunol 30 : 1538-1543, 2000.
    • (2000) Eur J Immunol , vol.30 , pp. 1538-1543
    • Cederbom, L.1    Hall, H.2    Ivars, F.3
  • 69
    • 1842581857 scopus 로고    scopus 로고
    • Cutting edge: Human CD4+CD25+ T cells restrain the maturation and antigen-presenting function of dendritic cells
    • Misra N., Bayry J., Lacroix-Desmazes S., Kazatchkine M. D., Kaveri S. V. : Cutting edge : human CD4+CD25+ T cells restrain the maturation and antigen-presenting function of dendritic cells. J Immunol 172 : 4676-4680, 2004.
    • (2004) J Immunol , vol.172 , pp. 4676-4680
    • Misra, N.1    Bayry, J.2    Lacroix-Desmazes, S.3    Kazatchkine, M.D.4    Kaveri, S.V.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.